Article
Environmental Sciences
Peng Xiao, Wenhua Li, Jinfang Lu, Yang Liu, Qiulan Luo, He Zhang
Summary: The study found that Bixafen has toxic effects on the retinal development of zebrafish embryos, leading to severe retinal defects and increased cell density in the ganglion cell layer.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Tiantong Qiu, Xin Chen, Peng Xiao, Liqiang Wang, Wenhua Li
Summary: In this study, the potential toxicity and underlying mechanisms of FLU on aquatic organisms were investigated using zebrafish embryos as a model organism. The results showed that FLU can cause microphthalmia in zebrafish embryos by inducing retinal cell apoptosis, indicating its developmental toxicity.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Environmental Sciences
Ana C. Oliveira, Maria L. Fascineli, Thayres S. Andrade, Diego Sousa-Moura, Ines Domingues, Nichollas S. Camargo, Rhaul Oliveira, Cesar K. Grisolia, Rolando A. R. Villacis
Summary: The study evaluated the toxic effects of NTP on zebrafish embryos and early larval stages, showing that exposure to environmentally relevant concentrations of NTP may modify locomotor behavior and reduce fitness in zebrafish larvae. Further research involving chronic exposure and sensitive endpoints is needed to better understand the effects of NTP in a more realistic exposure scenario.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Mengying Yang, Jinyu Qiu, Xin Zhao, XiZeng Feng
Summary: The research results demonstrated that 6-BA had adverse effects on the development and neurobehavior of zebrafish, including developmental delay, decreased survival and hatchability, accumulation of oxidative stress, as well as impaired locomotion and sleep/wake behavior.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Yves Moreira Ribeiro, Davidson Peruci Moreira, Andre Alberto Weber, Thayna Grazielle Rodrigues Miranda, Nilo Bazzoli, Elizete Rizzo
Summary: This study evaluated the effects of chronic exposure to estrone (E1) on spermatogenesis and semen quality in zebrafish. The results showed that even at environmentally relevant concentrations, E1 had deleterious effects on testicular function and semen quality in fish. Therefore, monitoring E1 concentrations in surface waters is important for fish conservation.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Environmental Sciences
Xueping Huang, Song Yang, Beixing Li, Aiping Wang, Hong Li, Xiuhuan Li, Jian Luo, Feng Liu, Wei Mu
Summary: The toxicity and accumulation of pyraclostrobin in adult zebrafish varied with different exposure routes, with the gill being the dominant portal and target organ. A future effective toxicity regulation strategy should focus on reducing the concentration in the branchial environment to protect key sites from pyraclostrobin attack.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Yung Chang, Jui-Feng Tsai, Pei-Jen Chen, Ying-Tzu Huang, Biing-Hui Liu
Summary: This study used zebrafish model to investigate the cardiotoxicity effects and mechanisms of thallium (I) on developing embryos. The results demonstrated that environmentally relevant concentrations of thallium (I) interfered with the anatomy, function, and transcriptomic alterations of the embryonic zebrafish heart, resulting in adverse effects on cardiac development.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Dan Li, Weijun Sun, Hongxing Chen, Haojun Lei, Xiao Li, Hongsong Liu, Guo-yong Huang, Wen-jun Shi, Guang-Guo Ying, Yongju Luo, Lingtian Xie
Summary: The study investigated the toxicity of cyclophosphamide on zebrafish embryos, revealing the effects on malformation, mortality, swimming capacity, retina and liver tissues, and key gene expressions. Low concentrations of cyclophosphamide pose ecological risks to aquatic organisms, highlighting the need for further research.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Le Qian, Yikai Zhang, Jia Jiang, Luyi Li, Shufei Miao, Xiaobo Huang, Zhiping Che, Genqiang Chen, Shengming Liu
Summary: This study demonstrates that Penthiopyrad can potentially impair the reproductive capacity of zebrafish by promoting steroidogenesis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Jie Shen, Peng Liu, Yongqi Sun, Xiaoxiao Xu, Longfei Guo, Qiong Rao, Minlan Chen, Xunyue Liu
Summary: This study found that prothioconazole is toxic to zebrafish embryos, causing malformations and apoptosis. Exposure to high concentrations of prothioconazole up-regulated the expression levels of oxidative stress defense-related genes and p53, leading to apoptosis in the early life stages of zebrafish.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Immunology
Michal Stosik, Beata Tokarz-Deptula, Wieslaw Deptula
Summary: This review presents Danio rerio as a model organism for studying hematopoiesis in vertebrates and discusses the development of this process in fish and mammals, as well as the impact of microenvironmental factors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Parnia Azimian Zavareh, Praneeth Silva, Nuwanthika Gimhani, Devi Atukorallaya
Summary: Zebrafish is an important animal model for studying the effects of alcohol on embryonic development. This study investigates the impact of alcohol on early zebrafish embryonic development and finds that alcohol affects tooth size and shape, the size and cell arrangement of the ethmoid bone, and the developmental process of skin melanocytes.
Article
Biochemistry & Molecular Biology
Ting Luo, Xiaoyu Wang, Yuanxiang Jin
Summary: This study found that low concentrations of IMI exposure induced gut toxicity in adult zebrafish, leading to tissue damage, oxidative stress, inflammation, and alterations in gut microbiota.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Environmental Sciences
Liyuan Qiang, Jinping Cheng
Summary: This study found that exposure to polystyrene microplastics can induce molecular responses and histological alterations in fish gonads, potentially causing adverse effects on fish reproductive organs.
Article
Environmental Sciences
Luis Felix, Paulo Carreira, Francisco Peixoto
Summary: This study investigates the biological effects of naturally weathered microplastics (MPs) on zebrafish, revealing anxiety-like behavior and mitochondrial dysfunction caused by the MPs. It also emphasizes the potential cumulative impact of these particles on aquatic ecosystems.
Article
Nutrition & Dietetics
Ann Hellstrom, William Hellstrom, Gunnel Hellgren, Lois E. H. Smith, Henri Puttonen, Ing-Marie Fyhr, Karin Savman, Anders K. Nilsson, Susanna Klevebro
Article
Immunology
Veronika Golubinskaya, Henri Puttonen, Ing-Marie Fyhr, Halfdan Rydbeck, Ann Hellstrom, Bo Jacobsson, Holger Nilsson, Carina Mallard, Karin Savman
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Physiology
Diego Baronio, Yu-Chia Chen, Amanda R. Decker, Louise Enckell, Blanca Fernandez-Lopez, Svetlana Semenova, Henri A. J. Puttonen, Robert A. Cornell, Pertti Panula
Summary: The study aimed to investigate the potential roles of vesicular monoamine transporter 2 (Vmat2) in brain monoamine regulation, turnover, behaviour, and development using a novel zebrafish model. Results showed that Vmat2 deficiency led to increased monoamine turnover, upregulation of amine-synthesising enzymes, and downregulation of genes involved in brain development. This zebrafish vmat2 mutant strain could be a valuable model for studying the impact of monoamine transport on brain development and function, as well as for drug screening purposes.
Article
Behavioral Sciences
Maria Sundvik, Henri Puttonen, Svetlana Semenova, Pertti Panula
Summary: The study on social hierarchy in zebrafish revealed that offspring of dominant animals have advantages in social interactions, subordinate animals have lower levels of serotonin and noradrenaline, and there are gender specific differences in cognitive tasks.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Cell Biology
Diego Baronio, Yu-Chia Chen, Pertti Panula
Summary: Deficiency of monoamine oxidase (MAO) and imbalanced levels of brain monoamines are associated with developmental delay, neuropsychiatric disorders, and aggressive behavior. This study introduces a novel genetic model using zebrafish to study the effects of mao loss of function. The results demonstrate alterations in neurotransmitter systems, expression of relevant genes, and behavioral changes in mao mutants.
DISEASE MODELS & MECHANISMS
(2022)
Article
Neurosciences
Samu N. Kurki, Jonas Kantonen, Karri Kaivola, Laura Hokkanen, Mikko I. Mayranpaa, Henri Puttonen, Juha Martola, Minna Poyhonen, Mia Kero, Jarno Tuimala, Olli Carpen, Anu Kantele, Olli Vapalahti, Marjaana Tiainen, Pentti J. Tienari, Kai Kaila, Johanna Hastbacka, Liisa Myllykangas
Summary: APOE4 is associated with severe COVID-19 and post-COVID mental fatigue; APOE4 carriers are more likely to have perivascular microhaemorrhages in intensive care patients; APOE4 carriers exhibit higher mental fatigue six months after initial illness.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Neurosciences
Anna Raunio, Ville Kivisto, Mia Kero, Jarno Tuimala, Sara Savola, Minna Oinas, Eloise Kok, Kia Colangelo, Anders Paetau, Tuomo Polvikoski, Pentti J. Tienari, Henri Puttonen, Liisa Myllykangas
Summary: This population-based study analyzes Lewy-related pathology in the spinal cord, dorsal root ganglion, and adrenal gland, providing support for the existence of at least two distinct types of Lewy-related pathology.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Behavioral Sciences
Laura DeOliveira-Mello, Diego Baronio, Pertti Panula
Summary: Prenatal exposure to VPA in zebrafish leads to delay in visual system development and sleep disturbances, along with a reduction in certain cell populations associated with ASD.
Article
Neurosciences
Yuxiao Yao, Diego Baronio, Yu-Chia Chen, Congyu Jin, Pertti Panula
Summary: This study found that the absence of the hrh1 gene in zebrafish leads to deficits in the dopaminergic and hypocretin systems during early development, but these deficits are compensated for in adulthood. However, adult fish exhibit impaired sociability and anxious-like behavior, along with downregulation of choline O-acetyltransferase and LIM homeodomain transcription factor Islet1.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Rheumatology
Marit Stockfelt, Gunilla Larsson, Hanna Engstrom, Henri Puttonen, Henrik Zetterberg, Kaj Blennow, Christopher Sjowall, Helena Strevens, Andreas Jonsen, Anders A. Bengtsson, Maria Majczuk Sennstrom, Agneta Zickert, Elisabet Svenungsson, Iva Gunnarsson, Estelle Trysberg, Bo Jacobsson, Anna-Karin Hultgard Ekwall, Karin Christenson, Johan Bylund, Mattias N. D. Svensson, Anna-Carin Lundell
Summary: Women with SLE have higher proportions of activated LDG cells in peripheral and intervillous blood, as well as increased levels of CXCL8 and CXCL1 in the placenta compared to healthy pregnancies. IFN alpha may play a role in SLE pregnancy with detectable levels in intervillous blood and upregulating CXCL8 gene expression in decidual stromal cells. Chorioamnionitis was more common in SLE placentas, indicating a potential contribution to placental inflammation and dysfunction.
LUPUS SCIENCE & MEDICINE
(2021)
Article
Oncology
Axel Stenmark Tullberg, Henri A. J. Puttonen, Martin Sjostrom, Erik Holmberg, S. Laura Chang, Felix Y. Feng, Corey Speers, Lori J. Pierce, Dan Lundstedt, Fredrika Killander, Emma Nimeus, Aniko Kovacs, Per Karlsson
Summary: The study demonstrates that an antitumoral immune infiltrate in the primary tumor is associated with a reduced risk of breast cancer recurrence and less benefit from adjuvant radiotherapy. These findings suggest potential implications for decisions regarding postoperative radiotherapy in early breast cancer.
CLINICAL CANCER RESEARCH
(2021)
Article
Endocrinology & Metabolism
Fatema Jabarkhel, Henri Puttonen, Lina Hansson, Andreas Muth, Oskar Ragnarsson
JOURNAL OF THE ENDOCRINE SOCIETY
(2020)