Review
Medicine, Research & Experimental
Ghader Babaei, Shiva Gholizadeh-Ghaleh Aziz, Nasrin Zare Zavieyh Jaghi
Summary: Epithelial-mesenchymal transition (EMT) and Cancer stem-like cells (CSCs) are major factors contributing to cancer cell metastasis. Autophagy has recently gained attention, playing a dual role in cancer cell development depending on cancer type, tissue, and stage. Studies show different signaling pathways are involved in cancer stem cells, autophagy, and EMT. Investigating effective signaling pathways in all three processes could help determine appropriate therapeutic goals.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Medicine, Research & Experimental
Ghader Babaei, Mehdi Asghari Vostakolaei, Masoumeh Rajabi Bazl, Shiva Gholizadeh-Ghaleh Aziz, Elham Gholipour, Kazem Nejati-Koshki
Summary: Exosomes play fundamental roles in cell-cell communications and are associated with cancer metastasis by modulating EMT and CSCs.
Article
Multidisciplinary Sciences
Maria do Carmo Greier, Annette Runge, Jozsef Dudas, Viktoria Pider, Ira-Ida Skvortsova, Dragana Savic, Herbert Riechelmann
Summary: Mitochondrial dysfunction can induce epithelial mesenchymal transition in head and neck cancer cell lines, thereby promoting cancer aggressiveness and metastasis. However, this phenomenon is observed only in one of the cell lines.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Huiling Zhou, Qing Guan, Xuyang Hou, Lijun Liu, Li Zhou, Wei Li, Haidan Liu
Summary: Our study reveals that Rictor is highly expressed in NSCLC and regulated transcriptionally, with its interaction with KLF4 affecting the migration and invasion ability of NSCLC cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Lin Shi, Jiayun Hou, Lin Wang, Huirong Fu, Yiwen Zhang, Yuanlin Song, Xiangdong Wang
Summary: The study found that OPN may act as a target molecule in lung cancer, associated with lymph node metastasis, postresection recurrence/metastasis, and patient prognosis. OPN's biological behaviors and pathological responses varied among diseases, challenges, and severities, with overexpression correlated with EMT. Internal and external OPN play crucial roles in lung cancer cell movement, proliferation, and EMT formation through the upregulation of specific pathways.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Khalid Rashid, Aqeel Ahmad, Semmal Syed Meerasa, Abdul Q. Khan, Xiaobo Wu, Li Liang, Yuehong Cui, Tianshu Liu
Summary: Although the mechanisms and pathways of cancer stem cell (CSC) maintenance and tumorigenicity have been extensively studied, research on the functional mechanisms of CSC-derived exosomes and their impact on malignancy is lacking. Understanding the interaction between CSCs/CSC-Exo and other key components of the tumor microenvironment can aid in cancer treatment by addressing factors such as proliferation, migration, differentiation, angiogenesis, and metastasis. This review aims to summarize the characteristics and functional mechanisms of CSC-Exo/MSC-Exo/CAF-Exo and their mutual impact on cancer progression and therapy resistance.
Article
Medicine, Research & Experimental
Min-Woo Nam, Hong Kyu Lee, Cho -Won Kim, Youngdong Choi, Dohee Ahn, Ryeo-Eun Go, Kyung-Chul Choi
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer type that is resistant to conventional treatments. This study investigated the role of CCN6 in PDAC and found that CCN6 promotes cell viability and tumorigenesis, as well as enhances metastatic potential through the p38 MAPK and BMPs signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Yuanyang Lai, Fang Lin, Xuejiao Wang, Jiao Zhang, Jinghua Xia, Ying Sun, Miaomiao Wen, Xiaofei Li, Zhipei Zhang, Jinbo Zhao
Summary: This study found that STYK1 is upregulated in NSCLC and correlated with poor clinical outcomes. STYK1 suppressed FoxO1 functions, thereby promoting metastasis and EMT in NSCLC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Namhee Kim, Chae Young Hwang, Taeyoung Kim, Hyunjin Kim, Kwang-Hyun Cho
Summary: The process of epithelial-to-mesenchymal transition (EMT) in cancer cells, which contributes to metastasis and drug resistance, can be reversed through a systems biology approach. By targeting a core-regulatory circuit involving SMAD4 and ERK signaling inhibition, along with p53 activation, complete EMT reversal (rEMT) can be achieved without hybrid EMT properties. This reprogramming strategy restores chemosensitivity, offering potential therapeutic targets to eradicate metastatic potential by subverting EMT while avoiding hybrid states.
Article
Biochemistry & Molecular Biology
YuJian Xia, Jian Chen, Guangyao Liu, WeiBin Huang, XiaoJing Wei, ZheWei Wei, YuLong He
Summary: The study revealed that STIP1 is highly expressed in CRC tissues and is associated with poor overall survival. STIP1 promotes CRC cell proliferation and invasion through the STAT3 pathway, while its knockdown inhibits these functions. This suggests that STIP1 could be a potential target for CRC therapy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Cell Biology
Fabrizio Fontana, Martina Anselmi, Patrizia Limonta
Summary: It has been found that obesity is associated with a higher risk of prostate cancer. The interaction between adipose tissue and prostate cancer is not fully understood. This study showed that adipocyte conditioned media can induce stemness properties in prostate cancer cells and promote certain gene expressions. Furthermore, exposure to adipocyte conditioned media led to partial epithelial-to-mesenchymal transition in the cancer cells, resulting in enhanced tumor aggressiveness and chemoresistance.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2023)
Article
Genetics & Heredity
Xiuying Chen, Li Yu, Junyang Zhou, Ji Ren, Shan Wang, Yujie Tan, Yan Ding
Summary: In esophageal squamous cell carcinoma, both NFE2L2 and SQSTM1 (p62) are upregulated and promote tumor progression and epithelial-mesenchymal transition (EMT) through autophagy activity. Inhibiting both proteins simultaneously can reverse the migration and EMT characteristics of the tumor, suggesting that targeting both proteins may be a viable treatment option for esophageal squamous cell carcinoma.
Article
Oncology
Kelin She, Wensheng Yang, Mengna Li, Wei Xiong, Ming Zhou
Summary: FAIM2 promotes the growth and bone metastasis of NSCLC cells by regulating the EMT process and Wnt/beta-catenin signaling pathway, and is associated with poor prognosis in NSCLC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Silvia Sideri, Francesco Petragnano, Roberto Maggio, Simonetta Petrungaro, Angela Catizone, Luisa Gesualdi, Viviana De Martino, Giulia Battafarano, Andrea Del Fattore, Domenico Liguoro, Paola De Cesaris, Antonio Filippini, Francesco Marampon, Anna Riccioli
Summary: The study found that highly metastatic prostate cancer cells show increased sensitivity to Docetaxel after radiotherapy failure and suggests immediate chemotherapy after radiotherapy failure may benefit certain patients. Furthermore, using a higher dose per fraction for radiotherapy in castration-resistant prostate cancer cells was not successful, but the results may vary between different cell lines.
Review
Endocrinology & Metabolism
Wenhu Zhao, Shipeng Dai, Lei Yue, Fan Xu, Jian Gu, Xinzheng Dai, Xiaofeng Qian
Summary: Colorectal cancer is a common malignant tumor with the liver being the most common site of metastasis. Metastasis to the liver from colorectal cancer is a complex process involving various stages. This review discusses the characteristics of CRC cells and their interactions with liver cells and immune cells. It also explores current immunotherapy approaches and challenges, as well as potential therapeutic targets based on novel sequencing technologies.
FRONTIERS IN ENDOCRINOLOGY
(2022)