Article
Cardiac & Cardiovascular Systems
Luciana C. Veiras, Ellen A. Bernstein, DuoYao Cao, Derick Okwan-Duodu, Zakir Khan, David R. Gibb, Arantxa Roach, Rachel Skelton, Ryan M. Williams, Kenneth E. Bernstein, Jorge F. Giani
Summary: This study found that in diabetes, IL-1β produced by renal tubular epithelial cells promotes the polarization of renal macrophages towards a proinflammatory phenotype, resulting in salt-sensitive hypertension.
CIRCULATION RESEARCH
(2022)
Article
Rheumatology
Anella Saviano, Adel Abo Manosour, Federica Raucci, Francesco Merlino, Noemi Marigliano, Anna Schettino, Mussarat Wahid, Jenefa Begum, Andrew Filer, Julia E. Manning, Gian Marco Casillo, Marialuisa Piccolo, Maria Grazia Ferraro, Simona Marzano, Pasquale Russomanno, Rosa Bellavita, Carlo Irace, Jussara Amato, Mohammed Alfaifi, Peter Rimmer, Tariq Iqbal, Stefano Pieretti, Valentina Vellecco, Francesco Caso, Luisa Costa, Roberto Giacomelli, Raffaele Scarpa, Giuseppe Cirino, Mariarosaria Bucci, Helen M. McGettrick, Paolo Grieco, Asif Jilani Iqbal, Francesco Maione
Summary: This study identified a novel IL-17A/F-derived peptide and generated a new anti-IL-17 antibody that can effectively reverse the pro-inflammatory actions of IL-17A/F. The antibody showed less off-target effects compared to the current gold-standard biologic. Preclinical and clinical evidence demonstrated the high efficacy and therapeutic potency of the antibody in patients with IMIDs.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Peripheral Vascular Disease
Jordyn M. Thomas, Yeong H. Ling, Brooke Huuskes, Maria Jelinic, Prerna Sharma, Narbada Saini, Dorota M. Ferens, Henry Diep, Shalini M. Krishnan, Barbara K. Kemp-Harper, Paul M. O'Connor, Eicke Latz, Thiruma V. Arumugam, Tomasz J. Guzik, Michael J. Hickey, Ashley Mansell, Christopher G. Sobey, Antony Vinh, Grant R. Drummond
Summary: IL-18 is elevated in hypertensive patients, and its production by tubular epithelial cells contributes to elevated blood pressure, renal inflammation, and fibrosis in a low-renin hypertension mouse model. This suggests IL-18 as a promising therapeutic target for hypertension and kidney disease.
Review
Cell Biology
Felix Ritzmann, Lars Peter Lunding, Robert Bals, Michael Wegmann, Christoph Beisswenger
Summary: IL-17 cytokines play an important role in chronic lung diseases, contributing to bacterial elimination but also potentially promoting disease progression.
Review
Immunology
Lanxuan Wei, David Abraham, Voon Ong
Summary: IL-17 is a pro-inflammatory cytokine that plays an important role in host defense. It activates transcription and stabilizes mRNAs through multiple pathways, mainly acting on stromal cells to promote the secretion of other immunomodulatory factors and support the growth and differentiation of immune cells. IL-17 has a dual role in immune reactions and inflammatory diseases, and it also plays a significant role in autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Michal Tomaszewski, Paulina Mertowska, Martyna Janczewska, Agnieszka Styczen, Sebastian Mertowski, Kamil Jonas, Ewelina Grywalska, Grzegorz Kopec
Summary: Pulmonary arterial hypertension (PAH) is a complex disorder where cytokines play a crucial role in deregulation of the immune system. This study found that PAH patients have abnormal immune function with decreased percentages of immune cell subpopulations and changes in cytokine concentration. Furthermore, significant differences were observed between PAH subtypes and immunological parameters, suggesting the important role of the immune system in the pathogenesis of PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Physiology
Dina Maaliki, Maha M. Itani, Hana A. Itani
Summary: Most cases of hypertension are primary and closely related to modifiable risk factors such as salt intake. Studies have shown that even small reductions in salt consumption can lower blood pressure in people of all ages. Salt-sensitivity has been identified as an independent risk factor for cardiovascular events and mortality. However, the pathogenesis of salt-sensitive hypertension is still unclear due to its multifactorial etiology, complex genetic influences, and the lack of a diagnostic tool.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Immunology
Jean-Claude Lecron, Sandrine Charreau, Jean-Francois Jegou, Nadjet Salhi, Isabelle Petit-Paris, Emmanuel Guignouard, Christophe Burucoa, Laure Favot-Laforge, Charles Bodet, Anne Barra, Vincent Huguier, Jiad Mcheik, Laure Dumoutier, Julien Garnier, Francois-Xavier Bernard, Bernhard Ryffel, Franck Morel
Summary: This study found that the proinflammatory cytokines IL-22 and IL-17 induced by bacterial infection delay the healing process of skin wounds, regardless of the presence of bacteria. This discovery reveals the underlying mechanisms of bacterial infection on wound healing.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Manik Chandra Shill, Bisshojit Biswas, Sadia Kamal, Moriam Islam, Sharmin Sultana Rima, Farhana Afrin Ferdausi, Qamruzzaman Chowdhury, Hasan Mahmud Reza, Asim Kumar Bepari
Summary: Lung cancer is a major cause of cancer deaths, and environmental contaminants are believed to be a risk factor in addition to smoking. This study investigated the use of IL-6 and IL-17 as diagnostic markers for lung cancer. The results showed significantly elevated levels of IL-6 in lung cancer patients, while IL-17 levels were slightly higher. Furthermore, IL-6 and IL-17 levels were higher in patients with adenocarcinoma compared to other subtypes of lung cancer.
Article
Multidisciplinary Sciences
Steven C. Wilson, Nathanael A. Caveney, Michelle Yen, Christoph Pollmann, Xinyu Xiang, Kevin M. Jude, Maximillian Hafer, Naotaka Tsutsumi, Jacob Piehler, K. Christopher Garcia
Summary: The IL-17 family of cytokines and receptors play crucial roles in host defence and inflammatory diseases. The IL-25-IL-17RB-IL-17RA ternary complex is a C2-symmetric complex, where IL-25 interacts with IL-17RB and two 'wing-like' IL-17RA co-receptors to initiate signal transduction through a 'tip-to-tip' geometry.
Review
Pharmacology & Pharmacy
Jordyn M. Thomas, Brooke M. Huuskes, Christopher G. Sobey, Grant R. Drummond, Antony Vinh
Summary: Chronic kidney disease (CKD) is an inflammatory condition, and the inflammasome and pro-inflammatory cytokine IL-18 play important roles in its development. Regulating the signaling pathways of the inflammasome and IL-18 may serve as potential targets for CKD treatment.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Oncology
Kevin James Baker, Elizabeth Brint, Aileen Houston
Summary: IL-36 cytokines play a crucial role in the pathogenesis of inflammatory diseases and malignancies. This study demonstrates that IL-36 gene expression increases with the development of colorectal cancer and decreased IL-36 receptor expression is associated with better patient outcome. The IL-36/IL-17/IL-23 axis is found to be influential in IL-36-mediated colon tumorigenesis.
BRITISH JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Xin Li, Yimeng Lei, Ziyu Gao, Gang Wu, Wei Gao, Liping Xia, Jing Lu, Hui Shen
Summary: IL-34 promotes proliferation and inhibits apoptosis of FLSs in RA, with IL-17 inhibitor reducing the effects of IL-34, indicating the significant role of IL-17 in this process. IL-34 also induces the expression of inflammatory cytokines and angiogenic factors in RA-FLSs.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Kingston H. G. Mills
Summary: IL-17 cytokines have both protective and pathological functions in the context of infection and autoimmunity. They promote protective immunity against pathogens but can also drive inflammatory pathology. Dysregulated IL-17 responses can contribute to immunopathology, and IL-17 is implicated in various inflammatory diseases.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Immunology
Leandro do Nascimento Camargo, Renato Fraga Righetti, Francine Maria de Almeida, Tabata Maruyama dos Santos, Silvia Fukuzaki, Nilo Arthur Bezerra Martins, Miguel Cantadori Barbeiro, Beatriz Mangueira Saraiva-Romanholo, Fernanda Degobbi Tenorio Quirino dos Santos Lopes, Edna Aparecida Leick, Carla Maximo Prado, Iolanda de Fatima Lopes Calvo Tiberio
Summary: Inhibiting IL-17 can modulate cell-associated cytokine production, extracellular matrix remodeling, and oxidative stress in ACO.
FRONTIERS IN IMMUNOLOGY
(2023)