Article
Nutrition & Dietetics
Jun Chen, Zhiguang Duan, Yannan Liu, Rongzhan Fu, Chenhui Zhu
Summary: This study found that ginsenoside Rh4 inhibits the metastasis of esophageal squamous cell carcinoma (ESCC) by regulating the Wnt/beta-catenin signaling pathway and the level of c-Myc. In vitro and in vivo experiments confirmed the inhibitory effect of Rh4 on ESCC metastasis.
Article
Cell Biology
Ce Li, Wenming Li, Shengda Cao, Jianing Xu, Ye Qian, Xinliang Pan, Dapeng Lei, Dongmin Wei
Summary: This study confirmed the carcinogenic effect of circ_0058106 in promoting tumorigenesis, metastasis, invasion, and EMT process of HSCC cells by regulating the Wnt2b/β-catenin/c-Myc pathway through sponging miR-185-3p, suggesting circ_0058106 may be a new therapeutic target and prognostic marker for HSCC.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Adnan Shami Shah, Xiaofu Cao, Andrew C. White, Jeremy M. Baskin
Summary: The study identifies PLEKHA4 as a crucial factor for melanoma proliferation and survival, demonstrating its essential role in Wnt/beta-catenin signaling. Knocking down PLEKHA4 attenuated tumor growth in both BRAF- and NRAS-mutant melanoma models, with an additive effect when combined with the clinically used inhibitor encorafenib in the BRAF-mutant model. As an E3 ubiquitin ligase regulator, PLEKHA4 presents promising opportunities for targeting in melanoma therapy.
Article
Biochemistry & Molecular Biology
Aravinda-Bharathi Ramakrishnan, Peter E. Burby, Kavya Adiga, Ken M. Cadigan
Summary: Activation of the Wnt/beta-catenin pathway leads to the formation of a beta-catenin-TCF complex, regulating gene expression. SOX9, a transcription factor, can repress many Wnt target genes by downregulating beta-catenin protein levels. Interestingly, SOX9 also directly activates multiple Wnt-responsive enhancers in colorectal cancer cells, promoting cell proliferation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Oncology
Hu Han, Yan Li, Wan Qin, Lu Wang, Han Yin, Beibei Su, Xianglin Yuan
Summary: The study found that miR-199b-3p is significantly up-regulated in CTx-resistant colorectal cancer cells. Inhibiting miR-199b-3p can improve the sensitivity of CTx-resistant cells to CTx by regulating the Wnt/β-catenin signaling pathway. Mouse models confirmed that down-regulating miR-199b-3p can restore the inhibitory effect of CTx on tumor growth.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Ryosuke Wakabayashi, Yasunao Hattori, Shigekuni Hosogi, Yuki Toda, Kazuyuki Takata, Eishi Ashihara
Summary: Compound 31 was identified as an inhibitor of the Wnt/beta-catenin pathway, showing potential as a novel anti-AML agent by suppressing TCF activity, reducing AML cell proliferation, inducing apoptosis, and synergistically inhibiting cell growth when combined with idarubicin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Yihui Wang, Guohu Di, Kaier Zhang, Ying Bai, Xin Cao, Hui Zhao, Dianqiang Wang, Peng Chen
Summary: AQP5 is crucial for corneal transparency and barrier function. In Aqp5(-/-) mice, loss of AQP5 leads to increased neovascularization, inflammation, and haze in the cornea. AQP5 regulates corneal epithelial homeostasis and function through the Wnt/beta-catenin signaling pathway. This finding provides a potential therapeutic target for corneal epithelial dysfunction.
Article
Cell Biology
Peipei Ding, Yanqing Xu, Luying Li, Xinyue Lv, Ling Li, Jianfeng Chen, Danlei Zhou, Xiaochao Wang, Qi Wang, Wei Zhang, Tian Liao, Qing-Hai Ji, Qun-Ying Lei, Weiguo Hu
Summary: This study uncovers the activation of C5 complement within tumor cells, which affects colorectal tumorigenesis by regulating the stability of beta-catenin. The findings provide a potential target for tumor prevention and treatment.
Article
Cell Biology
Vikash Singh, Vonn Walter, Irina Elcheva, Yuka Imamura Kawasawa, Vladimir S. Spiegelman
Summary: In this study, the role of IGF2BP1 in the post-transcriptional regulation of Wnt/beta-catenin-induced genes in colorectal cancer (CRC) cells was investigated using iCLIP and RNA sequencing techniques. The study revealed that CRC cells exhibit a stronger dependency on IGF2BP1 expression for Wnt/beta-catenin-regulated genes compared to normal cells. iCLIP analysis showed significant changes in IGF2BP1-binding sites and enrichment of 6-mer motifs associated with IGF2BP1 binding in response to Wnt/beta-catenin signaling. Additionally, a signature of IGF2BP1-regulated genes significantly associated with colon cancer-free survival in humans was identified.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Cyrollah Disoma, Yuzheng Zhou, Shanni Li, Jian Peng, Zanxian Xia
Summary: The Wnt/β-catenin signaling pathway plays a crucial role in colorectal carcinogenesis, but no clinically approved therapies targeting this pathway currently exist. New modulators of the pathway are involved not only in cancer initiation but also in chemoresistance, epithelial-mesenchymal transition, and cancer stem cell renewal. CDX2 shows potential as a promising molecular target for colorectal cancer therapeutics, although further studies are needed to determine its significance. Overall, the regulation of the Wnt/β-catenin signaling pathway remains complex and not fully understood, posing a major barrier to the development of targeted chemotherapeutic agents.
Review
Medicine, Research & Experimental
Yong Ji, Jian Lv, Di Sun, Yufeng Huang
Summary: This review explores the significant role of the Wnt/β-catenin signaling pathway in colorectal cancer tumorigenesis, metastasis, and recurrence, as well as its potential value in diagnosis and therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Oncology
Hong-Yong Cui, Wei Wei, Mei-Rui Qian, Ruo-Fei Tian, Xin Fu, Hong-Wei Li, Gang Nan, Ting Yang, Peng Lin, Xi Chen, Yu-Meng Zhu, Bin Wang, Xiu-Xuan Sun, Jian-Hua Dou, Jian-Li Jiang, Ling Li, Shi-Jie Wang, Zhi-Nan Chen
Summary: This study identified PDAP1 as a key player in colorectal cancer (CRC) development. PDAP1 overexpression was associated with cell proliferation, migration, invasion, and metastasis in CRC. Inhibiting PDAP1 may be an effective strategy for treating CRC patients with PDAP1 overexpression.
CANCER COMMUNICATIONS
(2022)
Article
Plant Sciences
Shengen Yi, Xiaoxin Jin, Bo Liu, Peidong Wu, Wang Xiao, Weidong Chen
Summary: This study found that Portulaca oleracea extract (POE) inhibited the development of colorectal cancer (CRC) by regulating gut microbiota imbalance, inactivating the Wnt/beta-catenin signaling pathway, and downregulating the expression of c-Myc and cyclin D1.
Article
Oncology
Shijun Yu, Li Li, Hui Cai, Bin He, Yong Gao, Yandong Li
Summary: In gastric cancer, overexpression of NELFE is negatively correlated with the prognosis of patients, and NELFE promotes proliferation and metastasis of GC cells both in vitro and in vivo. CSNK2B is identified as a downstream effector of NELFE, and Wnt/beta-catenin signaling may mediate the regulation of CSNK2B by NELFE. Additionally, NELFE, beta-catenin, and CSNK2B are all significantly upregulated in tumor tissues and their expression levels in GC are positively correlated with each other.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Rosalie G. Hoyle, Huiqun Wang, Yana Cen, Yan Zhang, Jiong Li
Summary: The study reveals that in human colorectal cancer, KDM3 may play a more essential role than KDM4 in regulating the Wnt signaling, and that IOX1, a known histone demethylase inhibitor, significantly suppresses Wnt target gene transcription and colorectal cancer tumorigenesis through inhibiting KDM3 enzymatic activity.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Qingding Wang, Yuning Zhou, Piotr Rychahou, Teresa W-M Fan, Andrew N. Lane, Heidi L. Weiss, B. Mark Evers
CELL DEATH AND DIFFERENTIATION
(2017)
Article
Multidisciplinary Sciences
Jing Li, Jun Song, Yekaterina Y. Zaytseva, Yajuan Liu, Piotr Rychahou, Kai Jiang, Marlene E. Starr, Ji Tae Kim, Jennifer W. Harris, Frederique B. Yiannikouris, Wendy S. Katz, Peter M. Nilsson, Marju Orho-Melander, Jing Chen, Haining Zhu, Timothy Fahrenholz, Richard M. Higashi, Tianyan Gao, Andrew J. Morris, Lisa A. Cassis, Teresa W. -M. Fan, Heidi L. Weiss, Paul R. Dobner, Olle Melander, Jianhang Jia, B. Mark Evers
Meeting Abstract
Gastroenterology & Hepatology
Yuning Zhou, Qingding Wang, Piotr Rychahou, Heidi L. Weiss, B. Mark Evers
Article
Pharmacology & Pharmacy
Steven Rheiner, Derek Reichel, Piotr Rychahou, Tadahide Izumi, Hsin-Sheng Yang, Younsoo Bae
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2017)
Article
Oncology
Dasha E. Kenlan, Piotr Rychahou, Vitaliy M. Sviripa, Heidi L. Weiss, Chunming Liu, David S. Watt, B. Mark Evers
MOLECULAR CANCER THERAPEUTICS
(2017)
Article
Nanoscience & Nanotechnology
Fengmei Pi, Daniel W. Binzel, Tae Jin Lee, Zhefeng Li, Meiyan Sun, Piotr Rychahou, Hui Li, Farzin Haque, Shaoying Wang, Carlo M. Croce, Bin Guo, B. Mark Evers, Peixuan Guo
NATURE NANOTECHNOLOGY
(2018)
Article
Chemistry, Multidisciplinary
Derek Reichel, Louis T. Curtis, Elizabeth Ehlman, B. Mark Evers, Piotr Rychahou, Hermann B. Frieboes, Younsoo Bae
PHARMACEUTICAL RESEARCH
(2017)
Article
Oncology
Liqing Li, Xiang Li, Lei Qi, Piotr Rychahou, Naser Jafari, Cai Huang
Article
Chemistry, Multidisciplinary
Piotr Rychahou, Younsoo Bae, Derek Reichel, Yekaterina Y. Zaytseva, Eun Y. Lee, Dana Napier, Heidi L. Weiss, Nick Roller, Heather Frohman, Anh-Thu Le, B. Mark Evers
JOURNAL OF CONTROLLED RELEASE
(2018)
Article
Surgery
Heather A. Frohman, Piotr G. Rychahou, Jing Li, Tong Gan, B. Mark Evers
JOURNAL OF SURGICAL RESEARCH
(2018)
Article
Cell Biology
Jeremy Johnson, Zeta Chow, Dana Napier, Eun Lee, Heidi L. Weiss, B. Mark Evers, Piotr Rychahou
Article
Oncology
Jeremy Johnson, Zeta Chow, Eun Lee, Heidi L. Weiss, B. Mark Evers, Piotr Rychahou
Summary: The study demonstrates that transient decrease in AMPK isoforms expression alone or in combination with Akt1 in circulating tumor cells does not synergistically reduce TNBC metastatic lung colonization. Our results also provide evidence that Akt1 and Akt2 expression serve as a bottleneck that can challenge colonization of lungs by TNBC cells.
Article
Oncology
Ruozheng Wei, Yuning Zhou, Chang Li, Piotr Rychahou, Shulin Zhang, William B. Titlow, Greg Bauman, Yuanyuan Wu, Jinpeng Liu, Chi Wang, Heidi L. Weiss, B. Mark Evers, Qingding Wang
Summary: This study identifies ketogenesis as a critical regulator of the tumor microenvironment in colorectal cancer and suggests the potential for ketogenic diets as a metabolic strategy to overcome immunosuppression and prolong survival.
Article
Oncology
Hui Zhang, Tricia Fredericks, Gaofeng Xiong, Yifei Qi, Piotr G. Rychahou, Jia-Da Li, Taina Pihlajaniemi, Wei Xu, Ren Xu
BREAST CANCER RESEARCH
(2018)