期刊
CANCER TREATMENT REVIEWS
卷 63, 期 -, 页码 61-70出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ctrv.2017.12.001
关键词
Chromosomal translocations; Fusion genes; Sarcomas; Therapeutic strategies
类别
资金
- Gattegno and Wechsler funds
- Sarcoma Foundation of America (SFA)
- National Cancer Institute (NCI)/National Institutes of Health (NIH) [CA151452-01]
- China Scholarship Council
Chromosomal translocations and fusion genes are very common in human cancer especially in subtypes of sarcomas, such as rhabdomyosarcoma, Ewing's sarcoma, synovial sarcoma and liposarcoma. The discovery of novel chromosomal translocations and fusion genes in different tumors are due to the advancement of next-generation sequencing (NGS) technologies such as whole genome sequencing. Recently, many novel chromosomal translocations and gene fusions have been identified in different types of sarcoma through NGS approaches. In addition to previously known sarcoma fusion genes, these novel specific fusion genes and associated molecular events represent important targets for novel therapeutic approaches in the treatment of sarcomas. This review focuses on recent advances in chromosomal translocations and fusion genes in sarcomas and their potential therapeutic applications in the treatment of sarcomas. (C) 2017 Elsevier Ltd. All rights reserved.
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