Article
Medicine, General & Internal
Xi Guo, Naijiang Liu, Mingkai Liu
Summary: This study aimed to investigate the role of LINC00336 in the tumorigenesis of bladder cancer (BCa). LINC00336 was found to be significantly up-regulated in BCa tissues and cell lines. Knockdown of LINC00336 blocked cell proliferation and invasion, and induced cell cycle arrest and apoptosis. These findings suggested that LINC00336 may serve as an oncogene in the initiation and progression of BCa and could be a potential therapeutic target.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Oncology
Yue An, Boyang Xu, Guanyu Yan, Ningning Wang, Zhidong Yang, Mingjun Sun
Summary: circLECRC is significantly downregulated in colorectal cancer and its overexpression inhibits CRC cell proliferation, migration, invasion, and promotes apoptosis. It directly binds to miR-135b-5p to relieve its suppression on KLF4, and it also inhibits YAP1 hyperactivation, leading to the downregulation of downstream genes in the YAP1 pathway.
Review
Cell Biology
Soudeh Ghafouri-Fard, Sajad Najafi, Bashdar Mahmud Hussen, Aryan R. Ganjo, Mohammad Taheri, Mohammad Samadian
Summary: Long non-coding RNAs (lncRNAs) are a heterogeneous group of ncRNAs with a characteristic size of more than 200 nucleotides. DLX6-AS1 is an lncRNA that has been found to be up-regulated in various cancers, and it promotes the oncogenic phenotype of cancer cells by affecting signaling pathways. It is associated with clinicopathological features and shorter survival in cancer patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Oliver Treeck, Florian Weber, Juergen Fritsch, Maciej Skrzypczak, Susanne Schueler-Toprak, Christa Buechler, Olaf Ortmann
Summary: This study reveals the overexpression of DSCAM-AS1 in endometrial adenocarcinoma and its association with shorter overall survival. Silencing of DSCAM-AS1 reduces tumor cell growth and the expression of proliferation activators, while activating anti-tumoral response.
Article
Genetics & Heredity
Huiyuan Xiao, Wen Huang, Yanlei Li, Rongxin Zhang, Long Yang
Summary: The study showed that higher expression of TTN-AS1 was associated with poorer DFS in BC patients, especially in those who underwent Re-TURBT. Knocking down TTN-AS1 could inhibit the proliferation and invasion abilities of BC cells. ATF2 may act as a downstream target of TTN-AS1 in BC, and high expression of ATF2 is also related to adverse DFS in patients.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Bingxian Bian, Li Li, Xing Ke, Hui Chen, Yi Liu, Naisheng Zheng, Yingxia Zheng, Yanhui Ma, Yunlan Zhou, Junyao Yang, Lanshu Xiao, Lisong Shen
Summary: Urinary exosomal long non-coding RNAs have been identified as potential noninvasive biomarkers for the diagnosis of bladder cancer through high-throughput RNA sequencing. A panel of genes has been established for the diagnosis of bladder cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Alina Catalina Palcau, Valeria Canu, Sara Donzelli, Sabrina Strano, Claudio Pulito, Giovanni Blandino
Summary: Circular RNAs, particularly circPVT1, play an important role in oncogenesis and have the potential to serve as diagnostic and prognostic markers. Their resistance to degradation and correlation with lncPVT1 and c-MYC expression highlight their significance in cancer research.
Article
Oncology
Jian Hou, Zhenquan Lu, Xiaobao Cheng, Runan Dong, Yi Jiang, Guoqing Wu, Genyi Qu, Yong Xu
Summary: This study suggests that ferroptosis-associated long non-coding RNAs can serve as prognostic predictors for bladder cancer patients, and explores the inter-regulatory relationships between ferroptosis-related genes and immune cell infiltration, immune checkpoints, and m(6)A methylation genes.
Article
Cell Biology
Zhenglei Xu, Dingguo Zhang, Zhuliang Zhang, Weixiang Luo, Ruiyue Shi, Jun Yao, Defeng Li, Lisheng Wang, Bihong Liao
Summary: In pancreatic cancer, miR-505 is suppressed by LINC01448, and it can inhibit cell proliferation, invasion, sphere formation, and other biological processes by targeting HK2, acting as a tumor suppressor.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Huamei Li, Hongjia Liu, Qiongyu Hao, Xianglin Liu, Yongzhong Yao, Meng Cao
Summary: This study established a reliable prognostic signature for breast cancer patients based on oncogenic signaling pathways related lncRNAs, which stratified patients into high- and low-risk groups. The high-risk group exhibited shorter survival and lower immune cell infiltration.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Alina Catalina Palcau, Renata Brandi, Nikolay Hristov Mehterov, Claudio Botti, Giovanni Blandino, Claudio Pulito
Summary: Breast cancer remains a leading cause of mortality among women globally. Triple-negative breast cancer (TNBC), characterized by the absence of molecular targets, poses the greatest challenge as an aggressive and orphan malignancy. Non-coding RNAs, with their involvement in various cellular processes including cancer, offer potential opportunities as therapeutic targets and biomarkers in TNBC. This review focuses on the oncogenic or oncosuppressor roles of long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) in TNBC, highlighting their mechanisms of action and potential applications in non-coding RNA-based therapeutics.
Review
Biochemistry & Molecular Biology
Radu Pirlog, Rares Drula, Andreea Nutu, George Adrian Calin, Ioana Berindan-Neagoe
Summary: CCAT2 is a highly studied lncRNA with diverse functions in cancer regulation, including interactions with various RNA binding proteins and transcription factors. It has been shown to play a role in promoting chromosome instability and altering glutamine metabolism, potentially affecting cancer therapy resistance and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Gaurav Kumar Pandey, Chandrasekhar Kanduri
Summary: This article reviews the functional role and potential therapeutic applications of long non-coding RNA (lncRNA) in tumor development and discusses the extent of their decisive contribution to cancer development.
Review
Oncology
Xuyu Chen, Qian Luo, Yanan Xiao, Jing Zhu, Yirao Zhang, Jie Ding, Juan Li
Summary: Long non-coding RNAs (lncRNAs) have been found to play essential roles in cell proliferation, fission and differentiation, and their relationship with tumors has attracted much interest. LINC00467, an oncogenic lncRNA, is highly expressed in various malignant tumors and is associated with proliferation, migration, invasion and apoptosis.
CANCER CELL INTERNATIONAL
(2022)
Review
Cell Biology
Hui-Jin Li, Xue Gong, Zheng-Kun Li, Wei Qin, Chun-Xia He, Lu Xing, Xin Zhou, Dong Zhao, Hui-Ling Cao
Summary: Bladder cancer is characterized by dysregulated lncRNAs, which play key roles in tumorigenesis, progression, and prognosis. These lncRNAs can serve as potential diagnostic and prognostic biomarkers for bladder cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Bo Cheng, Qidan He, Yong Cheng, Haifan Yang, Lijun Pei, Qingfu Deng, Hao Long, Likun Zhu, Rui Jiang
FRONTIERS IN GENETICS
(2020)
Article
Andrology
Wenju Xiong, Xiangjun Kong, Jun Jiang, Zhihui Yang, Rui Jiang
Article
Andrology
Qin-Wen Liu, Zhi-Hui Yang, Jun Jiang, Rui Jiang
Summary: Treatment with icariin in SHR rats led to increased NO and cGMP levels in penile cavernous tissue, enhanced interaction between eNOS and HSP90 while reducing interaction between eNOS and caveolin-1, thereby improving erectile function.
Article
Andrology
Ling-Tao Yan, Zhi-Hui Yang, Haocheng Lin, Jun Jiang, Rui Jiang
Summary: Low androgen levels can affect the production of EVs and NO in endothelial cells of rat corpus cavernosum, leading to a decrease in eNOS-expressing EVs and subsequently reducing NO levels.
Article
Andrology
Zhi-bin Chen, Ge Li, Haocheng Lin, Jun Jiang, Rui Jiang
Summary: The research suggests that low androgen status inhibits erectile function in rats by promoting cavernous fibrosis and decreasing NO synthesis through inducing pyroptosis of smooth muscle cells and endothelial cells in the corpus cavernosum.
Article
Medicine, Research & Experimental
Xiao-Ling Zhu, Tao Li, Yu Cao, Qing-Ping Yao, Xing Liu, Ying Li, Yang-Yang Guan, Ji-Jun Deng, Rui Jiang, Jun Jiang
Summary: tRFs and tiRNAs are generated from specific cleavage of tRNAs or their precursors, regulating gene expression in stressful cellular conditions. This study showed that tRF(GlnCTG) is overexpressed in injured arteries and negatively regulates FAS gene expression, promoting vascular smooth muscle cell proliferation. Investigating the roles of tRFs/tiRNAs is crucial for understanding intimal hyperplasia mechanisms and potential treatments.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Andrology
Xu Li, Hai-Fan Yang, Yong Chen, Li-Jun Pei, Rui Jiang
Summary: The study found that icariin can improve erectile function in spontaneously hypertensive rats by reducing the content of endothelial microparticles in blood and inhibiting platelet activation. Endothelial microparticles, endothelial progenitor cells, and platelet activation-related indicators (mean platelet volume, platelet distribution width, and vitronectin receptor) can be used to evaluate the improvement of erectile function in spontaneously hypertensive rats by icariin.
Article
Andrology
Zhi-fu Ou, Li-kun Zhu, Qin-Wen Liu, Jun Jiang, Rui Jiang
Summary: The exact mechanism by which testosterone deficiency causes erectile dysfunction (ED) is still unknown. This study investigates the effect of androgens on TRPCs and their relationship with erectile function. Low androgen levels may inhibit erectile function through up-regulation of TRPC3, TRPC4, and TRPC6 expression in rat penile cavernous tissue. Inhibition of TRPC4 levels in the penile tissue may improve erectile function in low androgen levels.
Article
Andrology
Hao-Zhou Yang, Wen-ju Xiong, Xiong Li, Jun Jiang, Rui Jiang
Summary: The effect of low androgen status on mitochondria-associated membranes (MAMs) and its relationship with erectile function were investigated. Low androgen status upregulated the expressions of PACS-2 in MAMs and inhibited the eNOS/NO/cGMP signaling pathway, resulting in impaired erectile function.
Article
Andrology
Yu-Hao Zhao, Ze-Xiu Wu, Xin Zhao, Jun Jiang, Rui Jiang
Summary: This study aimed to investigate the mechanism by which low androgen status inhibits erectile function. The study found that inhibiting the expression of Ng and subsequently upregulating the expression of CaN was one of the upstream mechanisms of low androgen status inhibiting erectile function.
Article
Andrology
Chang-Jian Deng, Xiong Li, Yang Zeng, Jun Jiang, Rui Jiang
Summary: This study found that the formation of MAMs may be increased in rats after prostate radiotherapy, leading to impaired erectile function. Icariin may improve erectile function by inhibiting the expression of IP(3)R1, PACS2, and FACL4 and increasing p-eNOS/eNOS.
Article
Andrology
Na Wang, Qilan Jiang, Libo Xie, Bo Cheng, Qin-Wen Liu, Rui Jiang
Summary: Low androgen levels and type 1 diabetes may cause erectile dysfunction by methylating the promoter region of eNOS. In the rat experiment, castration and hyperglycemia led to increased methylation level in the eNOS promoter region, resulting in decreased nitric oxide level and erectile function. Methylation inhibitors can partially improve erectile function in type 1 diabetic rats.
Article
Medicine, General & Internal
Piao Yuan, Xiong Li, Wen-ju Xiong, Jun Jiang, Rui Jiang
Summary: The relationship between galanin and erectile function under low testosterone levels was investigated in rats. It was found that low testosterone levels decreased the expression of galanin and GalR in the penile tissues, as well as inhibited the eNOS/NO signaling pathway. Upregulating the expression of galanin in the penile corpus cavernosum might be a novel method of treating erectile dysfunction caused by low androgen levels.
Article
Medicine, General & Internal
JianBin Gu, Li-kun Zhu, Xin Zhao, Jun Jiang, Rui Jiang
Summary: This study explored the influence of low testosterone levels on G protein-coupled receptor kinase interactor 1 (GIT1) and its impact on erectile function. The results showed that low testosterone levels inhibited erectile function in rats by reducing the expression of GIT1 and the protein interaction between GIT1 and eNOS.
Article
Oncology
Yu Cao, Yan Wang, Ling Xiao, Jia-Ying Xu, Ying Liu, Rui Jiang, Tao Li, Jun Jiang
Summary: Exosomes released from endothelial cells exposed to bacterial lipopolysaccharides were found to enhance cell viability and attenuate injury of cardiomyocytes. These exosomes contained increased expression of miRNAs that could promote the survival of cardiomyocytes by down-regulating apoptosis-related proteins. This study suggests that these exosomes have a cardiac protective effect on cardiomyocytes through miRNA regulation.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
