期刊
BIOSENSORS & BIOELECTRONICS
卷 115, 期 -, 页码 53-60出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2018.05.024
关键词
Dopamine; Hematite; Reduced graphene oxide; Direct electrochemical reduction; Self-assembly
类别
资金
- Department of Science and Technology Solar Energy Research Initiative (DST-SERI) [DST/SERI/FR/2016/S 170]
An unusual approach is reported herein to fabricate magnetic hematite (alpha-Fe2O3) decorated electrochemically reduced graphene oxide (alpha-Fe2O3@erGO) nanocomposite. The method utilizes direct electrochemical reduction of self-assembled, ex-situ synthesized alpha-Fe2O3 anchored GO to erGO (alpha-Fe2O3@erGO) on glassy carbon electrode (GCE) for selective detection dopamine (DA), an important biomarker of Parkinson's disease. The formation of alpha-Fe2O3@erGO/GCE has been confirmed by XPS and Raman spectroscopy. alpha-Fe2O3@erGO modified GCE exhibits synergistic catalytic activity nearly 2.2 and 5 fold higher than alpha-Fe2O3@GO and other modified electrodes, respectively towards oxidation of DA. The fabricated sensor exhibited linear dynamic ranges over 0.25 - 100 mu M in response to DA with a LOD of 0.024 mu M (S/N = 3), LOQ of 0.08 mu M (S/N = 10), and a sensitivity of 12.56 mu A mu M-1 cm(-2). Finally, the practical analytical application of the proposed alpha-Fe2O3@erGO/GCE was investigated for the determination of DA in commercially available pharmaceutical formulation and human serum samples, and showed satisfactory recovery results towards DA.
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