Article
Pharmacology & Pharmacy
Lena Radtke, Aleksandra Majchrzak-Celinska, Charles Awortwe, Inga Vater, Inga Nagel, Susanne Sebens, Ingolf Cascorbi, Meike Kaehler
Summary: This study demonstrates the significance of ABCB1 in GBM cells, affecting the response to temozolomide and carmustine treatment, while ABCG2 plays a marginal role.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Danijela D. Nikodijevic, Jovana V. Jovankic, Danijela M. Cvetkovic, Marko Z. Andelkovic, Aleksandra G. Nikezic, Milena G. Milutinovic
Summary: The study evaluated the potential antitumor activity of snake venom and L-amino acid oxidase on colorectal cancer cells, showing that snake venom primarily led to necrosis while L-amino acid oxidase induced apoptosis correlated with oxidative imbalances in cancer cells. Additionally, the gene expression profiles and levels of membrane transporters also impacted the sensitivity of treatment across different cell lines. The findings suggest that L-amino acid oxidase could be a promising substance for further research on its antitumor effects, potentially with lower risk of drug resistance in vitro.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Lenka Hruba, Viswanath Das, Marian Hajduch, Petr Dzubak
Summary: Nucleoside-based drugs, widely used in the treatment of various diseases, have been hindered by drug resistance. This review explores the mechanisms of resistance, including changes in membrane transporters, activating kinases, drug elimination strategies, and DNA damage repair mechanisms. The critical analysis in this review points towards novel therapeutic strategies such as targeted therapies, new nucleoside analogs, and synergistic drug combinations to overcome resistance and improve patient outcomes.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Environmental Sciences
Jian Yin, Jia Hu, Xudong Deng, Yu Zheng, Jingjing Tian
Summary: This paper summarizes the recent advances in the understanding of ABC transporter-mediated multi-xenobiotic resistance (MXR) mechanism in fish embryos and the potential interaction between ABC transporters and nanoparticles (NPs). The research found that ABC transporters can be maternally transferred to fish embryos and play a crucial role in the detoxification of various chemical pollutants and NPs, thus protecting aquatic resources.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Teresa Kreinest, Ines Volkmer, Martin S. Staege
Summary: Melittin from bee venom showed high toxicity for HL cell lines KM-H2 and L-428, as well as increased cisplatin sensitivity in chemo-resistant L-428 cells. However, melittin did not reduce ABC transporter activity. These findings suggest that melittin or its analogs could be promising agents for treating HL patients with resistant disease in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jianyi Li, Yuntong Lv, Kunpeng Yan, Fengting Yang, Xuewei Chen, Xiwu Gao, Shuyuan Wen, Hongfei Xu, Yiou Pan, Qingli Shang
Summary: The study revealed that ATP-binding cassette transporters (ABCs) play important roles in cyantraniliprole resistance. Inhibition of ABCs increased the toxicity of cyantraniliprole, while overexpression of ABCs in fruit flies enhanced their tolerance to cyantraniliprole. Suppression of specific ABC transporters increased the sensitivity of cyantraniliprole-resistant strains. These findings provide valuable insights for resistance management strategies.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Magdalena Jurczyk, Janusz Kasperczyk, Dorota Wrzesniok, Artur Beberok, Katarzyna Jelonek
Summary: There is a growing interest in the use of chemosensitizers and cytostatics in combination to overcome cancer resistance to treatment. To overcome challenges such as poor bioavailability and chemical instability of drugs, attempts have been made to create nanoparticles for the delivery of docetaxel (Dtx) and resveratrol (Res). Recent reports suggest that nano-delivery systems for Dtx and Res exhibit better efficiency in cancer treatment than free drugs, and the simultaneous release of both drugs in cancer cells may help overcome limitations caused by multidrug resistance.
Article
Microbiology
Sonam Kumari, Mohit Kumar, Brooke D. Esquivel, Mohd Wasi, Ajay Kumar Pandey, Nitesh Kumar Khandelwal, Alok K. Mondal, Theodore C. White, Rajendra Prasad, Naseem A. Gaur
Summary: The study reveals that under nitrogen-depleted conditions, Candida glabrata's CgYor1 independently displays sensitivity to antifungals, unrelated to the function of the major transporter CgCdr1. Furthermore, it appears that the deletion of CgYor1 affects fluconazole susceptibility by modulating the TOR and calcineurin signaling cascades.
Article
Microbiology
Sonam Kumari, Mohit Kumar, Brooke D. Esquivel, Mohd Wasi, Ajay Kumar Pandey, Nitesh Kumar Khandelwal, Alok K. Mondal, Theodore C. White, Rajendra Prasad, Naseem A. Gaur
Summary: In this study, the mechanisms of azole resistance mediated by CgYor1, a multidrug resistance-associated protein (MRP) subfamily ABC transporter, were analyzed. It was found that CgYor1 does not transport oligomycin but is involved in azole resistance. Under normal growing conditions, its function is masked by the major transporter CgCdr1; however, under nitrogen-depleted conditions, it displays its azole resistance function independently. It is proposed that the removal of CgYor1 affects azole susceptibility through modulation of TOR and calcineurin cascades.
Article
Biochemistry & Molecular Biology
Janaina Alessandra Silva, Alison Colquhoun
Summary: This study investigated the effects of polyunsaturated fatty acids (PUFAs) on U87MG cells and TMZ-resistant cells. PUFAs altered the fatty acid composition and caused lipid droplet accumulation in the cytoplasm. EPA had the most significant inhibitory effect on cell growth and GLA and EPA had larger effects on ABC transporter expression than DHA. Overall, PUFAs can modulate ABC transporters in glioblastoma cells.
Article
Chemistry, Analytical
Yanyan Ma, Zhanchen Guo, Chuanwen Fan, Jingran Chen, Shuxin Xu, Zhen Liu
Summary: This study developed aptamers that can target ABCG2 and reverse multidrug resistance, showing great potential in cancer diagnosis and treatment. The aptamers can specifically bind to human colorectal cancer stem cells and effectively reverse drug resistance in liver cancer cells.
ANALYTICAL CHEMISTRY
(2022)
Article
Microbiology
Sophia Krauss, Alexander Zipperer, Sebastian Wirtz, Julian Saur, Martin C. Konnerth, Simon Heilbronner, Benjamin O. Torres Salazar, Stephanie Grond, Bernhard Krismer, Andreas Peschel
Summary: Lugdunin is a nonribosomally synthesized antibiotic produced by Staphylococcus lugdunensis in human microbiomes, which can eliminate the pathogen Staphylococcus aureus. It belongs to a new class of fibupeptide antibiotics with a novel mode of action. The specific mechanism of resistance to lugdunin suggests potential for use in preventing and treating S. aureus infections without conferring cross-resistance to other antimicrobials.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Ales Sorf, Dimitrios Vagiannis, Fahda Ahmed, Jakub Hofman, Martina Ceckova
Summary: This study found that dabrafenib inhibits ABCG2 and ABCB1 transporters and also inhibits CYP2C8, CYP2C9, CYP3A4, and CYP3A5 enzymes. Additionally, dabrafenib increases the mRNA levels of ABCB1, ABCG2, ABCC1, and CYP3A4. These findings suggest that caution should be taken when using dabrafenib in patients with polypharmacy, but its interactions with other drugs could be utilized to improve the treatment outcome of drug-resistant cancer.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Yuntong Lv, Kunpeng Yan, Xiwu Gao, Xuewei Chen, Jianyi Li, Yaping Ding, Hang Zhang, Yiou Pan, Qingli Shang
Summary: This study explores the involvement of ATP-binding cassette (ABC) transporters in spirotetramat resistance in cotton aphids. The results show that several ABC transporter genes, including ABCB4, ABCB5, ABCF2, MRP11, and MRP12, are upregulated in the spirotetramat-resistant strains. Functional analysis confirms the contribution of these genes to spirotetramat tolerance.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Valerio Taggi, Mario Riera Romo, Micheline Piquette-Miller, Henriette E. Meyer zu Schwabedissen, Sibylle Neuhoff
Summary: Drug transporters are crucial for maintaining chemical balance and homeostasis in tissues, as well as for the absorption, distribution, and elimination of clinically important drugs. Diseases can alter the expression and function of drug transporters. However, there is limited knowledge on transporter regulation in critical protective barriers, which requires further research.
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.