The novel μ-opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception

Biased Agonism in Drug Discovery—Is It Too Soon to Choose a Path?

(2018) Martin C. Michel et al.   MOLECULAR PHARMACOLOGY

Biased signalling: from simple switches to allosteric microprocessors

(2018) Jeffrey S. Smith et al.   NATURE REVIEWS DRUG DISCOVERY

Effect of Tamoxifen and Brain-Penetrant Protein Kinase C and c-Jun N-Terminal Kinase Inhibitors on Tolerance to Opioid-Induced Respiratory Depression in Mice

(2017) Sarah L. Withey et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Discovery of new GPCR ligands to illuminate new biology

(2017) Bryan L Roth et al.   Nature Chemical Biology

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

(2017) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

Designing Safer Analgesics via μ-Opioid Receptor Pathways

(2017) H.C. Stephen Chan et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

G-protein–gated Inwardly Rectifying Potassium Channels Modulate Respiratory Depression by Opioids

(2016) Gaspard Montandon et al.   ANESTHESIOLOGY

Biased ligand quantification in drug discovery: from theory to high throughput screening to identify new biased μ opioid receptor agonists

(2016) David Winpenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structure-based discovery of opioid analgesics with reduced side effects

(2016) Aashish Manglik et al.   NATURE

Experimental design and analysis and their reporting: new guidance for publication in BJP

(2015) Michael J Curtis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP

(2015) John C McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ethanol Reversal of Tolerance to the Respiratory Depressant Effects of Morphine

(2015) Rob Hill et al.   NEUROPSYCHOPHARMACOLOGY

Novel GPCR paradigms at the μ-opioid receptor

(2014) G L Thompson et al.   BRITISH JOURNAL OF PHARMACOLOGY

Efficacy and ligand bias at the μ-opioid receptor

(2013) E Kelly   BRITISH JOURNAL OF PHARMACOLOGY

Signalling bias in new drug discovery: detection, quantification and therapeutic impact

(2013) Terry Kenakin et al.   NATURE REVIEWS DRUG DISCOVERY

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY