Article
Gastroenterology & Hepatology
Xiaolin Wang, Yong He, Bryan Mackowiak, Bin Gao
Summary: MicroRNAs are small, non-coding RNAs that play crucial roles in regulating liver functions and are associated with various liver diseases, making them promising for early diagnosis and treatment strategies. Continued research on miRNAs in the liver may lead to the identification of biomarkers and therapeutic targets for liver diseases in the future.
Review
Genetics & Heredity
Ruike Wang, Yingying Wu, Rundong Liu, Mengchen Liu, Qiong Li, Yue Ba, Hui Huang
Summary: This paper provides an up-to-date evaluation of the neuroprotective mechanisms of SIRT1 in modulating neurodegeneration, highlighting the importance of protein homeostasis, aging-related signaling pathways, neurogenesis, and synaptic plasticity. The potential of targeting SIRT1 to block the occurrence and progression of neurodegenerative diseases is also discussed.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Review
Oncology
Zhe Huang, Mingli Yang
Summary: This article summarizes the current knowledge on the molecular network of colorectal cancer, including cellular signaling pathways, tumor microenvironment, epigenetic changes, and biomarkers for diagnosis and predictive/prognostic use. It also provides an overview of opportunities for treatment and prevention strategies in this field.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ali A. Rabaan, Seham A. Al-Shwaikh, Wadha A. Alfouzan, Ali M. Al-Bahar, Mohammed Garout, Muhammad A. Halwani, Hawra Albayat, Norah B. Almutairi, Mohammed Alsaeed, Jeehan H. Alestad, Maha A. Al-Mozaini, Tala M. Al Ashgar, Sultan Alotaibi, Abdulmonem A. Abuzaid, Yahya Aldawood, Abdulmonem A. Alsaleh, Hani M. Al-Afghani, Jaffar A. Altowaileb, Abeer N. Alshukairi, Kovy Arteaga-Livias, Kirnpal Kaur Banga Singh, Mohd Imran
Summary: The purpose of this review is to provide an up-to-date and comprehensive overview of monkeypox, a severe infectious viral disease. It also discusses the latest treatment options for monkeypox. Monkeypox virus (MPXV) remains the most virulent poxvirus in humans, mainly distributed in central and west Africa. Monkeypox, which transfers from animals to humans, has become a major threat to global health security, requiring a quick response from various professionals to develop efficient diagnostic tests, vaccines, antivirals, and infection control techniques. The emergence of outbreaks outside Africa highlights the global significance of this disease, and increased surveillance and case identification can help better understand its dynamic epidemiology.
Review
Biochemistry & Molecular Biology
Viorica Rarinca, Mircea Nicusor Nicoara, Dorel Ureche, Alin Ciobica
Summary: Oxidative stress occurs when there is an excess of reactive oxygen species in the body, leading to cell and tissue damage. Quercetin, a flavonoid compound found in vegetables and fruits, has been shown to have antioxidant, anticancer, and anti-inflammatory properties, with the potential to improve cognitive function and prevent neurodegenerative diseases. This review focuses on experimental studies supporting the neuroprotective effects of Quercetin in Alzheimer's disease, Parkinson's disease, Huntington's disease, and epilepsy.
Review
Pharmacology & Pharmacy
Shi-Feng Huang, Xiao-Fei Peng, Lianggui Jiang, Ching Yuan Hu, Wen-Chu Ye
Summary: Lipid metabolism is crucial for biological processes, and dysregulation can lead to lipid-related diseases. lncRNAs play essential roles in the regulation of lipid-related diseases, and understanding their functions can help identify potential biomarkers and therapeutic targets.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Susmita Sahoo, Marta Adamiak, Prabhu Mathiyalagan, Franziska Kenneweg, Sabine Kafert-Kasting, Thomas Thum
Summary: Exosomes are small membrane-bound vesicles actively secreted by cells. Research on the potential and challenges of exosomes in biological signaling in myocardial function highlights their significance in cardiac physiology and pathology, emphasizing the need for scientific innovations in isolation and characterization methodologies.
Review
Geriatrics & Gerontology
Panyue Gao, Xinrong Li, Xinzhe Du, Sha Liu, Yong Xu
Summary: Neurodegenerative diseases present challenges in pathophysiology research due to limitations in brain tissue acquisition. However, exosomes, as potential biomarkers and therapeutic carriers, play a significant role in these diseases by linking peripheral changes to CNS events and delivering molecules specifically to the CNS.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Sergii Tkach, Andrii Dorofeyev, Iurii Kuzenko, Nadiya Boyko, Tetyana Falalyeyeva, Luigi Boccuto, Emidio Scarpellini, Nazarii Kobyliak, Ludovico Abenavoli
Summary: Alteration of the intestinal microbiota is associated with the development of various gastrointestinal and extraintestinal diseases. Fecal microbiota transplantation is considered an interesting potential therapy.
MEDICINA-LITHUANIA
(2022)
Review
Biochemistry & Molecular Biology
Farah Omran, Ioannis Kyrou, Faizel Osman, Ven Gee Lim, Harpal Singh Randeva, Kamaljit Chatha
Summary: Cardiovascular diseases (CVDs) are a major healthcare burden worldwide. Early detection is crucial for prevention and treatment, and biomarkers play a critical role. Traditional cardiac biomarkers have been replaced by new ones, but their limitations remain. Further research is needed to evaluate the value of future cardiac biomarkers in improving CVD detection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Yang Bai, Xing Su, Lianhua Piao, Zheng Jin, Rihua Jin
Summary: Astrocytes play a crucial role in the pathogenesis of neurodegenerative diseases, and miRNAs may be involved in this process by regulating astrocyte function.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Fabiana Tortora, Evelina La Civita, Pankaj Trivedi, Ferdinando Febbraio, Daniela Terracciano, Amelia Cimmino
Summary: Renal cell carcinoma, bladder cancer, and prostate cancer are the most common genitourinary tumors. Recent advancements in understanding oncogenic factors and molecular mechanisms have greatly improved their treatment and diagnosis. Non-coding RNAs, such as microRNAs, long non-coding RNAs, and circular RNAs, have been found to play important roles in the occurrence and progression of genitourinary cancers. Interactions of DNA, protein, and RNA with lncRNAs and other biological macromolecules contribute to cancer phenotypes. This review focuses on the mechanisms of abnormal lncRNA expression in genitourinary tumors and their potential applications in diagnostics, prognosis, and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Allergy
David Egg, Ina Caroline Rump, Noriko Mitsuiki, Jessica Rojas-Restrepo, Maria-Elena Maccari, Charlotte Schwab, Annemarie Gabrysch, Klaus Warnatz, Sigune Goldacker, Virginia Patino, Daniel Wolff, Satoshi Okada, Seiichi Hayakawa, Yoshiaki Shikama, Kenji Kanda, Kohsuke Imai, Manabu Sotomatsu, Makoto Kuwashima, Takahiro Kamiya, Tomohiro Morio, Kazuaki Matsumoto, Takeshi Mori, Yuri Yoshimoto, Ingunn Dybedal, Maria Kanariou, Zeynep Yesim Kucuk, Hugo Chapdelaine, Lenka Petruzelkova, Hanns-Martin Lorenz, Kathleen E. Sullivan, Jennifer Heimall, Michel Moutschen, Jiri Litzman, Mike Recher, Michael H. Albert, Fabian Hauck, Suranjith Seneviratne, Jana Pachlopnik Schmid, Antonios Kolios, Gary Unglik, Christian Klemann, Scott Snapper, Lisa Giulino-Roth, Michael Svaton, Craig D. Platt, Sophie Hambleton, Olaf Neth, Geraldine Gosse, Steffen Reinsch, Dirk Holzinger, Yae-Jean Kim, Shahrzad Bakhtiar, Faranaz Atschekzei, Reinhold Schmidt, Georgios Sogkas, Shanmuganathan Chandrakasan, William Rae, Beata Derfalvi, Hanne Vibeke Marquart, Ahmet Ozen, Ayca Kiykim, Elif Karakoc-Aydiner, Pavlina Kralickova, Godelieve de Bree, Dimitra Kiritsi, Markus G. Seidel, Robin Kobbe, Jennifer Dantzer, Laia Alsina, Thais Armangue, Vassilios Lougaris, Philipp Agyeman, Sofia Nystrom, David Buchbinder, Peter D. Arkwright, Bodo Grimbacher
Summary: Heterozygous germline mutations in cytotoxic T lymphocyte-associated antigen-4 (CTLA4) can lead to life-threatening autoimmune and lymphoproliferative complications. Treatment options include systemic immunosuppressants, immunoglobulin replacement, and stem cell transplantation for potential cure.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Behavioral Sciences
A. Khayachi, L. Schorova, M. Alda, G. A. Rouleau, A. J. Milnerwood
Summary: The effectiveness and mode of action of lithium treatment for neurological conditions remains not fully understood, although studies have shown its impact on protein posttranslational modifications and neuronal physiology. Determining specific posttranslational modification patterns could be a promising strategy to develop disease biomarkers and predict lithium responsiveness.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Hematology
Antonio Junior Lepedda, Gabriele Nieddu, Zoi Piperigkou, Konstantina Kyriakopoulou, Nikolaos Karamanos, Marilena Formato
Summary: Cell-surface heparan sulfate proteoglycans (HSPGs) play crucial roles in regulating cell behavior and signaling, with their soluble forms potentially serving as diagnostic and prognostic markers and targets for immunotherapy. This comprehensive review critically surveys clinical findings from the past 20 years and discusses the involvement of HSPGs in various pathologies, highlighting their potential diagnostic and therapeutic value.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2021)