Article
Obstetrics & Gynecology
Christos A. Venetis
Summary: Embryo cryopreservation is an important part of ART, and the freeze-all strategy has shown higher live birth rates in high responders. However, there is no significant difference in normal responders. The freeze-all policy reduces the risk of ovarian hyperstimulation syndrome, but both strategies have their own risks and there is no clear safer approach.
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
J. Kanter, S. M. Gordon, S. Mani, A. Sokalska, J. Y. Park, S. Senapati, D. D. Huh, M. Mainigi
Summary: Hormonal stimulation during ART alters maternal immune cell distribution and function, reducing the ability of uterine natural killer cells to promote trophoblast invasion.
HUMAN REPRODUCTION
(2023)
Review
Biochemistry & Molecular Biology
Brian J. Cox, Kendra Naismith
Summary: Trophoblast plays a critical role in reproduction, cancer, and transplantation. Researchers integrate different datasets to validate the utility and applicability of hTSC models, and also study the process of human embryonic development.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Obstetrics & Gynecology
He Li, Xiaoxi Sun, Junyi Yang, Lu Li, Wenbi Zhang, Xiang Lu, Junling Chen, Hua Chen, Min Yu, Wei Fu, Xiandong Peng, Jiazhou Chen, Ernest Hung Yu Ng
Summary: The study compared immediate and delayed frozen embryo transfers following a stimulated IVF cycle and found that immediate FET resulted in significantly higher ongoing pregnancy and live birth rates. This suggests that immediate FET may be more effective after a stimulated IVF cycle.
HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Yong Zhu, Feng Zhang, Hua Chen, Xiaoxi Sun, Feng Jiang
Summary: This retrospective study aimed to uncover the effects of using frozen sperm and embryos on the outcomes of in vitro fertilization treatments. The results showed that using frozen embryos and frozen sperm increased the clinical pregnancy rate, live birth rate, and low birth weight rate. The study also found accumulative effects of frozen gametes. These findings are important for both clinical and basic research.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Genetics & Heredity
Ranit Hizkiyahu, Eva Suarthana, Einav Kadour Peero, Ido Feferkorn, William Buckett
Summary: This study compared the effects of fixed estrogen dose and increasing estrogen doses during hormone therapy frozen embryo transfer (HT-FET) cycles. The results showed that despite using higher doses of estrogen and longer treatment duration, the increased-dose group had thinner endometrium. However, the pregnancy rates were similar between the two groups.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Obstetrics & Gynecology
M. L. Boutet, G. Casals, B. Valenzuela-Alcaraz, L. Garcia-Otero, F. Crovetto, M. S. Civico, A. Borras, D. Manau, E. Gratacos, F. Crispi
Summary: The study found that embryos transfer impacts fetal cardiac remodeling and suboptimal function, with more pronounced changes after fresh embryo transfer compared to frozen embryo transfer. Fetuses conceived by assisted reproductive technologies showed larger atria, more globular ventricles, and thicker myocardial walls, as well as signs of suboptimal systolic and diastolic function as compared to spontaneously conceived pregnancies.
HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
S. J. Leathersich, C. S. Roche, M. Walls, E. Nathan, R. J. Hart
Summary: Does the season of oocyte retrieval affect live birth rates in frozen embryo transfers? A study found that frozen embryo transfers resulting from oocytes retrieved in summer have a 30% higher odds of live birth compared to those retrieved in autumn, regardless of the season at the time of embryo transfer.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Hadas Ganer Herman, Alexander Volodarsky-Perel, Tuyet Nhung Ton Nu, Alexandre Machado-Gedeon, Yiming Cui, Jonathan Shaul, Michael H. Dahan
Summary: The study investigates if obstetric outcomes and placental findings differ according to embryo quality in pregnancies conceived with IVF. The results suggest that pregnancies following the transfer of lower-quality embryos are associated with a higher rate of low-lying placentas and several adverse placental lesions.
HUMAN REPRODUCTION
(2023)
Article
Medicine, General & Internal
Ayse Ozdemir, Pervin Karli, Cagri Gulumser
Summary: This study aimed to investigate the effect of estrogen levels on the pregnancy and abortion rate in autologous frozen embryo transfer with hormone replacement therapy (HRT). The results showed that estrogen levels did not have a significant effect on the pregnancy or abortion rate in autologous frozen embryo transfer with HRT.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Endocrinology & Metabolism
Yun-Chiao Hsieh, Tzu-Ching Kao, Ih-Jane Yang, Po-Kai Yang, Kuang-Han Chao, Mei-Jou Chen, Jehn-Hsiahn Yang, Shee-Uan Chen
Summary: This study found that serum estradiol levels in early pregnancy may impact the risk of preeclampsia, particularly following FET programmed cycles. The association between estradiol levels in early pregnancy and preeclampsia deserves further investigation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Michal Youngster, Alon Kedem, Sarit Avraham, Gil Yerushalmi, Micha Baum, Ettie Maman, Ariel Hourvitz, Itai Gat
Summary: This retrospective cohort study found no significant association between extremely high oestradiol levels and complications in IVF treatments. The study group had higher average peak oestradiol levels, age, and number of oocytes compared to the control group, but there were no significant differences in major complications and hospitalization rates. Some patients may experience discomfort, particularly abdominal pain, after retrieval.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Obstetrics & Gynecology
K. M. Wong, M. van Wely, H. R. Verhoeve, E. M. Kaaijk, F. Mol, F. van der Veen, S. Repping, S. Mastenbroek
Summary: A study in the Netherlands compared the freeze-all strategy with the conventional strategy in IVF treatments, and found that the conventional strategy had a higher cumulative ongoing pregnancy rate per woman. However, further research is needed to determine the efficacy of the freeze-all strategy in different patient subgroups and embryonic development stages, and to weigh the potential benefits and risks for mothers and children.
HUMAN REPRODUCTION
(2021)
Article
Multidisciplinary Sciences
Kaela M. Varberg, Khursheed Iqbal, Masanaga Muto, Mikaela E. Simon, Regan L. Scott, Keisuke Kozai, Ruhul H. Choudhury, John D. Aplin, Rebecca Biswell, Margaret Gibson, Hiroaki Okae, Takahiro Arima, Jay L. Vivian, Elin Grundberg, Michael J. Soares
Summary: Invasive trophoblast cells play a crucial role in placental development and pregnancy outcomes. ASCL2 is identified as a key regulator of invasive trophoblast cell lineage development in humans and rats. ASCL2 deficiency impairs EVT cell differentiation and impacts placental morphogenesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Obstetrics & Gynecology
Pietro Bortoletto, Phillip A. Romanski, Brady I. Magaoay, Zev Rosenwaks, Steven D. Spandorfer
Summary: The timing from oocyte retrieval to frozen embryo transfer in the natural cycle did not significantly impact live birth rate or neonatal outcomes, with preimplantation genetic testing (PGT) being the only factor associated with increased odds of live birth.
FERTILITY AND STERILITY
(2021)
Editorial Material
Obstetrics & Gynecology
Alexander Melamed, Julian N. Robinson
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2019)
Article
Obstetrics & Gynecology
Malavika Prabhu, Alexander Melamed, Allison S. Bryant
AMERICAN JOURNAL OF PERINATOLOGY
(2019)
Article
Oncology
Amy Bregar, Amirkasra Mojtahed, Aoife Kilcoyne, Vikram Kurra, Alexander Melamed, Whitfield Growdon, J. Alejandro Rauh-Hain, Marcela del Carmen, Susanna Lee
GYNECOLOGIC ONCOLOGY
(2019)
Article
Oncology
J. Alejandro Rauh-Hain, Michael K. Hidrue, Peter Gaccione, Alexander Melamed, Larissa A. Meyer, Nancy L. Keating, Sharon H. Giordano, Laurel W. Rice, Michael J. Birrer, Marcela G. del Carmen
GYNECOLOGIC ONCOLOGY
(2019)
Article
Multidisciplinary Sciences
Yanxia Zhao, Jinghong Cao, Alexander Melamed, Michael Worley, Allison Gockley, Dennis Jones, Hadi T. Nia, Yanling Zhang, Triantafyllos Stylianopoulos, Ashwin S. Kumar, Fotios Mpekris, Meenal Datta, Yao Sun, Limeng Wu, Xing Gao, Oladapo Yeku, Marcela G. del Carmen, David R. Spriggs, Rakesh K. Jain, Lei Xu
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Obstetrics & Gynecology
Koji Matsuo, Ling Chen, Rachel S. Mandelbaum, Alexander Melamed, Lynda D. Roman, Jason D. Wright
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2019)
Review
Oncology
Haley A. Moss, Alexander Melamed, Jason D. Wright
GYNECOLOGIC ONCOLOGY
(2019)
Editorial Material
Surgery
Jason D. Wright, Fady Khoury-Collado, Alexander Melamed
Letter
Surgery
Seema Kumar, Jobayer Hossain, Thomas Inge, P. Babu Balagopal
Article
Oncology
Aaron M. Praiss, Yongmei Huang, Caryn M. St Clair, Ana Tergas, Alexander Melamed, Fady Khoury-Collado, June Y. Hou, Chin Hur, Cande Ananth, Alfred Neugut, Dawn L. Hershman, Jason D. Wright
GYNECOLOGIC ONCOLOGY
(2020)
Review
Obstetrics & Gynecology
Anne Knisely, Charlotte R. Gamble, Caryn M. St Clair, June Y. Hou, Fady Khoury-Collado, Allison A. Gockley, Jason D. Wright, Alexander Melamed
Summary: The study did not find deleterious survival effects associated with minimally invasive surgery for ovarian cancer, but caution is needed in interpreting the data due to significant methodologic shortcomings in existing literature.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Yukio Suzuki, Akiko Sukegawa, Yutaka Ueda, Masayuki Sekine, Takayuki Enomoto, Alexander Melamed, Jason Wright, Etsuko Miyagi
Summary: In Japan, where there is vaccine hesitancy, providing adequate information to parents about HPV vaccination is crucial. A study found that sharing a cervical cancer survivor's story increases parents' willingness to consider HPV vaccination, but the effect diminishes after 3 months. Furthermore, this narrative approach does not increase the vaccination rates in eligible children.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2022)
Article
Oncology
Jacob C. Cogan, Melissa K. Accordino, Melissa P. Beauchemin, John H. Spivack, Sophie R. Ulene, Elena B. Elkin, Alexander Melamed, Bret Taback, Jason D. Wright, Dawn L. Hershman
Summary: The use of an inexpensive pill-dispensing device with mail return capacity is a feasible strategy to enhance disposal of unused postoperative opioids. Most patients were willing to participate and return unused medications on time.
Letter
Obstetrics & Gynecology
Alexander Melamed
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2022)
Letter
Medicine, General & Internal
Alexander Melamed, Jason D. Wright, J. Alejandro Rauh-Hain
NEW ENGLAND JOURNAL OF MEDICINE
(2019)