期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 164, 期 4, 页码 554-560出版社
SPRINGER
DOI: 10.1007/s10517-018-4031-z
关键词
multipotent mesenchymal stromal cells; muscular tissue; inflammation; sclerosis macrophages
资金
- Program of Fundamental Scientific Research Development of Technologies of Obtaining Materials for Regenerative Mand Methods for Correction of Reproductive H [VI.62.2.1, 0309-2016-0006]
- Program of Basic Research in priority direction I.30P Development of New Cell Technologies for Correction of Venous Thrombotic Processes Based on Introduction of Mesenchymal Stromal Cells into the Site of Clot Formation [FIMT-254, 0309-2015-0017]
Changes in the muscular tissue after subcutaneous injection of autologous bone marrow multipotent mesenchymal stromal cells transfected with GFP gene and additionally stained with cell membrane dye Vybrant CM-Dil in the projection of ligated femoral vein were studied by light microscopy with luminescence. Stromal cells injected through the skin can appear not only in the damaged tissue where acceleration of regeneration processes is required, but also in intact structures located in superficial or deeper layers. In intact muscular tissue, stromal cells spreading in the perivascular tissue initiate inflammation and migration of macrophages, activate and even trigger sclerotic processes due to differentiation into connective tissue cells (fibroblasts) and stimulation of proliferation and collagen synthesis by host fibroblasts. Injected multipotent mesenchymal stromal cells are gradually phagocytized by macrophages.
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