Article
Pharmacology & Pharmacy
Xiao-Yu Cheng, Shu-Fang Li, Yong Chen, Ying-Jie Zhao, Wei Hu, Chao Lu, Ren-Peng Zhou
Summary: TRPM7 is a channel protein located on the cell membrane that regulates the balance of intracellular Mg2+. It plays an important role in cell proliferation, adhesion, migration, and is directly related to disease occurrence and development.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Md Zubayer Hossain Saad, Liuruimin Xiang, Yan-Shin Liao, Leah R. Reznikov, Jianyang Du
Summary: The study identified molecular determinants responsible for the pH regulation of TRPM3, showing that both intracellular and extracellular protons block TRPM3 through binding sites in the pore region. Specific residue D1073 was found to be essential for pH sensitivity in TRPM3 channel.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Ana Flavia F. Ferreira, Luiz Roberto G. Britto
Summary: Transient receptor potential melastatin 2 (TRPM2) is an oxidative stress-activated calcium-permeable cation channel that plays a role in neurodegenerative diseases such as Alzheimer's disease and ischemia. However, its involvement in Parkinson's disease pathology has only recently been studied. This review summarizes and discusses the existing studies on the role of TRPM2 in Parkinson's disease, highlighting its activation and enhanced expression in different models, as well as the protective effects of TRPM2 antagonists and genetic approaches.
NEURAL REGENERATION RESEARCH
(2023)
Article
Immunology
Omar Rafael Aleman, Nancy Mora, Carlos Rosales
Summary: Human neutrophils express two unique antibody receptors for IgG, Fc gamma RIIa and Fc gamma RIIIb, which are capable of initiating distinct cellular functions. Fc gamma RIIa induces an increase in L-selectin expression and phagocytosis, while Fc gamma RIIIb promotes actin polymerization, activation of beta 1 integrins, and formation of neutrophils extracellular traps (NET) more efficiently.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiao-Min Zhang, Ying Song, Xin-Yi Zhu, Wen-Jun Wang, Xu-Li Fan, Tarek Mohamed Abd El-Aziz
Summary: Mitochondria are crucial for oxidative stress and maintenance of cell functionality and energy demand. The TRPM2 channel, which influences mitochondrial function, plays a role in the occurrence and progression of diseases. TRPM2 promotes Ca2+ influx affecting TSPO, MMP, ROS, ATP production, and mitochondrial autophagy. The mechanism of Ca2+ influx by TRPM2 into mitochondria is diverse. Interestingly, TRPM2 inhibits mitochondrial ROS production in cancer cells but promotes it in normal cells, leading to cell death in normal cells and proliferation in cancer cells. TRPM2 can be a potential target for treating various diseases by acting as a molecular link between mitochondria and Ca2+ signals.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Andras Szollosi, Janos Almassy
Summary: The TRPM2 cation channel plays a critical role in insulin secretion, immune cell activation, and body heat control. This study demonstrates that the purified nvTRPM2 protein is fully functional when reconstituted into lipid bilayers, and its activation is co-dependent on cytosolic Ca2+ and either ADPR or ADPRP. The results also suggest a high affinity binding of PIP2 or some other activating phosphoinositol lipid to nvTRPM2 under physiological conditions.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Hiroshi Moriyama, Sadahiro Nomura, Hirochika Imoto, Takao Inoue, Yuichi Fujiyama, Kohei Haji, Yuichi Maruta, Hideyuki Ishihara, Michiyasu Suzuki
Summary: TRPM8 agonist suppresses EDs and epileptic seizures in wildtype mice, but not in TRPM8KO mice. TRPM8KO mice show exacerbated EDs and epileptic seizures compared to wildtype mice.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jian Huang, Ruilin Zhang, Shangwen Wang, Dongxian Zhang, Chi-Kwan Leung, Genmeng Yang, Yuanyuan Li, Liu Liu, Yue Xu, Shucheng Lin, Chan Wang, Xiaofeng Zeng, Juan Li
Summary: The cooperation between METH and HIV-Tat exacerbates BBB impairment, involving oxidative stress and TRPM2 channel activation. Inhibiting oxidative stress or TRPM2 channel activity may provide therapeutic targets for attenuating BBB injury in HIV-positive METH abusers.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Marc Behrendt, Hans Juergen Solinski, Martin Schmelz, Richard Carr
Summary: This study found that the inflammatory mediators prostaglandins and bradykinin inhibit TRPM3, while preceding activation of cultured mouse DRG neurons by bradykinin enhances TRPM3-mediated calcium responses. These findings suggest that BK-mediated activation of intracellular signaling pathways may contribute to TRPM3 sensitization during inflammation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Peripheral Vascular Disease
Rheure Alves-Lopes, Silvia Lacchini, Karla B. Neves, Adam Harvey, Augusto C. Montezano, Rhian M. Touyz
Summary: The activation of NOX4 has been shown to have vasoprotective and blood pressure-lowering effects. This study reveals that NOX4-induced regulation of TRPM2 and effects on eNOS-nitric oxide signaling may play a crucial role in these effects.
JOURNAL OF HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Yong-Xu Cai, Bao-Long Zhang, Miao Yu, Yan-Chao Yang, Xue Ao, Di Zhu, Qiu-Shi Wang, Jie Lou, Chen Liang, Liang-Liang Tang, Ming-Ming Wu, Zhi-Ren Zhang, He-Ping Ma
Summary: Cholesterol regulates TRPM4 channel activity by modulating its sensitivity to Ca2+, but does not affect the protein abundance of the channel on the plasma membrane. This regulation is likely mediated through a PI(4,5)P-2-dependent mechanism.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chiaki Yoshikawa, Hiroharu Maegawa, Nayuka Usami, Hiroshi Hanamoto, Chiho Kudo, Hitoshi Niwa
Summary: TRPM2 antagonist administration can suppress hypersensitivity to mechanical stimulation and microglial activation caused by infraorbital nerve ligation, suggesting TRPM2 as a potential target for treating orofacial neuropathic pain.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Minwoo Lee, Song Hee Lee, Seunghyuk Choi, Bo Young Choi, Sang Won Suh
Summary: Carvacrol inhibits TRPM7 expression, alleviates zinc neurotoxicity induced by TBI, reduces oxidative stress, mitigates dendritic damage and neuronal degeneration, delays neuronal death, and improves neurological outcomes after TBI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Feng Hu, Yun Yu, Feng Lu, Xiaoshu Cheng
Summary: The study demonstrated that TRPM2 gene silencing significantly attenuated fibrosis and inflammation in the kidneys of mice with HFD/STZ-induced diabetes, largely achieved via the inhibition of TGF-I31-activated JNK1 activation.
Article
Immunology
Helene Cabanas, Katsuhiko Muraki, Natalie Eaton-Fitch, Donald Ross Staines, Sonya Marshall-Gradisnik
Summary: The study found that ME/CFS patients taking LDN had restored TRPM3-like ionic currents in NK cells, suggesting LDN may be a potential treatment for ME/CFS. The therapeutic effect of LDN in regulating the underlying mechanisms involving TRPM3 and opioid receptors in NK cells was highlighted. This study may lead to the repurpose of marketed drugs and support prospective randomized clinical studies on the role and dose of NTX in treating ME/CFS patients.
FRONTIERS IN IMMUNOLOGY
(2021)