Article
Cardiac & Cardiovascular Systems
Sebastian Rosch, Karl-Patrik Kresoja, Christian Besler, Karl Fengler, Anne Rebecca Schoeber, Maximilian von Roeder, Christian Luecke, Matthias Gutberlet, Karin Klingel, Holger Thiele, Karl-Philipp Rommel, Philipp Lurz
Summary: In this study, patients with heart failure with preserved ejection fraction (HFpEF) were stratified based on left ventricular ejection fraction (LVEF), resulting in distinct morphologic and pathophysiologic subphenotypes. Patients with LVEF ranging from 50% to 60% demonstrated reduced contractility, impaired ventriculo-arterial coupling, and higher extracellular volume fraction, while patients with LVEF >60% exhibited a hypercontractile state with excessive left ventricular afterload and diminished preload reserve.
Article
Cardiac & Cardiovascular Systems
Shaohua Guo, Mengqi Gong, Gary Tse, Guangping Li, Kang-Yin Chen, Tong Liu
Summary: This study found that plasma IGFBP-1 and IGFBP-1/IGF-1 ratio can distinguish patients with and without HF. In HF patients, IGFBP-1 and IGFBP-1/IGF-1 ratio are positively correlated with NT-proBNP levels.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Annemarijn R. de Boer, Ilonca Vaartjes, Aisha Gohar, Mark J. M. Valk, Jasper J. Brugts, Leandra J. M. Boonman-de Winter, Evelien E. van Riet, Yvonne van Mourik, Hans-Peter Brunner-La Rocca, Gerard C. M. Linssen, Arno W. Hoes, Michiel L. Bots, Hester M. den Ruijter, Frans H. Rutten
Summary: This study found significant variations in both the types of HF and the distribution by sex among HF patients aged 65-79 in different healthcare settings. The proportion of female patients decreased from high-risk communities to general practice to cardiology outpatient settings, with HFpEF being the most common type of HF.
Article
Cardiac & Cardiovascular Systems
Yogesh N. Reddy, Barry A. Borlaug, Bernard J. Gersh
Summary: Atrial fibrillation is the most common arrhythmia in heart failure patients and can be both the cause and consequence of clinical heart failure. Some patients may benefit from maintaining sinus rhythm with catheter ablation. There is a close relationship between atrial fibrillation, left atrial myopathy, mitral regurgitation, and heart failure with preserved ejection fraction, with potential clinical benefits to catheter ablation therapy. Treatment of atrial fibrillation also requires consideration of the degree of atrial myopathy and chronicity of atrial fibrillation.
Review
Medicine, General & Internal
Davide Stolfo, Enrico Fabris, Lars H. Lund, Gianluigi Savarese, Gianfranco Sinagra
Summary: Historically, heart failure (HF) has been classified into two distinct subgroups based on ejection fraction (EF), HF with reduced EF (HFrEF) and HF with preserved EF (HFpEF). However, recent research has shown potential benefits of new therapies for patients with EF between 41% and 49%, leading to the renaming of this subgroup as HF with mildly reduced EF (HFmrEF). This review discusses the reasons behind this modification, summarizes the characteristics of HFmrEF and its similarities and differences with the other EF categories, and provides a comprehensive overview of the current available evidence supporting the treatment of patients with HFmrEF.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Gijs van Woerden, Dirk J. van Veldhuisen, Olivier C. Manintveld, Vanessa P. M. van Empel, Tineke P. Willems, Rudolf A. de Boer, Michiel Rienstra, B. Daan Westenbrink, Thomas M. Gorter
Summary: This study evaluated the prognostic value of epicardial adipose tissue (EAT) volume in patients with HF with mid-range and preserved ejection fraction. The results showed that EAT accumulation is associated with adverse prognosis in these patients.
CIRCULATION-HEART FAILURE
(2022)
Letter
Medicine, General & Internal
Elric Zweck, Ralf Westenfeld, Bjorn Redfors, Elmir Omerovic, Robin A. P. Weir, Domenico Gabrielli, Fabrizio Oliva, Giuseppe Zuccala, Scott D. Solomon, Muthiah Vaduganathan, John J. V. McMurray
Summary: Solomon et al. report on the DELIVER trial, which showed that dapagliflozin reduced risks of heart failure-related outcomes in patients with a mildly reduced or preserved left ventricular ejection fraction. These findings are expected to influence guidelines and clinical practice. The trial also confirmed dapagliflozin's efficacy in patients with a left ventricular ejection fraction of 60% or above.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Letter
Medicine, General & Internal
Debdatta Bhattacharyya, Ayan Kar, Saurabh Dhumale, Filippos K. Triposkiadis, Andrew Xanthopoulos, Efstathios K. Iliodromitis, James Amato, Hiddo J. L. Heerspink, Lesley Inker, Tom Greene, Stefan D. Anker, Javed Butler, Milton Packer
Summary: In patients with heart failure and preserved ejection fraction, Empagliflozin reduced the incidence of primary outcome events compared to other drugs, but had higher rates of cardiovascular death, death from any cause, and hospitalization for heart failure compared to spironolactone.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Mingming Yang, Toru Kondo, Jawad H. Butt, William T. Abraham, Inder S. Anand, Akshay S. Desai, Lars Kober, Milton Packer, Marc A. Pfeffer, Jean L. Rouleau, Marc S. Sabatine, Scott D. Solomon, Karl Swedberg, Michael R. Zile, Pardeep S. Jhund, John J. McMurray
Summary: Patients with heart failure who have a history of stroke are at a high risk of subsequent cardiovascular events, regardless of ejection fraction. This study investigated the prevalence of stroke history in patients with heart failure and found that they had more vascular comorbidity and worse heart failure compared to those without stroke history. Targeting underutilization of guideline-recommended treatments might improve outcomes in this high-risk population.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Mohanad Alkhodari, Herbert F. Jelinek, Angelos Karlas, Stergios Soulaidopoulos, Petros Arsenos, Ioannis Doundoulakis, Konstantinos A. Gatzoulis, Konstantinos Tsioufis, Leontios J. Hadjileontiadis, Ahsan H. Khandoker
Summary: This study explores the use of deep learning to predict LVEF and classify HF based on patient clinical information. Seven clinical markers were identified as important for discriminating between HF categories, and both regression and classification models showed high accuracy in estimating LVEF levels and categorizing HF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Yuta Seko, Takao Kato, Takeshi Morimoto, Hidenori Yaku, Yasutaka Inuzuka, Yodo Tamaki, Neiko Ozasa, Masayuki Shiba, Erika Yamamoto, Yusuke Yoshikawa, Yugo Yamashita, Takeshi Kitai, Ryoji Taniguchi, Moritake Iguchi, Kazuya Nagao, Takafumi Kawai, Akihiro Komasa, Ryusuke Nishikawa, Yuichi Kawase, Takashi Morinaga, Mamoru Toyofuku, Yutaka Furukawa, Kenji Ando, Kazushige Kadota, Yukihito Sato, Koichiro Kuwahara, Takeshi Kimura
Summary: Starting both ACE-I/ARB and a beta-blocker in hospitalized patients with HFmrEF and HFpEF is associated with a reduced risk of all-cause death or HF hospitalization compared with patients not starting on an ACE-I/ARB or beta-blocker.
CIRCULATION JOURNAL
(2022)
Review
Cardiac & Cardiovascular Systems
Kaiyuan Zhu, Teng Ma, Yang Su, Xin Pan, Rongrong Huang, Fenglei Zhang, Chunxi Yan, Dachun Xu
Summary: This review summarizes current knowledge on HFmrEF patients in comparison to HFrEF and HFpEF, with recommended treatments focusing on comorbidity management. More research is needed to characterize HFmrEF and identify effective management strategies to reduce cardiovascular morbidity and mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Ning Ding, Amil M. Shah, Michael J. Blaha, Patricia P. Chang, Wayne D. Rosamond, Kunihiro Matsushita
Summary: This study aimed to evaluate the association between smoking and different phenotypes of heart failure. The results showed a significant association between smoking and the incidence of HFpEF and HFrEF, and smoking cessation significantly reduced the risk of HF.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jawad H. Butt, Toru Kondo, Pardeep S. Jhund, Josep Comin-Colet, Rudolf A. de Boer, Akshai S. Desai, Adrian F. Hernandez, Silvio E. Inzucchi, Stefan P. Janssens, Mikhail N. Kosiborod, Carolyn S. P. Lam, Anna Maria Langkilde, Daniel Lindholm, Felipe Martinez, Magnus Petersson, Sanjiv J. Shah, Jorge Thierer, Muthiah Vaduganathan, Subodh Verma, Ulrica Wilderang, Brian C. Claggett, Scott D. Solomon, John J. V. McMurray
Summary: This study examined the effects of dapagliflozin in patients with atrial fibrillation (AF) and found that its benefits were consistent across different types of AF.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Xiaoqian Wu, Huan Liu, Alan Brooks, Suowen Xu, Jinque Luo, Rebbeca Steiner, Deanne M. Mickelsen, Christine S. Moravec, Alexis D. Jeffrey, Eric M. Small, Zheng Gen Jin
Summary: The study reveals that reduced endothelial SIRT6 expression is associated with the development of diabetes-related HFpEF, and improving cardiac function by inhibiting endothelial fatty acid uptake. Activation of SIRT6 with medication reduces cardiac lipid accumulation and improves diastolic function.
CIRCULATION RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Cheng Kong, Lei Liang, Guang Liu, Lutao Du, Yongzhi Yang, Jianqiang Liu, Debing Shi, Xinxiang Li, Yanlei Ma
Summary: This study investigated the interactions between gut microbiome, metabolites, and microbial enzymes in early-onset colorectal cancer (EO-CRC) patients. The results showed distinct associations between microbiome and metabolome in EO-CRC compared to late-onset CRC (LO-CRC). The study identified potential biomarkers for EO-CRC and achieved a powerful classification performance for distinguishing EO-CRC from controls. This research provides valuable insights into the pathogenesis of EO-CRC and highlights the potential of microbiome-derived biomarkers for non-invasive detection.
Article
Engineering, Civil
Haoran Chen, Xuedong Yan, Xiaobing Liu, Tao Ma
Summary: With the rapid development of internet technologies and shared mobility services, online ridesharing services have become popular worldwide. This study compares the operational performance of two major online ridesharing modes, ridesplitting and carpooling, using actual operating data provided by DiDi Chuxing. The findings indicate that ridesplitting has lower fuel-saving and distance-saving ratios compared to carpooling, and online ridesharing is not considered fuel-saving in terms of transportation system's fuel economy.
Article
Information Science & Library Science
Pengzhen Yin, Chuang Wang, Liang Liang
Summary: This study examines the antecedents (i.e. characteristics of MICT) and outcomes (i.e. employee affective and cognitive well-being) of routine MICT use in the remote work context. The findings show that routine MICT use increases employee affective well-being, such as job satisfaction, and mitigates cognitive well-being issues, such as technology overload. The study also highlights the mediation effects of routine MICT use on the relationship between its characteristics and employee well-being.
INFORMATION TECHNOLOGY & PEOPLE
(2023)
Article
Chemistry, Physical
Zengqi Lu, Xiaolong Fu, Jiamao Li, Jingwei Hou, Guangming Ran, Chengjian Xiao, Xiaolin Wang
Summary: A hydrophobic microscopic reaction environment was constructed through the modification of mesoporous silica, which helped improve the catalytic activity of the LPCE reaction. The Pt@SBA-15-tetramethyldisilazane catalyst, prepared by modifying the SBA-15 carrier and loading metal Pt, exhibited a superhydrophobic structure with a water contact angle of 158 degrees. This structure enhanced the catalytic performance and prevented catalyst deactivation. Experimental results showed that the catalyst had good catalytic activity in tritium water and maintained high activity after 30 days.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Agriculture, Multidisciplinary
Yuxiang Gu, Haoran Chen, Xing Li, Dan Li, Yue Sun, Lin Yang, Ying Ma, Eric Chun Yong Chan
Summary: This study found that Lactobacillus paracasei IMC 502 can prevent and alleviate type 2 diabetes by mediating the gut microbiota-SCFA-hormone/inflammation pathway.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Liyun Zheng, Chun Yang, Liang Liang, Shengxiang Rao, Yongming Dai, Mengsu Zeng
Summary: This study aimed to explore the feasibility of pancreatic imaging at 5 T and evaluate the practical improvement of T2-weighted MRI and diffusion-weighted imaging (DWI) at 5 T as compared with 3 T. The results showed that imaging at 5 T provided higher image quality ratings and SNR compared to 3 T for both T2-weighted and DWI images. However, there were no significant differences in the mean ADC values and CV of ADC between 3 T and 5 T measurements.
Article
Chemistry, Organic
Mao-Lin Yang, Hao-Ran Chen, Long Zhao, Ming-Wu Ding
Summary: A new efficient synthesis method for the preparation of 6,12-dihydro-5H-quinazolino[3,2-a]quinazolin-5-ones has been developed. This method involves sequential Ugi/Staudinger/aza-Wittig/addition/nucleophilic acyl substitution reactions and provides a domino and effective strategy for the preparation of various substituted quinazolino[3,2-a]quinazolin-5-ones under mild reaction conditions.
SYNTHESIS-STUTTGART
(2023)
Article
Engineering, Environmental
Qiang Liu, Youjin Gong, Boyu Liu, Shunshun Xiong, Hui-Min Wen, Xiaolin Wang
Summary: In this study, an ultra-microporous alkyl Cu-based MOF-11 was developed for highly selective adsorption of xenon. The unique pore system of MOF-11 not only enables strong binding affinity with xenon, but also allows for dense packing of xenon molecules. MOF-11 demonstrates record-high xenon storage density, uptake, and selectivity, making it a promising candidate for xenon separation and capture.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Rheumatology
Haoran Chen, Huarui Liu, Wenting Lyu, Yin Liu, Mei Huang, Yingwei Zhang, Yuying Qiu, Yonglong Xiao, Hourong Cai, Jinghong Dai
Summary: This study retrospectively analyzed the clinical characteristics and risk factors of clinical recurrence in interstitial lung disease related to antisynthetase syndrome (ARS-ILD). Recurrence of ARS-ILD was common during medication intensity reduction, and age, lactate dehydrogenase (LDH), medication tapering duration, and discontinuation were identified as risk factors for recurrence.
CLINICAL RHEUMATOLOGY
(2023)
Article
Automation & Control Systems
Yuanmao Ye, Yongbin Zhang, Xiaolin Wang, Ka-Wai Eric Cheng
Summary: This article presents a new type of step-up multilevel inverter (MLI) using a front-side quasi-Z-source unit, which effectively limits the charging current variation and enhances the total voltage gain.
IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS
(2023)
Article
Engineering, Electrical & Electronic
Yuanmao Ye, Minhao Chen, Xiaolin Wang, Lingling Cao
Summary: This article introduces a new boost-type common-ground photovoltaic (PV) inverter, which solves the problems of inrush charging current, input current quality, and boost capability by inserting a quasi-Z-source (qZS) unit into an SC-based common-ground inverter, and is experimentally verified.
INTERNATIONAL JOURNAL OF ELECTRICAL POWER & ENERGY SYSTEMS
(2023)
Article
Engineering, Electrical & Electronic
Jianqiang Luo, Fei Teng, Siqi Bu, Zhongda Chu, Ning Tong, Anbo Meng, Ling Yang, Xiaolin Wang
Summary: This paper proposes a solution to address the traditional operational constraint issue in power systems considering converter-driven stability and elaborates on a power sensitivity-based power dispatch method to enhance stability margin and update operational constraint solutions.
INTERNATIONAL JOURNAL OF ELECTRICAL POWER & ENERGY SYSTEMS
(2023)
Review
Chemistry, Multidisciplinary
Hui-Ying Tan, Jiali Wang, Sheng-Chih Lin, Tsung-Rong Kuo, Hao Ming Chen
Summary: Single-atom catalysts (SACs) are promising electrocatalysts for energy conversion and storage due to their efficient atom utilization and unique electronic properties. The local coordination structures of single metal centers play a significant role in catalytic performances, and understanding the dynamic changes of SACs during reactions is crucial for improving catalytic activity.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Gastroenterology & Hepatology
Xiaoduan Zhuang, Shaoheng Zhang, Guiquan Chen, Zongqi Luo, Huiqin Hu, Wenfeng Huang, Yu Guo, Yongwen Ouyang, Liang Peng, Qing Qing, Huiting Chen, Bingsheng Li, Jie Chen, Xinying Wang
Summary: This study aimed to explore the unsatisfactory histologically complete resection (CR) rate of small rectal neuroendocrine tumors (RNETs) and its associated risk factors and clinical outcomes. The study found that polypectomy, a central depression, and treatment in the early period were risk factors for incomplete resection (IR). Further analysis revealed that an atypical hyperemic appearance and treatment in the early period were significant predisposing factors for inappropriate choice of polypectomy.
GASTROENTEROLOGY REPORT
(2023)
Article
Automation & Control Systems
Zhongjing Yu, Gangyi Zhang, Jingyu Chen, Haoran Chen, Duo Zhang, Qinli Yang, Junming Shao
Summary: This paper proposes a noise-resistant graph embedding method, called NGE, which leverages subspace clustering information to capture community structure and reinforce the relationship between topology and attributes. Experimental results demonstrate the superiority of this method in tasks such as community detection, link prediction, and node classification.
IEEE TRANSACTIONS ON CYBERNETICS
(2023)
