A new perspective of the hippocampus in the origin of exercise–brain interactions

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults

(2018) Shawn F. Sorrells et al.   NATURE

Impact of a single bout of high-intensity interval exercise and short-term interval training on interleukin-6, FNDC5, and METRNL mRNA expression in human skeletal muscle

(2018) Malcolm Eaton et al.   Journal of Sport and Health Science

Running promotes spatial bias independently of adult neurogenesis

(2017) Jason S. Snyder et al.   HIPPOCAMPUS

Health benefits of exercise — more than meets the eye!

(2017) Mark A. Febbraio   Nature Reviews Endocrinology

Neuroprotective Effects of Physical Activity: Evidence from Human and Animal Studies

(2017) Sergio Chieffi et al.   Frontiers in Neurology

Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function

(2016) Hyo Youl Moon et al.   Cell Metabolism

The mechanisms underlying the beneficial effects of exercise on bone remodeling: Roles of bone-derived cytokines and microRNAs

(2016) Zhengtang Qi et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Aerobic fitness is associated with greater hippocampal cerebral blood flow in children

(2016) Laura Chaddock-Heyman et al.   Developmental Cognitive Neuroscience

The Effect of Exercise Training on Resting Concentrations of Peripheral Brain-Derived Neurotrophic Factor (BDNF): A Meta-Analysis

(2016) Adam Dinoff et al.   PLoS One

Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

(2015) P. Darrell Neufer et al.   Cell Metabolism

Navigating life

(2015) Neal J. Cohen   HIPPOCAMPUS

SMAD3 negatively regulates serum irisin and skeletal muscle FNDC5 and peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) during exercise.

(2015) Joseph P. Tiano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of cerebrovascular patterning by neural activity during postnatal development

(2015) Baptiste Lacoste et al.   MECHANISMS OF DEVELOPMENT

Speed cells in the medial entorhinal cortex

(2015) Emilio Kropff et al.   NATURE

Locomotion, Theta Oscillations, and the Speed-Correlated Firing of Hippocampal Neurons Are Controlled by a Medial Septal Glutamatergic Circuit

(2015) Falko Fuhrmann et al.   NEURON

Exercise-mimetic AICAR transiently benefits brain function

(2015) Davide Guerrieri et al.   Oncotarget

Blood-Borne Revitalization of the Aged Brain

(2015) Joseph M. Castellano et al.   JAMA Neurology

Impact of exercise on muscle and nonmuscle organs

(2015) Pontus A. Boström et al.   IUBMB LIFE

Behavioral and Pharmacological Evaluation of a Selectively Bred Mouse Model of Home Cage Hyperactivity

(2014) Petra Majdak et al.   BEHAVIOR GENETICS

Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression

(2014) Leandro Z. Agudelo et al.   CELL

Increased adult hippocampal neurogenesis is not necessary for wheel running to abolish conditioned place preference for cocaine in mice

(2014) M. L. Mustroph et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neuronal activity alters BDNF–TrkB signaling kinetics and downstream functions

(2014) Wei Guo et al.   JOURNAL OF CELL SCIENCE

AMPK agonist AICAR improves cognition and motor coordination in young and aged mice

(2014) T. Kobilo et al.   LEARNING & MEMORY

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

(2014) Saul A Villeda et al.   NATURE MEDICINE

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

(2014) L. Katsimpardi et al.   SCIENCE

Neuroprotective effects of physical activity on the brain: a closer look at trophic factor signaling

(2014) Cristy Phillips et al.   Frontiers in Cellular Neuroscience

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

Speed modulation of hippocampal theta frequency correlates with spatial memory performance

(2013) Gregory R. Richard et al.   HIPPOCAMPUS

Exercise reduces activation of microglia isolated from hippocampus and brain of aged mice

(2013) Rachel A Kohman et al.   Journal of Neuroinflammation

Physical Exercise Prevents Stress-Induced Activation of Granule Neurons and Enhances Local Inhibitory Mechanisms in the Dentate Gyrus

(2013) T. J. Schoenfeld et al.   JOURNAL OF NEUROSCIENCE

Grid cells require excitatory drive from the hippocampus

(2013) Tora Bonnevie et al.   NATURE NEUROSCIENCE

Memory, navigation and theta rhythm in the hippocampal-entorhinal system

(2013) György Buzsáki et al.   NATURE NEUROSCIENCE

Activity-Dependent Neural Plasticity from Bench to Bedside

(2013) Karunesh Ganguly et al.   NEURON

Multisensory Control of Hippocampal Spatiotemporal Selectivity

(2013) P. Ravassard et al.   SCIENCE

Bridging animal and human models of exercise-induced brain plasticity

(2013) Michelle W. Voss et al.   TRENDS IN COGNITIVE SCIENCES

Ablating Adult Neurogenesis in the Rat Has No Effect on Spatial Processing: Evidence from a Novel Pharmacogenetic Model

(2013) James O. Groves et al.   PLoS Genetics

Brain-derived neurotrophic factor as a regulator of systemic and brain energy metabolism and cardiovascular health

(2012) Sarah M. Rothman et al.   Annals of the New York Academy of Sciences

Neurogenesis, inflammation and behavior

(2012) Rachel A. Kohman et al.   BRAIN BEHAVIOR AND IMMUNITY

New neurons generated from running are broadly recruited into neuronal activation associated with three different hippocampus-involved tasks

(2012) Peter J. Clark et al.   HIPPOCAMPUS

Running Speed Alters the Frequency of Hippocampal Gamma Oscillations

(2012) O. J. Ahmed et al.   JOURNAL OF NEUROSCIENCE

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Muscles, exercise and obesity: skeletal muscle as a secretory organ

(2012) Bente K. Pedersen et al.   Nature Reviews Endocrinology

Changes in hippocampal theta rhythm and their correlations with speed during different phases of voluntary wheel running in rats

(2012) J.-Y. Li et al.   NEUROSCIENCE

Aerobic exercise is the critical variable in an enriched environment that increases hippocampal neurogenesis and water maze learning in male C57BL/6J mice

(2012) M.L. Mustroph et al.   NEUROSCIENCE

How vision and movement combine in the hippocampal place code

(2012) G. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Muscle Fatigue and Cognition: What is the Link?

(2012) Tali Kobilo et al.   Frontiers in Physiology

Wheel running attenuates microglia proliferation and increases expression of a proneurogenic phenotype in the hippocampus of aged mice

(2011) Rachel A. Kohman et al.   BRAIN BEHAVIOR AND IMMUNITY

Genetic influences on exercise-induced adult hippocampal neurogenesis across 12 divergent mouse strains

(2011) P. J. Clark et al.   GENES BRAIN AND BEHAVIOR

Greater running speeds result in altered hippocampal phase sequence dynamics

(2011) Andrew P. Maurer et al.   HIPPOCAMPUS

Hippocampal functional hyperemia mediated by NMDA receptor/NO signaling in rats during mild exercise

(2011) Takeshi Nishijima et al.   JOURNAL OF APPLIED PHYSIOLOGY

Changes in hippocampal theta activity during initiation and maintenance of running in the rat

(2011) T.B.J. Kuo et al.   NEUROSCIENCE

Induction of c-Fos, Zif268, and Arc from acute bouts of voluntary wheel running in new and pre-existing adult mouse hippocampal granule neurons

(2011) P.J. Clark et al.   NEUROSCIENCE

Primary motor cortex activity is elevated with incremental exercise intensity

(2011) V. Brümmer et al.   NEUROSCIENCE

Speed Controls the Amplitude and Timing of the Hippocampal Gamma Rhythm

(2011) Zhiping Chen et al.   PLoS One

Exercise training increases size of hippocampus and improves memory

(2011) K. I. Erickson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Spatial Periodicity of Grid Cells Is Not Sustained During Reduced Theta Oscillations

(2011) J. Koenig et al.   SCIENCE

Adult hippocampal neurogenesis and c-Fos induction during escalation of voluntary wheel running in C57BL/6J mice

(2010) Peter J. Clark et al.   BEHAVIOURAL BRAIN RESEARCH

Treadmill exercise prevents decline in spatial learning and memory in APP/PS1 transgenic mice through improvement of hippocampal long-term potentiation

(2010) Hui-li Liu et al.   BEHAVIOURAL BRAIN RESEARCH

Exercise Induces a Marked Increase in Plasma Follistatin: Evidence That Follistatin Is a Contraction-Induced Hepatokine

(2010) Jakob Hansen et al.   ENDOCRINOLOGY

Functional imaging of hippocampal place cells at cellular resolution during virtual navigation

(2010) Daniel A Dombeck et al.   NATURE NEUROSCIENCE

Activity-dependent structural plasticity

(2009) Markus Butz et al.   BRAIN RESEARCH REVIEWS

Functional analysis of neurovascular adaptations to exercise in the dentate gyrus of young adult mice associated with cognitive gain

(2009) Peter J. Clark et al.   HIPPOCAMPUS

Aerobic fitness is associated with hippocampal volume in elderly humans

(2009) Kirk I. Erickson et al.   HIPPOCAMPUS

Intracellular dynamics of hippocampal place cells during virtual navigation

(2009) Christopher D. Harvey et al.   NATURE

Spike Timing–Dependent Plasticity: A Hebbian Learning Rule

(2008) Natalia Caporale et al.   Annual Review of Neuroscience

AMPK and PPARδ Agonists Are Exercise Mimetics

(2008) Vihang A. Narkar et al.   CELL

Effects of exercise on adipokines and the metabolic syndrome

(2008) Tongjian You et al.   Current Diabetes Reports

Latent Stem and Progenitor Cells in the Hippocampus Are Activated by Neural Excitation

(2008) T. L. Walker et al.   JOURNAL OF NEUROSCIENCE

Hippocampal Network Dynamics Constrain the Time Lag between Pyramidal Cells across Modified Environments

(2008) K. Diba et al.   JOURNAL OF NEUROSCIENCE

Early age-related changes in adult hippocampal neurogenesis in C57 mice

(2008) Nada M.-B. Ben Abdallah et al.   NEUROBIOLOGY OF AGING

Be smart, exercise your heart: exercise effects on brain and cognition

(2007) Charles H. Hillman et al.   NATURE REVIEWS NEUROSCIENCE