Article
Chemistry, Physical
Juan Shen, Chaoran Luan, Nelson Rowell, Yang Li, Meng Zhang, Xiaoqin Chen, Kui Yu
Summary: This article discusses the research on promoting the selective production of colloidal semiconductor metal chalcogenide (ME), magic-size clusters (MSCs), or quantum dots (QDs). The study reveals that the size of precursors determines the evolution pathways of MSCs and QDs. The addition of carboxylic acid can regulate the self-assembly behavior of the precursors, leading to directed evolution of either MSCs or QDs.
Article
Multidisciplinary Sciences
Serife Ustuner, Mark A. Lindsay, Pedro Estrela
Summary: A promising electrochemical detection method has been developed for detecting miRNAs in diluted serum with a detection limit of 0.38 fM. The accuracy and reliability of the sensors are further improved by using locked nucleic acids-modified magnetic beads. Interferences from other nucleotides or biomolecules in the sample are eliminated effectively in this approach.
SCIENTIFIC REPORTS
(2021)
Review
Electrochemistry
Rubin Gulaboski, Ivan Bogeski
Summary: This article introduces the significance of polarography and its derivative technique, pulse voltammetry, which has been developed for a century. It emphasizes the importance of pulse voltammetry as a simple and viable alternative method for mechanistic studies, analytical applications, and kinetic and thermodynamic evaluations. Furthermore, it highlights the contributions made by several women electrochemists in the theoretical and practical application of pulse voltammetric techniques.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Chemistry, Analytical
Yijing Ai, Lisi Wang, Wanting Fu, Xiang Ye, Juan Zhou, Xiaoping Zhang, Shuhai He, Wei Sun
Summary: In this paper, a graphdiyne (GDY)-modified glassy carbon electrode was prepared and used for the sensitive and simultaneous detection of Zn2+, Cd2+ and Hg2+ heavy metal ions. The GDY-modified electrode provided a larger surface area and more active sites for the absorption of metal ions. By codeposition with Bi3+, the heavy metal ions were pre-concentrated on the GDY-modified electrode surface, resulting in high sensitivity and selectivity during stripping analysis. The detection ranges and limits for Zn2+, Cd2+ and Hg2+ were determined using differential pulse anodic stripping voltammetry.
Article
Biochemistry & Molecular Biology
Jin Zou, Jiawei Liu, Guanwei Peng, Haiyan Huang, Linyu Wang, Limin Lu, Yansha Gao, Dongnan Hu, Shangxing Chen
Summary: In this work, a new electrochemical Hg2+ sensing platform based on porous activated carbon (BC/Cu2O) modified with cuprous oxide was developed. Differential pulse anodic stripping voltammetry (DPASV) was used to investigate the sensing capability of the BC/Cu2O electrode towards Hg2+. The BC/Cu2O electrode exhibited excellent electrochemical activity due to the excellent conductivity and large specific surface area of BC, and the excellent catalytic activity of Cu2O nanoparticles. The sensor showed high sensitivity with a low detection limit of 0.3 ng/L and a wide linear response range from 1.0 ng/L to 1.0 mg/L, as well as good accuracy, acceptable precision, and reproducibility.
Article
Chemistry, Analytical
Qingxia Ran, Fangfang Sheng, Guorui Chang, Min Zhong, Shuxia Xu
Summary: A glassy carbon electrode modified with sulfur-doped reduced graphene oxide (S-rGO) and chitosan (CTS) was used to create an electrochemical sensor for the selective detection of trace amounts of Hg2+ in fish muscle samples. The sensor showed excellent selectivity and sensitivity, paving the way for potential applications in environmental testing.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Grace W. Muna, Emily Barrera, Lucas Robinson, Hiba Majeed, Keon Jones, Abigail Damschroder, Andrew Vila
Summary: This study reports on the electroanalytical performance of a glassy carbon electrode (GCE) modified with antimony and bismuth (Sb/Bi-GCE) for detecting heavy metal ions, using lead and cadmium as model analytes. The Sb/Bi-GCE showed superior performance compared to Bi-GCE and Sb-GCE surfaces. For instance, the limit of detection for lead was 0.01 ppb using Sb/Bi-GCE, while it was 0.1 ppb on Bi-GCE and 1 ppb on Sb-GCE.
Article
Chemistry, Physical
Najat Hamid Sibit, Mahmoud Roushani, Zahra Mirzaei Karazan
Summary: A novel sensor was developed using electropolymerization to modify a glassy carbon electrode for the fast determination of mercury ions in different samples. The sensor showed selective detection of mercury ions and displayed satisfactory recovery in various samples, with good reproducibility, repeatability, and stability.
Article
Chemistry, Multidisciplinary
Azar Yousefi, Hossein Aghaie, Masoud Giahi, Laleh Maleknia
Summary: This paper investigates the electrochemical behavior of Cd2+ and Pb2+ sensing using polyindole (PIN)/Mn2O3 nanocomposite and PIN/Mn2O3/polyaniline (PANI) nanofibers modified on a glassy carbon electrode. The study varied the amount of (PIN)/Mn2O3 nanocomposite to find the best performance. The results show that the PIN/Mn2O3/PANI nanofibers modified electrode exhibits good linear relationships for Cd2+ and Pb2+ in the concentration range of 0.05-450 mu g L-1, with detection limits of 0.05 and 0.02 mu g L-1, respectively.
Article
Electrochemistry
Mohamed B. Ali, Ahmed M. Abdel-Raoof, Hassan A. M. Hendawy, Wael Talaat, Gamal A. Omran, Samir Morshedy
Summary: A sensitive voltammetric technique for the determination of avanafil was developed using a carbon paste electrode modified with Zinc oxide nanoparticles and multi-walled carbon nanotubes. The technique showed good recovery in commercial dosage form and human plasma, and was validated to be accurate and reproducible according to ICH guidelines.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Electrochemistry
Luz E. Rebolledo-Perales, Giaan A. Alvarez Romero, Israel Ibarra, Carlos Andres Galan-Vidal, Juan Francisco Flores-Aguilar, I Perez-Silva
Summary: A highly selective sensor based on carbon paste electrodes (CPE) and ion-imprinted polymers (IIP) was proposed for the analysis of lead (II) in real water samples. By optimizing the analysis parameters, a linear concentration range and low detection limit were achieved. The method allows accurate quantification of lead (II) in complex samples without pre-treatment.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Minwoo Kim, Joohyung Park, Hyunjun Park, Wonjun Jo, Wonseok Lee, Jinsung Park
Summary: In this study, Nafion-blanketed bismuth nanoplates were developed for the ultrasensitive detection of heavy metals in water. The Nafion-blanketing method selectively adsorbs cadmium and lead ions. The ecofriendly bismuth nanoplates were synthesized using ultrasonic energy and used as electrochemical sensors due to their high affinity toward heavy metal ions. The Nafion-blanketed bismuth nanoplates exhibited outstanding sensing performance in real samples such as tap water and effluent, with detection limits of 0.376 nM for Cd2+ and 0.178 nM for Pb2+.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Inorganic & Nuclear
Baitong Niu, Meihua Zhu, Hongxu Guo, Shaoming Ying, Xuguang Huang
Summary: A V2O5@MOF(V, Co) composite material was prepared and used for electrochemical detection of Pb2+ in aqueous solution, with optimized operational parameters, providing a feasible research method and practical strategy for sensitive and online detection of lead ions.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Zahra Lotfi, Mohammad Bagher Gholivand, Mojtaba Shamsipur, Mahin Mirzaei
Summary: A novel nanocomposite was prepared as an excellent modifier for the electrochemical detection of acyclovir. The fabricated sensor showed satisfactory performance in the quantitative detection of acyclovir in blood serum, tablet, and topical cream samples.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Chemistry, Analytical
Emilia Konowal, Anna Modrzejewska-Sikorska, Anna Maria Kopaczewska, Bozena Karbowska
Summary: A new method for producing nanosilver using lignosulfonic acid derivative and developing a chemically modified GCE/AgNPs-LS/Hg electrode material is presented in this research. The modified electrode shows enhanced performance in detecting Tl+ ions compared to unmodified electrode. The novel AgNPs-LS/Hg2+ complex is assumed to be suitable for preparing functionalized nanostructured material and can serve as an electrochemical sensing platform for heavy metals.
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)