期刊
BRAIN STRUCTURE & FUNCTION
卷 223, 期 6, 页码 2999-3006出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00429-018-1661-x
关键词
Anterior cingulate cortex; Visual cortices; Parietal association cortex; Optogenetics; Macrocircuit; Top-down
资金
- National Institute on Alcohol Abuse and Alcoholism [K22AA021414, R01AA024845]
- Whitehall Foundation [2014-12-68]
- National Institute of Mental Health [F31MH112350]
- National Institute of General Medical Sciences Grant [T32GM008181]
- National Institute of Neurological Disorders and Stroke Grant [T32NS063391]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM008181] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [T32MH064913, F31MH112350] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [T32NS063391] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [K22AA021414, R01AA024845] Funding Source: NIH RePORTER
The claustrum is a telencephalic gray matter nucleus that is richly interconnected with the neocortex. This structure subserves top-down executive functions that require frontal cortical control of posterior cortical regions. However, functional anatomical support for the claustrum allowing for long-range intercortical communication is lacking. To test this, we performed a channelrhodopsin-assisted long-circuit mapping strategy in mouse brain slices. We find that anterior cingulate cortex input to the claustrum is transiently amplified by claustrum neurons that, in turn, project to parietal association cortex or to primary and secondary visual cortices. Additionally, we observe that claustrum drive of cortical neurons in parietal association cortex is layer-specific, eliciting action potential generation briefly in layers II/III, IV, and VI but not V. These data are the first to provide a functional anatomical substrate through claustrum that may underlie top-down functions, such as executive attention or working memory, providing critical insight to this most interconnected and enigmatic nucleus.
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