Article
Chemistry, Medicinal
Seonhwa Kim, Na-Yeon Kim, Jae-Young Park, Hyo-Min Park, Chae-Min Lim, Jinju Kim, Hee Pom Lee, Jin Tae Hong, Do-Young Yoon
Summary: MMPP is a novel synthetic analog that exerts anti-inflammatory and anticancer effects by downregulating the STAT3 pathway and enhancing glucose uptake and insulin sensitivity. It can inhibit the expression of inflammatory cytokines and COX-2 in LPS-stimulated monocytes. MMPP directly binds to CD14 and MD2, inhibits the activation of NF-kappa B and JNK/AP-1 pathways, and shows anti-inflammatory activity.
Article
Endocrinology & Metabolism
Mengbo Zhu, Wenbin Xu, Jiuzhou Jiang, Yining Wang, Yanjing Guo, Ruijia Yang, Yaqiong Chang, Bin Zhao, Zhenyu Wang, Jianfeng Zhang, Te Wang, Liqin Shangguan, Shaowei Wang
Summary: The study found that peiminine can inhibit the differentiation and function of OCs by regulating the levels of specific genes and proteins, with potential targets including NF-kappa B and ERK1/2 signaling pathways. In an animal model, peiminine can alleviate bone loss in ovariectomized mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Junsheng Liu, Jun Liu, Liu Liu, Guangwen Zhang, Xichun Peng
Summary: Researchers found that dexamethasone-induced osteoporosis and APS-ameliorated osteoporosis altered the gene expression profile of the intestine, resulting in intestinal dysfunction. APS was able to restore intestinal functions by affecting 53 differentially expressed genes, contributing to the improvement of osteoporosis. This study supports the concept of a gut-bone axis and suggests new therapeutic opportunities for osteoporosis treatment through this axis.
Article
Nutrition & Dietetics
Junquan Tian, Xuetai Bao, Fan Yang, Xiongzhuo Tang, Qian Jiang, Yuying Li, Kang Yao, Yulong Yin
Summary: Age-related osteoporosis is a common disease in the elderly, mainly caused by excessive activity of osteoclasts. Most approved drugs inhibit osteoclasts to treat osteoporosis. This study shows that supplementing dimethyl alpha-ketoglutarate (DM-AKG) can inhibit the differentiation of osteoclasts. The mechanism involves regulating NF-kappa B signaling pathway and oxidative phosphorylation through PHD1-dependent manner.
Article
Chemistry, Medicinal
Xuedong Li, Xixi Lin, Zuoxing Wu, Yuangang Su, Jiamin Liang, Runfeng Chen, Xue Yang, Lei Hou, Jinmin Zhao, Qian Liu, Feng Xu
Summary: The study demonstrates that PRI has therapeutic potential in treating osteolytic diseases like osteoporosis by inhibiting osteoclast formation and bone resorption activity both in vitro and in vivo. PRI exerts its effects through the suppression of NF-κB and ERK MAPK signaling pathways, preventing the production of mature osteoclasts.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Medicine, Research & Experimental
Xiaoyu Zhang, Yuan Kang, Ximeng Li, Yunfeng Huang, Ruijuan Qi, Yixin Han, Runlan Cai, Yuan Gao, Yun Qi
Summary: Potentilla discolor Bunge (PD) is a traditional Chinese medicine with strong anti-inflammatory effects by suppressing the expressions of iNOS, TNF-α, and MCP-1, as well as inhibiting the activation of NF-kappa B and AP-1. The ethanol extract of the whole herbs of PD (EPD) shows promising therapeutic potential for inflammatory diseases, especially intestinal inflammation, through its ability to modulate inflammatory mediators and signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Tong Yu, Yanyan Liu, Junwen Xue, Xiang Sun, Di Zhu, Lu Ma, Yingying Guo, Tongzhu Jin, Huiying Cao, Yingzhun Chen, Tong Zhu, Xuelian Li, Haihai Liang, Zhimin Du, Hongli Shan
Summary: This study found that Gankyrin is upregulated in non-small cell lung cancer (NSCLC) and plays a role in promoting cancer progression through the regulation of YAP1 and glycolysis. The inhibition of Gankyrin could potentially be a therapeutic strategy for NSCLC.
CELL DEATH DISCOVERY
(2022)
Article
Chemistry, Medicinal
Jun-ming Huang, Chen-zhong Wang, Shun-yi Lu, Zhe Wang, Zuo-qin Yan
Summary: The study demonstrated that Oroxin B may act as an anti-osteoporosis agent by inhibiting osteoclast maturation and attenuating bone resorption.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Pharmacology & Pharmacy
Xiaodi Zhang, Zhengfang Sun, Ying Zhang, Liuzhu Pan, Wei Jiang, Hui Dong, Zhengxin Jin, Jianning Kang, Ronghan Liu, Bin Ning
Summary: This study demonstrates that Periplocin can reduce inflammation and attenuate bone resorption in osteoporosis by inhibiting MAPK and NF-kappa B signaling pathways. It also exerts anti-inflammatory and anti-osteoclastic effects by binding to LRP4. These findings provide new possibilities for the treatment of osteoporosis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xue Yang, Jiamin Liang, Ziyi Wang, Yuangang Su, Yunfei Zhan, Zuoxing Wu, Jing Li, Xuedong Li, Runfeng Chen, Jinmin Zhao, Jiake Xu, Qian Liu, Bo Zhou
Summary: This study found that sesamolin has the potential to treat osteoporosis by effectively inhibiting the formation of osteoclasts in vitro, attenuating bone loss through modulating multiple signaling pathways and gene expression, and demonstrating a preventive effect against bone loss induced by estrogen deficiency in vivo.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Chunchun Xue, Huan Luo, Libo Wang, Qing Deng, Wenyun Kui, Weiwei Da, Lin Chen, Shuang Liu, Yongpeng Xue, Jiafan Yang, Lingxing Li, Wenlan Du, Qi Shi, Xiaofeng Li
Summary: Aconine (AC) is a potential natural compound for treating osteoporosis by reversing osteoclast ferroptosis and formation mediated by NF-kappa B signaling.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Yue Wu, Yunjiao Yang, Lan Wang, Yiding Chen, Xuke Han, Lisha Sun, Huizhen Chen, Qiu Chen
Summary: Osteoporosis is a bone disease characterized by low bone quality and density, causing bone fragility and vulnerability to fractures. Increased osteoclast differentiation and activity contribute to bone loss, a common manifestation of osteoporosis. The TNF-a/NF-κB inflammatory pathway plays a key role in regulating osteoclast formation, along with the classical RANKL/RANK/OPG pathway. Probiotics, particularly Bifidobacterium, have shown potential beneficial effects on bone health by modulating this pathway. This review discusses the molecular mechanisms of the TNF-a/NF-κB pathway in osteoclast formation and explores the secretions produced by Bifidobacterium, providing new directions for future research.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Rong Hu, Libo Chen, Xiaolong Chen, Zhong Xie, Chao Xia, Yong Chen
Summary: Aloperine has been shown to inhibit osteoclast activity and formation mediated by RANKL, indicating its potential as a new drug for the prevention and treatment of postmenopausal osteoporosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mina Ding, Eunjin Cho, Zhihao Chen, Sang-Wook Park, Tae-Hoon Lee
Summary: In this study, the effects of EPZ compounds, PRMT5 inhibitors, on RANKL-induced osteoclast differentiation were investigated. EPZ015866 attenuated osteoclast differentiation more effectively than EPZ015666. The compounds inhibited the nuclear translocation of NF-kappa B, preventing osteoclast differentiation and bone resorption. EPZ015866 may be a potential drug candidate for the treatment of osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Jin Ha Park, Jiae Lee, Gong-Rak Lee, Minjeong Kwon, Hye In Lee, Narae Kim, Hee Jin Kim, Mi-Ock Lee, Woojin Jeong
Summary: Cholesterol sulfate (CS) activates retinoic acid-related orphan receptor a (ROR alpha). CS and ROR alpha inhibit osteoclast differentiation. The mechanism involves the AMPK-Sirt1 axis, leading to NF-kappa B inhibition. CS also induces apoptosis and protects against bone loss in mouse models.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chao Song, Peng Tan, Zheng Zhang, Wei Wu, Yonghui Dong, Liming Zhao, Huiyong Liu, Hanfeng Guan, Feng Li
Article
Materials Science, Biomaterials
Hao Zhu, Xiongfa Ji, Hanfeng Guan, Liming Zhao, Libo Zhao, Changyu Liu, Cong Cai, Weijing Li, Tenghui Tao, Janne Min Reseland, Havard Jostein Haugen, Jun Xiao
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2019)
Article
Materials Science, Ceramics
Fen Chen, Hao Zhu, Jia-Min Wu, Shuang Chen, Li-Jin Cheng, Yu-Sheng Shi, Yuan-Chang Mo, Chen-Hui Li, Jun Xiao
CERAMICS INTERNATIONAL
(2020)
Article
Cell Biology
Hao Zhu, Veronika Hefka Blahnova, Giuseppe Perale, Jun Xiao, Felice Betge, Fabio Boniolo, Eva Filova, Stale Petter Lyngstadaas, Havard Jostein Haugen
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Engineering, Multidisciplinary
Hao Zhu, Havard Jostein Haugen, Giuseppe Perale, Janne Elin Reseland, Liebert Parreiras Nogueira, Antonio Gonzalez Cantalapiedra, Fernando Maria Guzon Munoz, Maria Permuy Mendana, Felice Betge, Stale Petter Lyngstadaas, Jun Xiao
Summary: The study demonstrates that gelatins from different sources can be successfully used in designing xeno-hybrid bone grafts, showing positive effects on bone regeneration and providing solutions for optimizing bone resorption and regeneration balance.
Correction
Materials Science, Biomaterials
Hao Zhu, Xiongfa Ji, Hanfeng Guan, Liming Zhao, Libo Zhao, Changyu Liu, Cong Cai, Weijing Li, Tenghui Tao, Janne Elin Reseland, Havard Jostein Haugen, Jun Xiao
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Engineering, Manufacturing
Fen Chen, Ya-Ru Wu, Jia-Min Wu, Hao Zhu, Shuang Chen, Shuai-Bin Hua, Zi-Xuan He, Chang-Yu Liu, Jun Xiao, Yu-Sheng Shi
Summary: This study prepared ZrO2-Al2O3 bioceramics using SL technology, showing excellent mechanical properties and biocompatibility suitable for all-ceramic restorations, with great application prospects in dental field.
ADDITIVE MANUFACTURING
(2021)
Article
Engineering, Manufacturing
Shuai-Bin Hua, Jin Su, Ze-Lin Deng, Jia-Min Wu, Li-Jin Cheng, Xi Yuan, Fen Chen, Hao Zhu, Da-Hu Qi, Jun Xiao, Yu-Sheng Shi
Summary: The research focuses on manufacturing porous bioceramic scaffolds with favorable mechanical properties and good bioactivity using a combination of 45S5 bioglass and BCP. By optimizing the solid loading and exposure energy, scaffolds with desired pore sizes and compressive strength can be successfully fabricated. The bioglass plays a crucial role in enhancing compressive strength and promoting the growth of ceramic grains in the scaffolds.
ADDITIVE MANUFACTURING
(2021)
Article
Materials Science, Biomaterials
Jin Su, Shuaibin Hua, Annan Chen, Peng Chen, Lei Yang, Xi Yuan, Dahu Qi, Hao Zhu, Chunze Yan, Jun Xiao, Yusheng Shi
Summary: In this study, gyroid-structured ternary composite scaffolds were developed using digital light processing 3D printing technology. The active crystalline phases in the scaffolds accelerated the formation of carbonated hydroxyapatite, similar to natural bone tissue, and provided a large surface area for cell adhesion and proliferation. Additionally, increasing the content of a certain component improved the degradability of the scaffolds.
BIOMATERIALS ADVANCES
(2022)
Article
Materials Science, Multidisciplinary
Hao Zhu, Meng Li, Xiaolong Huang, Dahu Qi, Liebert Parreiras Nogueira, Xi Yuan, Wenbin Liu, Zehua Lei, Jiawei Jiang, Honglian Dai, Jun Xiao
Summary: Ceramic scaffolds have been used in bone defect treatment for a long time. In this study, a TCP/BG scaffold with gyroid structure was successfully manufactured, showing potential to effectively induce bone ingrowth and integration while maintaining the natural trabecular structure.
APPLIED MATERIALS TODAY
(2021)
Article
Materials Science, Biomaterials
Dahu Qi, Jin Su, Song Li, Hao Zhu, Lijin Cheng, Shuaibin Hua, Xi Yuan, Jiawei Jiang, Zixing Shu, Yusheng Shi, Jun Xiao
Summary: Magnesium-doped beta-TCP scaffolds show excellent biological performance and bone defect repair capability, making them a promising option for clinical translation.
BIOMATERIALS ADVANCES
(2022)
Article
Nanoscience & Nanotechnology
Hao Zhu, Manuel Gomez, Jun Xiao, Giuseppe Perale, Felice Betge, Stale Petter Lyngstadaas, Havard Jostein Haugen
ACS APPLIED BIO MATERIALS
(2020)
Article
Medicine, Research & Experimental
Xiongfa Ji, Zehua Lei, Meng Yuan, Hao Zhu, Xi Yuan, Wenbin Liu, Hongxu Pu, Jiawei Jiang, Yu Zhang, Xulin Jiang, Jun Xiao
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.