Article
Neurosciences
Tobias Overath, Joon H. Paik
Summary: This study found that the cortical processing of speech-specific temporal structure is modulated by higher-level linguistic analysis. The superior temporal sulcus (STS) was involved in the acoustic analysis of temporal speech properties, while the left inferior gyrus (IFG) was found to be responsible for linguistic processing of temporal speech properties.
Review
Neurosciences
Yuhui Chai, Tina T. Liu, Sean Marrett, Linqing Li, Arman Khojandi, Daniel A. Handwerker, Arjen Alink, Lars Muckli, Peter A. Bandettini
Summary: The study examines laminar activity patterns in different topographical subfields of human PT under unimodal and multisensory stimuli, revealing a division of function between visual and auditory processing in PT and distinct feedback mechanisms in different subareas.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Neurosciences
Ane Gurtubay-Antolin, Ceren Battal, Chiara Maffei, Mohamed Rezk, Stefania Mattioni, Jorge Jovicich, Olivier Collignon
Summary: This study investigated the presence of direct white matter connections between visual and auditory motion-selective regions in humans, confirming the potential existence of occipitotemporal projections between hMT(+)/V5 and hPT. The findings suggest functional specificity of these connections, supporting the exchange of motion information between specialized auditory and visual regions.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Seung-Goo Kim, Tobias Overath, William Sedley, Sukhbinder Kumar, Sundeep Teki, Yukiko Kikuchi, Roy Patterson, Timothy D. Griffiths
Summary: The study recorded neural responses in human participants to different types of pitch-evoking stimuli, finding cortical sensitivity to temporal regularity relevant to pitch in the Heschl's sulcus, which was consistent across different types of pitch-relevant stimuli.
Article
Neurosciences
Ceren Battal, Ane Gurtubay-Antolin, Mohamed Rezk, Stefania Mattioni, Giorgia Bertonati, Valeria Occelli, Roberto Bottini, Stefano Targher, Chiara Maffei, Jorge Jovicich, Olivier Collignon
Summary: The study found that early blindness alters the connectivity of occipitotemporal networks in the brain, resulting in enhanced response to moving sounds. This alteration is not only specific to motion features, but also involves sound source location information. In blind individuals, the anterior portion of the occipitotemporal cortex responds more strongly to moving sounds compared to sighted individuals, while the posterior portion selectively responds to moving sounds only in blind participants. Additionally, the functional properties of the human planum temporale, a region involved in auditory motion processing, are also altered in blind individuals.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Mark A. Eckert, Kenneth I. Vaden, Federico Iuricich
Summary: The ability to map speech sounds to letters is crucial for proficient reading. This study explores the relationship between the phonological processing ability and the asymmetry of brain structures supporting language. The results suggest that the magnitude of structural asymmetry in certain cortical regions is associated with phonological decoding accuracy, supporting both the cerebral lateralization hypothesis and the canalization hypothesis to some extent.
Article
Clinical Neurology
Iseul An, Minji Bang, Sang-Hyuk Lee
Summary: The study suggests that early trauma exposure may impact brain structures differently based on a diagnosis of panic disorder, and individual variations in brain alterations after early trauma may confer susceptibility to developing panic disorder. Further longitudinal studies are needed to elucidate the neurobiological mechanisms underlying early trauma and psychiatric outcomes.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Multidisciplinary Sciences
Haewon Nam, Chongwon Pae, Jinseok Eo, Maeng-Keun Oh, Hae-Jeong Park
Summary: The study aims to establish functional homology between human and macaque cortices by proposing an iterative functional network-based registration scheme. The iterative procedure calculates the functional connectivity matrix to estimate a deformation field between the two cortices, showing higher variability and asymmetry in functional homology compared to structural homology. This emphasizes the significance of functional network-based cortical registration across individuals within a species and across species.
Article
Biology
Lisa Bartha-Doering, Kathrin Kollndorfer, Ernst Schwartz, Florian Ph. S. Fischmeister, Georg Langs, Michael Weber, Sonja Lackner-Schmelz, Patric Kienast, Marlene Stuempflen, Athena Taymourtash, Sophie Mandl, Johanna Alexopoulos, Daniela Prayer, Rainer Seidl, Gregor Kasprian
Summary: The depth asymmetry of the superior temporal sulcus (STS) may serve as a potential biomarker for the maturity and integrity of neural correlates of language. This study explored the prognostic value of STS depth asymmetry in healthy fetuses for later language abilities. The findings suggest that less right fetal STS depth asymmetry is associated with better verbal abilities and increased left language localization during childhood.
COMMUNICATIONS BIOLOGY
(2023)
Article
Audiology & Speech-Language Pathology
Benjamin Isler, Nathalie Giroud, Sarah Hirsiger, Tobias Kleinjung, Martin Meyer
Summary: The study investigated the relationship between age-related brain atrophy and behavioral, as well as electrophysiological markers of vowel perception in healthy younger and older adults with normal pure-tone hearing. Older adults performed worse in vowel discrimination despite having normal pure-tone hearing, with those showing greater age-related cortical atrophy in the left and right planum temporale (PT) exhibiting weaker vowel discrimination. In contrast, younger participants with greater cortical thickness in only the left PT performed weaker in the vowel discrimination task. The study suggests that deficient vowel processing is influenced by both aging-related changes in auditory-related cortices and not solely by pure-tone hearing loss.
Article
Psychiatry
Judith Schmitz, Mo Zheng, Kelvin F. H. Lui, Catherine McBride, Connie S. -H. Ho, Silvia Paracchini
Summary: The heritability of hand, foot, and eye preference was investigated, with parental left-side preference found to increase the chance of left-sidedness in the offspring. Quantitative multidimensional laterality phenotypes were found to capture the underlying genetics better than binary traits.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Behavioral Sciences
Elkhonon Goldberg, Jaan Tulviste
Summary: The two main large-scale distributed networks, Central Executive (CEN) and Default Mode (DMN), have been found to be neuroanatomically asymmetric, with CEN components being larger in volume in the right hemisphere and DMN components being larger in volume in the left hemisphere. This suggests the possibility of functional asymmetry in these networks and highlights the importance of further investigating hemispheric specialization.
Article
Biology
Yu-Chi Chen, Aurina Arnatkeviciute, Eugene McTavish, James C. Pang, Sidhant Chopra, Chao Suo, Alex Fornito, Kevin M. Aquino, Alzheimer's Disease Neuroimaging Initiative
Summary: Asymmetries of the whole cortical shape, independent of size, are highly individualized and robust, similar to a cortical fingerprint, and can identify individuals more accurately than size-based descriptors. Coarse-scale shape asymmetries are highly personalized, sexually dimorphic, associated with individual differences in cognition, and primarily driven by subject-specific environmental effects. Unihemispheric cortical shape shows significant heritability at coarse scales, but shape asymmetries are determined primarily by stochastic environmental influences.
Article
Clinical Neurology
Lukas Schnaufer, Alisa Gschaidmeier, Magdalena Heimgaertner, Pablo Hernaiz Driever, Till-Karsten Hauser, Marko Wilke, Karen Lidzba, Martin Staudt
Summary: This study aimed to assess the impact of atypical language organization after early left-hemispheric brain lesions on grey matter in the contralesional hemisphere. The findings suggest that patients with atypical language organization show an increase in grey matter in the middle frontal gyrus, indicating a compensatory effect. However, all patients, regardless of language organization, showed areas of grey matter reduction compared to typically developing controls.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Psychology, Biological
Karin Saltoun, Ralph Adolphs, Lynn K. Paul, Vaibhav Sharma, Joern Diedrichsen, B. T. Thomas Yeo, Danilo Bzdok
Summary: This study characterized whole-brain asymmetry patterns and found their associations with specific phenotypes using data from UK Biobank participants.
NATURE HUMAN BEHAVIOUR
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Claes Hakansson, Ashkan Tamaddon, Henrik Andersson, Gustav Torisson, Gustav Martensson, My Truong, Marten Annertz, Elisabet Londos, Isabella M. Bjorkman-Burtscher, Oskar Hansson, Danielle van Westen
Summary: The study found that radiologists with varying experience achieve satisfactory inter-modality agreement and similar accuracy when rating medial temporal lobe atrophy using Scheltens' MTA scale on a non-demented population. Junior radiologists achieved satisfactory agreement in Cohen's kappa, while all raters achieved satisfactory agreement in Cohen's kappa(w) and ICC. True positive rates and true negative rates varied between radiologists, but no underestimation or overestimation of MTA was observed.
EUROPEAN RADIOLOGY
(2022)
Article
Neurosciences
Lara Langensee, Theodor Rumetshofer, Hamid Behjat, Mikael Noven, Ping Li, Johan Martensson
Summary: Childhood is a critical period for brain development, and myelination of axons plays a role in signal propagation and skill development. The T1w/T2w ratio has been proposed as a measure of cortical myelination, but its applicability for between-subject comparisons is questionable.
Article
Endocrinology & Metabolism
Khazar Ahmadi, Joana B. Pereira, David Berron, Jacob Vogel, Silvia Ingala, Olof T. Strandberg, Shorena Janelidze, Frederik Barkhof, Josef Pfeuffer, Linda Knutsson, Danielle van Westen, Sebastian Palmqvist, Henk J. M. M. Mutsaerts, Oskar Hansson
Summary: This study investigated the role of decreased cerebral blood flow in Alzheimer's disease and found that tau tangles and neurodegeneration are more closely connected with GM-CBF changes than A beta pathology.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Clinical Neurology
Anika Wuestefeld, Alexa Pichet Binette, David van Berron, Nicola Spotorno, Danielle van Westen, Erik Stomrud, Niklas Mattsson-Carlgren, Olof Strandberg, Ruben Smith, Sebastian Palmqvist, Trevor Glenn, Svenja Moes, Michael Honer, Konstantinos Arfanakis, Lisa L. Barnes, David A. Bennett, Julie A. Schneider, Laura E. M. Wisse, Oskar Hansson
Summary: This study found that tau pathology, independent of amyloid-beta, may exist outside of the medial temporal lobe and affect cognition and brain structures. These findings have implications for understanding the spread of tau in Alzheimer's disease and suggest the potential use of tau-targeting treatments.
Article
Clinical Neurology
Eske Christiane Gertje, Shorena Janelidze, Danielle van Westen, Nicholas Cullen, Erik Stomrud, Sebastian Palmqvist, Oskar Hansson, Niklas Mattsson-Carlgren
Summary: There is an association between white matter lesions (WML) and CSF biomarkers of neuroinflammation in individuals without dementia. Especially, PlGF is associated with WML independent of Aβ status and cognitive impairment.
Article
Clinical Neurology
Claudia Cicognola, Niklas Mattsson-Carlgren, Danielle van Westen, Henrik Zetterberg, Kaj Blennow, Sebastian Palmqvist, Khazar Ahmadi, Olof Strandberg, Erik Stomrud, Shorena Janelidze, Oskar Hansson
Summary: CSF PDGFRβ is associated with age-related blood-brain barrier dysfunction and neuroinflammation, but not with Alzheimer-related pathologies.
Article
Multidisciplinary Sciences
Pelle Soderstroem, Anne Cutler
Summary: In this study, the researchers examined early electrophysiological responses to spoken English words in neutral sentence frames using a lexical decision paradigm. Similar-sounding lexical items competed for recognition within 200 milliseconds after word onset. Previous studies investigating event-related potentials during this time window in English and French showed varying results in terms of effects and scalp distribution. The findings from this study suggest that there may be a similar process occurring in English, where increased certainty of a 'word' response in a lexical decision task is reflected in the amplitude of an early left-anterior brain potential beginning around 150 milliseconds after word onset. This is proposed to be connected to the probabilistically driven activation of possible upcoming word forms.
Article
Multidisciplinary Sciences
Jan Brabec, Elisabet Englund, Johan Bengzon, Filip Szczepankiewicz, Danielle van Westen, Pia C. Sundgren, Markus Nilsson
Summary: A significant problem in diffusion MRI is the lack of understanding regarding which microstructural features account for the variability in the diffusion tensor imaging parameters observed in meningioma tumors. To investigate this, ex-vivo DTI was performed on meningioma tumor samples and the data was coregistered with histology sections. The raw, processed, and coregistered data are available for research and education purposes.
Article
Neurosciences
Etzel Cardena, Lena Lindstrom, Philippe Goldin, Danielle van Westen, Johan Martensson
Summary: The purpose of this study was to evaluate the neurophenomenology of automatic writing in a spontaneous automatic writer and four high hypnotizables. The results showed that compared to copying, automatic writing was associated with decreased sense of control and agency and decreased BOLD signal responses in brain regions implicated in the sense of agency. Additionally, there were increased BOLD signal responses in certain cortical regions during automatic writing.
BRAIN AND COGNITION
(2023)
Review
Neurosciences
Bjorn Lampinen, Filip Szczepankiewicz, Jimmy Latt, Linda Knutsson, Johan Martensson, Isabella M. Bjorkman-Burtscher, Danielle van Westen, Pia C. Sundgren, Freddy Stahlberg, Markus Nilsson
Summary: Diffusion MRI utilizes water molecules' random displacement to detect brain microstructure and cell properties, but faces challenges due to relatively featureless signal and variations in tissue microstructure. Multidimensional diffusion encoding techniques increase information content and reveal inaccuracies in assumptions and the differential capability of microscopic diffusion anisotropy in gray and white matter.
Article
Neuroimaging
David Jakabek, Brian D. Power, Nicola Spotorno, Matthew D. Macfarlane, Mark Walterfang, Dennis Velakoulis, Christer Nilsson, Maria Landqvist Waldo, Jimmy Latt, Markus Nilsson, Danielle van Westen, Olof Lindberg, Jeffrey C. L. Looi, Alexander F. Santillo
Summary: This study used multimodal neuroimaging to investigate changes in behavioural variant frontotemporal dementia (bvFTD). The results revealed bilateral anterior-dorsal thalamic atrophy, reduction in mean diffusivity of thalamic projections, and frontotemporal cortical thinning as the main features predicting bvFTD. Overall, the study highlights the importance of combined structural network dysfunction in bvFTD.
NEUROIMAGE-CLINICAL
(2023)
Article
Linguistics
Mikael Roll, Pelle Soderstrom, Anna Hjortdal, Merle Horne
Summary: We propose that the PrAN component of ERP reflects the brain's anticipation of upcoming speech and indexes the predictive strength of phonological cues. The effect can be divided into two time windows, with early activity mainly in auditory cortices and later activity in Broca's area. The PrAN reflects disinhibition of neurons sensitive to the expected acoustic signal and inhibition of irrelevant linguistic elements.
LABORATORY PHONOLOGY
(2023)
Article
Clinical Neurology
Nicola Spotorno, Chloe Najac, Erik Stomrud, Niklas Mattsson-Carlgren, Sebastian Palmqvist, Danielle van Westen, Itamar Ronen, Oskar Hansson
Summary: This study provides further evidence of the important role of astrocytes in the pathophysiology of Alzheimer's disease and investigates the relationship between APOE genotype, myo-inositol concentration, and Alzheimer's disease pathology. The results show an interaction between myo-inositol concentration and amyloid-beta deposition in APOE ε4 carriers.
BRAIN COMMUNICATIONS
(2022)
Meeting Abstract
Neurosciences
Filip Ventorp, Jesper Lindahl, Danielle van Westen, Jimmy Jensen, Johannes Bjorkstrand, Daniel Lindqvist
BIOLOGICAL PSYCHIATRY
(2022)