期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 26, 期 7, 页码 1374-1377出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2017.08.008
关键词
Natural compounds; Fungal gene expression; Oxidative phenol coupling; Atropisomers; Coumarins
资金
- DAAD
Regio- and stereoselective phenol coupling is difficult to achieve using synthetic strategies. However, in nature, cytochrome P450 enzyme-mediated routes are employed to achieve complete axial stereo- and regiocontrol in the biosynthesis of compounds with potent bioactivity. Here, we report a synthetic biology approach whereby the bicoumarin metabolic pathway in Aspergillus niger was specifically tailored towards the formation of new coupling products. This strategy represents a manipulation of the bicoumarin pathway in A. niger via interchange of the phenol-coupling biocatalyst and could be applied to other components of the pathway to access a variety of atropisomeric natural product derivatives. (C) 2017 Elsevier Ltd. All rights reserved.
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