4.7 Article

A high-resolution genetic linkage map and QTL fine mapping for growth-related traits and sex in the Yangtze River common carp (Cyprinus carpio haematopterus)

期刊

BMC GENOMICS
卷 19, 期 -, 页码 -

出版社

BIOMED CENTRAL LTD
DOI: 10.1186/s12864-018-4613-1

关键词

Genetic map; QTL mapping; Growth-related traits; Sex; Candidate gene; Cyprinus carpio Haematopterus

资金

  1. Chinese Academy of Sciences [XDA0810405]
  2. FEBL Program [2016FBZ05]
  3. MOST 973 Project of China [2010CB126305]

向作者/读者索取更多资源

Background: A high-density genetic linkage map is essential for QTL fine mapping, comparative genome analysis, identification of candidate genes and marker-assisted selection for economic traits in aquaculture species. The Yangtze River common carp (Cyprinus carpio haematopterus) is one of the most important aquacultured strains in China. However, quite limited genetics and genomics resources have been developed for genetic improvement of economic traits in such strain. Results: A high-resolution genetic linkage map was constructed by using 7820 2b-RAD (2b-restriction site-associated DNA) and 295 microsatellite markers in a F2 family of the Yangtze River common carp (C. c. haematopterus). The length of the map was 4586.56 cM with an average marker interval of 0.57 cM. Comparative genome mapping revealed that a high proportion (70%) of markers with disagreed chromosome location was observed between C. c. haematopterus and another common carp strain (subspecies) C. c. carpio. A clear 2:1 relationship was observed between C. c. haematopterus linkage groups (LGs) and zebrafish (Danio rerio) chromosomes. Based on the genetic map, 21 QTLs for growth-related traits were detected on 12 LGs, and contributed values of phenotypic variance explained (PVE) ranging from 16.3 to 38.6%, with LOD scores ranging from 4.02 to 11.13. A genome-wide significant QTL (LOD = 10.83) and three chromosome-wide significant QTLs (mean LOD = 4.84) for sex were mapped on LG50 and LG24, respectively. A 1.4 cM confidence interval of QTL for all growth-related traits showed conserved synteny with a 2. 06 M segment on chromosome 14 of D. rerio. Five potential candidate genes were identified by blast search in this genomic region, including a well-studied multi-functional growth related gene, Apelin. Conclusions: We mapped a set of suggestive and significant QTLs for growth-related traits and sex based on a high-density genetic linkage map using SNP and microsatellite markers for Yangtze River common carp. Several candidate growth genes were also identified from the QTL regions by comparative mapping. This genetic map would provide a basis for genome assembly and comparative genomics studies, and those QTL-derived candidate genes and genetic markers are useful genomic resources for marker-assisted selection (MAS) of growth-related traits in the Yangtze River common carp.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Computer Science, Artificial Intelligence

Attention Enhanced Reinforcement Learning for Multi agent Cooperation

Zhiqiang Pu, Huimu Wang, Zhen Liu, Jianqiang Yi, Shiguang Wu

Summary: In this article, a novel method called AERL is proposed to address complex interaction and communication issues in multi agent cooperation. The method utilizes attention mechanism and parameter sharing to achieve effective and robust performance, as demonstrated in simulation experiments in three representative scenarios.

IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS (2023)

Article Public, Environmental & Occupational Health

The 100 most-cited articles on bibliotherapy: a bibliometric analysis

Zheng Xu, Ru Liu, Liping Guo, Ziyi Gao, Zicheng Gao, Xiaowei Liu, Jieyun Li, Bin Li, Kehu Yang

Summary: This scientometric investigation provides a comprehensive analysis of the development and emerging research trends in bibliotherapy. The study identifies the leading countries and institutions in the field and highlights the hot topics of research, such as depression and anxiety. The findings of this study serve as a valuable reference for researchers in the field of bibliotherapy.

PSYCHOLOGY HEALTH & MEDICINE (2023)

Article Environmental Sciences

Research hotspots and trends of Kinesio Taping from 2011 to 2020: a bibliometric analysis

Yu Qin, Meixuan Li, Jiani Han, Gecheng Cui, Weiping Du, Kehu Yang

Summary: This study explored the research hotspots and trends of Kinesio Taping in the past decade through bibliometric analysis. The results revealed that pain relief, sports injury prevention and treatment, and proprioception enhancement for improved postural control were important research areas in the field of Kinesio Taping.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2023)

Article Soil Science

The effect of different biocrusts on soil hydraulic properties in the Tengger Desert, China

Wei Shi, Yan-xia Pan, Ya-feng Zhang, Rui Hu, Xin-ping Wang

Summary: Water redistribution has a profound impact on the function of dryland ecosystems. Biological soil crusts (BSCs or biocrusts), which cover a large portion of arid land soil surface, have conflicting effects on water redistribution at a regional scale. This study clarified the effects of different biocrusts on soil hydraulic properties in the Tengger Desert. The results showed that biocrusts significantly altered soil hydraulic properties, including water holding capacity, soil hydrophobicity, water sorptivity, and unsaturated hydraulic conductivity. Understanding the role of biocrusts in hydraulic properties can help improve our understanding of soil water distribution, movement, and retention in the area.

GEODERMA (2023)

Article Biochemistry & Molecular Biology

The Pyramiding of Elite Allelic Genes Related to Grain Number Increases Grain Number per Panicle Using the Recombinant Lines Derived from Indica-japonica Cross in Rice

Xuhui Liu, Xiaoxiao Deng, Weilong Kong, Tong Sun, Yangsheng Li

Summary: Using genomics resources, we found that hybridization can significantly increase rice yield, especially by combining specific genotypes to increase grain number per panicle (GNPP).

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Review Oncology

Biological effects of cancer stem cells irradiated by charged particle: a systematic review of in vitro studies

Qian Wang, Ruifeng Liu, Qiuning Zhang, Hongtao Luo, Xun Wu, Tianqi Du, Yanliang Chen, Mingyu Tan, Zhiqiang Liu, Shilong Sun, Kehu Yang, Jinhui Tian, Xiaohu Wang

Summary: The purpose of this study was to evaluate the biological effects of cancer stem cells (CSCs) irradiated by charged particle, including proliferation, invasion, migration, and changes in the molecular level. The results showed that CSCs have obvious radio-resistance compared with non-CSCs, and charged particle irradiation or in combination with drugs could overcome this resistance, specifically manifested in inhibiting CSCs' proliferation, invasion, migration, and causing more and harder to repair DNA double-stranded breaks (DSB) of CSCs.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2023)

Article Health Care Sciences & Services

Reporting and methodological quality of acupuncture network meta-analyses could be improved: an evidence mapping

Yan Wang, Nan Chen, Kangle Guo, Yanfei Li, Fenfen E, Chaoqun Yang, Xue Shang, Xiuxia Li, Kehu Yang

Summary: This study evaluated and mapped the reporting and methodological quality of network meta-analysis (NMA) on acupuncture. The reporting quality of NMAs was found to be moderate, but the methodological quality was very low, especially for Chinese studies. Future NMAs, especially those from China, need to improve their reporting and methodological quality further.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2023)

Review Pharmacology & Pharmacy

The Comparative Effectiveness and Safety of Insomnia Drugs: A Systematic Review and Network Meta-Analysis of 153 Randomized Trials

Bei Pan, Long Ge, Honghao Lai, Liangying Hou, Chen Tian, Qi Wang, Kelu Yang, Yao Lu, Hongfei Zhu, Mengting Li, Deren Wang, Xiuxia Li, Yuqing Zhang, Ya Gao, Ming Liu, Guowu Ding, Jinhui Tian, Kehu Yang

Summary: This study aimed to compare the effectiveness, safety, and tolerability of different drugs for treating insomnia. The results showed that non-benzodiazepines, antidepressants, and orexin receptor antagonists may have positive effects on improving total sleep time, sleep onset latency, and wake time after sleep onset. The choice of insomnia drugs should consider the individual's insomnia phenotype, as well as the safety and tolerability of each drug.
Review Nutrition & Dietetics

Association of soft drinks and 100% fruit juice consumption with risk of cancer: a systematic review and dose-response meta-analysis of prospective cohort studies

Bei Pan, Honghao Lai, Ning Ma, Dan Li, Xiyuan Deng, Xiaoman Wang, Qian Zhang, Qiuyu Yang, Qi Wang, Hongfei Zhu, Mengting Li, Xiao Cao, Jinhui Tian, Long Ge, Kehu Yang

Summary: Through a systematic review and meta-analysis of 37 cohort studies, it was found that an increased consumption of sugar-sweetened beverages (SSBs) per 250 mL/day was associated with a higher risk of breast, colorectal, biliary tract, and prostate cancer. Increased consumption of artificially sweetened beverages (ASBs) per 250 mL/day was associated with a higher risk of leukemia. Increased consumption of 100% fruit juice per 250 mL/day was associated with a higher risk of overall cancer, melanoma, squamous cell carcinoma, and thyroid cancer. There were linear dose-response associations between SSBs consumption and breast and kidney cancer, and between ASBs and fruit juices consumption and pancreatic cancer.

INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY (2023)

Review Clinical Neurology

A Meta-analysis of the Clinical Efficacy of the Head-of-Bed Elevation for Patients With Acquired Brain Injury

Ying Che, Tingting Lu, Tianming Wang, Hairong Zhao, Xulin Song, Qing Zhan, Chengzu Zhang, Haibang Pan, Kehu Yang, Bo Wang

Summary: This study evaluated the effects of head-of-bed elevation on patients with acquired brain injury (ABI). The results showed that elevating the head of the bed by 30 degrees can significantly reduce intracranial pressure (ICP), but did not have statistical differences on cerebral perfusion pressure (CPP) and disability at 90 days. Therefore, head-of-bed elevation of 30 degrees may be an effective noninvasive nursing practice for the prognosis and rehabilitation of ABI patients.

JOURNAL OF NEUROSCIENCE NURSING (2023)

Review Sport Sciences

Pilates and multiple health outcomes: An umbrella review

Meng Xu, Chen Tian, Yong Wang, Shanshan Liang, Yiyun Wang, Xiuxia Li, Kehu Yang

Summary: This study conducted an umbrella review to summarize the evidence of associations between Pilates and multiple health outcomes, and evaluated the strength and validity of these associations. It found that Pilates can reduce body mass index and body fat percentage, relieve pain and disability, and improve sleep quality and balance. However, the certainty of the evidence was mostly low, and further high quality randomized controlled trials are needed to support these promising findings.

JOURNAL OF SCIENCE AND MEDICINE IN SPORT (2023)

Review Integrative & Complementary Medicine

Adverse effects associated with acupuncture therapies: An evidence mapping from 535 systematic reviews

Meng Xu, Chaoqun Yang, Tao Nian, Chen Tian, Liying Zhou, Yanan Wu, Yanfei Li, Xinxin Deng, Xiuxia Li, Kehu Yang

Summary: This study examines the adverse effects of acupuncture and finds that there are various types of adverse reactions, but the symptoms are mild. However, most of the included studies have low quality, indicating a need for further randomized controlled trials and systematic reviews to comprehensively analyze acupuncture-related adverse events.

CHINESE MEDICINE (2023)

Review Emergency Medicine

Effectiveness of intraoperative peritoneal lavage with saline in patient with intra-abdominal infections: a systematic review and meta-analysis

Qi Zhou, Wenbo Meng, Yanhan Ren, Qinyuan Li, Marja A. Boermeester, Peter Muli Nthumba, Jennifer Rickard, Bobo Zheng, Hui Liu, Qianling Shi, Siya Zhao, Zijun Wang, Xiao Liu, Zhengxiu Luo, Kehu Yang, Yaolong Chen, Robert G. Sawyer

Summary: This study reviewed the effectiveness of intraoperative peritoneal lavage (IOPL) with saline in patients with intra-abdominal infections (IAIs). The findings suggest that IOPL with saline does not significantly reduce the risk of mortality, intra-abdominal abscess, incisional surgical site infection, postoperative complication, reoperation, and readmission when compared to non-IOPL. Therefore, routine use of IOPL with saline in patients with IAIs is not supported.

WORLD JOURNAL OF EMERGENCY SURGERY (2023)

Article Biochemistry & Molecular Biology

Genome-Wide Identification and Evolution Analysis of the CYP76 Subfamily in Rice (Oryza sativa)

Mingao Zhou, Yifei Jiang, Xuhui Liu, Weilong Kong, Chenhao Zhang, Jian Yang, Simin Ke, Yangsheng Li

Summary: The CYP76 subfamily, which belongs to the CYP superfamily, is crucial for phytohormone biosynthesis and response to environmental stresses in plants. Genome-wide analysis of the CYP76 subfamily in seven AA genome species revealed three groups, with Group 1 having the largest number of members. Analysis of cis-acting elements showed a high number of elements related to jasmonic acid and light response. Gene duplication analysis indicated expansion mainly through SD/WGD and tandem forms, with strong purifying selection during evolution. Expression pattern analysis showed that OsCYP76s exhibit restricted expression patterns in leaves and roots. qRT-PCR analysis of CYP76s under abiotic stresses revealed specific response patterns and functional divergence between japonica and indica rice. These findings provide valuable insights into the functional diversity and evolution of the CYP76 subfamily and have implications for improving stress tolerance and agronomic traits in rice.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Article Health Care Sciences & Services

Use of GRADE in systematic reviews of health effects on pollutants and extreme temperatures: A cross-sectional survey

Xuping Song, Yan Ma, Jing Tang, Jiali Peng, Yue Hu, Yunze Han, Xinyu Fu, Xufei Luo, Xiuxia Li, Long Ge, Kehu Yang, Yaolong Chen

Summary: This study analyzed the trends and gaps in evidence of health effects on pollutants and extreme temperatures through evidence mapping, and conducted a cross-sectional survey on the use of GRADE in systematic reviews or meta-analyses. The results showed that GRADE is not widely used in these evaluations, and the certainty of evidence is generally low.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2023)

暂无数据