Article
Urology & Nephrology
Daniel R. Greenberg, Hriday P. Bhambhvani, Satvir S. Basran, Brett P. Salazar, Luis Carl Rios, Sin-Jin Li, Che-Hong Chen, Daria Mochly-Rosen, Michael L. Eisenberg
Summary: This study found an association between alcohol intake and semen parameters among East Asian men carrying the ALDH2*2 allele. Alcohol consumption was associated with significantly lower total and progressive sperm motility in ALDH2*2 carriers. Furthermore, ALDH2 expression in spermatozoa was significantly lower in ALDH2*2 carriers.
JOURNAL OF UROLOGY
(2022)
Article
Multidisciplinary Sciences
Yi-Cheng Chang, Hsiao-Lin Lee, Wenjin Yang, Meng-Lun Hsieh, Cai-Cin Liu, Tung-Yuan Lee, Jing-Yong Huang, Jiun-Yi Nong, Fu-An Li, Hsiao-Li Chuang, Zhi-Zhong Ding, Wei-Lun Su, Li-Yun Chueh, Yi-Ting Tsai, Che-Hong Chen, Daria Mochly-Rosen, Lee-Ming Chuang
Summary: Obesity and type 2 diabetes are global pandemics. Mutations in the ALDH2 gene result in reduced enzymatic activity, leading to metabolic disorders. Activating ALDH2 can improve diet-induced obesity, fatty liver, and glucose homeostasis.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Georgia Martimianaki, Gianfranco Alicandro, Claudio Pelucchi, Rossella Bonzi, Matteo Rota, Jinfu Hu, Kenneth C. Johnson, Charles S. Rabkin, Linda M. Liao, Rashmi Sinha, Zuo-Feng Zhang, Michela Dalmartello, Nuno Lunet, Samantha Morais, Domenico Palli, Monica Ferraroni, Guo-Pei Yu, Shoichiro Tsugane, Akihisa Hidaka, Maria Paula Curado, Emmanuel Dias-Neto, David Zaridze, Dmitry Maximovitch, Jesus Vioque, Manoli Garcia de la Hera, Lizbeth Lopez-Carrillo, Raul Ulises Hernandez-Ramirez, Gerson Shigueaki Hamada, Mary H. Ward, Lina Mu, Reza Malekzadeh, Farhad Pourfarzi, Antonia Trichopoulou, Anna Karakatsani, Robert C. Kurtz, Areti Lagiou, Pagona Lagiou, Stefania Boccia, Paolo Boffetta, M. Constanza Camargo, Eva Negri, Carlo La Vecchia
Summary: There is a weak inverse association between tea consumption and gastric cancer, especially among regular green tea drinkers in China and Japan, individuals with H. pylori infection, and those with gastric cardia cancer.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Chang Kyun Choi, Jungho Yang, Sun-Seog Kweon, Sang-Hee Cho, Hye-Yeon Kim, Eun Myung, Min-Ho Shin
Summary: In Eastern Asians, ALDH2 rs671 polymorphisms are associated with esophageal cancer, which may be linked to acetaldehyde accumulation. The study found that in men, the risk of esophageal cancer was higher with GA and AA genotypes, while in women, the risk was higher with GA and AA genotypes as well. Additionally, in men, the association between ALDH2 polymorphisms and esophageal cancer was influenced by alcohol consumption.
Article
Oncology
Kexin Jin, Rayjean J. Hung, Sera Thomas, Loic Le Marchand, Keitaro Matsuo, Adeline Seow, Hongbing Shen, Woon-Puay Kok, Jian-Min Yuan, Ming Wu, Liming Li, Jin-Kou Zhao, Zuo-Feng Zhang
Summary: Late onset of menarche and menopause in Asian women is associated with increased risk of lung cancer, while nonnatural menopause has a higher risk. Having more live births is associated with a lower risk of lung cancer, while delivering the first child at an older age is associated with an increased risk. The use of oral contraceptives may have a protective effect against lung cancer.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Endocrinology & Metabolism
Antonella Turla, Manuel Zamparini, Massimo Milione, Salvatore Grisanti, Vito Amoroso, Rebecca Pedersini, Deborah Cosentini, Alfredo Berruti
Summary: Ovarian strumal carcinoid is a rare tumor that consists of both thyroid and carcinoid components. Most cases exhibit a benign behavior and surgery is the main treatment. However, a small group of patients may experience disease recurrence with both thyroid and neuroendocrine (carcinoid) components.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Zahra Maleki, Mohebat Vali, Hossein-Ali Nikbakht, Soheil Hassanipour, Aida Kouhi, Saman Sedighi, Roya Farokhi, Haleh Ghaem
Summary: Ovarian cancer is a common and deadly disease among women. This study evaluates the survival rate of ovarian cancer patients in Asia, providing valuable information for improving standard of care and developing effective interventions for prevention and treatment. The results show that the 1-year survival rate is higher than the 3- and 5-year rates, and there is no relationship between the year of study and survival rate.
Article
Oncology
Zhuxuan Fu, Maria Mori Brooks, Sarah Irvin, Susan Jordan, Katja K. H. Aben, Hoda Anton-Culver, Elisa Bandera, Matthias W. Beckmann, Andrew Berchuck, Angela Brooks-Wilson, Jenny Chang-Claude, Linda S. Cook, Daniel W. Cramer, Kara L. Cushing-Haugen, Jennifer A. Doherty, Arif B. Ekici, Peter A. Fasching, Renee T. Fortner, Simon A. Gayther, Aleksandra Gentry-Maharaj, Graham G. Giles, Ellen L. Goode, Marc T. Goodman, Holly R. Harris, Alexander Hein, Rudolf Kaaks, Lambertus A. Kiemeney, Martin Koebel, Joanne Kotsopoulos, Nhu D. Le, Alice W. Lee, Keitaro Matsuo, Valerie McGuire, John R. McLaughlin, Usha Menon, Roger L. Milne, Kirsten B. Moysich, Celeste Leigh Pearce, Malcolm C. Pike, Bo Qin, Susan J. Ramus, Marjorie J. Riggan, Joseph H. Rothstein, Joellen M. Schildkraut, Weiva Sieh, Rebecca Sutphen, Kathryn L. Terry, Pamela J. Thompson, Linda Titus, Anne M. van Altena, Emily White, Alice S. Whittemore, Anna H. Wu, Wei Zheng, Argyrios Ziogas, Sarah E. Taylor, Lu Tang, Thomas Songer, Nicolas Wentzensen, Penelope M. Webb, Harvey A. Risch, Francesmary Modugno
Summary: The lifetime ovulatory years (LOY) are positively associated with nonmucinous epithelial ovarian cancer (EOC) risk, implicating factors beyond ovulation in the development of EOC. The protective effects of parity and oral contraceptive use may not solely depend on anovulation.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Giulia Collatuzzo, Claudio Pelucchi, Eva Negri, Lizbeth Lopez-Carrillo, Shoichiro Tsugane, Akihisa Hidaka, Gerson Shigueaki Hamada, Raul Ulises Hernandez-Ramirez, Malaquias Lopez-Cervantes, Reza Malekzadeh, Farhad Pourfarzi, Lina Mu, Zuo-Feng Zhang, Nuno Lunet, Carlo La Vecchia, Paolo Boffetta
Summary: The analysis revealed that there is a super-multiplicative interaction between Hp infection and alcohol drinking, as well as high salt intake, while the interaction with smoking and socioeconomic status is weaker. The interactions were more pronounced in individuals with a history of peptic ulcer.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Marco Mariani, Roberta Pastorino, Denise Pires Marafon, Ken C. Johnson, Jinfu Hu, Antonio Jose Molina de la Torre, Guillermo Fernandez-Tardon, David Zaridze, Dmitry Maximovich, Eva Negri, Carlo La Vecchia, Zuo-Feng Zhang, Robert C. Kurtz, Claudio Pelucchi, Matteo Rota, Stefania Boccia
Summary: This study aimed to estimate the association between leisure-time physical activity (PA) and gastric cancer (GC) through a pooled analysis of case-control studies. The results showed no significant relationship between leisure-time PA and GC, except for a slight decreased risk below age 55 and in control population-based studies.
Review
Pharmacology & Pharmacy
Hong Zhang, Liwu Fu
Summary: ALDH2 plays a crucial role in tumorigenesis and progression, with the ALDH2*2 polymorphism associated with tumor development. This study summarizes the essential functions and potential mechanisms of ALDH2 in cancer. Therefore, ALDH2 is considered a potential therapeutic target for cancer treatment.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Substance Abuse
Won Kim Cook, Christina C. Tam, Susan E. Luczak, William C. Kerr, Nina Mulia, Camillia Lui, Libo Li
Summary: The relationship between alcohol consumption and cardiovascular disease and related conditions in Asian Americans, as well as how these risks vary among subgroups, are poorly understood. Alcohol consumption was found to be associated with hypertension in Asian males, while the higher ALDH2*2 ethnic group had a lower risk of CVD-related conditions overall. However, among females in the higher ALDH2*2 group, consuming more than 7 drinks per week was associated with increased risk of various conditions.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Ophthalmology
Yee Ling Wong, Xiangjia Zhu, Yih Chung Tham, Jason C. S. Yam, Keke Zhang, Charumathi Sabanayagam, Carla Lanca, Xiujuan Zhang, So Young Han, Wenwen He, Pradeep Susvar, Mihir Trivedi, Nan Yuan, Sarang Lambat, Rajiv Raman, Su Jeong Song, Ya Xing Wang, Mukharram M. Bikbov, Vinay Nangia, Li Jia Chen, Tien Yin Wong, Ecosse Luc Lamoureux, Chi-Pui Pang, Ching Yu Cheng, Yi Lu, Jost B. Jonas, Seang Mei Saw
Summary: In this study, older age, female, lower education, greater myopia severity and longer AL were identified as predictors of myopic macular degeneration. Myopic spherical equivalent (SE) was found to be the strongest single predictor of MMD, with a marginally higher AUC when combined with age, education and gender.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Oncology
Soo Jin Park, Eun Ji Lee, Taek Sang Lee, Kung-Liahng Wang, Aikou Okamoto, Kazunori Ochiai, Hee Seung Kim, Jae-Weon Kim
Summary: In Asia, the practice patterns in debulking surgery for advanced ovarian cancer often lean towards relatively lenient criteria for optimal debulking surgery and a preference for neoadjuvant chemotherapy. Many practitioners still rely on aggressive surgery performed by specialists.
Article
Clinical Neurology
Akram Hernandez-Vasquez, Rodrigo Vargas-Fernandez, Guido Bendezu-Quispe
Summary: This study aimed to evaluate the relationship between binge drinking and suicidal ideation in Peruvian adolescents. The study found that between 2013 and 2019, nine out of every 100 Peruvian adolescents had suicidal ideation, and six out of every 100 adolescents engaged in binge drinking. The study also found an association between binge drinking and suicidal ideation in Peruvian adolescents.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Peripheral Vascular Disease
Shohei Chatani, Ryota Tsukii, Kyohei Nagasawa, Takaaki Hasegawa, Shinichi Murata, Mina Kato, Hidekazu Yamaura, Hiroaki Onaya, Keitaro Matsuo, Yoshiyuki Watanabe, Yoshitaka Inaba
Summary: This study investigated the difficulty in removing totally implantable venous access devices (TIVADs) and identified associated risk factors. Interventional radiology (IR) approaches for difficult removal were also explored. The results showed that indwelling duration and subcutaneous leakage of fluid were significant risk factors for difficult removal. IR techniques were found to be minimally invasive and useful in some cases.
JOURNAL OF VASCULAR ACCESS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Neerav Goyal, Max Hennessy, Erik Lehman, Wenxue Lin, Antonio Agudo, Wolfgang Ahrens, Stefania Boccia, Paul Brennan, Hermann Brenner, Gabriella Cadoni, Cristina Canova, Chu Chen, David Conway, Maria Paula Curado, Luigino Dal Maso, Alexander W. Daudt, Valeria Edefonti, Eleonora Fabianova, Leticia Fernandez, Silvia Franceschi, Werner Garavello, Maura Gillison, Richard B. Hayes, Claire Healy, Rolando Herrero, Ivana Holcatova, Jossy L. Kanda, Karl Kelsey, Bo T. Hansen, Rosalina Koifman, Pagona Lagiou, Carlo La Vecchia, Fabio Levi, Guojun Li, Jolanta Lissowska, Rossana Mendoza Lopez, Daniele Luce, Gary Macfarlane, Dana Mates, Keitaro Matsuo, Michael McClean, Ana Menezes, Gwenn Menvielle, Hal Morgenstern, Kirsten Moysich, Eva Negri, Andrew F. Olshan, Tamas Pandics, Jerry Polesel, Mark Purdue, Loredana Radoi, Heribert Ramroth, Lorenzo Richiardi, Stimson Schantz, Stephen M. Schwartz, Diego Serraino, Oxana Shangina, Elaine Smith, Erich M. Sturgis, Beata Swiatkowska, Peter Thomson, Thomas L. Vaughan, Marta Vilensky, Deborah M. Winn, Victor Wunsch-Filho, Guo-Pei Yu, Jose P. Zevallos, Zuo-Feng Zhang, Tongzhang Zheng, Ariana Znaor, Paolo Boffetta, Mia Hashibe, Yuan-Chin A. Lee, Joshua E. Muscat
Summary: This study analyzed the relationship between cigarette smoking, alcohol consumption, and head and neck cancer risk factors in less developed and more developed countries. The results showed that the duration of smoking and alcohol consumption had different effects on the risk of specific cancer sites depending on the country's level of development. These findings suggest that the degree of industrialization and economic development affects the relationship between smoking, alcohol, and head and neck cancer.
Article
Gastroenterology & Hepatology
Julia Schroeder, Laura Chegwidden, Carlo Maj, Jan Gehlen, Jan Speller, Anne C. Boehmer, Oleg Borisov, Timo Hess, Nicole Kreuser, Marino Venerito, Hakan Alakus, Andrea May, Christian Gerges, Thomas Schmidt, Rene Thieme, Dominik Heider, Axel M. Hillmer, Julian Reingruber, Orestis Lyros, Arne Dietrich, Albrecht Hoffmeister, Matthias Mehdorn, Florian Lordick, Gertraud Stocker, Michael Hohaus, Daniel Reim, Jennis Kandler, Michaela Mueller, Alanna Ebigbo, Claudia Fuchs, Christiane J. Bruns, Arnulf H. Holscher, Hauke Lang, Peter P. Grimminger, Dani Dakkak, Yogesh Vashist, Sandra May, Siegfried Gorg, Andre Franke, David Ellinghaus, Sara Galavotti, Lothar Veits, Josef Weismuller, Jens Dommermuth, Udo Benner, Thomas Roesch, Helmut Messmann, Brigitte Schumacher, Horst Neuhaus, Carsten Schmidt, Thaddaus T. Wissinowski, Markus M. Noethen, Jing Dong, Jue-Sheng Ong, Matthew F. Buas, Aaron P. Thrift, Thomas L. Vaughan, Ian Tomlinson, David C. Whiteman, Rebecca Claire Fitzgerald, Janusz Jankowski, Michael Vieth, Andreas Mayr, Puya Gharahkhani, Stuart MacGregor, Ines Gockel, Claire Palles, Johannes Schumacher
Summary: This study utilized GWAS, genetic correlation analysis, and polygenic risk modeling to investigate the genetic causes of BE/EA. The findings identified new risk loci and candidate genes associated with BE/EA development. The study also revealed differences in the etiology of BE and EA and demonstrated improved risk prediction models when combining PRS with risk factors. These findings provide valuable insights into the mechanisms underlying BE/EA and improve our understanding of the disease.
Article
Genetics & Heredity
David A. Mackey, Jue-Sheng Ong, Stuart MacGregor, David C. Whiteman, Jamie E. Craig, M. Isabel, G. Lopez-Sanchez, Lisa S. Kearns, Sandra E. Staffieri, Linda Clarke, Myra B. McGuinness, Wafaa Meteoukki, Sona Samuel, Jonathan B. Ruddle, Celia Chen, Clare L. Fraser, John Harrison, Neil Howell, Alex W. Hewitt
Summary: Pedigree analysis showed that most LHON family members carrying a mitochondrial risk variant do not develop vision loss. Mitochondrial haplotype plays a major role in the risk of vision loss from LHON. The prevalence of LHON variants in the general population is relatively low, and the penetrance of LHON is very low in carriers.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Oncology
Yukari Taniyama, Isao Oze, Yuriko N. Koyanagi, Yukino Kawakatsu, Yuri Ito, Tomohiro Matsuda, Keitaro Matsuo, Tetsuya Mitsudomi, Hidemi Ito
Summary: Introduction of EGFR-TKIs and EGFR mutation testing has led to improved survival in NSCLC patients, particularly in women with adenocarcinoma and at advanced stages.
Letter
Dermatology
Jean Claude Dusingize, Catherine M. M. Olsen, Matthew H. H. Law, Nirmala Pandeya, Rachel E. E. Neale, Stuart MacGregor, David C. C. Whiteman, Jue-Sheng Ong
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Oncology
Azam Majidi, Renhua Na, Susan J. Jordan, Anna DeFazio, Andreas Obermair, Michael Friedlander, Peter Grant, Penelope M. Webb
Summary: This study investigated the association between nonsteroidal antiinflammatory drug (NSAID) use and 5-year cancer-specific survival in Australian women with ovarian cancer. The results showed that frequent use of NSAIDs, including aspirin and nonaspirin NSAIDs, was associated with better survival compared to nonusers and infrequent users. These findings suggest that NSAID use might improve ovarian cancer survival.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Zhuxuan Fu, Maria Mori Brooks, Sarah Irvin, Susan Jordan, Katja K. H. Aben, Hoda Anton-Culver, Elisa Bandera, Matthias W. Beckmann, Andrew Berchuck, Angela Brooks-Wilson, Jenny Chang-Claude, Linda S. Cook, Daniel W. Cramer, Kara L. Cushing-Haugen, Jennifer A. Doherty, Arif B. Ekici, Peter A. Fasching, Renee T. Fortner, Simon A. Gayther, Aleksandra Gentry-Maharaj, Graham G. Giles, Ellen L. Goode, Marc T. Goodman, Holly R. Harris, Alexander Hein, Rudolf Kaaks, Lambertus A. Kiemeney, Martin Koebel, Joanne Kotsopoulos, Nhu D. Le, Alice W. Lee, Keitaro Matsuo, Valerie McGuire, John R. McLaughlin, Usha Menon, Roger L. Milne, Kirsten B. Moysich, Celeste Leigh Pearce, Malcolm C. Pike, Bo Qin, Susan J. Ramus, Marjorie J. Riggan, Joseph H. Rothstein, Joellen M. Schildkraut, Weiva Sieh, Rebecca Sutphen, Kathryn L. Terry, Pamela J. Thompson, Linda Titus, Anne M. van Altena, Emily White, Alice S. Whittemore, Anna H. Wu, Wei Zheng, Argyrios Ziogas, Sarah E. Taylor, Lu Tang, Thomas Songer, Nicolas Wentzensen, Penelope M. Webb, Harvey A. Risch, Francesmary Modugno
Summary: The lifetime ovulatory years (LOY) are positively associated with nonmucinous epithelial ovarian cancer (EOC) risk, implicating factors beyond ovulation in the development of EOC. The protective effects of parity and oral contraceptive use may not solely depend on anovulation.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Clinical Neurology
Adrian Campos, Nathan Ingold, Yunru Huang, Brittany L. Mitchell, Pik-Fang Kho, Xikun Han, Luis M. Garcia-Marin, Jue-Sheng Ong, Matthew H. Law, Jennifer S. Yokoyama, Nicholas G. Martin, Xianjun Dong, Gabriel Cuellar-Partida, Stuart MacGregor, Stella Aslibekyan, Miguel E. Renteria
Summary: Through genome-wide association study and multi-trait analysis, this study identified multiple genetic loci associated with sleep apnea risk, improving our understanding of the etiology of this condition and its relationship with other complex traits.
Article
Oncology
Tomoharu Mori, Yusuke Okamoto, Anfeng Mu, Yoshimi Ide, Akiyo Yoshimura, Noriko Senda, Yukiko Inagaki-Kawata, Masahiro Kawashima, Hiroyuki Kitao, Eriko Tokunaga, Yasuo Miyoshi, Shozo Ohsumi, Koichiro Tsugawa, Tomohiko Ohta, Toyomasa Katagiri, Shigeru Ohtsuru, Kaoru Koike, Seishi Ogawa, Masakazu Toi, Hiroji Iwata, Seigo Nakamura, Keitaro Matsuo, Minoru Takata
Summary: The ALDH2 enzyme's ability to break down aldehydes is impaired by a specific gene polymorphism, leading to alcohol flushing and an increased risk of esophageal cancer in East Asians. Recent studies suggest that this gene variant may result in higher levels of DNA damage caused by naturally occurring aldehydes. However, in breast epithelial cells, this loss of function does not appear to have an impact on the initiation and development of cancer.
Article
Biology
Anthony M. Musolf, Annechien E. G. Haarman, Robert N. Luben, Jue-Sheng Ong, Karina Patasova, Rolando Hernandez Trapero, Joseph Marsh, Ishika Jain, Riya Jain, Paul Zhiping Wang, Deyana D. Lewis, Milly S. Tedja, Adriana I. Iglesias, Hengtong Li, Cameron S. Cowan, Ginevra Biino, Alison P. Klein, Priya Duggal, David A. Mackey, Caroline Hayward, Toomas Haller, Andres Metspalu, Juho Wedenoja, Olavi Parssinen, Ching-Yu Cheng, Seang-Mei Saw, Dwight Stambolian, Pirro G. Hysi, Anthony P. Khawaja, Veronique Vitart, Christopher J. Hammond, Cornelia M. van Duijn, Virginie J. M. Verhoeven, Caroline C. W. Klaver, Joan E. Bailey-Wilson
Summary: Refractive error is a complex eye condition caused by genetic and environmental factors. Genome-wide association studies have identified common genetic risk factors, but a significant portion of the heritability is still unexplained. By conducting gene-based association tests, we identified 129 unique genes associated with refractive error in a large dataset. Some of the novel candidates, such as PDCD6IP, PER3, and P4HTM, show promise for future functional studies and validation.
COMMUNICATIONS BIOLOGY
(2023)
Article
Oncology
Yuriko Koyanagi, Keitaro Matsuo, Hidemi Ito, Chaochen Wang, Akiko Tamakoshi, Yumi Sugawara, Ichiro Tsuji, Ayami Ono, Shoichiro Tsugane, Norie Sawada, Keiko Wada, Chisato Nagata, Taro Takeuchi, Tetsuhisa Kitamura, Mai Utada, Ritsu Sakata, Tetsuya Mizoue, Sarah Krull Abe, Manami Inoue
Summary: The effect of body mass index (BMI) on esophageal and gastric carcinogenesis varies depending on subtype or subsite. In this study, a pooled analysis of 10 population-based cohort studies in Japan, we observed an inverse association between BMI and esophageal squamous cell carcinoma, but a positive association with gastric cardia cancer. Additionally, a positive association was found for overweight or obese individuals with esophageal adenocarcinoma and gastric cardia cancer. The study highlights the subtype- or subsite-specific impact of BMI on upper gastrointestinal cancer in the Japanese population.
Article
Multidisciplinary Sciences
David M. Goldsbury, Amy Vassallo, Marianne Weber, Julia Steinberg, Penelope Webb, Anna DeFazio, Karen Canfell
Summary: This study aimed to estimate the direct health system costs of women diagnosed with ovarian cancer in Australia during 2006-2013, and found that the costs are substantial. Continued investment in ovarian cancer research, including prevention, early detection, and personalized treatments, is necessary to reduce the burden of the disease.
Article
Multidisciplinary Sciences
Yasushi Kojima, Emi Mishiro-Sato, Teruaki Fujishita, Kiyotoshi Satoh, Rie Kajino-Sakamoto, Isao Oze, Kazuki Nozawa, Yukiya Narita, Takatsugu Ogata, Keitaro Matsuo, Kei Muro, Makoto Mark Taketo, Tomoyoshi Soga, Masahiro Aoki
Summary: Cancer cachexia is a metabolic disorder characterized by a decrease in B vitamin-related liver enzymes. The relationship between enzymes and their associated metabolites may depend on protein abundance and cofactor subtype. These metabolic/proteomic changes can be utilized for the diagnosis of cancer cachexia through blood samples.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Michi Sawabe, Daisuke Kawakita, Isao Oze, Shinichi Iwasaki, Yasuhisa Hasegawa, Shingo Murakami, Hidemi Ito, Nobuhiro Hanai, Keitaro Matsuo
Summary: This study is the first to suggest an association between prediagnostic folate intake and head and neck squamous cell carcinoma (HNSCC) survival that differs based on fluorouracil (FU)-containing chemotherapy. In the FU-containing chemotherapy group, higher folate intake is associated with better overall survival, while no clear association is observed in the non-FU-containing chemotherapy group. This finding indicates that the folate status affects the heterogeneity of one-carbon metabolism in HNSCC.
