Article
Medicine, General & Internal
Joohyun Woo, Hyeonkyeong Kim, Hyungju Kwon
Summary: Multifocality is an independent predictor of recurrence in PTC patients, closely associated with high-risk features. Patients with multifocal PTC may require more judicious treatment and follow-up.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Hyeji Kim, Hyungju Kwon
Summary: This study demonstrated that patients with bilateral thyroid cancer have a more aggressive disease and higher recurrence rates. Careful treatment and follow-up approaches are required for patients with bilateral thyroid cancer.
Article
Oncology
Ri Sa, Rui Liang, Xian Qiu, Ziyan He, Zhiyan Liu, Libo Chen
Summary: In this study, it was found that IGF2BP2 plays a role in promoting the dedifferentiation of RR-PTC by binding to the m6A modification site of the RUNX2 gene and enhancing its stability. High expression of IGF2BP2 is associated with I-131 nonavidity in metastatic PTCs. Targeting IGF2BP2 can increase I-125 uptake and enhance the expression of the sodium/iodide symporter (NIS) in RR-PTC cells. Therefore, IGF2BP2 can serve as a diagnostic marker for RR-PTC and may be targeted for differentiation therapy.
Article
Oncology
Hyeji Kim, Hyungju Kwon, Byung-In Moon
Summary: Men with papillary thyroid carcinoma do not have an increased risk of recurrence compared to women, despite having more aggressive disease. The impact of sex on recurrence is not associated with tumor size or patient age.
Article
Chemistry, Multidisciplinary
Qinglin Li, Lizhuo Zhang, Jiayan Lang, Zhuo Tan, Qingqing Feng, Fei Zhu, Guangna Liu, Zhangguo Ying, Xuefei Yu, He Feng, Heqing Yi, Qingliang Wen, Tiefeng Jin, Keman Cheng, Xiao Zhao, Minghua Ge
Summary: This research developed a new nanoparticle (LPm NP) that efficiently delivers mRNA to increase NIS expression in anaplastic thyroid cancer (ATC) cells. In vivo studies show that intratumoral injection of NIS mRNA formulated in optimized LPm NP significantly increases NIS expression in ATC tumor tissue, resulting in increased iodine 131 accumulation and significant inhibition of tumor growth.
Article
Oncology
Joonseon Park, Solji An, Kwangsoon Kim, Ja Seong Bae, Jeong Soo Kim
Summary: BRAF(V600E) positivity is associated with increased aggressiveness of papillary thyroid cancer (PTC). Younger patients with BRAF(V600E)-positive PTC have a higher risk of recurrence compared to older patients.
Article
Medicine, General & Internal
Chiara Offi, Claudia Misso, Giovanni Antonelli, Maria Grazia Esposito, Umberto Brancaccio, Stefano Spiezia
Summary: The study analyzed 10 patients with lymph node recurrence in the laterocervical compartment after total thyroidectomy. All patients underwent a single laser ablative session with no reported complications and showed significant reduction in lymph node volume during follow-up.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Jelena Lukovic, Irina Petrovic, Zijin Liu, Susan M. Armstrong, James D. Brierley, Richard Tsang, Jesse D. Pasternak, Karen Gomez-Hernandez, Amy Liu, Sylvia L. Asa, Ozgur Mete
Summary: The study aimed to review the clinicopathologic characteristics, outcome, and RAI use in patients with oncocytic papillary thyroid carcinoma and oncocytic poorly differentiated thyroid carcinoma. Patients with oncocytic PTC showed excellent clinical outcomes and similar risk factors for recurrence as non-oncocytic counterparts, while oncocytic PDTC patients exhibited a higher frequency of DM and lower RAI uptake.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Na Lae Eun, Jeong-Ah Kim, Hye Mi Gweon, Ji Hyun Youk, Eun Ju Son
Summary: This study investigated whether ultrasound imaging features can serve as prognostic markers for predicting recurrence in patients with N1b papillary thyroid carcinoma (PTC), and found that preoperative ultrasound features, including lymph node size and hyperechogenicity, may be valuable in predicting recurrence.
Review
Oncology
Di Ou, Chen Chen, Tian Jiang, Dong Xu
Summary: Clinical studies have shown that thermal ablation treatment has certain efficacy and safety for thyroid cancer. However, further research is needed to verify the effectiveness and long-term outcomes of this treatment method due to the slow growth of thyroid cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Dongmei Huang, Jingtai Zhi, Jinming Zhang, Xuan Qin, Jingzhu Zhao, Xiangqian Zheng, Ming Gao
Summary: This study aimed to investigate the relationship between clinicopathological features, prognosis, and preoperative thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) status in children and adolescents with papillary thyroid carcinoma (PTC). The results showed that the presence of preoperative TPOAb and TgAb could serve as novel prognostic factors for predicting recurrence of PTC in children.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Sandeep Kumar Parvathareddy, Abdul K. Siraj, Padmanaban Annaiyappanaidu, Nabil Siraj, Saif S. Al-Sobhi, Fouad Al-Dayel, Khawla S. Al-Kuraya
Summary: This study retrospectively analyzed 1283 patients with papillary thyroid carcinoma (PTC) and found a high incidence of bilateral multifocality. Bilateral multifocality was closely associated with clinical pathological characteristics such as age, gender, tumor size, and lymph node metastasis. It was also identified as an independent predictor of PTC recurrence. Therefore, patients with bilateral multifocal PTC may benefit from more frequent follow-up to detect recurrences earlier.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Surgery
Jordan Reilly, Erfan Faridmoayer, Morta Lapkus, Jacquelyn Pastewski, Fionna Sun, Heba Elassar, Diane M. Studzinski, Rose E. Callahan, Peter Czako, Sapna Nagar
Summary: This study found that vascular invasion in Papillary Thyroid Carcinoma (PTC) is associated with other aggressive pathologic features and a higher recurrence rate. Therefore, vascular invasion should be considered as an important tumor characteristic when determining the extent of treatment.
AMERICAN JOURNAL OF SURGERY
(2022)
Article
Oncology
Jessica Limberg, Yeon J. J. Lee-Saxton, Caitlin E. E. Egan, AlAnoud AlAnazi, Imaani Easthausen, Dessislava Stefanova, Alexia Stamatiou, Toni Beninato, Rasa Zarnegar, Theresa Scognamiglio, Thomas J. J. Fahey III, Brendan M. M. Finnerty
Summary: This study found that perineural invasion (PNI) is associated with aggressive behavior, increased locoregional recurrence, and decreased survival in papillary thyroid cancer (PTC). Patients with PNI had higher rates of lymphovascular invasion and nodal metastasis, as well as poorer prognosis.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Surgery
Dharmesh Patel, Richard A. Prinz, Reilly
Summary: This study reveals that vascular invasion in Papillary Thyroid Carcinoma (PTC) is associated with other aggressive pathological features and an increased recurrence rate, suggesting that vascular invasion should be considered as an important factor in determining the extent of treatment.
AMERICAN JOURNAL OF SURGERY
(2022)
Article
Endocrinology & Metabolism
Aline Machado Larcher de Almeida, Ricardo Luiz Costantin Delfim, Ana Paula Aguiar Vidal, Maria Clara d'Araujo Couto Martins Chaves, Ana Carolina Lopes Santiago, Marcos Feijo Gianotti, Manuel Domingos da Cruz Goncalves, Mario Vaisman, Denise Pires de Carvalho, Patricia de Fatima dos Santos Teixeira
Summary: The study evaluated the cancer risk of indeterminate thyroid nodules by considering both cytological subcategories and the American Thyroid Association (ATA)-based US risk classification. The highest RoM was related to nuclear atypia (NA) and both architectural and nuclear atypia (ANA) subcategories, while architectural atypia (AA) and oncocytic pattern (OP) had lower RoM. NA and ANA were independently associated with cancer, as were high and intermediate-risk US categories according to ATA. The presence of NA or ANA combined with intermediate US patterns had high RoM values, and combining cytological features with high-risk US categories resulted in RoM exceeding 70%.
Article
Cardiac & Cardiovascular Systems
Raphael Braz Levigard, Henrique Serrao, Camille Castro, Priscila Matos, Fernanda Mattos, Eduardo Madeira, Camila Ludke Rosseti, Denise Pires de Carvalho, Joana Rodrigues Dantas, Lenita Zajdenverg, Miguel Madeira
Summary: Bariatric arterial embolization (BAE) was found to be effective in reducing weight, insulin resistance, and ghrelin levels, as well as improving quality of life and binge eating symptoms in adults with class I and II obesity and metabolic syndrome. The procedure was also safe, with only minor complications observed in a small number of participants, such as gastric ulcers and asymptomatic arterial thrombus.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2021)
Article
Neurosciences
Renee de Caldas Honorato, Alex Soares Marreiros Ferraz, Witalo Kassiano, Denise Pires Carvalho, Vania Marilande Ceccatto
Summary: The study found high to excellent reliability in EIM components for assessing hamstring muscle tissue, with the exception of reactance which had MDC ranging from 2.0 to 10.8. This indicates that EIM technique is reliable for evaluating muscle tissue changes and adaptations in clinical and applied contexts.
JOURNAL OF ELECTROMYOGRAPHY AND KINESIOLOGY
(2021)
Article
Cell Biology
Leonardo Matta, Tulio S. Fonseca, Caroline C. Faria, Niedson Correia Lima-Junior, Dahienne F. De Oliveira, Leonardo Maciel, Luiz F. Boa, Ana Paola T. R. Pierucci, Andrea C. F. Ferreira, Jose H. M. Nascimento, Denise P. Carvalho, Rodrigo S. Fortunato
Summary: Research indicates that a single bout of aerobic exercise has significant effects on the redox homeostasis, mitochondrial metabolism, and cytoprotective gene expression of white adipose tissue. Immediate and 30-minute post-exercise groups showed higher NADPH oxidase activity and extramitochondrial ROS production, along with an increase in mitochondrial respiration and decrease in ATP production. Antioxidant enzyme activity was reduced, while oxidative stress biomarkers exhibited transient changes, and aerobic exercise led to an upregulation of cytoprotective gene expression.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Environmental Sciences
Niedson Correia de Lima Junior, Juliana Franco Camilo, Pamella Rodrigues do Carmo, Marcelle Novaes de Andrade, Bernardo Ferreira Braz, Ricardo Erthal Santelli, Lycia de Brito Gitirana, Andrea Claudia Freitas Ferreira, Denise Pires de Carvalho, Leandro Miranda-Alves, Glaecir Roseni Mundstock Dias
Summary: Subacute exposure to lead acetate disrupts thyroid gland function in both sexes, leading to changes in learning and memory abilities.
ENVIRONMENTAL POLLUTION
(2021)
Review
Biochemistry & Molecular Biology
Jessica Bouviere, Rodrigo S. Fortunato, Corinne Dupuy, Joao Pedro Werneck-de-Castro, Denise P. Carvalho, Ruy A. Louzada
Summary: Physical exercise induces acute and adaptative responses at the cellular and systemic levels through the modulation of various signaling pathways in skeletal muscle. Antioxidants can blunt these adaptations, highlighting the crucial role of ROS in exercise. Understanding the balance between beneficial and harmful effects of ROS during and after exercise is a challenging question in exercise biology.
Article
Biochemistry & Molecular Biology
Paula Rodrigues-Pereira, Marcelle Novaes Andrade, Ana Paula Santos-Silva, Mariana Pires Teixeira, Paula Soares, Jones Bernardes Graceli, Denise Pires de Carvalho, Glaecir Roseni Mundstock Dias, Andrea Claudia Freitas Ferreira, Leandro Miranda-Alves
Summary: TBT, an endocrine disruptor, has subacute effects on the HPT axis in male and female rats. TBT exposure leads to thyroid alterations and different toxicological effects in male and female rats.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Juliana Cazarin, Corinne Dupuy, Denise Pires de Carvalho
Summary: Radioiodine therapy is a standard and effective treatment for differentiated thyroid cancers, but some patients develop resistance to this treatment due to cell dedifferentiation leading to NIS repression. Oxidative stress may play a crucial role in thyroid cancer, affecting NIS expression and function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Caroline Coelho de Faria, Fabio Hecht Castro Medeiros, Juliana Cazarin Menezes, Victor Hugo Ortenzi de Andrade Silva, Andrea Claudia Freitas Ferreira, Denise Pires de Carvalho, Rodrigo Soares Fortunato
Summary: Thyroid diseases are more common in women, and this may be related to the higher levels of oxidative stress found in the thyroid of females. The study found that TGF-131 treatment increased ROS generation, NOX4 expression, and reduced antioxidant enzyme activities in rat thyroid cells. Moreover, estrogen was found to enhance TGF-131 expression. These findings suggest that the higher levels of TGF-131 in females may contribute to the sex disparity in thyroid disorders.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Cell Biology
Marcelle Novaes Andrade, Francisca Diana Melo-Paiva, Mariana Pires Teixeira, Niedson Correia de Lima-Junior, Paula Soares, Jones Bernardes Graceli, Denise Pires de Carvalho, Eduardo Andres Rios Morris, Andrea Claudia Freitas Ferreira, Leandro Miranda-Alves
Summary: The present study found that exposure to TBT can induce oxidative stress in the thyroid gland, increasing the expression of thyroperoxidase and reducing the activity of antioxidant enzymes. Some of these effects may be mediated by the estrogen receptor alpha pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Nelson do Rosario Caldas, Valeria Bender Braulio, Marco Antonio Alves Brasil, Valeria Cristina Soares Furtado, Denise Pires de Carvalho, Ervin Michelstaedter Cotrik, Joana Rodrigues Dantas, Lenita Zajdenverg
Summary: Individuals with obesity and BED exhibit greater psychiatric comorbidity, worse eating patterns, and a worse inflammatory profile compared to those without BED. BED should be assessed as an indicator of clinical severity in patients with obesity.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Leonardo Matta, Caroline Coelho de Faria, Dahienne F. De Oliveira, Iris Soares Andrade, Niedson Correia Lima-Junior, Bianca Martins Gregorio, Cristina Maeda Takiya, Andrea Claudia Freitas Ferreira, Jose Hamilton M. Nascimento, Denise Pires de Carvalho, Alexander Bartelt, Leonardo Maciel, Rodrigo Soares Fortunato
Summary: The study reveals that chronic exercise improves redox homeostasis and mitochondrial function in white adipose tissue, leading to enhanced antioxidant capacity. This hormetic remodeling of adipocyte redox balance is directly associated with the beneficial effects of exercise.
Review
Endocrinology & Metabolism
Camila Ludke Rossetti, Juliana Cazarin, Fabio Hecht, Fabyan Esberard de Lima Beltrao, Andrea Claudia Freitas Ferreira, Rodrigo Soares Fortunato, Helton Estrela Ramos, Denise Pires de Carvalho
Summary: COVID-19 is not only a respiratory disease, but can also affect organs such as the thyroid gland. Patients with controlled hypothyroidism and hyperthyroidism do not have a higher risk or worse prognosis when infected with COVID-19. However, abnormal thyroid function has been observed in COVID-19 patients during and after recovery. Further studies are needed to understand the cellular and molecular mechanisms of thyroid dysfunction induced by COVID-19.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Mariana Pires Teixeira, Natalia Ferreira Haddad, Eliza Freitas Passos, Marcelle Novaes Andrade, Maria Luisa Arantes Campos, Joyle Moreira Carvalho da Silva, Camila Saggioro de Figueiredo, Elizabeth Giestal-de-Araujo, Denise Pires de Carvalho, Leandro Miranda-Alves, Luciana Souza de Paiva
Summary: In this study, the effects of ouabain on human anaplastic thyroid carcinoma cells were evaluated. The results showed that ouabain may reduce the viability and migratory ability of 8505C cells by inhibiting proliferation. However, the treated cells still maintained an aggressive and undifferentiated profile.
