Review
Biochemistry & Molecular Biology
Dmytro Boiko, Anastasiia D. Shkodina, Mohammad Mehedi Hasan, Mainak Bardhan, Syeda Kanza Kazmi, Hitesh Chopra, Prerna Bhutra, Atif Amin Baig, Andrii M. Skrypnikov
Summary: Depressive disorders involve multiple physiological systems and disruption of circadian rhythms. Melatonin, through its action on MT1 and MT2 receptors, may serve as a potential target for novel antidepressants by regulating neurotrophins, neurotransmitters, and reducing inflammation. Targeting melatonergic receptors could improve the quality of therapeutic interventions in treating depression.
NEUROCHEMICAL RESEARCH
(2022)
Article
Psychiatry
Ahmet Yardimci, Mehmet Ridvan Ozdede, Haluk Kelestimur
Summary: Insomnia and menopausal depression are common symptoms associated with osteoporosis in middle-aged women, with pharmacological interventions and hormone therapy often used in treatment. Melatonin has been proposed as a potential therapy for bone loss, and agomelatine, an MT-1 and MT-2 receptor agonist, could hold promise for combined treatment of insomnia, depression, and osteoporosis during menopause.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Sara Moreno-SanJuan, Jose D. Puentes-Pardo, Jorge Casado, Julia Escudero-Feliu, Huda Khaldy, Javier Arnedo, Angel Carazo, Josefa Leon
Summary: The potential use of agomelatine as an alternative treatment for colorectal cancer is evaluated in this study. In vitro and in vivo models were used to study the effects of agomelatine on cell lines with different p53 statuses. Both agomelatine and melatonin showed inhibitory effects on the cells, with agomelatine being more effective. Agomelatine also regulated more clock genes and demonstrated a greater oncostatic effect in colorectal cancer.
Article
Endocrinology & Metabolism
Shaunak Deota, Satchidananda Panda
Summary: Metabolic homeostasis is regulated by endocrine factors, signaling cascades, and metabolic pathways, which are also modulated by circadian rhythm. Disruption of circadian rhythm can increase the risk for metabolic diseases. Understanding factors affecting circadian rhythm allows for implementing new interventions to prevent and manage metabolic disorders.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Clinical Neurology
Sui-yi Xu, Ling Li, Wen-xiu Sun, Jia-yu Shen, Chang-xin Li
Summary: This article presents a case study where agomelatine showed promising results as a prophylactic treatment for hypnic headache.
FRONTIERS IN NEUROLOGY
(2023)
Article
Genetics & Heredity
Christos M. Polymeropoulos, Justin Brooks, Emily L. Czeisler, Michaela A. Fisher, Mary M. Gibson, Kailey Kite, Sandra P. Smieszek, Changfu Xiao, Sarah H. Elsea, Gunther Birznieks, Mihael H. Polymeropoulos
Summary: The study confirmed that tasimelteon significantly improved sleep quality and total sleep time in patients with Smith-Magenis syndrome.
GENETICS IN MEDICINE
(2021)
Review
Psychiatry
Yumeng Xie, Zuotian Wu, Limin Sun, Lin Zhou, Gaohua Wang, Ling Xiao, Huiling Wang
Summary: Exercise therapy is effective in treating depression in all age groups, either as a standalone therapy or in combination with traditional treatments. Moderate intensity exercise can reduce depressive symptoms, while higher doses of exercise may improve overall functioning. Exercise therapy is becoming more widely used due to its benefits on cardiovascular health, emotional wellbeing, and systemic functions.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Medicine, Research & Experimental
Yu Jiang, Nan Gen, Peisong Wang, Ninghang Feng, Xiaojie Lu
Summary: This study investigated the effects of prednisolone (PN) on sleep in zebrafish. The results showed that PN decreased melatonin secretion, shortened sleep time, and disrupted the internal circadian rhythm. The mechanism behind these effects involves the repression of certain genes via the glucocorticoid receptor, leading to a decrease in melatonin secretion and subsequent sleep disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Mei-li Wei, Shi-min He, An-qi Chen, Zi-xuan Fan, Wei Liu, Ling Zhang, Shi-jie Lv, Cheng-zeng Qiu, Hui-ru Liu, Mu-xian Hao, Zong-jun Yin, Da-long Ren
Summary: This study investigated the effects of FLX on circadian rhythm using zebrafish as a model. The results showed that FLX treatment led to down-regulation of clock genes expression, reduction in amplitude and phase shift of circadian rhythms, as well as inhibition of melatonin secretion. These findings provide valuable insights into the impact of FLX exposure on circadian rhythm and locomotor activity, and may have implications for its clinical application.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Cell Biology
Yihao Tian, Jian Ming
Summary: Osteoporosis is a common and impactful disease with no known treatments. Recent studies have shown that melatonin can be used to treat osteoporosis by regulating biological rhythms in bone tissue, promoting bone formation and inhibiting bone resorption. This review provides an overview of these processes and offers treatment and management strategies for individuals with osteoporosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Psychology, Developmental
Lauren D. Asarnow, Adriane Soehner, Emily Dolsen, Lulu Dong, Allison G. Harvey
Summary: This study aims to test the effectiveness of a cognitive behavioral sleep intervention for adolescents with an evening circadian preference and clinically significant depressive symptoms, and to evaluate the improved alignment between circadian biology and sleep-wake behavior as a potential mechanism for improving depression symptoms.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Emily J. Ricketts, Helen J. Burgess, Gabrielle E. Montalbano, Meredith E. Coles, Joseph F. McGuire, Hardian Thamrin, Dana L. McMakin, James T. McCracken, Mary A. Carskadon, John Piacentini, Christopher S. Colwell
Summary: Individuals with TD commonly experience sleep disturbances. This study found that adults with TD had greater eveningness and sleep disturbances compared to healthy controls. Morning light therapy showed some benefits, including advances in DLMO phase and reductions in daytime sleepiness and anxiety. Further exploration of spectral tuning the photic environment as part of treatment for TD subjects is recommended.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Francisco Borja Belloch, Elena Beltran, Elisabeth Venzala, Javier Montalt-Tordera, Teresa Diaz-Perdigon, Erika Cecon, Elena Puerta, Philippe Delagrange, Rosa Maria Tordera
Summary: Research on the specific roles of melatonin receptor subtypes MT1 and MT2 in regulating circadian core body temperature and depressive-like behaviors revealed that MT2-/- mice exhibited poorer performance in depression and core body temperature, and increased vulnerability to ultra-mild stress.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Paul A. S. Sheppard, Deepthi Chandramohan, Alanna Lumsden, Daniella Vellone, Matthew C. S. Denley, Deepak P. Srivastava, Elena Choleris
Summary: Social memory is crucial for social animals, and estrogens can affect social memory through non-genomic mechanisms. This study reveals the necessity of ERK and PI3K signaling pathways in the rapid facilitation of short-term social memory and synaptogenesis. The bidirectional and rapid actions of estrogens on the brain and behavior highlight the importance of estrogen signaling in social behavior.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Eric Barbato, Rebecca Darrah, Thomas J. Kelley
Summary: Disordered sleep in people with cystic fibrosis (CF) may be associated with disrupted circadian regulation due to loss of cystic fibrosis transmembrane conductance regulator (Cftr) function. A CF mouse model showed significant alterations in locomotor activity timing and duration, as well as disrupted circadian gene expression and reduced melatonin production. Microtubules were found to play a role in regulating these outcomes, and targeting this microtubule-related mechanism may provide a therapeutic intervention for CF.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Luis M. Montano, Bettina Sommer, Hector Solis-Chagoyan, Bianca S. Romero-Martinez, Arnoldo Aquino-Galvez, Juan C. Gomez-Verjan, Eduardo Calixto, Georgina Gonzalez-Avila, Edgar Flores-Soto
Summary: The COVID-19 pandemic continues to have a significant impact on human health. One interesting observation is that older males seem to be more susceptible to the disease, similar to previous epidemics caused by SARS-CoV and the Middle East respiratory syndrome. This gender-related difference in COVID-19 death toll could be linked to testosterone levels in men. Decreased testosterone levels with age may lead to a decrease in the health benefits it provides, making individuals more vulnerable to infections. Low testosterone levels could also affect cell calcium homeostasis, potentially facilitating the replication of the SARS-CoV-2 virus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Psychiatry
Marcela Valdes-Tovar, Alejandra Monserrat Rodriguez-Ramirez, Leslye Rodriguez-Cardenas, Carlo E. Sotelo-Ramirez, Beatriz Camarena, Marco Antonio Sanabrais-Jimenez, Hector Solis-Chagoyan, Jesus Argueta, German Octavio Lopez-Riquelme
Summary: Schizophrenia and bipolar disorder are disabling psychiatric disorders with a worldwide prevalence of approximately 1%. Both disorders share clinical and neurobiological traits, including abnormalities in oligodendroglial function and myelinated fibers. These abnormalities may lead to disconnection between brain regions associated with symptoms. Molecular components of the axo-myelin unit play important roles in both disorders and provide potential targets for novel therapeutic approaches.
WORLD JOURNAL OF PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Luis M. Montano, Bettina Sommer, Juan C. Gomez-Verjan, Genaro S. Morales-Paoli, Gema Lizbeth Ramirez-Salinas, Hector Solis-Chagoyan, Zuly A. Sanchez-Florentino, Eduardo Calixto, Gloria E. Perez-Figueroa, Rohan Carter, Ruth Jaimez-Melgoza, Bianca S. Romero-Martinez, Edgar Flores-Soto
Summary: Theophylline is a potential adjuvant in the treatment of COVID-19 patients, as it down-regulates the inflammatory processes activated by the virus through various mechanisms. Computational simulation studies have been used to explore its applications and effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jesus Argueta, Hector Solis-Chagoyan, Rosa Estrada-Reyes, Luis A. Constantino-Jonapa, Julian Oikawa-Sala, Javier Velazquez-Moctezuma, Gloria Benitez-King
Summary: Research has found that melatonin's regulation of the Ca2+-CaM/CaMKII pathway is limited. This study aimed to investigate the interaction between MEL and CaM, and its effects on CaMKII activity, showing that MEL has regulatory effects in different cellular environments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
Daniel Arrieta-Baez, Mayra Beatriz Gomez-Patino, Noe Jurado Hernandez, Lilian Mayagoitia-Novales, Ana Maria Dorantes-Barron, Rosa Estrada-Reyes
Summary: The methanol extract of Leonotis nepetifolia showed antidepressant-like effects in mice, especially under chronic stress conditions. Administration of the extract improved body weight gain and reduced corticosterone levels in stressed mice, possibly through modulation of the hypothalamus-pituitary-adrenal axis to achieve its antidepressant actions.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Rosa Estrada-Reyes, Daniel B. Quero-Chavez, Salvador Alarcon-Elizalde, Montserrat G. Cercos, Citlali Trueta, Luis A. Constantino-Jonapa, Julian Oikawa-Sala, Jesus Argueta, Ricardo Cruz-Garduno, Margarita L. Dubocovich, Gloria A. Benitez-King
Summary: The combination of melatonin (MEL) and ketamine (KET) stimulates neurogenesis in human neuronal precursors, potentially providing a fast treatment option for depression.
Review
Biology
Manuel Castillejos-Lopez, Luz Maria Torres-Espindola, Juan Carlos Huerta-Cruz, Edgar Flores-Soto, Bianca S. Romero-Martinez, Rafael Velazquez-Cruz, Anjarath Higuera-Iglesias, Angel Camarena, Ana Karen Torres-Soria, Citlaltepetl Salinas-Lara, Rosario Fernandez-Plata, Noe Alvarado-Vasquez, Hector Solis-Chagoyan, Victor Ruiz, Arnoldo Aquino-Galvez
Summary: The SARS-CoV-2 pandemic has confirmed the predictions made by virologists for decades. The challenge faced by the world is to find a treatment, and repurposing drugs is a viable and fast option. However, the mechanisms of action of some drugs are unknown even though they are approved for human use. Therefore, it is ideal, but not necessary, to understand the basic mechanisms of action in order to justify the therapeutic application of a drug to a new disease.
Article
Biochemistry & Molecular Biology
Liliana Hernandez-Vazquez, Julia Cassani, Ivo Heyerdahl-Viau, Rubria M. Martinez-Casares, Hector Luna, Ana Maria Dorantes-Barron, Daniel Arrieta-Baez, Rosa Estrada-Reyes
Summary: This study developed an efficient chemical method to extract naringin-rich flavonoid compounds from the waste of grapefruits, and evaluated their anxiolytic- and antidepressant-like effects in mice. The results showed that the extract exhibited significant anti-anxiety and antidepressant effects in behavioral predictive paradigms.
Review
Biochemistry & Molecular Biology
Bettina Sommer, Georgina Gonzalez-Avila, Edgar Flores-Soto, Luis M. Montano, Hector Solis-Chagoyan, Bianca S. Romero-Martinez
Summary: Studies have shown that plasma concentrations of estrogens, progesterone, or both are correlated with symptoms in asthmatic women. Fluctuations in female sex steroid concentrations during menstruation are closely related to asthma symptoms, while menopause induces significant physiological changes that may necessitate hormonal replacement therapy. Late-onset asthma (LOA) is a specific asthma phenotype that includes menopausal women. Further research on therapeutic alternatives for menopausal asthmatic women suffering from LOA is needed. This review suggests phytoestrogens as a promising HRT option for relieving symptoms of menopause and asthma in these women. In addition to their well-known anti-inflammatory and antioxidant properties, phytoestrogens activate estrogen receptors and promote mild hormone-like responses that benefit postmenopausal women, particularly those with asthma. This potential therapy is highly attractive due to its low toxicity and minimal side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
