期刊
BIOORGANIC CHEMISTRY
卷 77, 期 -, 页码 236-244出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2018.01.016
关键词
Dehydroacetic acid; Chalcone; 1,2,3-triazole; Molecular hybridization; Antimicrobial activity
资金
- Haryana State Council for Science & Technology (HSCST)
- Guru Jambheshwar University of Science & Technology, Hisar
A series of new dehydroacetic acid chalcone-1,2,3-triazole hybrids as potential antimicrobial agents was designed, synthesized and characterized by FTIR, NMR and HRMS spectral techniques. All the synthesized compounds were screened in vitro against four bacterial strains (Staphylococcus epidermidis, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa) and two fungal strains (Aspergillus niger and Candida albicans). The antimicrobial results indicated that some of the compounds showed remarkable activities comparable to the standard drugs. Most of the compounds exhibited better efficacy compared to the DHA, which is itself an antimicrobial agent. The synergistic effect in biological activity was observed when DHA, chalcone and 1,2,3-triazole are conjugated. The molecular modeling studies of compound 5j into E. coll. topoisomerase II DNA gyrase B were also performed. (C) 2018 Elsevier Inc. All rights reserved.
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