An IL-15 superagonist/IL-15Rα fusion complex protects and rescues NK cell-cytotoxic function from TGF-β1-mediated immunosuppression
出版年份 2018 全文链接
标题
An IL-15 superagonist/IL-15Rα fusion complex protects and rescues NK cell-cytotoxic function from TGF-β1-mediated immunosuppression
作者
关键词
NK cells, IL-15, TGF-β1, Immunosuppression, Tumor microenvironment
出版物
CANCER IMMUNOLOGY IMMUNOTHERAPY
Volume 67, Issue 4, Pages 675-689
出版商
Springer Nature
发表日期
2018-02-01
DOI
10.1007/s00262-018-2121-4
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- A potential therapy for chordoma via antibody-dependent cell-mediated cytotoxicity employing NK or high-affinity NK cells in combination with cetuximab
- (2018) Rika Fujii et al. JOURNAL OF NEUROSURGERY
- IL-15 super-agonist (ALT-803) enhances natural killer (NK) cell function against ovarian cancer
- (2017) M. Felices et al. GYNECOLOGIC ONCOLOGY
- ADCC employing an NK cell line (haNK) expressing the high affinity CD16 allele with avelumab, an anti-PD-L1 antibody
- (2017) Caroline Jochems et al. INTERNATIONAL JOURNAL OF CANCER
- BOS Is Associated With Increased Cytotoxic Proinflammatory CD8 T, NKT-Like, and NK Cells in the Small Airways
- (2017) Greg Hodge et al. TRANSPLANTATION
- Analyses of the peripheral immunome following multiple administrations of avelumab, a human IgG1 anti-PD-L1 monoclonal antibody
- (2017) Renee N. Donahue et al. Journal for ImmunoTherapy of Cancer
- TGF-β Signaling in Gastrointestinal Cancers: Progress in Basic and Clinical Research
- (2017) Takehiko Yokobori et al. Journal of Clinical Medicine
- IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells
- (2016) Y. Mao et al. BLOOD
- Targeting natural killer cells in cancer immunotherapy
- (2016) Camille Guillerey et al. NATURE IMMUNOLOGY
- TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway
- (2016) Sébastien Viel et al. Science Signaling
- IL-15 superagonist/IL-15RαSushi-Fc fusion complex (IL-15SA/IL-15RαSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity against murine breast and colon carcinomas
- (2016) Peter S. Kim et al. Oncotarget
- TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway
- (2016) Sébastien Viel et al. Science Signaling
- Targeting NK Cells for Anticancer Immunotherapy: Clinical and Preclinical Approaches
- (2016) Sebastian Carotta Frontiers in Immunology
- Phenotypic and Functional Dysregulated Blood NK Cells in Colorectal Cancer Patients Can Be Activated by Cetuximab Plus IL-2 or IL-15
- (2016) Yamila Sol Rocca et al. Frontiers in Immunology
- The IL-15-Based ALT-803 Complex Enhances Fc RIIIa-Triggered NK Cell Responses and In Vivo Clearance of B Cell Lymphomas
- (2015) M. Rosario et al. CLINICAL CANCER RESEARCH
- Therapeutic administration of IL-15 superagonist complex ALT-803 leads to long-term survival and durable antitumor immune response in a murine glioblastoma model
- (2015) Dimitrios Mathios et al. INTERNATIONAL JOURNAL OF CANCER
- Redistribution, Hyperproliferation, Activation of Natural Killer Cells and CD8 T Cells, and Cytokine Production During First-in-Human Clinical Trial of Recombinant Human Interleukin-15 in Patients With Cancer
- (2015) Kevin C. Conlon et al. JOURNAL OF CLINICAL ONCOLOGY
- Comparison of the Superagonist Complex, ALT-803, to IL15 as Cancer Immunotherapeutics in Animal Models
- (2015) P. R. Rhode et al. Cancer Immunology Research
- Antibody-Dependent Cellular Cytotoxicity Activity of a Novel Anti-PD-L1 Antibody Avelumab (MSB0010718C) on Human Tumor Cells
- (2015) B. Boyerinas et al. Cancer Immunology Research
- Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer
- (2015) Guy Berchem et al. OncoImmunology
- A combination trial of vaccine plus ipilimumab in metastatic castration-resistant prostate cancer patients: immune correlates
- (2014) Caroline Jochems et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- A comparative study of the effects of inhibitory cytokines on human natural killer cells and the mechanistic features of transforming growth factor-beta
- (2014) Hae mi Lee et al. CELLULAR IMMUNOLOGY
- The IL-2 cytokine family in cancer immunotherapy
- (2014) Geok Choo Sim et al. CYTOKINE & GROWTH FACTOR REVIEWS
- TGF- Utilizes SMAD3 to Inhibit CD16-Mediated IFN- Production and Antibody-Dependent Cellular Cytotoxicity in Human NK Cells
- (2014) R. Trotta et al. JOURNAL OF IMMUNOLOGY
- IL-2: The First Effective Immunotherapy for Human Cancer
- (2014) S. A. Rosenberg JOURNAL OF IMMUNOLOGY
- The TGF-β-inducible miR-23a cluster attenuates IFN-γ levels and antigen-specific cytotoxicity in human CD8+ T cells
- (2014) P. Anoop Chandran et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Intravesical ALT-803 and BCG Treatment Reduces Tumor Burden in a Carcinogen Induced Bladder Cancer Rat Model; a Role for Cytokine Production and NK Cell Expansion
- (2014) Evan Gomes-Giacoia et al. PLoS One
- TGF-β signaling to chromatin: How Smads regulate transcription during self-renewal and differentiation
- (2014) Tessa Gaarenstroom et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Efficacy and Mechanism-of-Action of a Novel Superagonist Interleukin-15: Interleukin-15 Receptor Su/Fc Fusion Complex in Syngeneic Murine Models of Multiple Myeloma
- (2013) W. Xu et al. CANCER RESEARCH
- Cytokine patterns in patients with cancer: a systematic review
- (2013) Bodo E Lippitz LANCET ONCOLOGY
- Capillary Isoelectric-Focusing Immunoassays to Study Dynamic Oncoprotein Phosphorylation and Drug Response to Targeted Therapies in Non–Small Cell Lung Cancer
- (2013) Jin-Qiu Chen et al. MOLECULAR CANCER THERAPEUTICS
- The Critical Role of the Tumor Microenvironment in Shaping Natural Killer Cell-Mediated Anti-Tumor Immunity
- (2013) Joanna Baginska et al. Frontiers in Immunology
- IL-2- or IL-15-activated NK cells enhance Cetuximab-mediated activity against triple-negative breast cancer in xenografts and in breast cancer patients
- (2012) María P. Roberti et al. BREAST CANCER RESEARCH AND TREATMENT
- IL-15:IL-15 receptor alpha superagonist complex: High-level co-expression in recombinant mammalian cells, purification and characterization
- (2011) Kai-ping Han et al. CYTOKINE
- Human Tumour Immune Evasion via TGF-β Blocks NK Cell Activation but Not Survival Allowing Therapeutic Restoration of Anti-Tumour Activity
- (2011) Erica B. Wilson et al. PLoS One
- Novel Human Interleukin-15 Agonists
- (2009) X. Zhu et al. JOURNAL OF IMMUNOLOGY
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