Article
Fisheries
Guo-Juan Niu, Xiao-Xu Zhu, Peng-Yuan Lu, Ming-Chong Yang, Wen-Jie Yuan, Jin-Xing Wang
Summary: This study identified a dyslexia-associated protein, MjKIAA0319L, in shrimps, which recognizes white spot syndrome virus (WSSV) via its extracellular domain and induces endocytosis of WSSV through its intracellular domain. The MjKIAA0319L-AP2-clathrin pathway is involved in the phagocytosis of WSSV to restrict viral infection in shrimps.
Article
Environmental Sciences
Mana Ito, Jun Satoh, Takeshi Hano, Tohru Mekata, Katsutoshi Ito
Summary: The study showed that prolonged exposure to phenanthrene impairs the immune system of kuruma shrimp, leading to fatal proliferation of WSSV. Additionally, combined exposure to phenanthrene and WSSV resulted in increased shrimp mortality and higher numbers of WSSV gene copies.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Multidisciplinary Sciences
Michael Onyema Edeh, Surjeet Dalal, Ibidun Christiana Obagbuwa, B. V. V. Siva Prasad, Shalini Zanzote Ninoria, Mohd Anas Wajid, Ademola Olusola Adesina
Summary: Technology is crucial in healthcare for disease prevention and detection. This study presents a predictive model for diagnosing and detecting White Spot Disease among shrimp farmers using machine learning algorithms and visualization techniques. The achieved results show a high prediction accuracy, indicating the suitability of the model for real-time disease prediction.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Shaoqing Zang, Li-Xia Lv, Chen-Fei Liu, Peng Zhang, Cang Li, Jin-Xing Wang
Summary: The mechanisms of trained immunity in shrimp, a phenomenon identified in invertebrates, were investigated in this study. Metabolomic analysis revealed significant changes in metabolism, including enrichment of glycolysis, pentose phosphate pathway, and AMPK signaling pathway, in shrimp trained with UV-inactivated white spot syndrome virus (UV-WSSV). Histone monomethylation and trimethylation were found to be involved in trained immunity. These findings provide insights for WSSV control in shrimp aquaculture.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Yaqun Zhang, Na Yao, Chuantao Zhang, Xiangshan Sun, Jingxian Huang, Bingran Zhao, Hengde Li
Summary: This study assessed the survival hours of kuruma shrimps challenged with WSSV and found it to be a complex quantitative trait with moderate heritability. Comparisons between different models demonstrated the feasibility of breeding WSSV-resistant kuruma shrimps and suggested that selecting survival hours is preferable to hazard risk. Additionally, several potential genetic markers associated with defense-related immune mechanisms were detected, providing new insights into virus resistance in kuruma shrimps.
Article
Biochemistry & Molecular Biology
Hui-Ju Huang, Sen-Lin Tang, Yuan-Chih Chang, Hao-Ching Wang, Tze Hann Ng, Rees F. Garmann, Yu-Wen Chen, Jiun-Yan Huang, Ramya Kumar, Sheng-Hsiung Chang, Shang-Rung Wu, Chih-Yu Chao, Kyoko Matoba, Iwasaki Kenji, William M. Gelbart, Tzu-Ping Ko, Hwei-Jiung (Andrew) Wang, Chu-Fang Lo, Li-Li Chen, Han-Ching Wang
Summary: Transmission electron microscopy (TEM) and cryogenic electron microscopy (Cryo-EM) techniques were used to study the morphology and pathogenesis of White spot syndrome virus (WSSV). The mature WSSV virions were found to have an oval shape without tail-like extensions. Two distinct ends, a portal cap, and a closed base, were observed in WSSV nucleocapsids. A C14 symmetric structure of the WSSV nucleocapsid was proposed based on Cryo-EM map. Immunoelectron microscopy (IEM) revealed a ring-like architecture formed by VP664 proteins, the main components of the 14 assembly units, in WSSV. Furthermore, a unique helical dissociation process of WSSV nucleocapsids was observed. Based on these findings, a novel morphogenetic pathway of WSSV was proposed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Jie Gao, Ye-Jia Song, Hao Wang, Bao-Rui Zhao, Xian-Wei Wang
Summary: White spot syndrome virus (WSSV) utilizes host autophagy and lipid metabolism for reproduction, causing a serious impact on global shrimp farming. This study reveals the mechanism by which WSSV exploits host machinery for infection and provides targets for WSSV prevention and control.
Article
Biochemistry & Molecular Biology
Lei Liu, Li-Peng Shan, Yan Zhou, Jiong Chen
Summary: The synthesis of coumarin derivatives C2 and C7 has shown promising antiviral effects against white spot syndrome virus in Litopenaeus vannamei larvae, reducing toxicity and mortality while remaining stable in aquacultural water. These compounds have the potential for use in prevention and treatment of WSSV infection in shrimp seedling culture.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Fisheries
Xupeng Li, Sheng Luan, Kun Luo, Baoxiang Cao, Baolong Chen, Jie Kong, Xianhong Meng
Summary: White spot syndrome virus (WSSV) is a lethal virus in shrimp aquaculture, with Chinese shrimp being more susceptible to infection. Currently, there is no effective solution to the WSSV problem in Chinese shrimp aquaculture. Research shows that different individuals from the same family can carry varying viral loads after WSSV infection. Transcriptomic analysis revealed differentially expressed genes related to binding function and the extracellular matrix-receptor interaction pathway, suggesting their importance in the anti-WSSV processes in Chinese shrimp.
AQUACULTURE REPORTS
(2022)
Article
Fisheries
Kejia Weng, Hongliang Zuo, Zhiming Zhu, Zhixun Guo, Shaoping Weng, Jianguo He, Xiaopeng Xu
Summary: The NF-KB signaling pathway plays a crucial role in the immune response of shrimp, while Ftz-F1H is involved in antiviral response, promoting WSSV infection by inhibiting the activation of the Dorsal pathway.
Article
Fisheries
Warapond Wanna, Chitchanok Aucharean, Panmile Kaitimonchai, Wachira Jaengkhao
Summary: This study investigated the effect of Pediococcus pentosaceus MR001 on the resistance to white spot disease (WSD) and the intestinal microbiota of Litopenaeus vannamei. The results showed that probiotic supplementation significantly increased the survival rate of shrimp and upregulated immunity-related genes. P. pentosaceus MR001 also altered the gut microbiota, increasing the abundance of potential probiotics and decreasing the abundance of potential pathogens.
AQUACULTURE REPORTS
(2023)
Article
Fisheries
Warumporn Yingsunthonwattana, Wisarut Junprung, Premruethai Supungul, Anchalee Tassanakajon
Summary: The study investigated the involvement of Litopenaeus vannamei (Lv) HSP90 in white spot syndrome virus (WSSV) infections. Silencing LvHSP90 resulted in reduced shrimp mortality and viral replication, but also induced apoptosis and potentially led to shrimp death.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Qingna Lai, Chen Yu, Furong Zhao, Yunying Cheng, Qin Zheng, Changkun Pan, Zhenyue Lin, Suping Yang, Qian Zhang, Jianming Chen, Wei Wang
Summary: Nitric oxide plays a crucial role in immune defense against WSSV infection in shrimp, inhibiting viral replication and reducing mortality. This study provides theoretical support for the development of NO-based therapeutic strategies.
Article
Environmental Sciences
Guo-Juan Niu, Ming Yan, Cang Li, Peng-yuan Lu, Zhongtang Yu, Jin-Xing Wang
Summary: In this study, the effects of white spot syndrome virus (WSSV) infection on the microbiota in the gastrointestinal tract of kuruma shrimp were investigated. The results showed that WSSV infection decreased microbial diversity and affected the composition of bacteria in the stomachs, but not in the intestines. Firmicutes increased significantly, while Actinobacteria, Bacteroidetes, and Cyanobacteria decreased in the stomachs of WSSV-infected shrimp.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Fisheries
Wattana Weerachatyanukul, Charoonroj Chotwiwatthanakun, Pitchanee Jariyapong
Summary: The encapsulation of double stranded RNA into VLPs shows promise in combating shrimp viral infections, with co-encapsulation of dual dsRNA into IHHNV-VLPs demonstrating superior silencing ability against WSSV.
FISH & SHELLFISH IMMUNOLOGY
(2021)
