Review
Oncology
Jiping Li, Yuying Liu, Yidong Yuan, Bo Huang
Summary: Cellular mechanics is a major regulating factor of cellular architecture and biological functions, responding to intrinsic and extrinsic forces in the microenvironment. It plays a fundamental role in complicated immune responses and can be characterized using atomic force microscopy (AFM). AFM applications include studying neutrophil-extracellular-trap release, immunological functions of macrophages, and membrane pore formation.
FRONTIERS OF MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jiadi Lv, Yaoping Liu, Feiran Cheng, Jiping Li, Yabo Zhou, Tianzhen Zhang, Nannan Zhou, Cong Li, Zhenfeng Wang, Longfei Ma, Mengyu Liu, Qiang Zhu, Xiaohan Liu, Ke Tang, Jingwei Ma, Huafeng Zhang, Jing Xie, Yi Fang, Haizeng Zhang, Ning Wang, Yuying Liu, Bo Huang
Summary: Microfluidic devices can sort cancer stem cells into mechanically stiff and soft subpopulations, with soft tumor cells showing higher tumorigenicity. The upregulation of Wnt signaling protein BCL9L in soft tumor cells is associated with their stemness and tumorigenicity. These findings suggest that intrinsic softness can serve as a unique marker for highly tumorigenic and metastatic tumor cells.
Article
Immunology
Yuying Liu, Nannan Zhou, Li Zhou, Jing Wang, Yabo Zhou, Tianzhen Zhang, Yi Fang, Jinwei Deng, Yunfeng Gao, Xiaoyu Liang, Jiadi Lv, Zhenfeng Wang, Jing Xie, Yuanbo Xue, Huafeng Zhang, Jingwei Ma, Ke Tang, Yiliang Fang, Feiran Cheng, Chengjuan Zhang, Bing Dong, Yuzhou Zhao, Peng Yuan, Quanli Gao, Haizeng Zhang, F. Xiao-Feng Qin, Bo Huang
Summary: IL-2 acts as an environmental cue to induce CD8(+) T cell exhaustion within tumor microenvironments by activating STAT5, inducing tryptophan hydroxylase 1, and subsequently causing T cell dysfunction.
Editorial Material
Immunology
Jiadi Lv, Pin Yu, Zhenfeng Wang, Wei Deng, Linlin Bao, Jiangning Liu, Fengli Li, Qiangqiang Zhu, Nannan Zhou, Qi Lv, Guanpeng Wang, Shunyi Wang, Yabo Zhou, Jiangping Song, Wei-Min Tong, Yuying Liu, Chuan Qin, Bo Huang
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Zhenfeng Wang, Jiadi Lv, Pin Yu, Yajin Qu, Yabo Zhou, Li Zhou, Qiangqiang Zhu, Shunshun Li, Jiangping Song, Wei Deng, Ran Gao, Yuying Liu, Jiangning Liu, Wei-Min Tong, Chuan Qin, Bo Huang
Summary: The study demonstrates the potential therapeutic effect of ACE2-overexpressing A549 cell-derived microparticles (AO-MPs) against SARS-CoV-2 infection by changing endosomal pH and promoting viral degradation. In addition to inhibiting the inflammatory response of alveolar macrophages, AO-MPs increase treatment efficacy in a SARS-CoV-2-infected mouse model without side effects, highlighting the potential use of AO-MPs in treating SARS-CoV-2-infected patients and the feasibility of microparticle therapies for combating emerging respiratory viruses in the future.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Cell Biology
Jiadi Lv, Yuying Liu, Siqi Mo, Yabo Zhou, Fengye Chen, Feiran Cheng, Cong Li, Dilizhatai Saimi, Mengyu Liu, Huafeng Zhang, Ke Tang, Jingwei Ma, Zhenfeng Wang, Qiangqiang Zhu, Wei-Min Tong, Bo Huang
Summary: In this study, it was found that pancreatic ductal adenocarcinoma (PDAC) cells use gasdermin E (GSDME) to resist self-digestion by expressing mucin 1 and mucin 13. The GSDME-YBX1-mucin axis was confirmed in PDAC patients.
NATURE CELL BIOLOGY
(2022)
Article
Oncology
Haizhou Wang, Yabo Zhou, Yangyang Zhang, Shilin Fang, Meng Zhang, Haiou Li, Fei Xu, Lan Liu, Jing Liu, Qiu Zhao, Fan Wang
Summary: This study reveals the immunogenic heterogeneity of pMMR/MSS CRC and identifies GBP2 as a promising target for combinatorial therapy with immune checkpoint blockade.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Huafeng Zhang, Jincheng Liu, Zhuoshun Yang, Liping Zeng, Keke Wei, Liyan Zhu, Liang Tang, Dianheng Wang, Yabo Zhou, Jiadi Lv, Nannan Zhou, Ke Tang, Jingwei Ma, Bo Huang
Summary: Glycolysis plays a crucial role in the recall response of CD8(+) memory T cells. This study reveals that intracellular glycogen serves as the major carbon source for the early recall response, and TCR signaling regulates this process through the phosphorylation of PYGB. This discovery highlights the specific dependence of memory T cell activation on glycogen and its potential therapeutic implications.
Article
Cell Biology
Jiadi Lv, Yabo Zhou, Nannan Zhou, Zhenfeng Wang, Jie Chen, Haoran Chen, Dianheng Wang, Li Zhou, Keke Wei, Huafeng Zhang, Ke Tang, Jingwei Ma, Yuying Liu, Yonghong Wan, Yi Zhang, Haizeng Zhang, Bo Huang
Summary: Weak immunogenicity of tumor cells is a major obstacle in immunosurveillance and immunotherapy. The mechanisms determining the initial immunogenicity of tumor cells remain unclear. This study found that the activation status of STAT1 protein and the RNA binding protein CSDE1 play a role in determining the immunogenic heterogeneity of tumorigenic cells. The identified SMYD3-CSDE1 pathway may serve as a prognostic marker for cancer immunotherapy effectiveness.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Li Zhou, Dongxiao Wu, Yabo Zhou, Dianheng Wang, Haixia Fu, Qiusha Huang, Guohui Qin, Jie Chen, Jiadi Lv, Shaoyang Lai, Huafeng Zhang, Ke Tang, Jingwei Ma, Roland Fiskesund, Yi Zhang, Xiaohui Zhang, Bo Huang
Summary: Tumor-derived kynurenine activates the AhR-RUNX1 pathway, leading to the differentiation of MEPs into megakaryocytes and potentially causing thrombocytosis and erythrocytopenia in individuals with cancer.
Letter
Biochemistry & Molecular Biology
Zhenfeng Wang, Yabo Zhou, Linlin Bao, Dan Li, Jiadi Lv, Dianheng Wang, Shunshun Li, Jiangning Liu, Chuan Qin, Wei-Min Tong, Bo Huang
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)