期刊
FERTILITY AND STERILITY
卷 103, 期 2, 页码 478-486出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2014.11.012
关键词
Adolescents; age; cancer; fertility preservation; sperm cryopreservation
资金
- Ligue Nationale contre le Cancer, Paris, France
Objective: To determine the feasibility of fertility preservation in adolescent males with cancer. Design: Large multicenter retrospective study of male patients 20 years from 23 centers of a national network of sperm banks over a 34-year period. Setting: Sperm banks. Patient(s): A total of 4,345 boys and young men aged 11 to 20 years. Intervention(s): Age, cancer diagnosis, feasibility of sperm banking, and sperm parameters. Main Outcome Measure(s): Description of patients, and success of their fertility preservation. Result(s): We observed a mean yearly increase in referred patients of 9.5% (95% confidence interval, 9.1%-9.8%) between 1973 and 2007. Over the study period, the percentage of younger cancer patients who banked their sperm increased, especially in the 11-14 year age group, rising from 1% in 1986 to 9% in 2006. We found that 4,314 patients attempted to produce a semen sample, 4,004 succeeded, and sperm was banked for 3,616. The mean total sperm count was 61.75 x 10(6) for the 11-14 year age group, and 138.81 x 10(6) for the 18-20 year age group. It was noteworthy that intercenter variations in practices involving young patients seeking to preserve their fertility before cancer therapy were observed within this national network. Conclusion(s): Our results emphasize the need for decisive changes in public health policy to facilitate the access to reproductive health-care for young cancer patients. (C) 2015 by American Society for Reproductive Medicine.
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