Article
Cell Biology
Angela Ianniciello, G. Vignir Helgason
Summary: Minimal residual disease (MRD) is the main cause of relapse in solid cancers and leukemias. In chronic myeloid leukemia (CML), autophagy plays a crucial role in maintaining the survival of drug resistant leukemic stem cells. Inhibition of autophagy-initiating kinase ULK1 could lead to stress-induced differentiation of leukemic stem cells, making them sensitive to drug treatment, providing a promising strategy for selective eradication of leukemic stem cells in CML patients.
Article
Biochemistry & Molecular Biology
Rachid Lahlil, Anne Aries, Maurice Scrofani, Celine Zanetti, Desline Hennequin, Bernard Drenou
Summary: Chronic myeloid leukemia (CML) is a clonal myeloproliferative disease characterized by the presence of the BCR-ABL fusion gene. Treatment with tyrosine kinase inhibitors (TKIs) such as imatinib mesylate (IM) has significantly improved clinical outcomes for CML patients, but IM resistance remains a major challenge. The cause of IM resistance in CML cells is unclear, but additional genetic alterations in leukemic stem cells (LSCs) are a common cause of relapse. A study found that a rare subpopulation of stem cells called very small embryonic-like stem cells (VSELs) in adult CML patients is resistant to IM and less sensitive to apoptosis compared to leukemic hematopoietic stem cells (HSCs). The expression levels of certain miRNAs are also affected in these IM-resistant VSELs, including miR-126 and miR-21, which are involved in LSC leukemia-initiating capacity and growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Zhe Huang, Yan Yang, Xianming Fan, Wenzhe Ma
Summary: In this study, the pharmacological mechanisms of scutellarin for acute myeloid leukemia treatment were identified using network pharmacology and experimental validation. The results revealed the importance of the JNK pathway in scutellarin-mediated AML treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jae Hwan Shin, Anam Rana Gul, Moon Seop Hyun, Chang-Hyung Choi, Tae Jung Park, Jong Pil Park
Summary: In this study, a phage-based electrochemical biosensor was developed for the evaluation of cell apoptosis by detecting caspase-3. The sensor showed good binding affinity and detection limit for caspase-3 detection, and could be used for the diagnosis and prognosis of apoptosis-related diseases.
BIOELECTROCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Hyacinthe Johnson-Ansah, Benjamin Maneglier, Francoise Huguet, Laurence Legros, Martine Escoffre-Barbe, Martine Gardembas, Pascale Cony-Makhoul, Valerie Coiteux, Laurent Sutton, Wajed Abarah, Camille Pouaty, Jean-Michel Pignon, Bachra Choufi, Sorin Visanica, Benedicte Deau, Laure Morisset, Emilie Cayssials, Mathieu Molimard, Stephane Bouchet, Francois-Xavier Mahon, Franck Nicolini, Philippe Aegerter, Jean-Michel Cayuela, Marc Delord, Heriberto Bruzzoni-Giovanelli, Philippe Rousselot
Summary: This study evaluated the value of therapeutic drug monitoring (TDM) in imatinib treatment for patients with chronic myelogenous leukemia. The results showed that TDM strategy significantly increased the plasma concentration of imatinib and improved the treatment outcome for patients.
Review
Biochemistry & Molecular Biology
Rawan Nehme, Rawan Hallal, Maya El Dor, Firas Kobeissy, Fabrice Gouilleux, Frederic Mazurier, Kazem Zibara
Summary: Drug repurposing has shown great potential in cancer treatment, with Acriflavine (ACF) being an FDA approved molecule that has wide-ranging antimicrobial and anticancer effects, especially in Chronic Myeloid Leukemia (CML) therapy.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Spectroscopy
Xiaoyuan Ma, Jingna Zhang, Zhouping Wang
Summary: The study focused on real-time detection of caspase 3 in living cells using a dual-mode nanosensor based on SERS-fluorescence. The sensor showed good linear relationship between caspase 3 and both SERS and fluorescence signals, with a minimum detection limit of 0.001 nM. Activation of caspase 3 was observed in cells stimulated by AFB1, providing detailed information for apoptosis monitoring.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Oncology
Wenwen Zhang, Qian Ma, Bing Long, Zhangyi Sun, Lingling Liu, Dongjun Lin, Minyi Zhao
Summary: In this study, it was found that RUNX3 is a super-enhancer-associated gene highly expressed in AML cells, and its high expression is associated with poor prognosis in AML patients. Knockdown of Runx3 significantly inhibits leukemia progression by inducing DNA damage and apoptosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Raquel Alves, Ana Cristina Goncalves, Joana Jorge, Antonio M. Almeida, Ana Bela Sarmento-Ribeiro
Summary: This study evaluated the therapeutic potential of elacridar, a P-glycoprotein and BCRP inhibitor, in CML cell lines. The results showed that elacridar as monotherapy was not effective, but when combined with imatinib, it could overcome resistance. This provides a new treatment option for overcoming TKI resistance.
Article
Oncology
Fang Cheng, Guolin Yuan, Qiang Li, Zheng Cui, Weiming Li
Summary: This study confirmed the long-term efficacy and safety of imatinib for treating Chinese CML patients. Additionally, it demonstrated the feasibility of imatinib dose reduction and treatment-free remission attempts in patients with sustained stable deep molecular response after years of imatinib treatment in real-life settings.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Fang Cheng, Fang Zeng, Qiang Li, Zheng Cui, Yilin Chen, Weiming Li, Yu Zhang
Summary: This study explores the optimization of imatinib dose in CML patients based on therapeutic drug monitoring (TDM). The results show that imatinib concentration is closely associated with clinical response and adverse reactions. Dose reduction based on TDM is feasible and safe for patients exhibiting optimal response, improving adverse reactions without affecting molecular relapse-free survival rate.
Article
Oncology
Iga Stukan, Marek Gryzik, Grazyna Hoser, Andrew Want, Wioleta Grabowska-Pyrzewicz, Mikolaj Zdioruk, Mariola Napiorkowska, Marcin Cieslak, Karolina Krolewska-Golinska, Barbara Nawrot, Grzegorz Basak, Urszula Wojda
Summary: Chemotherapy is widely used for cancer treatment but often leads to therapy resistance. This study discovered that the novel compound BK124.1 can overcome chemotherapy resistance in chronic myeloid leukemia. BK124.1 showed efficacy in animal and cellular models, targeting multidrug resistant leukemia blasts and cancer stem cells. Future development of BK124.1 could offer a cure for chronic myeloid leukemia and other chemotherapy-resistant cancers.
Article
Biochemistry & Molecular Biology
Giordana Feriotto, Paolo Marchetti, Riccardo Rondanin, Federico Tagliati, Serena Aguzzi, Simone Beninati, Fabio Casciano, Claudio Tabolacci, Carlo Mischiati
Summary: In this study, the bis-ketone moiety of curcumin (CUR) was replaced to obtain more stable derivatives 2 and 22. The evaluation of their chemical-physical characteristics and cell experiments showed that derivatives 2 and 22 had better bioavailability and stability than CUR, and exhibited significant cytotoxicity and pro-apoptotic effects on chronic myeloid leukemia (CML) cells. Moreover, derivative 22 was able to reverse drug resistance in CML cells resistant to imatinib (IM).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Hai-Qun Dong, Shi-Jing Liang, Yu-Ling Xu, Yi Dai, Na Sun, Dong-Hong Deng, Peng Cheng
Summary: The study found that Liproxstatin-1 inhibited the proliferation of K562 leukemia cells and exerted anticancer effects by affecting the cell cycle and apoptotic signaling pathways. Liproxstatin-1 induced cell cycle arrest, apoptosis, and pyroptosis, providing new hope for leukemia treatment.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
Menghan Liu, Lin Yang, Xiaojun Liu, Ziyuan Nie, Xiaoyan Zhang, Yaqiong Lu, Yuxia Pan, Xingzhe Wang, Jianmin Luo
Summary: In this study, it was found that HNRNPH1 is upregulated in CML and correlated with disease progression. Knockdown of HNRNPH1 in CML cells inhibited cell proliferation, promoted apoptosis, and increased sensitivity to imatinib. The HNRNPH1-PTPN6-PI3K/AKT axis plays a critical role in CML tumorigenesis and targeting this pathway may represent a therapeutic approach for CML treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Metallurgy & Metallurgical Engineering
Pei-hao Zhao, Xiao-lan Wu, Yang Liu, Kun-yuan Gao, Sheng-ping Wen, Wu Wei, Li Rong, Hui Huang, Hong Wu, De-jing Zhou, Qian Zhang, Zuo-ren Nie
Summary: The effect of grain morphology and precipitates on the mechanical properties and corrosion behavior of two commercial 7N01 alloys was studied. The study found that the recrystallization degree and distribution of grain boundary precipitates play a role in determining the strength and corrosion resistance of the alloys.
TRANSACTIONS OF NONFERROUS METALS SOCIETY OF CHINA
(2022)
Article
Materials Science, Multidisciplinary
Dongmei Wang, Xiaolan Wu, Kunyuan Gao, Shengping Wen, Hong Wu, Jingwen Qiu, Wu Wei, Hui Huang, Dejing Zhou, Zuoren Nie
Summary: The microstructure, mechanical properties, and tribological properties of Al-Sn-Si alloys with different Mg contents were studied. The Al-12Sn-4Si-1.5 Mg alloy exhibited the smallest grain size, more uniform microstructure, and significantly better wear resistance.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Article
Materials Science, Multidisciplinary
Da Xue, Wu Wei, Wei Shi, Xiaorong Zhou, Li Rong, Shengping Wen, Xiaolan Wu, Peng Qi, Kunyuan Gao, Hui Huang, Zuoren Nie
Summary: In this study, an artificial neural network (ANN) was used to predict the hot deformation behavior of Al-Mg-Zn alloys containing small amounts of Er and Zr. A comparative study between experimental and computational results showed that the ANN model outperformed the Arrhenius constitutive equation in predicting the thermal deformation behavior of the alloys.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Biophysics
Yao-Wen Jiang, Wen-Jing Tang, Ge Gao, Yu-Qian Geng, Fu-Gen Wu, Qianhao Min, Jun-Jie Zhu
Summary: This study proposes a lipid droplet (LD)-hitchhiking strategy to create Trojan foam cells in situ for fluorescence/photoacoustic imaging of atherosclerotic plaques. The functional liposomes used in this strategy have shown great capability of inducing LDs in monocytes/macrophages and can be targeted to the plaque sites. Furthermore, the confinement in LDs enhances the efficiency of light absorption, resulting in intensified fluorescence/photoacoustic signals. This strategy provides new insights into the design of targeted imaging methodologies and facilitates the evaluation and treatment of atherosclerotic plaques.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Materials Science, Multidisciplinary
Huitong Du, Jiaju Fu, Li-Xia Liu, Shichao Ding, Zhaoyuan Lyu, Xin Jin, Fredrick O. Kengara, Bing Song, Qianhao Min, Jun-Jie Zhu, Dan Du, Cheng Gu, Yuehe Lin, Jin-Song Hu, Wenlei Zhu
Summary: This review summarizes the recent research progress in the development of ECOR, including advanced ECOR catalysts and reaction mechanisms. The challenges and prospects in this field are discussed, providing meaningful guidance for grasping ECOR and designing catalysts with enhanced C2+ product selectivity.
Article
Materials Science, Multidisciplinary
Peng Qi, Bolong Li, Wu Wei, Jimin Chen, Tongbo Wang, Hui Huang, Kunyuan Gao, Shengping Wen, Xiaolan Wu, Li Rong, Xiangyuan Xiong, Wenjun Wu, Lian Zhou, Zuoren Nie
Summary: The microstructural evolution of Ti-6Zr-4Fe alloy solution and aging treated at different temperatures was investigated, and its effects on microhardness and Young's modulus were studied. The formation of the θ phase resulted in an increase in microhardness and Young's modulus in the alloy.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Article
Chemistry, Multidisciplinary
Qianying Zhang, Yihan Wang, Wenjing Wang, Qianhao Min, Jian-Rong Zhang, Jun-Jie Zhu
Summary: Researchers have developed a clever DNA nanomachine that can regenerate in living cells through the activation of telomerase (TE). The nanomachine moves along tracks regenerated by TE and generates amplified signals, allowing for the imaging of apurinic/apyrimidinic endonuclease 1 (APE1) in situ. The regeneration of the nanomachines also reveals differential expression of TE in different cell lines. This study demonstrates the potential of using biomarkers to assist in the regeneration of nanomachines in living cells and opens up new possibilities for the development of more applicable and efficient DNA nanomachines.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Multidisciplinary
Hao Yin, Yanxin Chu, Wei Wang, Zhenzhen Zhang, Zhen Meng, Qianhao Min
Summary: Revealing multiple biomolecules simultaneously in biological and biomedical research is challenging due to their low abundance and poor ionization efficiency. Mass spectrometry (MS) offers unique advantages in multiplexed and label-free analyses, but direct MS profiling of these biomolecules remains difficult. A potential solution to this issue is the use of mass tag (MT)-encoded nanointerfaces, which convert the abundance or activity of biomolecules into amplified ion signals, enabling synchronous MS analysis of multiple targets. This review provides a comprehensive overview of recent advances in MT-encoded nanointerfaces for multiplexed MS bioanalysis and biomedical research, covering their structural characteristics, applications in biomarker assays, cell analysis, and tissue imaging, as well as future prospects.
Article
Chemistry, Multidisciplinary
Huitong Du, Li-Xia Liu, Pan Li, Qianhao Min, Shaojun Guo, Wenlei Zhu
Summary: This study presents an effective strategy for enhancing propanol electro-synthesis from carbon monoxide (CO) reduction through a structural design of Cu2O nanoparticles. The multishell structured catalyst enriches C1 and C2 intermediates by nanoconfinement space, allowing for further coupling and achieving a high Faraday efficiency of 22.22 +/- 0.38% toward propanol at a current density of 50 mA cm-2.
Article
Chemistry, Multidisciplinary
Shan Huang, Yuexin Song, Xiaojun Chen, Qianhao Min, Jian-Rong Zhang, Jun-Jie Zhu
Summary: By incorporating specific recognition, synergistic oxidative damage, and gene therapy, a multimodality therapeutic nanoplatform demonstrates the ability to inhibit the emergence of bacterial resistance and achieve broad-spectrum sterilization activity against multibacterial infections.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Xingkai Hou, Peng Qi, Bolong Li, Shengping Wen, Wu Wei, Yutong Qi, Jiaming Yin, Zuoren Nie
Summary: The precipitation and intergranular corrosion behavior of Al-1.0Mg-0.6Si-Cu (wt.%) alloys with added Cu ranging from 0.3 to 0.6 wt.% were investigated. Results showed that the addition of Cu significantly improved the hardness of the alloys during under-aging by accelerating the precipitation of GP zones. Cu addition changed the composition of precipitation and facilitated the formation of beta ''-Mg5Si6 precipitates with high density and fine distribution. However, the intergranular corrosion resistance decreased with increasing Cu content, mainly due to the segregation of Cu elements and the formation of continuous Q ' precipitates at the grain boundaries.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2023)
Article
Chemistry, Multidisciplinary
Zhenzhen Zhang, Hongmei Xu, Yinyin Fan, Xue Zhang, Wei Wang, Jun-Jie Zhu, Qianhao Min
Summary: In this study, a mass nanotags-enabled interfacial assembly system (MNTs-AS) was developed for multiplexed profiling of RNAs. This system allows simultaneous detection of multiple RNAs in biosystems using matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS). The MNTs-AS-based MS assay shows high sensitivity and multiplexing capability, making it a promising tool for studying biological events and distinguishing cancer subtypes.
Article
Chemistry, Multidisciplinary
Di Gao, Zhuodong Tang, Xueqin Chen, Rong Wu, Ye Tian, Qianhao Min, Jian-Rong Zhang, Zixuan Chen, Jun-Jie Zhu
Summary: We prepared self-assembled DNA nanowires with lengths of 30-120 nm using structural DNA nanotechnology and measured the transport current in these nanowires by plugging individual gold nanoparticles into a circuit. Contrary to previous reports, we observed a significant current attenuation with increasing nanowire length, confirming the prediction of the incoherent hopping model. We also proposed a mechanism for the reversible regulation of charge transport in DNA nanowires involving dynamic transitions in steric conformation.
Article
Chemistry, Multidisciplinary
Shengping Wen, Yue Yuan, Jingfu Chen
Summary: A plastic detection scheme based on deep learning is proposed in this paper for a waste plastics sorting system based on vision detection. The scheme improves the YOLOX object detection model and DeepSORT multiple object tracking algorithm, making them more suitable for plastic sorting.
APPLIED SCIENCES-BASEL
(2023)
Article
Multidisciplinary Sciences
Lizhi Dai, Xiaoxue Hu, Min Ji, Ningning Ma, Hang Xing, Jun- Jie Zhu, Qianhao Min, Ye Tian
Summary: Harnessing the programmable nature of DNA origami, researchers have demonstrated the ability to control structural features in crystalline materials and achieve different equilibrium phases and shapes using a single DNA origami morphology. By modulating the binding coordination with an allosteric factor, the DNA origami crystals undergo phase transitions and yield diverse crystal systems. This approach opens up new possibilities for developing crystalline materials with tunable properties and accessing a rich phase space.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)