Article
Endocrinology & Metabolism
Carrie Ye, Suzanne N. Morin, Lisa M. Lix, Eugene V. McCloskey, Helena Johansson, Nicholas C. Harvey, John A. Kanis, William D. Leslie
Summary: The study assessed the performance of the Fracture Risk Assessment Tool (FRAX) in predicting incident fractures in men with prostate cancer. The results showed that FRAX reliably predicts fractures in this population.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, Eugene McCloskey, Helena Johansson, Nicholas C. Harvey, John A. Kanis, William D. Leslie
Summary: This study found that medical comorbidity is associated with fracture risk and can increase the risk of fractures independently of FRAX. By using complex and simple measures of medical comorbidity, FRAX-based risk estimates can be modified to capture the increased fracture risk associated with multiple comorbid conditions in older patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Nicholas C. Harvey, John A. Kanis, Enwu Liu, Cyrus Cooper, Mattias Lorentzon, Jennifer W. Bea, Laura Carbone, Elizabeth M. Cespedes Feliciano, Deepika R. Laddu, Peter F. Schnatz, Aladdin H. Shadyab, Marcia L. Stefanick, Jean Wactawski-Wende, Carolyn J. Crandall, Helena Johansson, Eugene McCloskey
Summary: In the WHI study, associations between baseline appendicular lean mass (ALM) and incident fractures, falls, and mortality in older postmenopausal women were investigated. Higher ALM/height(2) was associated with lower risk of MOF but higher risk of death. These associations were independent of prior falls but attenuated by other factors such as FRAX probability and FN BMD T-score.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Nicholas C. Harvey, Eric Orwoll, Timothy Kwok, Magnus K. Karlsson, Bjorn E. Rosengren, Eva Ribom, Jane A. Cauley, Peggy M. Cawthon, Kristine Ensrud, Enwu Liu, Alfonso J. Cruz-Jentoft, Roger A. Fielding, Cyrus Cooper, John A. Kanis, Mattias Lorentzon, Claes Ohlsson, Dan Mellstrom, Helena Johansson, Eugene McCloskey
Summary: Adjustment for femoral neck bone mineral density (fnBMD) reduces the predictive value for fracture of sarcopenia definitions based on appendicular lean mass (ALM), but inclusion of physical performance measures strengthens it. Severe sarcopenia definitions incorporating chair stand time, gait speed, and grip strength demonstrate the highest predictability for fracture, even at low prevalence levels.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Oncology
Rayne de Almeida Marques Bernabe, Mariana de Souza Vieira, Vanusa Felicio de Souza, Luana Gomes Fontana, Ben-Hur Albergaria, Jose Luiz Marques-Rocha, Valdete Regina Guandalini
Summary: This study investigated the association between sarcopenia phenotypes and fracture risk in women with breast cancer, and found that low muscle strength was associated with fracture risk.
Article
Endocrinology & Metabolism
Melanie Kistler-Fischbacher, Jedidah S. Yong, Benjamin K. Weeks, Belinda R. Beck
Summary: The MEDEX-OP trial compared high-intensity resistance training (HiRIT) with low-intensity exercise control (BB) in postmenopausal women with low bone mass, finding that HiRIT significantly improved LS BMD and functional performance. Exercise compliance was good and both programs were well tolerated.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Raju Jaiswal, Michail Zoulakis, Kristian F. Axelsson, Anna Darelid, Robert Rudang, Daniel Sundh, Henrik Litsne, Lisa Johansson, Mattias Lorentzon
Summary: This prospective cohort study aimed to evaluate the association between the bone material strength index (BMSi) and the risk of incident fracture in older women. The study found that increasing BMSi was associated with a greater risk of fracture.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Namki Hong, Heajeong Park, Chang Oh Kim, Hyeon Chang Kim, Jin-Young Choi, Hwiyoung Kim, Yumie Rhee
Summary: Dual-energy X-ray absorptiometry (DXA)-based bone radiomics scores from hip images may improve hip fracture prediction in older women. The study showed that an increase in bone radiomics score was associated with an elevated risk of incident hip fracture.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
N. Sagalla, C. Colon-Emeric, R. Sloane, K. Lyles, J. Vognsen, R. Lee
Summary: FRAX without BMD showed good concordance, sensitivity, and specificity in predicting treatment recommendations after low trauma non-hip/non-vertebral fractures, offering a useful tool for risk stratification and treatment decision-making in such patients.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Charles Ginsberg, Andrew N. Hoofnagle, Ronit Katz, Jan Hughes-Austin, Lindsay M. Miller, Jessica O. Becker, Stephen B. Kritchevsky, Michael G. Shlipak, Mark J. Sarnak, Joachim H. Ix
Summary: Among a diverse cohort of community-dwelling older adults, a lower VMR was more strongly associated with both loss of bone mineral density (BMD) and fracture risk compared with 25(OH)D-3. Further trials are needed to evaluate the VMR as a therapeutic target in individuals at risk for worsening BMD and fracture.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Jonas Banefelt, Jen Timoshanko, Emma Soreskog, Gustaf Ortsater, Alireza Moayyeri, Kristina E. Akesson, Anna Spangeus, Cesar Libanati
Summary: The study confirmed a strong association between BMD T-score and fracture risk, with consistent marginal changes observed in bisphosphonate-treated patients. The results extend evidence from clinical trials, demonstrating the suitability of total hip BMD as a meaningful outcome for the clinical management of patients with osteoporosis.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
I-Ting Liu, Fu-Wen Liang, Chia-Chun Li, Yin-Fan Chang, Zih-Jie Sun, Tsung-Hsueh Lu, Chin-Sung Chang, Chih-Hsing Wu
Summary: The Taiwan FRAX(R) calculator has been validated for predicting incident fractures and cutoff values have been proposed for fracture risk prediction in Taiwanese individuals.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Endocrinology & Metabolism
Elina Gunsing, Philippe P. P. Wagner, Danielle E. E. Whittier, Steven K. K. Boyd, Roland Chapurlat, Pawel Szulc
Summary: Rapid cortical bone loss at the distal radius is associated with a higher risk of fracture in older men. However, repeated HR-pQCT measurements did not improve the assessment of fracture risk.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Charles Ginsberg, Terri Blackwell, Jonathan H. Cheng, O. Alison Potok, Jane A. Cauley, Kristine E. Ensrud, Simon Hsu, Deborah M. Kado, Eric Orwoll, Peggy M. Cawthon, Joachim H. Ix
Summary: This study evaluated the impact of the ratio of 24,25-dihydroxyvitamin D3 to 25(OH)D3 (VMR) and 25(OH)D3 on vBMD and bone strength in the distal radius and tibia of older men. The results showed that higher VMR was associated with higher vBMD and bone strength, while 25(OH)D3 had no impact on these outcomes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Lan Yang, Mary Dempsey, Attracta Brennan, Bryan Whelan, E. Erjiang, Tingyan Wang, Rebecca Egan, Kelly Gorham, Fiona Heaney, Catherine Armstrong, Guadalupe Morote Ibarrola, Amina Gsel, Ming J. Yu, John Carey
Summary: The appropriate use of FRAX can reduce the need for DXA scans and identify individuals at the highest risk. Comparing FRAX results with and without inclusion of BMD suggests that clinicians should carefully consider the importance of including BMD in fracture risk estimation for individual patients.
ARCHIVES OF OSTEOPOROSIS
(2023)
Article
Cell Biology
Janja Zupan, Klemen Strazar, Roland Kocijan, Thomas Nau, Johannes Grillari, Darja Marolt Presen
Summary: This article reviews the age-related alterations of MSCs in musculoskeletal tissues and explores the mechanisms of aging and senescence of MSCs. Additionally, the focus is on the properties of MSCs in osteoarthritis and osteoporosis, and how their changes contribute to the onset and progression of these disorders.
MECHANISMS OF AGEING AND DEVELOPMENT
(2021)
Article
Biochemistry & Molecular Biology
Kseniya Khamina, Andreas B. Diendorfer, Susanna Skalicky, Moritz Weigl, Marianne Pultar, Teresa L. Krammer, Catharine Aquino Fournier, Amy L. Schofield, Carolin Otto, Aaron Thomas Smith, Nina Buchtele, Christian Schoergenhofer, Bernd Jilma, Bernhard J. H. Frank, Jochen G. Hofstaetter, Regina Grillari, Johannes Grillari, Klemens Ruprecht, Christopher E. Goldring, Hubert Rehrauer, Warren E. Glaab, Matthias Hackl
Summary: The plasma levels of tissue-specific microRNAs can serve as diagnostic, disease severity and prognostic biomarkers. Combining diverse microRNAs into biomarker signatures using multivariate statistics is powerful in terms of tissue and condition specific microRNA shedding into the plasma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Christian Deininger, Andrea Wagner, Patrick Heimel, Elias Salzer, Xavier Monforte Vila, Nadja Weissenbacher, Johannes Grillari, Heinz Redl, Florian Wichlas, Thomas Freude, Herbert Tempfer, Andreas Herbert Teuschl-Woller, Andreas Traweger
Summary: In this study, silk scaffolds with axially aligned pores were generated and treated with simulated body fluid to create a calcium phosphate coating. In vivo experiments demonstrated that silk scaffolds loaded with a low dose of rhBMP-2 and coated with calcium phosphate significantly improved bone regeneration, providing effective bone repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
C. Muschitz, M. Hummer, J. Grillari, A. Hlava, A. H. Birner, M. Hemetsberger, H. P. Dimai
Summary: Fragility fractures are frequent and costly in Austria, and with the aging population, the number of these fractures and their associated costs are expected to increase even further.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Philipp Heher, Massimo Ganassi, Adelheid Weidinger, Elise N. Engquist, Johanna Pruller, Thuy Hang Nguyen, Alexandra Tassin, Anne-Emilie Decleves, Kamel Mamchaoui, Christopher R. S. Banerji, Johannes Grillari, Andrey V. Kozlov, Peter S. Zammit
Summary: FSHD is characterized by oxidative stress induced by DUX4, leading to metabolic dysfunction and impaired mitochondrial function. Increased mitochondrial ROS levels in FSHD muscle cells are associated with elevated steady-state mitochondrial membrane potential. DUX4 triggers mitochondrial membrane polarization, resulting in mitochondrial ROS generation and apoptosis.
Article
Medicine, General & Internal
Ali Zadehmohammad, Johannes Grillari, Vlado Stevanovic, Georg Brandl, Lukas Ernstbrunner, Thomas Hoffelner
Summary: This study assessed the long-term progression of osteoarthritis in athletes after isolated ACL reconstruction. The results showed that the progression of OA was significantly higher in the injured knee compared to the healthy contralateral knee.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Robert Soukup, Iris Gerner, Sinan Gueltekin, Hayeon Baik, Johannes Oesterreicher, Johannes Grillari, Florien Jenner
Summary: Extracellular vesicles (EVs) play an essential role in cellular crosstalk, and equine MSC-derived EVs have comparable therapeutic potential to their donor cells. The International Society for Extracellular Vesicles (ISEV) has proposed standards to define EVs and their functions, but their application in veterinary field is restricted by nonstandardised isolation methods and limited availability of cross-reacting markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
David Carro Vazquez, Lejla Emini, Martina Rauner, Christine Hofbauer, Johannes Grillari, Andreas B. Diendorfer, Richard Eastell, Lorenz C. Hofbauer, Matthias Hackl
Summary: This study investigates the regulation of miRNAs in bone disease associated with type 2 diabetes mellitus (T2DM). The results demonstrate unique dysregulation of miRNAs in serum and bone tissue of a rat model of T2DM. Insulin treatment strongly influences circulating miRNAs involved in metabolism, while anti-sclerostin treatment affects bone-enriched miRNAs. PTH treatment has no effect on circulating or bone miRNAs in the rat model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Johannes C. Heinzel, Viola Oberhauser, Claudia Keibl, Barbara Schaedl, Nicole Swiadek, Gregor Langle, Helen Frick, Cyrill Slezak, Cosima Prahm, Johannes Grillari, Jonas Kolbenschlag, David Hercher
Summary: This study evaluated the effects of ESWT on rat median nerve repair using either autografts or muscle-in-vein conduits. Although no direct positive effects of ESWT on peripheral nerve regeneration were found, the results after nerve repair with MVCs were significantly inferior to those after autograft repair.
Article
Biology
Magdalena Bauer, Magdalena Metzger, Marvin Corea, Barbara Schaedl, Johannes Grillari, Peter Dungel
Summary: In skin research, traditional 2D cell models are not sufficient in mimicking physiological properties, so there is a need for new 3D skin models. This study designed cell culture inserts fabricated with 3D printers for generating full-thickness skin models. The improved design of the inserts allows for easier and more efficient handling.
Article
Biology
Magdalena Metzger, Ara Hacobian, Lisa Karner, Leonie Krausgruber, Johannes Grillari, Peter Dungel
Summary: The increase in antibiotic resistance poses a significant global challenge, and blue light therapy may offer an alternative treatment option. Research shows that blue light with a wavelength of 475 nm is only effective against certain bacterial strains lacking the RecA DNA repair mechanism. Inserting the recA gene reduces the sensitivity of responsive bacterial strains, but inhibiting RecA activity does not increase bactericidal action. Combining a multitarget therapy like blue light with a RecA targeting treatment could be a promising strategy to overcome antibiotic resistance in the future.
Article
Biochemistry & Molecular Biology
Oleh Lushchak, Markus Schosserer, Johannes Grillari
Summary: Cellular senescence refers to a stable cell cycle arrest state with specific characteristics. Senescent cells accumulate in the body during normal aging, limiting lifespan and promoting aging-related as well as unrelated diseases. Diseases associated with cellular senescence are referred to as senopathies, and targeting senescent cells through senolytics or senomorphics may help mitigate these diseases. Animal studies provide mechanistic evidence for the connection between senescent cell accumulation and disease progression in various senopathies, including cardiovascular, metabolic, musculoskeletal, liver, kidney, lung diseases, and neurodegeneration. The development of novel senotherapies is hindered by the heterogeneity of senescence phenotypes, resulting in a lack of universal biomarkers and difficulties in distinguishing senescent from non-senescent cells.
Article
Multidisciplinary Sciences
Diana Swolin-Eide, Gun Forsander, Auste Pundziute Lycka, Daniel Novak, Johannes Grillari, Andreas B. Diendorfer, Matthias Hackl, Per Magnusson
Summary: This case-control study aimed to investigate potential differences in circulating miRNAs between young individuals with long-duration type 1 diabetes (T1D) and healthy controls, as well as the expression of these identified miRNAs across different tissues. The results showed that 27 miRNAs were upregulated and one was downregulated in T1D. Six of these miRNAs were tissue-enriched. These findings have important implications for studying biomarkers for diabetes-related complications.
SCIENTIFIC REPORTS
(2023)
Review
Materials Science, Multidisciplinary
Elisaveta Snezhkova, Heinz Redl, Johannes Grillari, Marcin Osuchowski
Summary: This article introduces the application of activated carbon or charcoal in alleviating inflammation and explains its mechanisms of protecting the microbiome and bone marrow, as well as its anti-inflammatory and anti-oxidant effects. Early application of activated carbon and its high adsorption capacity are essential in the treatment of preventing sepsis and multi-organ failure.
C-JOURNAL OF CARBON RESEARCH
(2023)
Meeting Abstract
Endocrinology & Metabolism
C. Muschitz, M. Hummer, J. Grillari, A. Hlava, A. Birner, M. Hemetsberger, H. P. Dimai
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.