Review
Obstetrics & Gynecology
Ke Zhu, Yuke Tian, Xiaomei Dong, Babatunde O. Akinwunmi, Casper J. P. Zhang, Jian Huang, Wai-kit Ming
Summary: The study found that the implementation of bivalent, quadrivalent and nine-valent HPV vaccination for adolescent girls was cost-effective in both high-income countries and regions and low- and middle-income countries and regions in Asia.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Public, Environmental & Occupational Health
Yu Liu, Zhiqiang Li, Li Yuan, Fang Liu, Kailang Wu, Xuan Xiao, Chengliang Zhu
Summary: This study investigated the status of HPV infection and genotypic characteristics in China under the age-expansion of the nine-valent HPV vaccination policy. The results showed a high and increasing HPV positivity rate, and the age-expansion of the vaccine would contribute to reducing the threat of disease. Attention should also be paid to HPV screening in males and opening up vaccination when appropriate.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Immunology
Laureen Majed, Xavier Bresse, Nadia El Mouaddin, Aurelie Schmidt, Vincent J. Daniels, Andrew Pavelyev, Laurie Levy-Bachelot, Elamin Elbasha
Summary: The study evaluated the public health impact and cost-effectiveness of a 9-valent gender-neutral HPV vaccination compared with a girls-only vaccination program in France. Results showed that the gender-neutral vaccination program had significant advantages in preventing HPV-related diseases and may be cost-effective at both low and high coverage rates.
Article
Health Care Sciences & Services
Rita Reyburn, Evelyn Tuivaga, Tupou Ratu, Seruwaia Young, Suzanne M. Garland, Gerald Murray, Alyssa Cornall, Sepehr Tabrizi, Cattram D. Nguyen, Kylie Jenkins, Lisi Tikoduadua, Joseph Kado, Mike Kama, Eric Rafai, Rachel Devi, Kim Mulholland, James Fong, Fiona M. Russell
Summary: Fiji vaccinated >30,000 girls aged 9-12 with 4vHPV vaccine in 2008/9, and the vaccine coverage was >60%. The vaccine effectiveness of one, two, and three doses of 4vHPV against oncogenic HPV genotypes 16/18 eight years later was 81%, 100%, and 89% respectively.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Immunology
Orsolya Rideg, Timea Dergez, Kornelia Farkas, Krisztina Kovacs, Endre Kalman, Tamas Tornoczky, Angela Oszter
Summary: This study compared the HPV genotypes in cytological and FFPE specimens of women diagnosed with HSIL. The results showed a high agreement in HPV genotypes between the two sample types, but multi-infections were more common in cytological specimens while single infections were more common in FFPE specimens. Additionally, nonavalent vaccinated type (VT) HPVs and non-nonavalent VT HPVs were both found in HSIL cases, highlighting the importance of vaccine development.
Article
Public, Environmental & Occupational Health
Chenxi Li, Thomas G. Hall, John J. Hall, Wen-Qiang He
Summary: This study assessed the effectiveness of HPV vaccine against both vaccine-type and non-vaccine-type high-risk HPV infection in the United States. The results showed that the vaccine was 58% effective against vaccine-type HPV infection and 47% effective against non-vaccine-type hrHPV infection. The study also found a significant reduction in the prevalence of diagnosed cervical cancer among vaccinated individuals.
EPIDEMIOLOGY AND INFECTION
(2023)
Review
Oncology
Janne Bigaard, Silvia Franceschi
Summary: Efforts to globally eliminate cervical cancer caused by HPV are underway, with high vaccination coverage being crucial. Successful public HPV vaccination programs in Italy and Denmark highlight the importance of overcoming challenges in maintaining recommended coverage levels.
MOLECULAR ONCOLOGY
(2021)
Article
Immunology
Rosa De Vincenzo, Nicola Caporale, Valentina Bertoldo, Caterina Ricci, Maria Teresa Evangelista, Nicolo Bizzarri, Luigi Pedone Anchora, Giovanni Scambia, Giovanni Capelli
Summary: This study evaluated the effect of 9-valent HPV vaccination on HPV and cytological test results in adult women. The results showed a significant reduction in clearance time for HPV HR+ and Pap positivity in women who received the third dose of the vaccine.
Article
Immunology
T. Shato, S. Humble, A. Anandarajah, A. Barnette, H. M. Brandt, J. Garbutt, L. Klesges, V. S. Thompson, M. I. Silver
Summary: This study examined the association between sociodemographic characteristics, HPV vaccination hesitancy, and HPV vaccination coverage in five US states. The results showed that age, sex, and parental vaccine hesitancy were significantly associated with the likelihood of HPV vaccination in low coverage areas.
Article
Oncology
Martin Garset-Zamani, Amanda F. Carlander, Kathrine K. Jakobsen, Jeppe Friborg, Katalin Kiss, Rasmus L. Marvig, Caroline Olsen, Finn C. Nielsen, Elo Andersen, Christian Gronhoj, Christian von Buchwald
Summary: This study investigated the impact of HPV genotypes on survival in HPV+ OPSCC patients. Results showed no significant difference in survival between HPV16 and non-HPV16 genotypes, but patients with other genotypes had worse survival outcomes. Genotyping in OPSCC may be interesting from an epidemiological perspective and in vaccination programs, but is not necessary for prognostication of HPV+ OPSCC.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Immunology
Clara Fappani, Silvia Bianchi, Donatella Panatto, Fabio Petrelli, Daniela Colzani, Stefania Scuri, Maria Gori, Antonella Amendola, Iolanda Grappasonni, Elisabetta Tanzi, Daniela Amicizia
Summary: This study investigated the prevalence of HPV infection in Italian individuals aged 18-40 years. Results showed a higher infection rate in females compared to males, with a decrease in vaccine types and circulating genotypes observed after 10 years. The importance of monitoring HPV infection in both genders for assessing the effectiveness of vaccination programs was emphasized.
Article
Virology
Alka Suresh, Parasmal Suresh, Raja Biswas, Anupama Rajanbabu, Sarala Sreedhar, Lalitha Biswas
Summary: The prevalence of high-risk HPV (hrHPV) genotypes, especially HPV16 and HPV33, was found to be significantly higher in Kerala compared to other HPV types. As the bivalent and quadrivalent vaccines offer limited protection against HPV33, the nonavalent vaccine would be more effective in preventing cervical carcinoma in Kerala.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Immunology
Eliana M. Wendland, Natalia Luiza Kops, Marina Bessel, Juliana Comerlato, Ana Goretti Kalume Maranhao, Flavia Moreno Alves Souza, Luisa Lina Villa, Gerson Fernando Mendes Pereira
Summary: The study demonstrated the effectiveness of HPV vaccination in Brazil, with higher vaccination rates among younger women and those from higher socioeconomic status. The use of quadrivalent vaccine significantly reduced HPV infection rates, particularly for HPV 6 and 16.
Article
Immunology
Gustavo Hermes Soares, Sneha Sethi, Joanne Hedges, Lisa Jamieson
Summary: This ecological study examined the geographic patterns in HPV vaccination rates among 15-year-old boys and girls in Australia and explored the contextual factors that may explain the variations in vaccination coverage. The results highlighted the importance of socioeconomic and education factors as predictors for HPV vaccination rates, with significant spatial heterogeneity identified across regions.
Article
Immunology
Smita Joshi, Devasena Anantharaman, Richard Muwonge, Neerja Bhatla, Gitika Panicker, Julia Butt, Usha Rani Reddy Poli, Sylla G. Malvi, Pulikkottil O. Esmy, Eric Lucas, Yogesh Verma, Anand Shah, Eric Zomawia, Sharmila Pimple, Kasturi Jayant, Sanjay Hingmire, Aruna Chiwate, Uma Divate, Shachi Vashist, Gauravi Mishra, Radhika Jadhav, Maqsood Siddiqi, Subha Sankaran, Thiraviam Pillai Rameshwari Ammal Kannan, Purnima Kartha, Surendra S. Shastri, Catherine Sauvaget, M. Radhakrishna Pillai, Tim Waterboer, Martin Mueller, Peter Sehr, Elizabeth R. Unger, Rengaswamy Sankaranarayanan, Partha Basu
Summary: The recent WHO recommendation on single-dose HPV vaccine can reduce costs, alleviate supply shortages, and simplify logistics, making it more accessible for low- and middle-income countries. This study examines the long-term immune response and compares it with unvaccinated women, showing sustained immune response in single-dose recipients at 10 years post-vaccination.
Article
Engineering, Environmental
B. Markiv, L. Ruiz-Azcona, A. Exposito, M. Santibanez, I Fernandez-Olmo
Summary: This study assessed the environmental exposure to metal(loid)s near a ferromanganese alloy plant and found that people living closer to the plant are exposed to higher levels of metal(loid)s, particularly manganese, which may affect neurological outcomes. The study also concluded that scalp hair and fingernails can serve as suitable biomarkers of long-term manganese exposure.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2022)
Article
Medicine, General & Internal
Manuel Herrero-Montes, Cristina Alonso-Blanco, Maria Paz-Zulueta, Amada Pellico-Lopez, Laura Ruiz-Azcona, Carmen Sarabia-Cobo, Victor Fradejas-Sastre, Ester Boixadera-Planas, Paula Paras-Bravo
Summary: Binge drinking is a common practice among college students. This study aimed to analyze the relationship between binge drinking and depressive symptoms and personality traits in university students. The results showed that binge drinking students had higher levels of extraversion and lower levels of conscientiousness compared to non-binge drinking students. However, there were no significant differences in the level of depressive symptoms between the two groups.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
David Ruiz, Miguel Santibanez, Bernardo Alio Lavin, Ana Berja, Coral Montalban, Luis Alberto Vazquez
Summary: The study aimed to investigate the evolution of mitochondrially derived peptides (MDPs) and their relationship with changes in insulin sensitivity in pregnant women during early stages of pregnancy. The levels of MDPs (humanin and MOTSc) were found to significantly decrease from the first to the second trimesters. The study also revealed a significant association between changes in MOTSc levels and insulin resistance, suggesting its involvement in the increase of insulin resistance during early pregnancy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Jose Tuells, Monica Parra-Grande, Francisco J. Santos-Calle, Ana C. Montagud, Cecilia M. Egoavil, Celia Garcia-Rivera, Pablo Caballero, Eva M. Gabaldon-Bravo, Juan Carlos Rodriguez-Diaz, Jose Antonio Hurtado-Sanchez
Summary: This study investigated the presence of neutralizing antibodies against SARS-CoV-2 among healthcare workers in a hospital in Alicante, Spain, and compared the efficiency of a rapid diagnostic test to an ELISA viral neutralization test. The rapid test demonstrated high specificity and sensitivity, and individuals immunized with the BioNTech/Pfizer vaccine maintained optimal levels of neutralizing antibodies after six months. The use of this rapid test could be a potential tool in population-based studies to detect antibody responses to vaccination and guide vaccination policies for high-risk populations.
Article
Infectious Diseases
Celia Garcia-Rivera, Monica Parra-Grande, Esperanza Merino, Vicente Boix, Juan C. Rodriguez
Summary: Our study evaluates the effectiveness of FilmArray Blood Culture Identification Panel 2 in rapid bacteremia diagnosis. The results show higher concordance in detecting monomicrobial bacteremia compared to polymicrobial bacteremia. Additionally, the methodology has a high concordance in detecting bacterial resistance mechanisms.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2022)
Article
Anesthesiology
Cesar Fernandez-de-las-Penas, Paula Paras-Bravo, Diego Ferrer-Pargada, Ignacio Cancela-Cilleruelo, Jorge Rodriguez-Jimenez, Jo Nijs, Lars Arendt-Nielsen, Manuel Herrero-Montes
Summary: This study investigated the association between various variables and Central Sensitization Inventory (CSI) in previously hospitalized COVID-19 survivors experiencing post-COVID pain. The results showed that psychological and cognitive variables, such as anxiety levels and pain intensity, were independently associated with CSI scores. This suggests a significant overlap with psychological constructs and indicates important changes in pain processing for managing post-COVID pain.
Article
Biology
Irving Cancino-Munoz, Mariana G. Lopez, Manuela Torres-Puente, Luis M. Villamayor, Rafael Borras, Maria Borras-Manez, Montserrat Bosque, Juan J. Camarena, Caroline Colijn, Ester Colomer-Roig, Javier Colomina, Isabel Escribano, Oscar Esparcia-Rodriguez, Francisco Garcia-Garcia, Ana Gil-Brusola, Concepcion Gimeno, Adelina Gimeno-Gascon, Barbara Gomila-Sard, Damiana Gonzales-Granda, Nieves Gonzalo-Jimenez, Maria Remedios Guna-Serrano, Jose Luis Lopez-Hontangas, Coral Martin-Gonzalez, Rosario Moreno-Munoz, David Navarro, Maria Navarro, Nieves Orta, Elvira Perez, Josep Prat, Juan Carlos Rodriguez, Ma Montserrat Ruiz-Garcia, Hermelinda Vanaclocha, Inaki Comas
Summary: Transmission is a driver of tuberculosis (TB) epidemics in high-burden regions, with assumed negligible impact in low-burden areas. However, we still lack a full characterization of transmission dynamics in settings with similar and different burdens. Genomic epidemiology can greatly help to quantify transmission, but the lack of whole genome sequencing population-based studies has hampered its application.
Article
Geriatrics & Gerontology
Monica Cueli Arce, Miguel Santibanez, Carmen Sarabia, Paula Paras-Bravo, Marta Gomez, Ana Rosa Alconero-Camarero
Summary: This study aimed to develop a transcultural adaptation of a caregiving appraisal scale among Spanish caregivers of dependent older people and examine its psychometric properties. The Spanish version of the scale was found to be valid and reliable, allowing for the assessment of both negative and positive perceptions among family caregivers of older dependent people.
INTERNATIONAL JOURNAL OF OLDER PEOPLE NURSING
(2023)
Article
Genetics & Heredity
Laura Lorenzo-Rebenaque, Cristina Casto-Rebollo, Gianfranco Diretto, Sarah Frusciante, Juan Carlos Rodriguez, Maria-Paz Ventero, Carmen Molina-Pardines, Santiago Vega, Clara Marin, Francisco Marco-Jimenez
Summary: This study investigated the impact of preventive therapy with bacteriophages on the microbiota in broilers, finding minimal alterations in the caecal microbiota but significant impacts on metabolites, regardless of the administration route. High-throughput sequencing and metabolomics analyses revealed changes in microbial diversity and metabolite composition after phage challenge, indicating a potential influence of bacteriophage therapy on gut health in poultry.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Monge-Garcia Victoria, Adelina Gimeno-Gascon, Maria Paz Ventero, Jose M. Climent-Barbera, Francisco Cholbi-Llobell, Juan Carlos Rodriguez, Elena Bano-Ruiz, Miguel Angel Caminero-Canas, Sergio Reus-Banuls
Summary: This study compares four methods to detect a possible infection of C. acnes in surgical disc samples. The results show that C. acnes was isolated from 5 out of 23 patient samples through culture. However, the genome of C. acnes could not be detected through Sanger sequencing, but qPCR and NGS were able to detect very few copies of the genome in all samples. The study suggests that C. acnes is likely a contamination from the skin microbiome and not associated with the clinical process.
Letter
Microbiology
Celia Garcia-Rivera, Isabel Escribano, Esperanza Merino, Juan Carlos Rodriguez
REVISTA ESPANOLA DE QUIMIOTERAPIA
(2023)
Article
Nursing
A. Fernandez-Feito, Y. Valcarcel-Alvarez, E. Andina-Diaz, P. Paras-Bravo, J. Diaz-Alonso, E. Garcia-Cueto, A. Lana
Summary: This study aimed to investigate the contributions of nursing students in clinical settings based on the perceptions of nurse preceptors. The findings showed that 70.7% of nurse preceptors considered the contributions of nursing students to be favorable, as they support the development of nurses' teaching role and serve as a link between the healthcare institution and the university. Furthermore, certain professional characteristics of Registered Nurses were associated with a positive perception of nursing students' contributions.
NURSE EDUCATION IN PRACTICE
(2023)
Article
Medicine, General & Internal
Manuel Herrero-Montes, Cesar Fernandez-de-las-Penas, Diego Ferrer-Pargada, Sheila Izquierdo-Cuervo, Beatriz Abascal-Bolado, Juan Antonio Valera-Calero, Paula Paras-Bravo
Summary: A study investigated variables associated with kinesiophobia in COVID-19 survivors with post-COVID pain. It found that anxiety, depression, sleep quality, catastrophism, and sensitization-associated symptoms were positively associated with kinesiophobia. Catastrophism and sensitization-associated symptoms were predictive factors for kinesiophobia, highlighting the importance of identifying high-risk patients for better therapeutic strategies.
Article
Biochemistry & Molecular Biology
Laura Lorenzo-Rebenaque, Cristina Casto-Rebollo, Gianfranco Diretto, Sarah Frusciante, Juan Carlos Rodriguez, Maria-Paz Ventero, Carmen Molina-Pardines, Santiago Vega, Clara Marin, Francisco Marco-Jimenez
Summary: This study investigated the influence of Salmonella phage on host physiology through caecal microbiota and metabolome modulation. It was found that phage therapy did not affect the diversity of the microbiota, but did cause changes in caecal metabolites. However, these changes had minimal impact on the blood serum and did not result in significant physiological response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Migle Ziemyte, Juan C. Rodriguez-Diaz, Maria P. Ventero-Martin, Alex Mira, Maria D. Ferrer
Summary: This study evaluated the sensitivity of Candida biofilms to two commonly used antifungal drugs and found that currently available antifungals are ineffective against mature biofilms. However, the natural compound andrographolide showed strong inhibitory effects on planktonic growth and biofilm formation of Candida species, and could eliminate mature biofilms, suggesting its potential as a new approach for treating multi-resistant Candida biofilm-related infections.