Article
Endocrinology & Metabolism
Hyo Jeong Kim, Ka-Young Ryu, Yong-Gun Kim, Myoung Ok Kim, Ji Hye Lee, Min-Kyoung Song, Young-Jin Youn, Nitin Kumar Pohkrel, Sung-Hyun Kim, Jae-Young Kim, Hye-Jin Jung, Woo-Shin Kim, Chang-Won Hong, Hong-Hee Kim, Youngkyun Lee
Summary: The study revealed the crucial role of PTP1B in osteoclast differentiation, with PTP1B deficiency leading to decreased osteoclast number and activity. This highlights the potential of PTP1B as a therapeutic target for bone-lytic diseases.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Chemistry, Medicinal
Yifeng Shi, Lin Ye, Shiwei Shen, Tianchen Qian, Youjin Pan, Yuhan Jiang, Jinghao Lin, Chen Liu, Yaosen Wu, Xiangyang Wang, Jiake Xu, Haiming Jin
Summary: The study demonstrated that morin can inhibit osteoclast formation through various pathways and attenuate bone loss induced by ovariectomy. This suggests that morin may be a potential therapeutic agent for postmenopausal osteoporosis treatment.
PHYTOTHERAPY RESEARCH
(2021)
Article
Plant Sciences
Huiqi Chen, Qian Liu, Xiangqi Liu, Jinlan Jin
Summary: Berberine showed a protective effect on septic cardiomyopathy rats possibly through inhibiting the activation of the TLR4/NF-kappa B signalling pathway. Further research is ongoing to explore whether it improves SCM through other mechanisms.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Z-M Liu, C-C Lu, P-C Shen, S-H Chou, C-L Shih, J-C Chen, Y. C. Tien
Summary: Suramin has been found to effectively inhibit IL-1 beta-induced apoptosis in NP cells, reduce the expression of catabolic proteins, and upregulate anabolic proteins. It also alleviates IL-1 beta-induced inflammation and proteoglycan depletion, representing a potential therapeutic approach for IDD.
BONE & JOINT RESEARCH
(2021)
Article
Cell Biology
Xiucheng Li, Jiawei Jiang, Zhifan Yang, Songtao Jin, Xuanyuan Lu, Yu Qian
Summary: Galangin treatment effectively reduces osteoclastogenesis in bone marrow-derived macrophages and inhibits the expression of osteoclast-specific genes, leading to impaired bone resorption function. Furthermore, Galangin exerts its therapeutic effects on osteoporosis by inhibiting the MAPK and NF-kappa B signaling pathways.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Juan Duan, Xuantao Hu, Tao Li, Gen Wu, Pengcheng Dou, Zhengxiao Ouyang
Summary: The study demonstrates that CIM has the potential to inhibit RANKL-induced osteoclastogenesis by suppressing the NF-kappa B signaling pathway in vitro, and prevent periprosthetic osteolysis in vivo. These findings suggest the therapeutic potential of CIM in the treatment of ALP.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hao Tian, Tao Jiang, Kai Yang, Ruonan Ning, Tianqi Wang, Qi Zhou, Niandong Qian, Ping Huang, Lei Guo, Min Jiang, Xiaobing Xi, Xing Xu, Lianfu Deng
Summary: This study found that alpha-asarone (ASA), a compound derived from the traditional Chinese medicinal herb Acorus tatarinowii, can inhibit the activity of overactivated osteoclasts and reduce bone resorption. ASA's effects on osteoclastogenesis are dose-dependent and mediated through multiple signaling pathways. In an estrogen-deficiency-induced osteoporosis model, ASA also improved bone microstructure.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Qinghe Zeng, Rui Xu, Houfu Ling, Shan Zhao, Xu Wang, Wenhua Yuan, Mancang Gu, Taotao Xu, Pinger Wang, Hongfeng Ruan, Hongting Jin, Hangbo Qu, Fusheng Ye, Jiali Chen
Summary: This study found that the N-butanol extract of modified You-Gui-Yin (MYGY-Nb) was more effective in suppressing bone loss in ovariectomized (OVX)-induced osteoporosis mice than the original formula. Liquid chromatography and mass spectrometry analysis identified 16 critical compounds in MYGY-Nb, some of which affect osteoclast functions. In vivo and in vitro experiments further demonstrated that MYGY-Nb attenuated osteoclastogenesis by down-regulating NF-kappa B signaling.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wang Yajun, Cui Jin, Gu Zhengrong, Fang Chao, Hu Yan, Weng Weizong, Li Xiaoqun, Zhou Qirong, Chen Huiwen, Zhang Hao, Guo Jiawei, Zhuang Xinchen, Sheng Shihao, Wang Sicheng, Chen Xiao, Su Jiacan
Summary: Betaine attenuated OA progression by inhibiting hyperactivated osteoclastogenesis and maintaining microarchitecture in subchondral bone. Additionally, betaine could reorganize the structure of subchondral bone and inhibit abnormal angiogenesis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Zhen Cao, Xuben Niu, Maihuan Wang, Siwang Yu, Mingkun Wang, Silong Mu, Chuan Liu, Yaxi Wang
Summary: AB4 can inhibit osteoclast differentiation and function by activating Nrf2, making it a potential candidate drug for treating osteoporosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Xiao-Lin Huang, Chao Liu, Xue-Mei Shi, Yu-Ting Cheng, Qian Zhou, Jian-Ping Li, Jian Liao
Summary: The present study aimed to investigate the role of ZOL in osteoclast differentiation and function, and to determine whether NF-kappa B and mitogen-activated protein kinase, and their downstream signalling pathways, are involved in this process. The results showed that ZOL significantly attenuated osteoclastogenesis and bone resorptive capacity in vitro.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Pharmacology & Pharmacy
Ji Hu, Ru Chen, Jie An, Yilong Wang, Minglu Liang, Kai Huang
Summary: The study demonstrates that dauricine can alleviate endothelial inflammation by suppressing the NF-κB pathway, leading to a decrease in adhesion of THP-1 cells to HUVECs and protection against acute lung injury in mice.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Shu-jun Wei, Qing Zhang, Yong-jing Xiang, Lan-yu Peng, Wei Peng, Qiang Ren, Yong-xiang Gao
Summary: Guizhi-Shaoyao-Zhimu decoction has shown anti-rheumatoid arthritis effects in CII-induced arthritis rats, suggesting its potential use as a supplement and alternative drug therapy for RA.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chen-Yi Tang, He Wang, Yan Zhang, Zhongliang Wang, Guochun Zhu, Abigail McVicar, Yi-Ping Li, Wei Chen
Summary: The GPCR125 gene is highly expressed in osteoclasts and positively regulates osteoclast formation and function through RANKL-stimulated MAPK and AKT-NF-kappa B signaling pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Xiaolong Yu, Jiawei Hu, Xinming Yang, Qiang Xu, Hangjun Chen, Ping Zhan, Bin Zhang
Summary: Sesamin has been found to inhibit osteoclast activation and bone resorption by blocking signaling pathways, making it a promising phytochemical agent for the treatment of osteolysis-related diseases caused by inflammation and excessive osteoclast activation.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Cell & Tissue Engineering
Yuanhao Xie, Chenqi Tang, Zizhan Huang, Sicheng Zhou, Yuwei Yang, Zi Yin, Boon Chin Heng, Weishan Chen, Xiao Chen, Weiliang Shen
Summary: In vitro extracellular matrix (ECM) remodeling is critical for maintaining stem cell (SC) function. This review summarizes how cells remodel ECM and the significance of ECM remodeling in ex vivo SC culture, as well as outlines the shortcomings of current research and future directions.
TISSUE ENGINEERING PART B-REVIEWS
(2022)
Article
Engineering, Biomedical
Jiaqing Chen, Jiabei Yang, Li Wang, Xuewei Zhang, Boon Chin Heng, Dong-An Wang, Zigang Ge
Summary: The study developed a novel hydrogel, AHAMA hydrogel, with excellent adhesive strength and stability, capable of enhancing proliferation and migration of bone marrow stem cells. In experiments, AHAMA hydrogel demonstrated significant potential in promoting cartilage regeneration in a rat osteochondral defect model.
BIOACTIVE MATERIALS
(2021)
Article
Engineering, Biomedical
Li Wang, Xiaolei Guo, Jiaqing Chen, Zhen Zhen, Bin Cao, Wenqian Wan, Yuandong Dou, Haobo Pan, Feng Xu, Zepu Zhang, Jianmei Wang, Daisong Li, Quanyi Guo, Qing Jiang, Yanan Du, Jiakuo Yu, Boon Chin Heng, Qianqian Han, Zigang Ge
Summary: With the interdisciplinary convergence of biology, medicine, and materials science, there is a growing need to bridge the gap between applied basic research and translational products in the field of biomaterials. This article critically examines the developmental pipeline of biodegradable biomaterials and proposes ideas to integrate different mindsets to guide research and translation, reducing unnecessary research efforts and funding.
BIOACTIVE MATERIALS
(2022)
Editorial Material
Biochemistry & Molecular Biology
Mei Zhuang, Wuwen Zhang, Nuo Cheng, Ling Zhou, Dan Liu, Hua Yan, Ge Fang, Boon Chin Heng, Yan Sun, Guoqing Tong
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Engineering, Biomedical
Ting Zou, Shan Jiang, Baicheng Yi, Qixin Chen, Boon Chin Heng, Chengfei Zhang
Summary: The study demonstrated that SCAPs induced in BDNF-GelMA with small molecule cocktail showed significant upregulation of neural markers, exhibiting morphological characteristics similar to neuronal cells, which may provide a therapeutic platform for neurological disorders.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Cell Biology
Jiabei Yang, Xuewei Zhang, Jiaqing Chen, Boon Chin Heng, Yangzi Jiang, Xiaoyu Hu, Zigang Ge
Summary: The study highlights the important role of macrophages in cartilage regeneration, showing that they promote regeneration by modulating proliferation and apoptosis. Exogeneous macrophages have therapeutic potential in promoting cartilage regeneration by regulating stem cells. Only M2c macrophages are able to promote regeneration of both cartilage tissues and subchondral bone.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biology
Kejia Li, Litong Fan, Jianjing Lin, Boon Chin Heng, Zhantao Deng, Qiujian Zheng, Jue Zhang, Yangzi Jiang, Zigang Ge
Summary: Mesenchymal stem cells (MSCs) can benefit from enhanced chondrogenesis through the combination of nanosecond pulsed electric fields and ghrelin. The sequential order of applying these two stimuli is crucial for promoting cartilage regeneration. This study provides new insights and strategies for future cell-based therapies.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Materials Science, Biomaterials
Xiaohan Dai, Yunyang Bai, Boon Chin Heng, Yiping Li, Zhangui Tang, Changjian Lin, Ousheng Liu, Ying He, Xuehui Zhang, Xuliang Deng
Summary: This study designed biomimetic micro/sub-micro hierarchical surfaces on titanium implants to mitigate inflammatory reactions and osteoclastogenesis, enhance osteogenic differentiation, and promote early osseointegration. The biomimetic hierarchical surfaces inhibited M1 macrophage-mediated inflammatory reactions and decreased osteoclast formation. In vivo, the implants with hierarchical surfaces underwent rapid and early osseointegration. This study offers a novel biomimetic strategy for implant-bone osseointegration in osteoporotic patients.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Cell Biology
Peiwen He, Dengfeng Ruan, Zizhan Huang, Canlong Wang, Yiwen Xu, Honglu Cai, Hengzhi Liu, Yang Fei, Boon Chin Heng, Weishan Chen, Weiliang Shen
Summary: This review discusses the processes of tendon development and repair, involving various regulatory factors and signaling pathways. By studying and comparing these processes, it can provide guidance for the treatment of tendon injuries.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Engineering, Biomedical
Yaru Guo, Feng Mei, Ying Huang, Siqin Ma, Yan Wei, Xuehui Zhang, Mingming Xu, Ying He, Boon Chin Heng, Lili Chen, Xuliang Deng
Summary: This study demonstrates that matrix stiffness promotes sprouting of endothelial cells and regulates the formation of tip cells through a specific signaling axis. The findings have significant implications for biomaterial design and treatment of pathological conditions.
BIOACTIVE MATERIALS
(2022)
Review
Endocrinology & Metabolism
Jaydeep Roy, Kan Yin Wong, Luca Aquili, Md. Sahab Uddin, Boon Chin Heng, George Lim Tipoe, Kah Hui Wong, Man Lung Fung, Lee Wei Lim
Summary: In this review, the developmental trends and neuroprotective mechanisms of melatonin therapies for Alzheimer's disease (AD) are examined. Melatonin has been shown to alleviate various pathological processes in AD and beneficially affect behavior in animal models. Clinical studies demonstrate positive effects of melatonin on sleep, cognition, behavior, and psychiatric symptoms in AD patients.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Chemistry, Physical
Ruyuan Ding, Yajun Liu, Dawei Cheng, Gang Yang, Wenjing Wu, Haoran Du, Xin Jin, Yihan Chen, Yuanyin Wang, Boon Chin Heng, Qing Yang, Jianguang Xu
Summary: The incorporation of pro-osteogenic growth factors into bone graft materials to enhance bone regeneration is a key research area. The combination of gene therapy and tissue engineering through gene-activated matrix (GAM) provides a solution to overcome the limitations of growth factors degradation. In this study, a novel GAM system with superior bone regeneration capacity was prepared, and in vitro experiments demonstrated excellent biocompatibility and sustained release of therapeutic genes.
Review
Dentistry, Oral Surgery & Medicine
Boon Chin Heng, Yunyang Bai, Xiaochan Li, Xuehui Zhang, Xuliang Deng
Summary: Dental and oral-derived stem cells have high potential for neurogenesis. Using electroactive or electroconductive tissue engineering scaffolds may enhance their neurogenesis. However, there is limited research on these cells, with most scientific information coming from studies on other mesenchymal stem cell lineages.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Article
Engineering, Biomedical
Fangyuan Bao, Junzhi Yi, Yixiao Liu, Yuliang Zhong, Hui Zhang, Zhonglin Wu, Boon Chin Heng, Ying Wang, Ziyang Wang, Lizi Xiao, Hua Liu, Hongwei Ouyang, Jing Zhou
Summary: This study investigates the optimal applied form and underlying mechanisms of nano-hydroxyapatite (nHAP) in bone repair. The results suggest that when nHAP is applied in the fixed state in a 3D form, it can induce optimal osteogenesis and increased bone volume through upregulation of the PI3K-AKT signaling pathway and ITGA7-mediated mechanisms, contrary to the results observed with free nHAP.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Xiaochan Li, Boon Chin Heng, Yunyang Bai, Qianqian Wang, Min Gao, Ying He, Xinwen Zhang, Xuliang Deng, Xuehui Zhang
Summary: The study confirms the dose-response effect of surface electrical charge on SHED neural differentiation and provides insights into the underlying molecular mechanisms and signaling pathways involved.
BIOACTIVE MATERIALS
(2023)