期刊
BIOSENSORS & BIOELECTRONICS
卷 99, 期 -, 页码 193-200出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2017.07.061
关键词
Shell; Encode; Tunable electroactivity; Amplified currents; Dual screening
类别
资金
- National Natural Science Foundation of China [21403090]
- China Postdoctoral Science Foundation [2015M570405, 2016T90417]
- foundation of Key Lab of Synthetic and Biological Colloids, Ministry of Education, Jiangnan University [JDSJ2015-08, JDSJ2016-01]
- 111 Project [B13025]
The exploration of electroactive labelling with tailorable and strong differential pulse voltammetry (DPV) responses is of great importance in accurate and sensitive screening of a panel of biomarkers related to cancer. Herein, shell-encoded gold nanoparticles (Au NPs) are fabricated and give rise to shell species-dominated DPV peak potentials. Two independent DPV peaks appear at -0.08 V for Au Cu2O core-shell NPs and 0.26 V for Au Ag core-shell NPs. Shell-encoded Au NPs drastically exhibit shell thickness-tunable amplified peak currents. The non-interfering and amplified DPV responses enable shell-encoded Au NPs to be an alternative electrochemical signal amplifier for dual screening of carcinoembryonic antigen (CEA) and alpha-fetoprotein (APP). The limits of detection (LODs) are calculated to be 1.8 pg/mL for CEA and 0.3 pg/mL for AFP. In comparison to the parallel single-analyte assays, shell-encoded Au NPs engineered electrochemical aptasensors offer multiplexing capability and show significant prospects in biomedical research and early diagnosis of diseases.
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