Article
Endocrinology & Metabolism
Annika Vestergaard Kvist, Mohamad I. Nasser, Peter Vestergaard, Morten Frost, Andrea M. Burden
Summary: A study in Denmark from 1997 to 2017 found that the incidence rates of fractures were higher in patients with type 1 and type 2 diabetes compared to those without diabetes, except for foot fractures. The incidence of hip fractures decreased by 35.2%, 47.0%, and 23.4% in patients with type 1 diabetes, type 2 diabetes, and without diabetes, respectively, over the last 5 years. However, vertebral fractures increased by 14.8%, 18.5%, and 38.9% in the same groups. After age adjustment, patients with type 1 diabetes still had a higher risk of fractures compared to those without diabetes, while patients with type 2 diabetes had a risk similar to those without diabetes.
Article
Environmental Sciences
Zhaoyang Li, Tengfei Long, Ruixin Wang, Yue Feng, Hua Hu, Yali Xu, Yue Wei, Fei Wang, Huan Guo, Xiaomin Zhang, Meian He
Summary: Limited evidence suggests a link between plasma levels of multiple metals and incident cancer risk in patients with type 2 diabetes mellitus. Copper and lead were significantly associated with increased cancer risk, while zinc and chromium were associated with decreased cancer risk. Monitoring metal levels in diabetic patients is crucial for cancer prevention.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Biochemistry & Molecular Biology
Cristina Rey-Renones, Jose Miguel Baena-Diez, Isabel Aguilar-Palacio, Cristina Miquel, Maria Grau
Summary: Individuals with type 2 diabetes are at higher risk for developing and dying from cancer, possibly due to metabolic abnormalities such as obesity. Understanding this link can aid in designing personalized preventive strategies.
Review
Public, Environmental & Occupational Health
Fabricio Ccami-Bernal, David R. Soriano-Moreno, Daniel Fernandez-Guzman, Kimberly G. Tuco, Sharong D. Castro-Diaz, Analis L. Esparza-Varas, Sebastian A. Medina-Ramirez, Brenda Caira-Chuquineyra, Andrea G. Cortez-Soto, Marlon Yovera-Aldana, David Rojas-Rueda
Summary: Epidemiological studies have shown that exposure to green spaces is associated with a lower prevalence of type 2 diabetes mellitus (T2DM). A systematic review of 13 cohort studies found that individuals with higher exposure to green spaces had a decreased incidence of T2DM. These findings suggest that promoting policies to preserve and increase green space could help reduce T2DM at the community level.
Article
Cardiac & Cardiovascular Systems
Araz Rawshani, Naveed Sattar, Darren K. McGuire, Oskar Wallstrom, Ulf Smith, Jan Boren, Goran Bergstrom, Elmir Omerovic, Annika Rosengren, Bjorn Eliasson, Deepak L. Bhatt, Aidin Rawshani
Summary: The study found that the incidence of valvular disease is increasing among patients with diabetes. In type 2 diabetes, systolic blood pressure, body mass index, and renal function were found to be associated with valvular lesions.
Article
Endocrinology & Metabolism
Melanie Lloyd, Jedidiah Morton, Helena Teede, Clara Marquina, Dina Abushanab, Dianna J. Magliano, Emily J. Callander, Zanfina Ademi
Summary: The aim of this study was to determine the long-term cost-effectiveness and return on investment of implementing a structured lifestyle intervention to reduce excessive gestational weight gain and associated incidence of gestational diabetes mellitus (GDM) and type 2 diabetes mellitus. The results showed that the intervention was cost-saving compared with usual care from a healthcare perspective, with a return on investment of AU$1.22 per dollar invested. These findings demonstrate significant cost savings and improved health outcomes for women during pregnancy and over their lifetime.
Article
Endocrinology & Metabolism
Jaejin An, Gregory A. Nichols, Lei Qian, Mercedes A. Munis, Teresa N. Harrison, Zhuoxin Li, Rong Wei, Tracey Weiss, Swapnil Rajpathak, Kristi Reynolds
Summary: In a US integrated healthcare system, the prevalence of chronic kidney disease (CKD) was highest among patients newly diagnosed with T2D, while the prevalence of cardiovascular disease (CVD) was lower. Factors such as older age, sex, A1C levels, smoking, and hypertension were associated with increased incidence of CKD and CVD in T2D patients. Despite lower incidence rates of T2D complications in more recent years, a significant number of patients had complications at diagnosis, emphasizing the importance of early preventive therapies and managing modifiable factors to delay development and progression of T2D complications.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Review
Biochemistry & Molecular Biology
Cristina Rey-Renones, Sara Martinez-Torres, Francisco M. Martin-Lujan, Carles Pericas, Ana Redondo, Carles Vilaplana-Carnerero, Angela Dominguez, Maria Grau
Summary: Type-2 diabetes mellitus (T2DM) is a chronic metabolic disorder that is increasing globally and has become epidemic in high- and middle-income countries. There is evidence of a bidirectional interaction between T2DM and COVID-19, with individuals with T2DM having worse prognosis and new cases of T2DM being diagnosed after SARS-CoV-2 infection. Understanding the link between T2DM and COVID-19 can help identify risk factors and develop strategies to improve the prognosis for these patients.
Article
Public, Environmental & Occupational Health
Jack Wang, Sarah H. Wild
Summary: The study revealed that socioeconomic inequalities in the prevalence of type 2 diabetes in Scotland have increased between 2001-2007 and 2021. Further research is needed to investigate potential medium-term effects of the COVID-19 pandemic.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2022)
Article
Endocrinology & Metabolism
Mark J. O'Connor, Philip Schroeder, Alicia Huerta-Chagoya, Paula Cortes-Sanchez, Silvia Bonas-Guarch, Marta Guindo-Martinez, Joanne B. Cole, Varinderpal Kaur, David Torrents, Kumar Veerapen, Niels Grarup, Mitja Kurki, Carsten F. Rundsten, Oluf Pedersen, Ivan Brandslund, Allan Linneberg, Torben Hansen, Aaron Leong, Jose C. Florez, Josep M. Mercader
Summary: GWAS using a recessive model identifies new loci associated with type 2 diabetes, including variants with larger effects.
Article
Oncology
Su Jung Lee, Chulho Kim, Hyunjae Yu, Dong-Kyu Kim
Summary: Previous studies have shown that type 2 diabetes may increase the risk of certain cancers, but it remains unclear if cancer contributes to the development of diabetes. This research aimed to investigate the risk of developing type 2 diabetes, insulin requirements, and diabetes-related complications in cancer patients. The findings suggest that cancer is associated with an increased risk of developing type 2 diabetes, and patients with cancer are more likely to require insulin. Certain cancer types are also linked to a higher risk of developing diabetic nephropathy. Therefore, clinicians should closely monitor the development of type 2 diabetes and its related complications in cancer patients.
Article
Cardiac & Cardiovascular Systems
Suzanne Arnold, Kamlesh Khunti, Fabrice Bonnet, Bernard Charbonnel, Hungta Chen, Javier Cid-Ruzafa, Andrew Cooper, Peter Fenici, Marilia B. Gomes, Niklas Hammar, Linong Ji, Gabriela Luporini-Saraiva, Jesus Medina, Antonio Nicolucci, Larisa Ramirez, Marina Shestakova, Iichiro Shimomura, Filip Surmont, Fengming Tang, Jiten Vora, Hirotaka Watada, Mikhail Kosiborod
Summary: In a global cohort of 14,057 patients with type 2 diabetes, 2.1% were diagnosed with heart failure at enrollment. The majority of incident cases of heart failure occurred in outpatients and in the absence of known coronary artery disease, highlighting the need for greater awareness of heart failure risk in patients with type 2 diabetes.
Article
Endocrinology & Metabolism
Hao Wu, Zongshi Lu, Runyao Chen, Quanfang Cai, Miaomiao Wang, Liting Zhang, Zhiming Zhu
Summary: This study identified AGI use, concomitant gastrointestinal diseases, higher TSH levels, and female sex as independent risk factors for the gastrointestinal side effects of liraglutide treatment in patients with T2DM. Further research is needed to understand these interactions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Zijing Wang, Yao Wu, Junhui Wu, Mengying Wang, Xiaowen Wang, Jiating Wang, Tao Wu, Yiqun Wu, Yonghua Hu
Summary: In Beijing, China, the prevalence of diagnosed type 2 diabetes increased steadily over 10 years, while the incidence decreased overall except in individuals under 40 years old. Efforts to prevent diabetes in China should be continuous.
Article
Endocrinology & Metabolism
Emma J. J. Bouman, Joline W. J. Beulens, Nicolette R. R. den Braver, Marieke T. T. Blom, Sharon Remmelzwaal, Petra J. M. Elders, Femke Rutters
Summary: This study assessed the associations between social jet lag and glycemic and metabolic control in people with type 2 diabetes. The results showed that high social jet lag was associated with higher blood glucose and blood pressure in working people, and lower blood glucose, blood pressure, and higher BMI in retired people. However, the prospective associations were not significant.
Letter
Rheumatology
Shahab Abtahi, Johanna H. M. Driessen, Andrea M. Burden, Patrick C. Souverein, Joop P. van den Bergh, Tjeerd P. van Staa, Annelies Boonen, Frank de Vries
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Shahab Abtahi, Johanna H. M. Driessen, Andrea M. Burden, Patrick C. Souverein, Joop P. van den Bergh, Annelies Boonen
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Urology & Nephrology
J. J. van Raaij, K. H. Hua, F. de Vries, Paddy K. C. Janssen
Summary: This study aimed to investigate the relationship between the His452Tyr polymorphism of the 5-HT2A receptor and the pathogenesis and intravaginal ejaculation latency time (IELT) differences in patients with lifelong premature ejaculation (LPE). The results showed no correlation between the polymorphism and IELT distribution in LPE patients.
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Richard L. Morrow, Barbara Mintzes, Patrick C. Souverein, Christine E. Hallgreen, Bilal Ahmed, Elizabeth E. Roughead, Marie L. De Bruin, Sarah Brogger Kristiansen, Joel Lexchin, Anna Kemp-Casey, Ingrid Sketris, Dee Mangin, Sallie-Anne Pearson, Lorri Puil, Ruth Lopert, Lisa Bero, Danijela Gnjidic, Ameet Sarpatwari, Colin R. Dormuth
Summary: A longitudinal study showed that hydroxyzine initiation decreased in the UK after the safety advisories, but remained unchanged in British Columbia, Canada.
Article
Endocrinology & Metabolism
Annika Vestergaard Kvist, Mohamad I. Nasser, Peter Vestergaard, Morten Frost, Andrea M. Burden
Summary: A study in Denmark from 1997 to 2017 found that the incidence rates of fractures were higher in patients with type 1 and type 2 diabetes compared to those without diabetes, except for foot fractures. The incidence of hip fractures decreased by 35.2%, 47.0%, and 23.4% in patients with type 1 diabetes, type 2 diabetes, and without diabetes, respectively, over the last 5 years. However, vertebral fractures increased by 14.8%, 18.5%, and 38.9% in the same groups. After age adjustment, patients with type 1 diabetes still had a higher risk of fractures compared to those without diabetes, while patients with type 2 diabetes had a risk similar to those without diabetes.
Article
Public, Environmental & Occupational Health
Maria Luisa Faquetti, Adrian Martinez-De la Torre, Theresa Burkard, Guillaume Obozinski, Andrea M. M. Burden
Summary: This study used the Apriori algorithm to analyze patients with polypharmacy who were first-time users of metformin. The most frequently co-prescribed drug with metformin was atorvastatin. Women and older patients were more likely to receive polypharmacy. The results of this study indicate the need to optimize polypharmacy to minimize drug-drug interactions and adverse drug reactions.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Rheumatology
Rasmus Westermann, Rene Lindholm Cordtz, Kirsten Duch, Lene Mellemkjaer, Merete Lund Hetland, Andrea Michelle Burden, Lene Dreyer
Summary: This study examined the risk of first primary cancer in patients with rheumatoid arthritis (RA) treated with janus kinase inhibitors (JAKi) compared to those treated with biologic disease-modifying antirheumatic drugs (bDMARDs) in a real-world setting. The results showed that JAKi treatment was not associated with a statistically significant increased risk of first primary cancer compared to bDMARDs treatment in RA patients.
Article
Pharmacology & Pharmacy
Dominik Stampfli, Rebecca Dommrich, Sharon Orbach-Zinger, Andrea M. Burden, Michael Heesen
Summary: This study analyzed the adverse drug events and haemodynamic profile of oxytocin and carbetocin using data from the World Health Organization's pharmacovigilance database. The results showed that carbetocin had a higher reporting of adverse hypertension, hypotension, and tachycardia compared to oxytocin. Therefore, clinicians should be cautious of their patients' susceptibility and the potential haemodynamic deterioration when using these drugs.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2023)
Article
Biochemical Research Methods
Maria Kalweit, Andrea. M. H. Burden, Joschka Boedecker, Thomas H. Hugle, Theresa Burkard
Summary: Machine learning techniques were used to identify five distinct patient groups with rheumatoid arthritis (RA) based on sex, disease burden/duration, and concomitant traditional RA treatment use. The results suggest that different RA patient clusters have different responses to first-line b/tsDMARD treatment.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Natalia Konstantelos, Andrea M. Burden, Angela M. Cheung, Sandra Kim, Paul Grootendorst, Suzanne M. Cadarette
Summary: This study aimed to compare fracture rates estimated using different definitions and found that coding decisions have a significant impact on fracture outcome definitions. The study highlights the importance and impact of coding decisions on fracture outcome identification and emphasizes the need for further research to inform best practice in fracture outcome identification.
Article
Multidisciplinary Sciences
Maria Luisa Faquetti, Enriqueta Vallejo-Yague, Rene Cordtz, Lene Dreyer, Andrea M. Burden
Summary: Janus Kinase inhibitors (JAKis) are important synthetic drugs used to treat rheumatoid arthritis (RA) patients. However, there have been debates regarding the safety concerns associated with JAKi use, including increased risk for venous thromboembolism (VTE), serious viral infection, and major adverse cardiovascular events (MACE). This study aims to enrich the safety profile of JAKis using real-world data from the Danish DANBIO registry.
Article
Medicine, General & Internal
Stefan Russmann, Fabiana Martinelli, Franziska Jakobs, Manjinder Pannu, David F. F. Niedrig, Andrea Michelle Burden, Martina Kleber, Markus Bechir
Summary: Potential medication errors and related adverse drug events (ADE) are challenging in clinical medicine. Clinical decision support systems (CDSSs) can help identify preventable prescription errors but often lack specificity. In this study, CDSS performance was analyzed using two systems (pharmaVISTA and MediQ) to evaluate drug-drug interactions and other factors. Automated analyses produced an average of 15.5 alerts per patient, but expert evaluation resulted in only 0.8 recommendations per patient. Co-factors such as comorbidities and laboratory results were decisive for classifying CDSS alerts as clinically relevant.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Mohamad Nasser, Annika Vestergaard Kvist, Peter Vestergaard, Richard Eastell, Andrea M. Burden, Morten Frost
Summary: The study investigated the trends in fracture incidence rates among men and women with type 1 and type 2 diabetes. The results showed a decrease in fracture incidence rates in men with both types of diabetes and in women with type 2 diabetes, highlighting the need for further attention to the stable trend observed in women with type 1 diabetes.
Article
Rheumatology
Theresa Burkard, Enriqueta Vallejo-Yague, Kim Lauper, Axel Finckh, Thomas Hugle, Andrea M. Burden
Summary: The study found that an increase in BMI may not result in changes in DAS28-esr in patients receiving infliximab, but may lead to a decrease in joint erosions.
