Article
Pharmacology & Pharmacy
Yonghua Bi, Kewei Ren, Jianzhuang Ren, Ji Ma, Xinwei Han
Summary: DEB-TACE loaded with oxaliplatin has shown promising outcomes in treating unresectable or recurrent HCC patients, with high response rates and good safety profiles.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Omar S. Sakr, Mohamed M. A. Zaitoun, Mohamed S. Amer, Mahmoud Qubisi, Ahmed H. Elshafeey, Olivier Jordan, Gerrit Borchard
Summary: This paper introduces a new treatment modality for hepatocellular carcinoma, using highly charged, drug loaded liposomes attached to beads, allowing for localized sustained delivery of hydrophilic drugs. In an animal study, it was found that this treatment method had a slower drug release pattern, lower drug concentration, and less impact on systemic circulation.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Gastroenterology & Hepatology
Guang Sheng Zhao, Song Liu, Ying Liu, Chuang Li, Ruo Yu Wang, Jie Bian, Yue Wei Zhang, Jun Zhou, Ya Jie Lin, Jianlin Wu
Summary: This study aimed to investigate the clinical efficacy and prognostic factors of Gelfoam for drug-eluting bead transarterial chemoembolization (GMD-TACE) in patients with unresectable large hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT). The results showed that GMD-TACE can be used as a core treatment for improving the quality of life and extending the median overall survival (OS) in these patients. The type of tumor thrombus and combination therapy were identified as important factors affecting prognosis.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Ningjie Li, Jiao Chen
Summary: DEB-TACE plus apatinib achieves prolonged progression-free survival (PFS) and overall survival (OS) in huge HCC patients, while exhibiting similar adverse events occurrence compared to DEB-TACE alone.
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Salvatore Alessio Angileri, Carolina Lanza, Serena Carriero, Pierpaolo Biondetti, Velio Ascenti, Giuseppe Pellegrino, Alessandro Caruso, Gianpaolo Carrafiello, Anna Maria Ierardi
Summary: This study evaluated the effectiveness and safety of an anti-reflux microcatheter during DEB-TACE with DC Bead LUMITM for treating HCC. The technical success rate was 100% with no major complications. Clinical response at 1-month follow-up showed a favorable outcome with no instances of non-target embolization.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Xuhua Duan, Juanfang Liu, Xinwei Han, Jianzhuang Ren, Hao Li, Fengyao Li, Shuguang Ju
Summary: DEB-TACE with CSM showed superior treatment response, survival profiles, and safety profiles compared with cTACE in huge HCC patients. DEB-TACE group had higher objective response rate, longer PFS and OS, and reduced liver function injury and incidence of fever and CINV.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Zhixiang Mou, Tianjun Guan, Lan Chen
Summary: This meta-analysis identified age, diabetes mellitus, and the number of transarterial chemoembolization sessions as risk factors for acute kidney injury (AKI) in hepatocellular carcinoma (HCC) patients after transarterial chemoembolization treatment. Male gender, age, diabetes mellitus, major resection of the liver, and operation-related transfusion were identified as risk factors for AKI in HCC patients after hepatectomy. The study also found a significantly higher risk of mortality in HCC patients with renal failure due to AKI in a short-term observation period after transarterial chemoembolization treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Marco Fronda, Francesco Mistretta, Marco Calandri, Fernanda Ciferri, Floriana Nardelli, Laura Bergamasco, Paolo Fonio, Andrea Doriguzzi Breatta
Summary: This study evaluated the efficacy of unenhanced CBCT in predicting early radiologic response of HCC nodules to DEB-TACE. The results showed that the presence of an intense contrast media deposit with clear and complete margins in treated HCC lesions is associated with complete response.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Isaure Roquette, Emilie Bogart, Thomas Lacornerie, Massih Ningarhari, Jean-Emmanuel Bibault, Marie-Cecile Le Deley, Eric F. Lartigau, David Pasquier, Xavier Mirabel
Summary: This study describes the treatment efficacy and safety of stereotactic body radiation therapy (SBRT) in patients with hepatocellular carcinoma (HCC). The analysis of data from 318 patients showed that SBRT is efficient for the management of HCC with a favorable toxicity profile.
Article
Oncology
Zhongxing Shi, Dongqing Wang, Tanrong Kang, Ru Yi, Liming Cui, Huijie Jiang
Summary: This study aimed to compare the outcomes of DEB-TACE with CalliSpheres microspheres and cTACE in the treatment of unresectable HCC. The results showed that DEB-TACE group had better treatment response and survival benefits than cTACE group, despite the occurrence of some side effects in the DEB-TACE group.
RADIOLOGY AND ONCOLOGY
(2023)
Article
Oncology
Yonghua Bi, Yang Wang, Wenguang Zhang, Huibin Lu, Jianzhuang Ren, Xinwei Han
Summary: The study aimed to report the preliminary outcomes of drug-eluting beads TACE loaded with raltitrexed in patients with unresectable or recurrent HCC. The results showed that this treatment regimen had good efficacy and safety, and could be considered as an effective palliative therapy for patients with unresectable or recurrent HCC.
Article
Oncology
Asahiro Morishita, Joji Tani, Takako Nomura, Kei Takuma, Mai Nakahara, Kyoko Oura, Tomoko Tadokoro, Koji Fujita, Tingting Shi, Hiroki Yamana, Takanori Matsui, Tadayuki Takata, Takayuki Sanomura, Yoshihiro Nishiyama, Takashi Himoto, Tetsu Tomonari, Akio Moriya, Tomonori Senoo, Koichi Takaguchi, Tsutomu Masaki
Summary: Recent studies have shown that the combination therapy of DEB-TACE followed by cTACE may be more effective for intermediate stage HCC patients, with a significantly higher complete response rate in the cTACE group. The total tumor number was the only factor that increased the complete response rate in the cTACE group, and the overall survival rate of complete response patients was higher than non-complete response patients in the cTACE group. Adverse events in the cTACE group were limited, with only one case of severe thrombocytopenia out of twenty-seven patients.
Review
Oncology
Shenglan Huang, Dan Li, LingLing Zhuang, Liying Sun, Jianbing Wu
Summary: This meta-analysis explored the efficacy and safety of sorafenib in hepatocellular carcinoma patients after radical surgery, revealing that sorafenib can improve overall survival, recurrence-free survival, and reduce recurrence rates without intolerable side effects. More evidence is needed for a definitive conclusion.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Bin Liang, Joyman Makamure, Shenglei Shu, Lijie Zhang, Tao Sun, Chuansheng Zheng
Summary: CSM-TACE shows superior treatment response, non-inferior survival profile, and better safety compared to cTACE in HCC patients. Data indicates that patients receiving CSM-TACE had higher complete response rates, objective response rates, and disease control rates, as well as improved efficacy at 3 and 6 months compared to those treated with cTACE.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Tianshi Lyu, Jian Wang, Xiaoqiang Tong, Tianai Mi, Chao An, Yinghua Zou
Summary: In this study, the efficacy and safety of bleomycin-loaded CalliSpheres (R) microsphere TACE (CSM-TACE) and conventional TACE (cTACE) in treating renal angiomyolipoma (RAML) patients were compared. The results showed that CSM-TACE is effective and well tolerated by RAML patients, suggesting its potential as an alternative therapy.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2023)
Article
Engineering, Civil
Tengfei Xu, Guoqing Chen, Kailai Deng, Limin Chen, Xiaolong Li, Song Lou
Article
Spectroscopy
Qiyun Xie, Lihuan Xu, Chengxiang Hu, Limin Chen, Jiajin Zheng, Wei Wang, Handi Yin, Guofeng Cheng, Xiaoqian Ai
Summary: Understanding the phonon-phonon anharmonic effect in HfTe5 is crucial for both scientific interest and potential thermoelectric applications. Raman spectroscopy was used to study the phonon anharmonicity by measuring the temperature dependence of phonon mode softening and broadening in HfTe5 single crystals. Results showed that four phonon anharmonic effects are significant, leading to low thermal conductivity in HfTe5 crystals due to reduced phonon lifetime from enhanced phonon scattering.
JOURNAL OF RAMAN SPECTROSCOPY
(2021)
Article
Nanoscience & Nanotechnology
Douglas K. Pleskow, Lei Zhang, Vladimir Turzhitsky, Mark F. Coughlan, Umar Khan, Xuejun Zhang, Conor J. Sheil, Maria Glyavina, Liming Chen, Shweta Shinagare, Yuri N. Zakharov, Edward Vitkin, Irving Itzkan, Lev T. Perelman, Le Qiu
Summary: The novel coherent confocal light scattering and absorption spectroscopic microscopy enables high-resolution imaging of structures in live cells, down to 10 nm spatial scales, and can sense differences in cancer aggressiveness in live cells and identify cancer grades in tumor tissues without labels.
Article
Pharmacology & Pharmacy
Daniel Rizzolo, Bo Kong, Stephanie Piekos, Liming Chen, Xiaobo Zhong, Jie Lu, Jian Shi, Hao-jie Zhu, Qian Yang, Albert Li, Linhao Li, Hongbing Wang, Anna Siemiatkowska, Celine Park, Leonid Kagan, Grace L. Guo
Summary: Fibroblast growth factors 15 and 19 are important in maintaining bile acid homeostasis, and are currently being tested as potential treatments for certain liver diseases. This study found that long-term elevations of these growth factors can lead to increased expression of drug metabolizing enzymes, affecting drug metabolism and pharmacokinetics. The overexpression of Fgf15 was also found to cause a switch in the expression pattern of these enzymes in male mice, similar to the pattern observed in female mice. This change was associated with differences in growth hormone secretion and STAT5 signaling.
DRUG METABOLISM AND DISPOSITION
(2022)
Review
Cell Biology
Mehrdad Izadirad, Zoufang Huang, Farideh Jafari, Amir Ali Hamidieh, Ahmad Gharehbaghian, Yi-Dong Li, Leila Jafari, Zhe-Sheng Chen
Summary: Despite their small size, extracellular vesicles (EVs) play a significant role in the pathogenesis of acute leukemia, especially as carriers of important molecules like miRNA. Research has shown a growing interest in the potential prognostic value and role of leukemia-derived EVs in clinical settings.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chunhong Mo, Zhao Wang, Jianying Yang, Yiqiang Ouyang, Qian Mo, Shuting Li, Ping He, Limin Chen, Xinchun Li
Summary: This study presents a facile design and construction of a nanodrug system integrating targeted drug delivery and synergistic chemo-photothermal antitumor activity. The prepared nanocarrier using MoS2 nanosheets modified by alpha(v)beta(3) integrin binding peptide (RGD) and thiolated doxorubicin (DOX) showed favorable stability, biocompatibility, and photothermal conversion efficiency. The nanodrug exhibited targeted delivery to Hela cells and significantly reduced cardiotoxicity compared to free DOX, demonstrating powerful photothermal induced tumor-killing efficacy.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lei Zhang, Yidong Li, Chaohua Hu, Yangmin Chen, Zhuo Chen, Zhe-Sheng Chen, Jian-Ye Zhang, Shuo Fang
Summary: This study reveals CDK6-PI3K as a novel target signaling axis to reverse ABCB1-mediated multidrug resistance for the first time in cancers. Deficiency of CDK6 leads to downregulation of ABCB1 expression and reversal of multidrug resistance.
Article
Pharmacology & Pharmacy
Lei Zhang, Biwei Ye, Yunfeng Lin, Yi-Dong Li, Jing-Quan Wang, Zhuo Chen, Feng-Feng Ping, Zhe-Sheng Chen
Summary: In this study, the researchers investigated the effect of the CDK4/6 inhibitor, ribociclib, on multidrug resistance (MDR) mediated by P-glycoprotein (P-gp) in human epidermoid carcinoma cells. They found that ribociclib increased the efficacy of a P-gp substrate drug, colchicine, by down-regulating the expression of P-gp and increasing its ATPase activity. Docking studies suggested that ribociclib interacted with the drug-substrate binding site of P-gp. Additionally, ribociclib inhibited the drug efflux activity of P-gp, leading to increased intracellular accumulation of doxorubicin. These findings suggest that ribociclib may be a potential agent for combined therapy in cancers with P-gp-mediated MDR.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Douglas K. Pleskow, Mandeep S. Sawhney, Paul K. Upputuri, Tyler M. Berzin, Mark F. Coughlan, Umar Khan, Maria Glyavina, Xuejun Zhang, Liming Chen, Conor J. Sheil, Jonah M. Cohen, Edward Vitkin, Yuri N. Zakharov, Irving Itzkan, Lei Zhang, Le Qiu, Lev T. Perelman
Summary: Bile duct cancer is a common type of liver cancer, often diagnosed in late stages resulting in poor survival rates. A reliable technique for detecting pre-cancerous changes in the bile duct is urgently needed. This study presents an endoscopic light scattering technique that can accurately evaluate the malignant potential of the bile duct. The technique showed high accuracy in detecting malignant transformation in a pilot study, indicating its potential for non-invasive in vivo identification of biliary duct pre-cancer.
NATURE COMMUNICATIONS
(2023)
Article
Integrative & Complementary Medicine
Juntao Li, Yue Wu, Xinxin Yu, Xinyu Zheng, Jiechen Xian, Senjie Li, Wanyin Shi, Yun Tang, Zhe-Sheng Chen, Guixia Liu, Shen Yao, Jian Xu, Xiangwei Zheng
Summary: This study revealed for the first time the pharmacodynamic mechanism of 8-isopentenyl flavonoids in Epimedium sagittatum Maxim. for treating erectile dysfunction (ED), and identified several compounds with significant inhibitory activities and the ability to activate cellular signaling pathways.
Review
Chemistry, Multidisciplinary
Yanyan Wang, Limin Chen, Siyang Li, Luhua Lai
Summary: Biomolecular condensates, formed as membraneless organelles, have diverse biological functions and are associated with diseases. Understanding the roles of intrinsically disordered proteins in their formation and regulation can guide the design of novel drugs.
PROGRESS IN CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yuhai Sun, Junliang Wu, Yaolin Wang, Jingjing Li, Ni Wang, Jonathan Harding, Shengpeng Mo, Limin Chen, Peirong Chen, Mingli Fu, Daiqi Ye, Jun Huang, Xin Tu
Summary: The reaction pathways of plasma-enhanced catalytic CO2 hydrogenation were investigated in this study. Placing Pd/ZnO in a DBD reactor under plasma environment significantly improved the conversion of CO2 and the yield of CO. In the Plasma + ZnO system, CO2 splitting played an important role in the conversion of CO2.
Meeting Abstract
Medicine, Research & Experimental
Giuseppe Pettinato, Mark F. Coughlan, Xuejun Zhang, Liming Chen, Maria Glyavina, Yuri N. Zakharov, Lei Zhang, Le Qiu, Robert A. Fisher, Lev T. Perelman
XENOTRANSPLANTATION
(2021)
Article
Medicine, Research & Experimental
Wei Chong, Liang Shang, Jin Liu, Zhen Fang, Fengying Du, Hao Wu, Yang Liu, Zhe Wang, Yang Chen, Shengtao Jia, Liming Chen, Leping Li, Hao Chen
Summary: Recent studies have shown that m(6)A modification is significantly associated with TME diversity, and different m(6)A modification patterns in colon cancer are correlated with distinct clinical outcomes and biological pathways.
Review
Biochemistry & Molecular Biology
Liming Chen, Yifan Bao, Suzhen Jiang, Xiao-bo Zhong