Article
Chemistry, Applied
Huong Thi Hoang, Sung-Han Jo, Quoc-Thang Phan, Hansol Park, Sang-Hyug Park, Chul-Woong Oh, Kwon Taek Lim
Summary: A dual pH-/thermo-responsive hydrogel was successfully designed using a polyelectrolyte complex and chemical crosslinking, demonstrating high drug loading capacity and controlled drug release properties at different pH levels, showing promising applications in colon-targeted drug delivery systems.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Haibin Zhang, Zhiyang Gu, Wenya Li, Lili Guo, Litong Wang, Lan Guo, Saibo Ma, Baoqin Han, Jing Chang
Summary: Oral drug delivery is the most preferred mode of treatment due to its convenience and non-invasiveness. However, delivering protein drugs orally has been a challenge. This study developed a novel OCMC/SA nanohydrogel that solves this problem, with high drug loading capacity and passive drug targeting function.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Thu Thao Pham, Tien Duc Pham, Shin-ichi Yusa
Summary: In this study, a diblock copolymer was synthesized via a reversible addition-fragmentation chain transfer radical polymerization. Water-soluble polyion complex (PIC) vesicles were formed by electrostatic interactions between the oppositely charged blocks. The vesicles exhibited pH- and thermo-responsive behavior, making them potential candidates for smart drug delivery systems.
Article
Multidisciplinary Sciences
Supachok Tanpichai, Farin Phoothong, Anyaporn Boonmahitthisud
Summary: This study successfully prepared cross-linked hydrogels from cellulose extracted from water hyacinth. The incorporation of borax provided superabsorbent properties to the cellulose hydrogels, and the gel fraction and swelling ratio of the cross-linked hydrogels increased significantly. Moreover, the cross-linked cellulose-based hydrogels showed antibacterial activity and flame retardancy.
SCIENTIFIC REPORTS
(2022)
Article
Materials Science, Multidisciplinary
Busra Sekizkardes, Esra Su, Oguz Okay
Summary: Polymers based on AMPS have high water absorption capacity when swollen in water. PAMPS hydrogels, synthesized via free-radical cross-linking copolymerization, have poor mechanical properties. Here, we demonstrate that terpolymerization of AMPS, MAAc, and DMAA without a chemical cross-linker produces mechanically strong hydrogen-bonded hydrogels. The water content during gelation affects the microstructure and mechanical properties of the hydrogels.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Ross D. Jansen-van Vuuren, Guilherme Drechsler Vilela, Maedeh Ramezani, Peter H. Gilbert, Danika Watson, Nathan Mullins, Allen K. Lucas, Alan Jeffrey Giacomin, Michael F. Cunningham, Philip G. Jessop
Summary: A CO2-responsive SAP hydrogel capable of switching between hydrophobic and hydrophilic states in the presence of CO2 has been reported. These hydrogels can absorb and release water with the presence or absence of CO2, demonstrating their reusability and potential for various applications.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Polymer Science
Munir Ahmad Khan, Abul Kalam Azad, Muhammad Safdar, Asif Nawaz, Muhammad Akhlaq, Pijush Paul, Md. Kamal Hossain, Md. Habibur Rahman, Roua S. Baty, Attalla F. El-kott, Mohamed Kamel, Simona G. Bungau, Mohamed M. Abdel-Daim
Summary: This study aimed to synthesize and characterize pH-sensitive hydrogels loaded with 5-fluorouracil and investigate their controlled release properties. The formulations exhibited different swelling and release behaviors at different pH conditions, suggesting their potential as oral controlled colon drug delivery carriers.
Article
Multidisciplinary Sciences
Parker Toews, Jeffrey Bates
Summary: Drug release kinetics in methacrylate hydrogels were modified by adjusting the molecular weight of the hydrogels, leading to increased stability and enhanced release performance. Spectroscopy techniques provided insights into the chemical structure, target molecule concentration, and optical performance of the hydrogels.
SCIENTIFIC REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Lin Liu, Wendong Yao, Xiaowei Xie, Jianqing Gao, Xiaoyang Lu
Summary: A novel dual drug delivery system was designed to achieve synergistic analgesia between najanajaatra venom protein and resveratrol. The Janus nanoparticles were able to pass through intestinal epithelial cells and showed significant synergistic analgesic effects in animal models. This study provides new insights into the oral administration and analgesic treatment of dual drug delivery systems containing peptide drugs.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Engineering, Chemical
Guoying Feng, Runkai Su, Zhiguo Yan, Shaoping Li, Man Xu, Cunwen Wang, Yanbo Li
Summary: In this study, polyelectrolyte complex nanofiltration membranes with lower molecular weight cut-off and lower salt rejections were prepared by electrostatic deposition method. The crosslinking steps reversed the charge property of the membrane surface and narrowed the pores of the membrane, resulting in higher rejections for both salts and organics. These results demonstrate the feasibility of using the simple electrostatic deposition method to prepare low molecular weight cut-off nanofiltration membranes for trace organic removal.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Polymer Science
Moises Bustamante-Torres, Victor H. Pino-Ramos, David Romero-Fierro, Sandra P. Hidalgo-Bonilla, Hector Magana, Emilio Bucio
Summary: The design of a new pH-sensitive hydrogel for localized prophylactic release of ciprofloxacin and silver nanoparticles was presented in this study. The hydrogel was copolymerized using gamma rays and characterized using various analytical techniques. The antimicrobial activity of the hydrogel against E. coli and MRSA was evaluated in vitro.
Article
Biochemistry & Molecular Biology
Madhappan Santhamoorthy, Kokila Thirupathi, Sathish Sundar Dhilip Kumar, Saravanan Pandiaraj, Mostafizur Rahaman, Thi Tuong Vy Phan, Seong-Cheol Kim
Summary: The development of a magnetic iron oxide nanoparticles integrated polyelectrolyte complex-based hydrogel (MPEC HG) system with dual stimuli responsiveness for specific drug delivery has been investigated. The magnetic nanoparticles were synthesized in the synthetic polymer polyhexamethylene guanidine (PHMG), and the natural biopolymer k-carrageenan (kCG) was used to form the polyelectrolyte complex (PEC) through charge-balancing interaction. The MPEC HG system demonstrated great drug loading efficiency and enhanced drug release under the combined pH and temperature stimuli conditions, making it a potential candidate for dual stimuli-responsive drug delivery applications in cancer therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Demet Kaya Aktas, Filiz Oztekin
Summary: Ionic hydrogels are suitable for drug delivery applications, and in this study, pH-sensitive P(AAc-co-AAm) hydrogels were investigated for swelling properties using a hydrophilic fluorescence probe, 4sPy. The fluorescence intensity of 4sPy was monitored during swelling processes at different pH values, showing similar behavior to trapped drug carriers. These hydrogels could be useful for targeted drug delivery systems in the jejunum, with potential for 4sPy as a monitoring probe for drug carriers.
Article
Pharmacology & Pharmacy
Xinyu Peng, Qi Han, Xuedong Zhou, Yanyan Chen, Xiaoyu Huang, Xiao Guo, Ruiting Peng, Haohao Wang, Xian Peng, Lei Cheng
Summary: Dental caries is a preventable infectious disease caused by interactions between oral bacteria and dietary sugars. pH-sensitive drug delivery systems have become innovative materials for caries prevention. In this study, a pH-sensitive carrier (poly(DMAEMA-co-HEMA)) was used to synthesize a nanomaterial loaded with chlorhexidine (p(DH)@CHX), which exhibited good pH sensitivity and sustained release of CHX in an acidic environment. It showed lower cytotoxicity than free CHX and had the same antibacterial effects on biofilms. In addition, it had the potential to alter oral microbiota composition and reduce caries risk.
Article
Chemistry, Applied
Minquan Xia, Zhaoyu Cui, Tao Zeng, LiZhi Lu, Long Sheng, Zhaoxia Cai
Summary: This work achieved pH-responsive oral delivery of IgY-Fab fragments using cellulose based multi-network composite hydrogels, demonstrating stability and interactions between Fab and the hydrogel matrix.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)