期刊
BLOOD
卷 131, 期 18, 页码 2001-2006出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2017-11-784108
关键词
-
类别
资金
- National Institutes of Health, National Institute of Neurological Disorders and Stroke [NS087296]
- National Heart, Lung, and Blood Institute [HL119391]
- Natural Science Foundation of China [81330029]
- [81271361]
- [81271359]
Traumatic brain injury (TBI)-induced coagulopathy is a common and well-recognized risk for poor clinical outcomes, but its pathogenesis remains poorly understood, and treatment options are limited and ineffective. We discuss the recent progress and knowledge gaps in understanding this lethal complication of TBI. We focus on (1) the disruption of the brain-blood barrier to disseminate brain injury systemically by releasing brain-derived molecules into the circulation and (2) TBI-induced hypercoagulable and hyperfibrinolytic states that result in persistent and delayed intracranial hemorrhage and systemic bleeding.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据