Article
Biochemistry & Molecular Biology
Donghui Bai, Tianxiao Sun, Fang Lu, Yancheng Shen, Yan Zhang, Bo Zhang, Guangli Yu, Haihua Li, Jiejie Hao
Summary: The study showed that Eupatilin can attenuate the inflammatory response in OVA-induced asthma by regulating NF-kappa B, MAPK, and Nrf2 signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Saeed Mohammadian Haftcheshmeh, Maliheh Abedi, Kazem Mashayekhi, Mohammad Javad Mousavi, Jamshid Gholizadeh Navashenaq, Asadollah Mohammadi, Amir Abbas Momtazi-Borojeni
Summary: This review discusses the modulatory effects of berberine (BBR) on various inflammatory signaling pathways in the immune system and explores its therapeutic efficacy and anti-inflammatory effects.
PHYTOTHERAPY RESEARCH
(2022)
Article
Plant Sciences
Yifeng Shi, Jiaoxiang Chen, Sunlong Li, Yuhao Wu, Caiyu Yu, LiBin Ni, Jian Xiao, Zhenxuan Shao, Huanqing Zhu, Jianshun Wang, Xiangyang Wang, Xiaolei Zhang
Summary: Tangeretin, a natural flavonoid with anti-inflammatory properties, has been found to inhibit inflammation and extracellular matrix (ECM) degradation, effectively preventing the progression of osteoarthritis (OA). These effects are mediated through the Nrf2/NF-kappa B and MAPK/NF-kappa B pathways.
Review
Immunology
Timothy C. Borbet, Marcus J. Hines, Sergei B. Koralov
Summary: B lymphocytes play a central role in host immune defense, and their development and function are regulated by miRNAs. Studies have found that miRNAs are crucial for B cell development in the bone marrow and their subsequent population of the peripheral immune system, preventing autoimmunity by regulating downstream signaling of the B cell antigen receptor.
IMMUNOLOGICAL REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Xue Yang, Jiamin Liang, Ziyi Wang, Yuangang Su, Yunfei Zhan, Zuoxing Wu, Jing Li, Xuedong Li, Runfeng Chen, Jinmin Zhao, Jiake Xu, Qian Liu, Bo Zhou
Summary: This study found that sesamolin has the potential to treat osteoporosis by effectively inhibiting the formation of osteoclasts in vitro, attenuating bone loss through modulating multiple signaling pathways and gene expression, and demonstrating a preventive effect against bone loss induced by estrogen deficiency in vivo.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Wenkan Zhang, Guangyao Jiang, Xiaozhong Zhou, Leyi Huang, Jiahong Meng, Bin He, Yiying Qi
Summary: The study found that alpha-mangostin can inhibit the formation and function of osteoclasts and prevent inflammatory osteolysis by inhibiting the activation of the NF-kappa B/mitogen-activated protein kinase signaling pathways. This has potential clinical applications for treating osteoclast-related diseases.
Article
Immunology
Yingchun Su, Yanting Liu, Dewei He, Guiqiu Hu, Hefei Wang, Bojian Ye, Yuan He, Xiyu Gao, Dianfeng Liu
Summary: Parkinson's disease is a common disease caused by degeneration of the central nervous system, characterized by the death of dopaminergic neurons. Neuroinflammation, particularly the excessive activation of microglia, plays a significant role in its pathogenesis. Hordenine has been found to have anti-oxidant and anti-inflammatory properties, and this study reveals its potential in inhibiting neuroinflammation by suppressing microglial activation and protecting dopaminergic neurons.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Donghui Bai, Yujie Sun, Qiong Li, Haihua Li, Yuerun Liang, Ximing Xu, Jiejie Hao
Summary: This study found that leonurine, extracted from Herba leonuri, has a protective effect on asthma by regulating the p38 MAPK/NF-κB signaling pathway to reduce inflammation and mucus overproduction.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Yong Zhang, Zhengxia Zha, Wenhua Shen, Dan Li, Naixin Kang, Zhong Chen, Yanli Liu, Guoqiang Xu, Qiongming Xu
Summary: The study demonstrated that anemoside B4 ameliorated TNBS-induced colitis symptoms by inhibiting tissue damage, inflammatory cell infiltration, pro-inflammatory cytokine production, apoptosis, and slowed proliferation in colon. Quantitative proteomic analyses revealed that anemoside B4 significantly altered 56 proteins in TNBS-induced rats, with a focus on proteins related to TCA cycle and respiratory electron transport chain. S100A9, one of the most significantly down-regulated proteins, was associated with NF-kappa B and MAPK signaling pathways in UC pathogenesis.
Article
Biochemistry & Molecular Biology
Da-Yeon Lee, Su-Jeong Lee, Prabha Chandrasekaran, Gopal Lamichhane, Jennifer F. O'Connell, Josephine M. Egan, Yoo Kim
Summary: This study investigated the effects of dietary curcumin (CUR) as an antioxidant on hepatic cellular senescence in aged mice. The results showed that CUR supplementation downregulated senescence-associated hepatic gene expressions, enhanced antioxidant properties, suppressed MAPK signaling cascades, and inhibited proinflammatory cytokines and SASPs expression, suggesting that CUR may be a nutritional strategy to prevent hepatic cellular senescence.
Article
Pharmacology & Pharmacy
Mingxin Dong, Xiaohao Zhang, Haotian Yu, Yan Wang, Ying Chang, Chengbiao Sun, Jianxu Zhang, Na Zhao, Kaikai Yu, Guangchao Sun, Guiru Zhao, Na Xu, Wensen Liu
Summary: This study identified circEpc1 as a promoter in RT-induced inflammation, functioning as a miR-5114 sponge to activate NF-kappa B and MAPK signaling pathways. The results provide new insights into the functions of circRNA in innate immunity and suggest potential immunotherapy targets for controlling RT-induced inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hongbo You, Rui Zhang, Lingying Wang, Qiyong Pan, Zekai Mao, Xiaojian Huang
Summary: Osteoarthritis (OA) is a major cause of cartilage pain and limited mobility in middle-aged and elderly individuals, with inflammation-induced cartilage degeneration playing a key role. Shikimic acid (SA) has been found to have significant anti-inflammatory effects and potential therapeutic effects for OA by suppressing IL-1 beta-induced pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Huanhuan Xu, Titi Liu, Yuankan Jia, Jin Li, Li Jiang, Caijiang Hu, Xuanjun Wang, Jun Sheng
Summary: EGCG in green tea can inhibit osteoclastogenesis by interfering with the interaction between RANK and RANKL, suppressing the phosphorylation of key regulatory factors, and negatively regulating NF-kappa B and MAPK signaling pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Abuyaseer Abusaliya, Pritam Bhagwan Bhosale, Hun Hwan Kim, Sang Eun Ha, Min Yeong Park, Se Hyo Jeong, Preethi Vetrivel, Joon-Suk Park, Gon Sup Kim
Summary: In this study, it was found that prunetinoside (PUG), a plant-based compound, possesses anti-inflammatory effects on mouse macrophage cells. PUG decreased the expression of inflammatory mediators and reduced the activation of phosphorylated signaling pathways. By blocking the NF-κB pathway and activating JNK, PUG could be a potential therapeutic compound for inflammatory-related conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Yongjie Chen, Linlin Zhang, Zongguang Li, Zuoxing Wu, Xixi Lin, Na Li, Rong Shen, Guojun Wei, Naichun Yu, Fengqing Gong, Gang Rui, Ren Xu, Guangrong Ji
Summary: Mogrol, an active component of Siraitia grosvenorii, exhibits anti-inflammatory, anticancer and neuroprotective effects. This study demonstrated that mogrol dose-dependently inhibited osteoclast formation and function by regulating gene expression and signaling pathway. Furthermore, mogrol reduced bone mass loss in postmenopausal mice, suggesting its promising potential for osteoporosis prevention or therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Christophe Deben, Edgar Cardenas de la Hoz, Maxim Le Compte, Paul Van Schil, Jeroen M. H. Hendriks, Patrick Lauwers, Suresh Krishan Yogeswaran, Filip Lardon, Patrick Pauwels, Steven Van Laere, Annemie Bogaerts, Evelien Smits, Steve Vanlanduit, Abraham Lin
Summary: A high-throughput and automated live-cell image analysis software called OrBITS was developed for kinetic monitoring of organoids. The software combines computer vision with convolutional network machine learning and was validated against standard assays. Using OrBITS, the drug screening of lung and pancreatic cancer treatments provided further insights into the drugs' mechanism of action.
Article
Anatomy & Morphology
Burhanuddin Sabuwala, Kishore Hari, Abhishek Shanmuga Vengatasalam, Mohit Kumar Jolly
Summary: Multistability is important in biological systems and can be achieved through positive feedback loops. This study investigates the bistability characteristics of mutual inhibition, mutual activation, and self-activation loops. The results show that mutual inhibition-based architecture provides discrete and robust control, multistability, and coordinated expression among multiple genes compared to mutual activation-based architecture. A combination of mutual inhibition and mutual activation architectures is proposed to improve coordination and multistability. This research improves our understanding of control structures in cell-fate decisions and provides insights for controlled decision-making in synthetic systems.
CELLS TISSUES ORGANS
(2023)
Article
Cell Biology
Guerman Molostvov, Mariam Gachechiladze, Abeer M. Shaaban, Steven Hayward, Isaac Dean, Irundika H. K. Dias, Nahla Badr, Irini Danial, Fiyaz Mohammed, Vera Novitskaya, Liliia Paniushkina, Valerie Speirs, Andrew Hanby, Irina Nazarenko, David R. Withers, Steven van Laere, Heather M. Long, Fedor Berditchevski
Summary: The immune microenvironment in breast cancer is regulated by cancer cell-derived extracellular vesicles, which control the recruitment and accumulation of B lymphocytes. The Liver X receptor (LXR)-dependent transcriptional network and the tetraspanin 6 (Tspan6) play key roles in this process by regulating the accumulation of oxysterol ligands in extracellular vesicles.
Article
Multidisciplinary Sciences
Sharaj Kunjar, Ariana Strandburg-Peshkin, Helge Giese, Pranav Minasandra, Sumantra Sarkar, Mohit Kumar Jolly, Nico Gradwohl
Summary: Consensus decision-making in social groups is influenced by communication links that determine information exchange. This study shows that strategically adjusting communication links can bias group-level outcomes and help achieve consensus, but strong preferences can lead to non-consensus outcomes.
ROYAL SOCIETY OPEN SCIENCE
(2023)
Article
Oncology
Michael C. Brown, Georgia M. Beasley, Zachary P. McKay, Yuanfan Yang, Annick Desjardins, Dina M. Randazzo, Daniel Landi, David M. Ashley, Darell D. Bigner, Smita K. Nair, Matthias Gromeier
Summary: This study reveals the contribution of pre-existing anti-polio immunity to the effectiveness of polio virotherapy for cancer treatment. Childhood vaccines such as polio and tetanus can enhance antitumor immune responses, particularly by activating CD4(+) T cells and eosinophils.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Viola Hedrich, Kristina Breitenecker, Gregor Ortmayr, Franziska Pupp, Heidemarie Huber, Doris Chen, Sarthak Sahoo, Mohit Kumar Jolly, Wolfgang Mikulits
Summary: This study identified PRAME as a target gene of the Gas6/Axl signaling pathway in hepatocellular carcinoma. PRAME promotes dedifferentiation, epithelial-to-mesenchymal transition, and invasion in liver cancer cells. The expression of PRAME is associated with an unfavorable prognosis in HCC patients.
Review
Chemistry, Multidisciplinary
Seemadri Subhadarshini, Joel Markus, Sarthak Sahoo, Mohit Kumar Jolly
Summary: Epithelial-mesenchymal plasticity (EMP) is a crucial factor in cancer metastasis and therapeutic resistance, allowing cancer cells to alter their characteristics along the epithelial-mesenchymal spectrum. Single-cell studies have provided valuable insights into the dynamics of EMP, showing the heterogeneity of hybrid epithelial/mesenchymal phenotypes and their impact on patient survival.
Article
Oncology
Pascale Mariani, Nouritza Torossian, Steven van Laere, Peter Vermeulen, Leanne de Koning, Sergio Roman-Roman, Olivier Lantz, Manuel Rodrigues, Marc-Henri Stern, Sophie Gardrat, Laetitia Lesage, Gabriel Champenois, Andre Nicolas, Alexandre Matet, Nathalie Cassoux, Vincent Servois, Emanuela Romano, Sophie Piperno-Neumann, Claire Lugassy, Raymond Barnhill
Summary: This study investigated the immune cell infiltrates in uveal melanoma liver metastases (UMLM) and found that CD68+ and CD163+ tumor-infiltrating macrophages, CD20+ peritumoral lymphocytes, and growth patterns were important prognostic factors.
BRITISH JOURNAL OF CANCER
(2023)
Article
Cell Biology
Shinjinee Sengupta, Namrata Singh, Ajoy Paul, Debalina Datta, Debdeep Chatterjee, Semanti Mukherjee, Laxmikant Gadhe, Jyoti Devi, Yeshwanth Mahesh, Mohit Kumar Jolly, Samir K. Maji
Summary: The study found a strong correlation between p53 amyloid load and cancer grades. Both mutant and wild-type p53 were capable of forming amyloids in cancer tissues. Furthermore, the p53 amyloids sequestered higher amounts of related proteins, suggesting a potential mechanism for loss of tumor-suppressive function and gain of oncogenic function in cancer progression.
JOURNAL OF CELL SCIENCE
(2023)
Review
Physics, Multidisciplinary
Federico Bocci, Dongya Jia, Qing Nie, Mohit Kumar Jolly, Jose Onuchic
Summary: The last decade has seen a rise in theoretical and computational models used to describe complex gene regulatory networks and their dynamics, which can result in multistable and heterogeneous cell populations. The application of theoretical modeling in genetic and biochemical circuits has become more widespread, with theoreticians incorporating concepts from statistical physics, non-linear dynamics, and network theory. This review provides an overview of important methodologies in the field, discusses current and future challenges, offers hands-on tutorials for solving and simulating biological system models, and presents concrete examples for theoreticians interested in this fast-developing field.
REPORTS ON PROGRESS IN PHYSICS
(2023)
Article
Mathematical & Computational Biology
Kishore Hari, William Duncan, Mohammed Adil Ibrahim, Mohit Kumar Jolly, Breschine Cummins, Tomas Gedeon
Summary: Mathematical modeling of gene regulatory networks (GRN) is challenging due to parameter dependence and lack of reliable experimental parameters. This study compares two approaches, RACIPE and DSGRN, for describing GRN dynamics across unknown parameters and finds agreement in simulation and predictions for cellular decision making. The observation is important as DSGRN parameter domains accurately predict ODE model dynamics within a biologically reasonable range of parameters.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2023)
Article
Oncology
Xuemei Xie, Gaurav B. Chauhan, Ramakrishna Edupuganti, Takahiro Kogawa, Jihyun Park, Moises Tacam, Alex W. Tan, Mohd Mughees, Fnu Vidhu, Diane D. Liu, Juliana M. Taliaferro, Mary Kathryn Pitner, Luke S. Browning, Ju-Hyeon Lee, Yu Shen, Jian Wang, Naoto T. Ueno, Savitri Krishnamurthy, Gabriel N. Hortobagyi, Debu Tripathy, Steven J. Van Laere, Geoffrey Bartholomeusz, Kevin N. Dalby, Chandra Bartholomeusz
Summary: Triple-negative breast cancer (TNBC) is characterized by high relapse and metastasis rates, as well as a high proportion of cancer stem-like cells (CSC) with self-renewal and tumor initiation capacity. In this study, researchers found that MELK, a protein kinase known to promote CSC maintenance, is highly expressed in TNBC tumors and associated with worse overall survival and distant metastasis-free survival. Knockdown or inhibition of MELK reduces invasiveness, reverses epithelial-to-mesenchymal transition, and limits CSC self-renewal and maintenance in TNBC cells, leading to suppressed metastasis and improved overall survival in mouse models.
CANCER RESEARCH COMMUNICATIONS
(2023)
Review
Computer Science, Interdisciplinary Applications
Maalavika Pillai, Emilia Hojel, Mohit Kumar Jolly, Yogesh Goyal
Summary: Computational models and tools have been used to understand the origins and nature of non-genetic heterogeneity in cancer, which has significant clinical implications. Non-genetic heterogeneity is increasingly associated with therapy resistance and metastasis in cancer. Identifying the origins of non-genetic heterogeneity is crucial for making clinical breakthroughs.
NATURE COMPUTATIONAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Paras Jain, Sophia Corbo, Kulsoom Mohammad, Sarthak Sahoo, Santhalakshmi Ranganathan, Jason T. George, Herbert Levine, Joseph Taube, Michael Toneff, Mohit Kumar Jolly
Summary: Epithelial-mesenchymal transition (EMT) and its reverse mesenchymal-epithelial transition (MET) play crucial roles in embryonic development, wound healing, and cancer metastasis. While short-term EMT induction can lead to reversible phenotypic changes, long-term EMT induction is often associated with irreversibility. In this study, we demonstrate that the phenotypic changes observed in MCF10A cells during long-term EMT induction by TGF-beta can in fact have longer timescales of reversibility. We also propose a mathematical model that explains how the epigenetic memory gained during long-term EMT induction can slow down the recovery to the epithelial state after TGF-beta withdrawal.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2023)
Article
Oncology
Manas Sehgal, Soundharya Ramu, Joel Markus Vaz, Yogheshwer Raja Ganapathy, Srinath Muralidharan, Sankalpa Venkatraghavan, Mohit Kumar Jolly
Summary: This study investigates the relationship between gene expression patterns and phenotypic plasticity and heterogeneity in colorectal cancer (CRC). The results demonstrate the interconnectedness between different Consensus Molecular Subtypes (CMS) of CRC and specific phenotypes such as epithelial and mesenchymal characteristics. Additionally, the study reveals correlations between metabolic pathways and phenotypic scores, as well as between PD-L1 activity and mesenchymal phenotype. Single-cell RNA sequencing analysis further confirms the heterogeneity of different CMS subtypes. These findings have important implications for understanding CRC heterogeneity and developing targeted therapies.
TRANSLATIONAL ONCOLOGY
(2024)