Oocyte donation outcome after oncological treatment in cancer survivors

Objective: To study reproductive outcome in patients cured of cancer who required oocyte donation (OD) owing to iatrogenic ovarian dysfunction. Design: Multicenter, unmatched, retrospective cohorts study. Setting: Private, university-affiliated group of clinics. Patient(s): Women treated and cured of cancer (n = 142) who underwent 333 cycles of OD (exposed group) and women without a previous cancer diagnosis (n = 17,844) who underwent 29,778 cycles of OD (unexposed cohort) between January 2000 and January 2012. Intervention(s): Retrospective chart review. Main Outcome Measure(s): Pregnancy, implantation, miscarriage, and ongoing pregnancy rates. Result(s): There were no differences in terms of pregnancy (55.7% vs. 54.7%), implantation (39.8% vs. 38.2%), miscarriage (29.5% vs. 26.9%), or delivery rates (39.3% vs. 39.9%) between the unexposed group and the patients previously diagnosed and cured of cancer, respectively. There was no correlation between OD outcome and cancer type. Conclusion(s): Endometrial receptivity in women treated and cured of cancer was comparable to that of general patients without previous malignancies who had received OD, based on the largest series available in the literature. (C) 2015 by American Society for Reproductive Medicine.