Article
Cell Biology
Sahar Sweetat, Keren Nitzan, Nir Suissa, Yael Haimovich, Michal Lichtenstein, Samar Zabit, Sandrine Benhamron, Karameh Akarieh, Kumudesh Mishra, Dinorah Barasch, Ann Saada, Tamar Ziv, Or Kakhlon, Haya Lorberboum-Galski, Hanna Rosenmann
Summary: We investigated the efficacy of mitochondrial transfer in 5XFAD transgenic mice and found that it improved cognitive impairment, reduced amyloid burden, and alleviated mitochondrial dysfunction. The exogenously injected mitochondria were detected in the liver, but not in the brain. We observed changes in the brain proteome and liver metabolome, suggesting that the beneficial effects of mitochondrial transfer may be mediated by metabolic signaling from the liver to the brain via the serum. These findings highlight the potential of mitochondrial transfer as a novel therapy for Alzheimer's disease.
Article
Plant Sciences
Min-Ji Jung, Namkwon Kim, Seung Ho Jeon, Min Sung Gee, Ji-Woon Kim, Jong Kil Lee
Summary: The study investigated the effects of eugenol on Alzheimer's disease (AD) and found that eugenol effectively improved cognitive function and reduced pathological changes in 5xFAD mice. The underlying mechanisms may involve inhibiting neuronal cell death and promoting beta-amyloid clearance.
Article
Neurosciences
Jonathan A. Zweig, Mikah S. Brandes, Barbara H. Brumbach, Maya Caruso, Kirsten M. Wright, Joseph F. Quinn, Amala Soumyanath, Nora E. Gray
Summary: Long-term treatment with Centella asiatica water extract improved cognitive function, increased antioxidant gene expression, reduced Aβ plaque burden, and may be beneficial for Alzheimer's disease. Targeting NRF2 activation could improve synaptic plasticity and cognitive function in Alzheimer's disease.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Geriatrics & Gerontology
Zhihai Huang, Dedrick Jordan, Quanguang Zhang
Summary: Alzheimer's disease (AD) is an age-related neurodegenerative disease characterized by memory loss and cognitive decline. Recent studies have highlighted the critical role of myelin degeneration in AD, which may occur prior to the development of amyloid pathology. These findings implicate myelin degeneration as a critical contributor to AD-related cognitive deficits and support targeting myelin repair as a promising therapeutic strategy for AD.
Article
Immunology
Antonietta Vilella, Martina Bodria, Bianca Papotti, Ilaria Zanotti, Francesca Zimetti, Giulia Remaggi, Lisa Elviri, Francesco Poti, Nicola Ferri, Maria Giovanna Lupo, Giovanni Panighel, Eleonora Daini, Eleonora Vandini, Michele Zoli, Daniela Giuliani, Franco Bernini
Summary: This study provides evidence that PCSK9 is involved in the pathophysiology of Alzheimer's disease (AD) and has a pro-inflammatory effect. Inhibiting PCSK9 may improve cognitive function, attenuate A beta pathology, and reduce neuroinflammation in AD.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Medicine, Research & Experimental
Eunbi Cho, Kumju Youn, Huiyoung Kwon, Jieun Jeon, Wan-Seob Cho, Se Jin Park, Seung Hwan Son, Dae Sik Jang, Chan Young Shin, Minho Moon, Mira Jun, Nam-Jung Kim, Dong Hyun Kim
Summary: This study investigated the effects of eugenitol in an AD mouse model and found that it inhibits the formation of A beta plaques and reduces neuronal cell death. In silico docking simulation showed that eugenitol may interact with A beta monomers and fibrils.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Nikita Zernov, Alexander V. Veselovsky, Vladimir V. Poroikov, Daria Melentieva, Anastasia Bolshakova, Elena Popugaeva
Summary: A new selective TRPC6 agonist, C20, has been identified, which can recover cognitive deficits caused by synaptic loss in the brains of Alzheimer's disease patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Victor James Drew, Mincheol Park, Tae Kim
Summary: This study examined the relationship between sleep disturbances and regional neuron and astrocyte pathologies in Alzheimer's disease (AD). The findings showed that 5XFAD mice demonstrated reduced NREM and REM sleep duration and bout counts, as well as decreased theta EEG power frequency during REM sleep. Sleep disturbances were correlated with the number and ratio of GFAP-positive astrocytes in sleep-promoting brain regions. This study reveals the link between neurotoxic reactive astrogliosis and sleep disturbances in AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
H. B. Kim, D. Kim, H. Kim, W. Kim, S. Chung, S. H. Lee, H. R. Kim, S. B. Oh
Summary: The study evaluated the masticatory behavior of 5XFAD mice and found decreased masticatory efficiency and maximum biting force, along with significant accumulation of A beta in the Vmo region. These results demonstrate a close association between masticatory dysfunction and dementia in AD.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Immunology
Xiaoyan Zeng, Stanley K. K. Cheung, Mengqi Shi, Penelope M. Y. Or, Zhining Li, Julia Y. H. Liu, Wayne L. H. Ho, Tian Liu, Kun Lu, John A. Rudd, Yubing Wang, Andrew M. Chan
Summary: This study found that increased expression of YKL-40 in astrocytes is associated with activated astrocytes in an Alzheimer's disease model. A beta 1-42 upregulates YKL-40 through the PI3-K signaling pathway in primary astrocytes, leading to synaptic degeneration and impaired neuronal function. Knockout of YKL-40 in astrocytes reduces amyloid plaque deposition, attenuates glial activation, reduces neuronal attrition, and restores memory function in symptomatic Alzheimer's disease mice.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Neurosciences
Surendra Maharjan, Andy P. Tsai, Peter B. Lin, Cynthia Ingraham, Megan R. Jewett, Gary E. Landreth, Adrian L. Oblak, Nian Wang
Summary: This study evaluated the age-dependent microstructure changes in 5xFAD mice using high-resolution diffusion tensor imaging (DTI). The results showed that fractional anisotropy (FA) was more sensitive in monitoring amyloid deposition in the mice.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Vu Thu Thuy Nguyen, Lena Bruecker, Ann-Kathrin Volz, Julia C. Baumgaertner, Malena dos Santos Guilherme, Francesco Valeri, Helen May-Simera, Kristina Endres
Summary: The study suggests a potential link between neurodegenerative diseases like Alzheimer's disease (AD) and abnormalities in gut function and alterations in primary cilia structure, warranting further investigation for confirmation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Filip Kosel, Jacob S. Hamilton, Sarah L. Harrison, Victoria Godin, Tamara B. Franklin
Summary: The study found that transgenic 5xFAD mice exhibit aggressive behaviors, but they do not directly attack conspecifics, instead avoiding novel social stimuli. Interactions between individuals with the AD phenotype may exacerbate aggressive behaviors.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Clinical Neurology
Eunji Oh, Jeong-Hwa Kang, Kyung Won Jo, Won-Sik Shin, Young-Hun Jeong, Byunghee Kang, Tae-Young Rho, So Yeon Jeon, Jihoon Lee, Im-Sook Song, Kyong-Tai Kim
Summary: In this study, a synthetic peroxisome proliferator-activating receptor (PPAR) agonist called DTMB was found to improve chronic inflammation and A beta plaque progression, suggesting its potential as a novel therapeutic agent for Alzheimer's disease.
Article
Neurosciences
Noelia Lopez-Sanchez, Morgan Ramon-Landreau, Cristina Trujillo, Alberto Garrido-Garcia, Jose M. Frade
Summary: Alzheimer's disease (AD) is a complex neurodegenerative disorder that requires a multifaceted approach for effective treatment. In this study, researchers focused on the transcription factor E2 factor 4 (E2F4), which is upregulated in the brains of AD patients and transgenic mice. They generated a mouse strain with neuronal expression of a variant of E2F4 lacking a specific motif (E2F4DN) and found that its expression in 5xFAD mice, a model of AD, attenuated the immune response, improved brain homeostasis, and prevented cognitive impairment and body weight loss. This study suggests that targeting E2F4DN through gene therapy could be a promising approach for treating AD.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Clinical Neurology
Hao Shu, Gang Chen, B. Douglas Ward, Guangyu Chen, Zan Wang, Duan Liu, Fan Su, Lihua Gu, Zhan Xu, Shi-Jiang Li, Zhijun Zhang
Summary: This study found that in carriers of the Alzheimer's disease variant, there is hippocampal hyperconnectivity in specific neural correlates, which is associated with imminent decline in episodic memory.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Gao-Jia Zhang, Di Wu, Yi-Xin Zhu, Hai-Feng Ni, Zhi-Jun Zhang
Summary: NIID is a rare progressive neurodegenerative disorder characterized by eosinophilic hyaline inclusions in neurons and somatic cells. Skin biopsy and FMR1 gene diagnosis after DWI showing abnormal corticomedullary junction hyperintensity were used to diagnose NIID cases. Inclusions were more easily detected in sweat gland cells, and autonomic nerve dysfunction may be a common manifestation in early stage of NIID.
NEUROLOGICAL SCIENCES
(2022)
Article
Computer Science, Interdisciplinary Applications
Jian Xie, Zaiheng Cheng, Lihua Gu, Bokai Wu, Gaojia Zhang, Wenshin Shiu, Rongliang Chen, Zan Wang, Chang Liu, Jie Tu, Xiaochuan Cai, Jia Liu, Zhijun Zhang
Summary: The study utilized a computational fluid dynamics (CFD) approach to detect cerebral hemodynamics, revealing that SVaD patients had reduced outlets, CAV, and tCBF index, along with an increased tCVR index compared to CNCs. Fewer outlets and more WMH were identified as risk factors for SVaD, partially mediated by the tCBF index.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Clinical Neurology
Yixin Zhu, Lihua Gu
Summary: The meta-analysis showed that both rTMS and tDCS are effective in improving swallowing function in poststroke dysphagia patients. However, more large-scale, blinded randomized controlled trials are needed to further investigate the effects of these therapies.
EUROPEAN NEUROLOGY
(2022)
Article
Neurosciences
Mengxue Wang, Qingguo Ren, Yachen Shi, Hao Shu, Duan Liu, Lihua Gu, Chunming Xie, Zhijun Zhang, Tiange Wu, Zan Wang
Summary: The relationship between brain aging and AD risk factors, such as APOE-ε4 and family history of dementia, is still unclear. However, the study found that female and individuals with higher education tend to have preserved brain aging. Additionally, BrainAGE combined with APOE-ε4 and hippocampus GMV could potentially be used as a pre-screening tool in early-stage AD.
NEUROSCIENCE LETTERS
(2022)
Review
Medicine, General & Internal
Sisi Feng, Yihao Zhou, Mingzhi Tang, JuMei Wang, YuLan Lv, LiHua Gu
Summary: This study aims to evaluate the efficacy and safety of acupuncture combined with rehabilitation in treating strephenopodia after stroke, providing more reliable evidence-based solutions for this condition.
Article
Clinical Neurology
Lihua Gu, Hui Xu
Summary: This study conducted a meta-analysis on Parkinson's disease patients and found a correlation between higher educational levels and better cognitive function, as well as a lower risk of longitudinal progression to mild cognitive impairment.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Juan Zu, Lei Zuo, Lin Zhang, Zan Wang, Yachen Shi, Lihua Gu, Zhijun Zhang
Summary: This study found that the level of circular RNA FUNDC1 (circFUNDC1) is associated with neurological status, early neurological deterioration, and long-term survival in acute ischemic stroke patients. High circFUNDC1 levels are closely related to a lower long-term survival rate.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Lihua Gu, Yanjuan Wang, Hao Shu
Summary: The meta-analysis revealed lower general cognitive function and language function in migraine patients compared to non-migraine subjects. There was no significant difference in visuospatial function, attention, executive function, and memory between the two groups. Additionally, migraine was associated with an increased risk of dementia.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Clinical Neurology
Lihua Gu, Hao Shu, Hui Xu, Yanjuan Wang
Summary: The ALE analysis in this study has confirmed functional deficits in motor-, emotion-, and cognition-related regions in PD. Deficits in these regions could play a role in the early diagnosis of PD.
NEUROLOGICAL SCIENCES
(2022)
Review
Clinical Neurology
Hui Xu, Lihua Gu, Shiyao Zhang, Yuchen Wu, Xiaojin Wei, Caiyan Wang, Yuhan Xu, Yijing Guo
Summary: The meta-analysis indicated that N200 and P300 components could potentially serve as electrophysiological biomarkers of early cognitive impairment in PD patients. Further studies are required to validate this conclusion. Estimates of N200 and P300 components could offer valuable support for clinicians in diagnosing early cognitive impairment in PD patients.
NEUROLOGICAL SCIENCES
(2022)
Review
Geriatrics & Gerontology
Lihua Gu, Hao Shu, Yanjuan Wang, Hui Xu
Summary: The present study analyzed neuroimaging studies to compare Parkinson's disease (PD) patients with and without impulse control disorder (PD-ICD). The results showed significant differences in brain structure and function between PD-ICD patients and PD-no ICD patients, particularly in the frontal, temporal, and basal ganglia regions.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Clinical Neurology
Sisi Feng, Mingzhi Tang, Gan Huang, JuMei Wang, Sijin He, Duo Liu, LiHua Gu
Summary: This study aimed to identify the most effective physical therapy intervention for improving clinical symptoms in patients with post-stroke shoulder-hand syndrome (SHS) through Bayesian network meta-analysis. The results showed that EMG biofeedback combined with rehabilitation training may be the best physical therapy for improving upper limb motor function and relieving pain in patients with post-stroke SHS. However, further analysis and validation by more high-quality RCTs are needed for these conclusions.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Lihua Gu, Hao Shu, Yanjuan Wang
Summary: Using the ALE method, this study explored the consistent functional brain changes in migraine patients. The results showed widespread functional changes in regions such as the cingulate gyrus, basal ganglia, and frontal cortex, which are associated with pain processing, cognitive dysfunction, and emotional problems. These findings provide important clues for understanding the pathophysiology of migraine.
NEUROLOGICAL RESEARCH
(2023)
Article
Clinical Neurology
Lihua Gu, Hao Shu, Yanjuan Wang
Summary: The study found elevated levels of sTREM2 in the cerebrospinal fluid of AD, MCI, and pre-AD patients, but no significant difference in plasma levels between AD patients and healthy controls. There was also no significant difference in sTREM2 levels in the cerebrospinal fluid or plasma of PD patients compared to healthy controls. CSF sTREM2 may be a promising biomarker for different clinical stages of AD, while further research is needed to explore sTREM2 alterations in PD.
NEUROLOGICAL SCIENCES
(2023)