Article
Medicine, General & Internal
Wen-Bin Xu, Juan-Juan Fu, Xiao-Ju Yuan, Qing-Jie Xian, Li-Jun Zhang, Ping-Ping Song, Zhi-Qing You, Cheng-Tan Wang, Qi-Gang Zhao, Feng Pang
Summary: This study successfully diagnosed a case of neurocysticercosis using mNGS, demonstrating the high reliability and sensitivity of this method in the diagnosis of neurocysticercosis.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Clinical Neurology
Bin Chen, Zheng Chen, Yi-shu Yang, Gui-lan Cai, Xiao-jiao Xu, Hong-zhi Guan, Hai-tao Ren, Hou-zhen Tuo
Summary: This study presented a case of NCC patient with over 20 years of symptomatic history who was successfully diagnosed using NGS analysis and immunological tests, resulting in substantial improvement after anti-helminthic treatment. The combination of CSF NGS and cysticercus IgG testing shows promise for diagnosing challenging cases of NCC, with further research needed to evaluate its potential for disease severity, stage, and therapeutic response monitoring.
Review
Microbiology
Oscar H. Del Brutto
Summary: Human cysticercosis is the most common helminthic infection of the CNS caused by Taenia solium. Neurocysticercosis (NCC) is the infection of the CNS and meninges by the larval stage of Taenia solium. It can cause various manifestations such as seizures, headache, focal deficits, intracranial hypertension, or cognitive decline. Accurate diagnosis can be made by interpreting clinical data, neuroimaging studies, and immunological tests. Cysticidal drugs have improved the prognosis of NCC patients. Controlling all stages of the T. solium life cycle is essential for eradicating the disease.
Article
Immunology
Javier A. Bustos, Gianfranco Arroyo, Robert H. Gilman, Percy Soto-Becerra, Isidro Gonzales, Herbert Saavedra, E. Javier Pretell, Theodore E. Nash, Seth E. O'Neal, Oscar H. Del Brutto, Armando E. Gonzalez, Hector H. Garcia
Summary: This study found that approximately 38% of parenchymal cysts in patients with neurocysticercosis calcify after antiparasitic treatment, with factors such as cyst size, baseline edema, and duration of seizures associated with calcification. Some factors associated with calcification are modifiable and may help reduce the risk of seizure relapses.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Clinical Neurology
Ryan Ta, Benjamin N. Blond
Summary: Neurocysticercosis is a common cause of acquired epilepsy worldwide and is often associated with pigs as an intermediate host. This review explores its epidemiology and common risk factors in endemic regions across Africa, Asia, and Latin America. Inadequate regulation of pig farms, poor sanitation, water contamination, and limited resources contribute to the prevalence of the disease. Effective limitation of neurocysticercosis can be achieved by addressing these common risk factors.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Han-Yu Zhang, Guo-Xing Wang, Yue-Yan Xing, Miao-Rong Xie
Summary: A 20-year-old female resident of Beijing accidentally ingested pork tapeworm eggs instead of the intended eggs for weight loss, resulting in a severe parasitic infection. After treatment, she fully recovered and remains in good health.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Public, Environmental & Occupational Health
Alfredo Maldonado-Barrueco, Cristina Utrilla, Ana Hernandez-Gonzalez, Maria J. Perteguer, Beatriz Diaz-Pollan, Yeray Untoria-Tabares, Marta Diaz-Menendez, Iker Falces-Romero, Almudena Gutierrez-Arroyo, Julio Garcia-Rodriguez, Dolores Montero-Vega
Summary: We present a confirmed case of intraventricular neurocysticercosis in a migrant from Choluteca, Honduras, in Madrid, Spain, based on epidemiological, radiological, and microbiological criteria.
JOURNAL OF TRAVEL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Daniel A. Andrade-Mogrovejo, Eloy Gonzales-Gustavson, Ana C. Ho-Palma, Joaquin M. Prada, Gabrielle Bonnet, Francesco Pizzitutti, Luis A. Gomez-Puerta, Gianfranco Arroyo, Seth E. O'Neal, Hector H. Garcia, Javier Guitian, Armando Gonzalez
Summary: This study systematically reviewed and analyzed pig infection experiments to evaluate the accuracy of dose-response models for Taenia solium cyst development. The exact beta-Poisson model was found to be the best fit for the data, providing important parameters for future experimental infections and transmission simulation models.
Article
Parasitology
Miguel A. Orrego, Manuela R. Verastegui, Carlos M. Vasquez, Hector H. Garcia, Theodore E. Nash
Summary: The study reveals that the proliferative growth of the bladder wall in racemose neurocysticercosis is associated with the insulin receptor-mediated MAPK signaling pathway. It is found that metformin inhibits this pathway, reducing cell proliferation and parasite growth. This discovery offers a new therapeutic approach for racemose neurocysticercosis.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2022)
Article
Microbiology
L. Toribio, C. Guzman, S. Noazin, A. Zimic-Sheen, M. Zimic, I. Gonzales, H. Saavedra, E. J. Pretell, J. A. Bustos, S. Handali, H. H. Garcia
Summary: Neurocysticercosis is a common helminthic infection of the human central nervous system. We report a new immunoprint assay (MAPIA) that simplifies the detection process, reduces cost, and shows comparable accuracy and specificity to traditional methods.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Clinical Neurology
P. H. Espino, R. G. Couper, J. G. Burneo
Summary: Neurocysticercosis (NCC) is a global public health problem and a preventable cause of epilepsy in developing countries. Epileptic seizures are the most common manifestation of NCC and can occur at any stage of the disease. The exact mechanisms underlying NCC-related epilepsy are still poorly understood, with potential explanations including direct causality, initial injury, external factors, and coincidence.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Article
Infectious Diseases
Jason Labuschagne, John Frean, Kaajal Parbhoo, Denis Mutyaba, Tanyia Pillay, Shareen Boughan, Hlezikuhle Nkala
Summary: This case report presents the first documented case of disseminated subarachnoid coenurosis caused by T. serialis, a tapeworm species not typically associated with central nervous system infection. The patient initially presented with acute hydrocephalus and underwent emergency surgery. Despite prolonged treatment, the patient's condition continued to deteriorate and ultimately led to death. The case highlights the importance of accurate identification and understanding of coenurosis for proper diagnosis and management.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Microbiology
Yesenia Castillo, Luz M. M. Toribio, Carolina Guzman, Gianfranco Arroyo, Cindy Espinoza, Herbert Saavedra, Javier A. A. Bustos, Pierre Dorny, Seth E. E. O'Neal, Hector H. H. Garcia
Summary: This study compared the performance of two antigen enzyme-linked immunosorbent assay (ELISA) techniques for the detection of neurocysticercosis (NCC). The results showed that both ELISA techniques were able to detect antigen levels across different types of NCC and demonstrated high concordance. The B158/B60 antigen ELISA performed better in parenchymal and calcified NCC, while the TsW8/TsW5 antigen ELISA showed better detection in subarachnoid NCC.
Article
Neurosciences
Laura E. Baquedano, Edson G. Bernal, Daniel J. Carrion, Ana D. Delgado, Cesar M. Gavidia, Daniela E. Kirwan, Robert H. Gilman, Manuela R. Verastegui
Summary: This study evaluated the impact of neurocysticercosis on spatial working memory and its correlation with hippocampal neuronal density in a rat model. The results showed a significant decline in spatial working memory over a 1-year period in NCC-infected rats, along with a decrease in hippocampal neuronal density. This rat model provides valuable support for the relationship between neurocysticercosis and cognitive impairment.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Clinical Neurology
Chenlong Yang, Tie Liu, Jian Wu, Jingcheng Xie, Tao Yu, Wenqing Jia, Jun Yang, Yulun Xu
Summary: This retrospective study analyzed the clinical manifestations, radiological features, treatment, and outcomes of seven patients with spinal cysticercosis. Spinal cysticercosis is an extremely rare cause of myelopathy, and characteristic MRI features can aid in preoperative diagnosis.