Article
Pharmacology & Pharmacy
Cancan Zheng, Xiaomei Yu, Taoyang Xu, Zhichao Liu, Zhili Jiang, Jiaojiao Xu, Jing Yang, Guogeng Zhang, Yan He, Han Yang, Xingyuan Shi, Zhigang Li, Jinbao Liu, Wen Wen Xu
Summary: Increasing evidences suggest the important role of calcium homeostasis in cancer, but its function and regulatory network in metastasis remain unclear. This study identifies KCTD4 as a driver of cancer metastasis and finds that high expression of KCTD4 is associated with poor prognosis in patients with esophageal squamous cell carcinoma. KCTD4 enhances cancer cell invasion by increasing fibronectin transcription via NFATc1 and its disruption of CLIC1 dimerization. Furthermore, a lead compound targeting the KCTD4-CLIC1 interaction significantly suppresses cancer metastasis.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Oncology
Wei-zhao Peng, Jin Zhao, Xin Liu, Chao-feng Li, Shuang Si, Ren Ma
Summary: The study shows that overexpression of hnRNPA2B1 in GC is associated with poor survival and is required for maintaining a malignant phenotype by promoting cell proliferation, inhibiting cell apoptosis, and increasing cell metastasis. Mechanistically, hnRNPA2B1 is co-expressed with several core spliceosome components and controls alternative splicing of the anti-apoptotic factor BIRC5. The BIRC5 isoform 202 plays an oncogenic role in GC cells, and overexpression of the BIRC5-202 transcript partially restores cisplatin resistance decreased by downregulation of hnRNPA2B1.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Tongke Chen, Junbo Chen, Tianni Zeng, Qianying Huang, Di Chen, Hong Chen, Jiayao Chen, Bin Zheng, Mengting Wang, Shinuo Chen, Jichen Dai, Hanxiao Sun, Tongzuan Chen, Yuwen Huang, Liqian Zhao, Shumei Ma, Xiaodong Liu
Summary: This study aimed to elucidate the crosstalk between redox reaction and metabolic remodeling in inhibiting gastric cancer cell metastasis. It demonstrated that WZ35, a curcumin analog, exhibited potent anti-proliferative and anti-metastasis properties. The study further identified the mechanism by which WZ35 maintained glutathione depletion in gastric cancer cells.
Review
Oncology
Jing Gao, Song Li, Qian Xu, Xue Zhang, Miao Huang, Xin Dai, Lian Liu
Summary: Exosomes play a crucial role in the formation of pre-metastatic niches in gastric cancer, facilitating tumor metastasis by establishing a supportive environment remotely. The cell components in pre-metastatic niches secrete exosomes that interact with each other, providing signals that promote tumor growth.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Bo-Kyung Kim, Da-Mi Kim, Hyunkyung Park, Seon-Kyu Kim, Mi-Aie Hwang, Jungwoon Lee, Mi-Jung Kang, Jae-Eun Byun, Joo-Young Im, Minho Kang, Kyung Chan Park, Young Il Yeom, Seon-Young Kim, Haiyoung Jung, Dae-Hyuk Kweon, Jae-Ho Cheong, Misun Won
Summary: This study identified Synaptotagmin 11 (SYT11) as a potential therapeutic target and prognostic biomarker in gastric cancer (GC), particularly in the stem-like molecular subtype. SYT11 was found to promote epithelial-mesenchymal transition (EMT) and affect tumor proliferation and metastasis by activating the JNK signaling pathway. Additionally, SYT11 was identified as a potential prognostic biomarker for diffuse-type GC. These findings suggest the potential value of SYT11 as a therapeutic target and prognostic indicator in GC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yaohui Wang, Xiang Li, Tiancheng Zhang, Fangyuan Li, Yuke Shen, Yani He, Qiang You, Yifan Zhang, Jing Zhai, Xuequan Yao, Lizong Shen
Summary: In gastric cancer, tumor-associated neutrophils (TANs) promote lymph node metastasis (LNM) through enhancing tumor cell invasiveness and epithelial-to-mesenchymal transition (EMT). The crosstalk between neutrophils and tumor cells is mediated by various signaling pathways including TGF beta 1, FAM3C, and JNK-ZEB1/Snail, and involves interaction of integrins alpha 6 beta 1 and alpha 6 beta 4 with CD151. Studies using tumor-bearing mice confirm the importance of neutrophils in gastric cancer tumorigenesis and invasiveness. Understanding the functional roles of TANs in promoting tumor invasion provides potential targets for developing strategies to prevent or treat LNM in gastric cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Oncology
Zikun Ma, Xiangdong Li, Yize Mao, Chen Wei, Zhuoli Huang, Guibo Li, Jianhua Yin, Xiaoyu Liang, Zhuowei Liu
Summary: In this study, a subset of cancer-associated fibroblasts (CAFs) characterized by overexpression of the urea transporter SLC14A1 was identified in bladder cancer patients. These CAFs were induced by interferon signaling and conferred stemness to bladder cancer cells through the WNT5A paracrine pathway. Inhibiting the formation of SLC14A1(+) CAFs sensitized tumor cells to chemotherapy. Importantly, bladder cancer patients with a high proportion of intratumoral SLC14A1(+) CAFs had a poor outcome and a worse response rate to neoadjuvant chemotherapy or immunotherapy.
Article
Oncology
Chao Wang, Zhi Yang, En Xu, Xiaofei Shen, Xingzhou Wang, Zijian Li, Heng Yu, Kai Chen, Qiongyuan Hu, Xuefeng Xia, Song Liu, Wenxian Guan
Summary: This study found that APOC2 is overexpressed in GC PM tissues and correlates with poor prognosis in GC patients. APOC2 promotes invasion, migration, and proliferation of GC cells through CD36-mediated PI3K/AKT/mTOR signaling pathway.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Wangkai Xie, Zheng Han, Ziyi Zuo, Dong Xin, Hua Chen, Juanjuan Huang, Siyu Zhu, Han Lou, Zhiqiang Yu, Chenbin Chen, Sian Chen, Yuanbo Hu, Jingjing Huang, Fabiao Zhang, Zhonglin Ni, Xian Shen, Xiangyang Xue, Kezhi Lin
Summary: This study analyzed the relationship between differential expression of cytoskeleton genes and prognosis in gastric cancer (GC). ASAP1 was found to play a key role in cytoskeletal remodeling and prognosis in GC patients, and its overexpression can be used as a predictor of poor prognosis.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Marina Saisana, S. Michael Griffin, Felicity E. B. May
Summary: The study found that gastric adenocarcinoma cells have higher expression of insulin receptor, which is negatively correlated with patient survival. Insulin promotes proliferation and survival of gastric adenocarcinoma cells through the PI3-kinase/Akt signaling pathway, and inhibiting receptor expression can suppress cell proliferation and induce apoptosis.
Article
Biochemistry & Molecular Biology
Yi Wu, Yanjie Hao, Qing'xin Zhuang, Xiaoli Ma, Chao Shi
Summary: This study found that M2 macrophage polarization is the main immune infiltration pattern in gastric cancer, and low expression of AKR1B10 induces M2 macrophage polarization and promotes the malignant transformation of gastric cancer.
BIOSCIENCE REPORTS
(2023)
Article
Oncology
Min Wang, Wei Cai, Ai-Jun Yang, Chen -Yu Wang, Chen -Li Zhang, Wei Liu, Xiao-Feng Xie, Yuan-Yuan Gong, Ying-Ying Zhao, Wen-Cheng Wu, Quan Zhou, Chan -Yuan Zhao, Jing-Fei Dong, Min Li
Summary: This study investigated the role of cancer cell-derived extracellular vesicles (CEVs) in promoting the metastasis of gastric cancer. The researchers made several important observations, including the correlation between plasma levels of CEVs and metastasis rate, the effects of CEVs on endothelial cells, and the promotion of cancer metastasis by CEVs.
Article
Cell Biology
Feifei Zhou, Wenqian Ai, Yixing Zhang, Qifan Hu, Mingxi Gan, Jian-Bin Wang, Tianyu Han
Summary: Rho GTPases play a crucial role in cellular processes, and ARHGEF3 has been identified as a potential therapeutic target in non-small cell lung cancer due to its involvement in promoting cancer cell proliferation through modulating protein homeostasis of ACLY, independent of its GEF activity.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Xuejian Li, Huifei Wang, Aran Jia, Yuanyuan Cao, Liuqing Yang, Zanhui Jia
Summary: The present study aimed to explore the significance and molecular mechanisms of galectin-1 (LGALS1) in ovarian cancer (OC). The results demonstrated that LGALS1 mRNA expression was markedly increased in OC and associated with advanced tumor, lymphatic metastasis and residual lesions. The enrichment analysis revealed that the upregulated differentially expressed genes were primarily associated with the metastasis of cancer cells. The study highlighted that LGALS1 may regulate cell adhesion and participate in the development of OC, making it a potential therapeutic target.
Article
Biochemistry & Molecular Biology
Lin Zhang, Yuting Xu, Enmin Cai, Maojin Zheng, Lei Liu, Qingling Wang, Shibao Li
Summary: This study reveals that TSPAN8 is significantly upregulated in gastric cancer tissues and is associated with clinicopathological characteristics and poor prognosis. TSPAN8 promotes cancer cell migration and invasion by activating the EGFR/AKT pathway and regulating EGFR expression. Therefore, TSPAN8 may serve as a promising therapeutic target for gastric cancer.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Oncology
Lezong Chen, Yongqiang Zheng, Kai Yu, Shuzhao Chen, Weida Wang, Robert Peter Gale, Ze-Xian Liu, Yang Liang
Summary: Causes of death in persons with haematological cancers include the index cancer, a new cancer, or unrelated causes such as cardio-vascular disease. The distribution of causes of death across haematological cancers reflects progress in some cancers and suggests strategies for improving survival.
Article
Biochemical Research Methods
Jing Liang, Zong-Wei Li, Cai-Tong Yue, Zhuo Hu, Han Cheng, Ze-Xian Liu, Wei-Feng Guo
Summary: This study developed a novel model (MMPDNB) that can provide multiple personalized biomarker modules and uncover their multi-modal properties. By validating genomic data of breast or lung cancer patients, the experimental results demonstrated that MMPDNB can more effectively predict key states with the highest early warning signals during cancer development.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Oncology
Jia Liu, Ze-Xian Liu, Jia-Jun Li, Zhao-Lei Zeng, Jin-Hong Wang, Xiao-Jing Luo, Chau-Wei Wong, Jia-Bo Zheng, Heng-Ying Pu, Hui Sheng, Qi-Nian Wu, Hao Li, Gang Wan, Bo Li, De-shen Wang, Rui-Hua Xu, Huai-Qiang Ju
Summary: Tumor-associated macrophages (TAM) are important for tumor development and progression. This study found that the long noncoding RNA MALR promoted aerobic glycolysis and angiogenesis in tumor cells by activating the HIF1a signaling pathway. It also identified the MALR-ILF3-HIF1a axis as a potential target for cancer therapy.
Editorial Material
Biochemical Research Methods
Jia Meng, Zhixiang Zuo, Tzong-Yi Lee, Zexian Liu, Yufei Huang
Article
Biochemistry & Molecular Biology
Kai Yu, Ye Wang, Yongqiang Zheng, Zekun Liu, Qingfeng Zhang, Siyu Wang, Qi Zhao, Xiaolong Zhang, Xiaoxing Li, Rui-Hua Xu, Ze-Xian Liu
Summary: Post-translational modifications (PTMs) play critical roles in regulating protein functions and understanding biological processes and diseases. The qPTM database serves as a comprehensive one-stop data resource, providing massive quantitative PTM proteome datasets and a scoring system to assess PTM site reliability.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Chunhua Zhao, Zekun Liu, Chia-Che Chang, Yi-Chia Chen, Qize Zhang, Xiao-Dong Zhang, Chrysalis Andreou, Jiadong Pang, Ze-Xian Liu, Di-Yan Wang, Moritz F. Kircher, Jiang Yang
Summary: Through bioinformatic analysis, researchers found that TNBC has a higher ferroptosis potential index (FPI) than non-TNBC. They developed a phototheranostic nanocrystal that can trigger both apoptosis and ferroptosis in TNBC cells, effectively limiting the growth and metastasis of TNBC.
Article
Biochemical Research Methods
Kai Yu, Zekun Liu, Haoyang Cheng, Shihua Li, Qingfeng Zhang, Jia Liu, Huai-Qiang Ju, Zhixiang Zuo, Qi Zhao, Shiyang Kang, Ze-Xian Liu
Summary: This study presents a novel software, dSCOPE, for predicting protein sequence segments critical for liquid-liquid phase separation (LLPS). The large-scale analysis of the human proteome based on dSCOPE reveals potential roles and associations with post-translational modifications, cancer mutations, and cellular signaling pathways.
BRIEFINGS IN BIOINFORMATICS
(2023)
Article
Oncology
Hao-Xiang Wu, Yi-Qian Pan, Ye He, Zi-Xian Wang, Wen-Long Guan, Yan-Xing Chen, Yi-Chen Yao, Ning-Yi Shao, Rui-Hua Xu, Feng Wang
Summary: This study found that PD-1 antibody plus chemotherapy had significant clinical benefit in patients with advanced esophageal squamous cell carcinoma with low PD-L1 expression, supporting its superiority over chemotherapy alone. Further research on predictive biomarkers is needed.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Genetics & Heredity
Ze-Xian Liu, Panqin Wang, Qingfeng Zhang, Shihua Li, Yuxin Zhang, Yutong Guo, Chongchong Jia, Tian Shao, Lin Li, Han Cheng, Zhenlong Wang
Summary: In this study, we developed an integrated resource (iHypoxia) for the expression dynamics of proteins in response to hypoxia. The database contains expression data of proteins from multiple mammals, candidate genes associated with hypoxia, and information about posttranslational modifications. iHypoxia provides a convenient way for users to access hypoxia-related information.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2023)
Letter
Oncology
Hao-Xiang Wu, Yi-Qian Pan, Zi-Xian Wang, Feng Wang
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Dermatology
Sharmeen Chagani, Mariana P. De Macedo, Fernando Carapeto, Feng Wang, Diego M. Marzese, Khalida Wani, Lauren E. Haydu, Weiyi Peng, Giang T. Ong, Sarah E. Warren, Joseph M. Beechem, Dave S. B. Hoon, Gordon B. Mills, Michael T. Tetzlaff, Alexander J. Lazar, Lawrence N. Kwong, Michael A. Davies
Summary: Loss of PTEN protein expression in melanoma is associated with increased cancer aggressiveness, decreased tumor immune infiltration, and resistance to immune and targeted therapies.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Genetics & Heredity
Ye Hong, Yan Yuan, Zekun Liu, Zexian Liu, Yizhuo Zhang
Summary: The dysregulation of cell death is closely associated with the development, progression, tumor microenvironment (TME), and prognosis of cancer. This study comprehensively explores the prognostic and immunological role of cell death in human pan-cancer using RNA-sequencing and clinical data. A reliable gene signature was constructed to distinguish prognosis-favorable and prognosis-unfavorable patients, showing significant associations with genomic mutation frequency, hypoxia score, immune gene expression, malignant signaling pathways, and cancer immunity cycle.
Article
Oncology
Bin Zhang, Chun-Mei Wang, Hao-Xiang Wu, Feng Wang, Yang-Yang Chai, Ye Hu, Bing-Jing Wang, Zhou Yu, Rong-Hua Xia, Rui-Hua Xu, Xue-Tao Cao
Summary: In this study, the researchers found that higher expression of MFSD2A was associated with better response to anti-PD-1 immunotherapy in advanced gastric cancer patients. MFSD2A expression was lower in gastric cancer tissues compared to normal tissues, and its overexpression enhanced the efficacy of anti-PD-1 immunotherapy in vivo by reprogramming the tumor microenvironment. MFSD2A inhibited the release of transforming growth factor beta 1 from gastric cancer cells by suppressing cyclooxygenase 2, thus promoting anti-tumor T cell activation.
CANCER COMMUNICATIONS
(2023)
Article
Oncology
Jia Liu, Wei-Yi Zhou, Xiao-Jing Luo, Yan-Xing Chen, Chau-Wei Wong, Ze-Xian Liu, Jia- Bo Zheng, Hai- Yu Mo, Jun-Quan Chen, Jia-Jun Li, Ming Zhong, Yu-Hong Xu, Qi-Hua Zhang, Heng-Ying Pu, Qi-Nian Wu, Ying Jin, Zi-Xian Wang, Rui-Hua Xu, Hui-Yan Luo
Summary: This study reveals the critical role of the RIME-MLL1-H3K4me3 axis in tumor immunosuppression. RIME may serve as a potential prognostic biomarker for immunotherapy, and developing drugs targeting RIME may be a new therapeutic strategy to overcome immunotherapy resistance.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Rongjie Cheng, Fanying Li, Maolei Zhang, Xin Xia, Jianzhuang Wu, Xinya Gao, Huangkai Zhou, Zhi Zhang, Nunu Huang, Xuesong Yang, Yaliang Zhang, Shunli Shen, Tiebang Kang, Zexian Liu, Feizhe Xiao, Hongwei Yao, Jianbo Xu, Chao Yan, Nu Zhang
Summary: This study identifies RASON as a positive regulator of oncogenic RAS signaling and reveals its aberrant overexpression in pancreatic ductal adenocarcinoma. RASON promotes tumor cell proliferation and tumor growth by sustaining the hyperactive state of KRAS through inhibiting GTP hydrolysis. Deprivation of RASON sensitizes KRAS mutant pancreatic cancer cells to EGFR inhibitors.