Article
Biochemistry & Molecular Biology
Hyun Hee Jang, Youngsook Son, Gabee Park, Ki-Sook Park
Summary: This study demonstrates that bone marrow-derived mesenchymal stem cells (MSCs) have vasculogenic properties. Different populations of MSCs vary in angiogenic factor expression and vasculogenic properties. The vasculogenic MSCs (vMSCs), distinct from endothelial progenitor cells (EPCs), may contribute to neovascularization and could be a promising cellular therapy for cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Wootak Kim, Aran Park, Hyun Hee Jang, Seung-Eun Kim, Ki-Sook Park
Summary: Breast tumor cells recruit bone marrow-derived mesenchymal stem cells (BM-MSCs) and alter their cellular characteristics to establish a tumor microenvironment. BM-MSCs enhance tumor angiogenesis through various mechanisms. Our study found that the increased expression of HIF-1 alpha in BM-MSCs under breast tumor conditions is mediated by ROS and JAK/Stat3. This increased expression promotes the angiogenic sprouting capacity of endothelial cells through a VEGF-dependent mechanism.
Article
Biochemistry & Molecular Biology
Szu-Hsien Wu, Yu-Ting Liao, Chi-Han Huang, Yi-Chou Chen, En-Rung Chiang, Jung-Pan Wang
Summary: ADSCs tend to spontaneously differentiate into neuron-like cells during high confluence culture, with enhanced expression of neuronal markers and neurotrophins, while BMSCs do not show this tendency. Additionally, ADSCs do not exhibit spontaneous adipogenic and osteogenic differentiation during this process.
Article
Cell Biology
Dawoon Baek, Kwang Hwan Park, Kyoung-Mi Lee, Sujin Jung, Soyeong Joung, Jihyun Kim, Jin Woo Lee
Summary: The study revealed that overexpression of USP53 can enhance osteogenic differentiation of hBMSCs by promoting the degradation of β-catenin through interaction with FBXO31, potentially promoting bone regeneration. Therefore, USP53 may be a promising target for gene therapy in bone regeneration.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Sanghyuk Choi, Jinyeong Yu, Wootak Kim, Ki-Sook Park
Summary: In this study, N-cadherin was identified as a key molecule in mediating the migration of BM-MSCs towards breast tumors. The expression of N-cadherin increased on the intercellular borders of BM-MSCs through TGF-beta canonical signaling, leading to their collective migration in response to breast tumor cells via N-cadherin-dependent cell-cell adhesion. This introduces a novel and promising strategy for controlling and re-engineering the breast tumor microenvironment.
Article
Biochemistry & Molecular Biology
Elise Aasebo, Annette K. Brenner, Maria Hernandez-Valladares, Even Birkeland, Frode S. Berven, Frode Selheim, Oystein Bruserud
Summary: Although the proteomic profiles of osteoblasts and MSCs show many similarities, there are still several specific differences, including extracellular matrix proteins and intracellular signaling networks. Targeting these specific proteins therapeutically may have minor effects on MSCs, and careful standardization of ex vivo handling will be required for the clinical use of cultured osteoblasts/MSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Meng Li, Jing Wu, Wenbo Geng, Yulu Yang, Xuan Li, Kun Xu, Ke Li, Yan Li, Qiaojian Duan, Pengfei Gao, Kaiyong Cai
Summary: Localized corrosion of 316L stainless steel reduces the viability, adhesion, proliferation, and osteogenic differentiation abilities of BMSCs. It causes cytotoxicity through the release of metallic ions and generates reactive oxygen species (ROS) around the corrosion pits, leading to oxidative stress and cell membrane depolarization. This study provides insights into corrosion-mediated degradation of cell function and material-cell interactions.
Review
Cell Biology
Xinyun Xu, Ling Zhao, Paul D. Terry, Jiangang Chen
Summary: Mesenchymal stem cells from bone marrow can differentiate into either adipocytes or osteoblasts, and external stimuli such as environmental contaminants, heavy metals, dietary, and physical factors can influence this fate decision. Maintaining a balance between osteogenesis and adipogenesis is crucial for bone homeostasis, and disruptions in lineage commitment of these stem cells are associated with various bone disorders. This review focuses on understanding how external stimuli affect the fate of mesenchymal stem cells and calls for future studies to investigate the impact on bone health and underlying mechanisms of differentiation.
Review
Cell & Tissue Engineering
Chuan Qin, Lin Bai, Yongning Li, Kewei Wang
Summary: Transplantation of bone marrow-derived mesenchymal stem cells can alleviate neuropathology and cognitive deficits in Alzheimer's disease models by activating autophagy and apoptosis pathways, inhibiting protein aggregation and neuroinflammation, and promoting synaptogenesis.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell Biology
Lili Chang, He Gao, Li Wang, Ning Wang, Shumei Zhang, Xiaona Zhou, Huijun Yang
Summary: The study found that miR-1228 is highly expressed in serum exosomes of gastric cancer patients, and up-regulation of miR-1228 can down-regulate MMP-14 expression, effectively hindering the development of gastric cancer.
Article
Genetics & Heredity
Dong-Hui Wang, Jia-Song Chen, Rong Hou, Yuan Li, Jun-Hui An, Ping He, Zhi-Gang Cai, Xiao-Hu Liang, Yu-Liang Liu
Summary: This study compared the gene expression differences between bone marrow mesenchymal stem cells (bmMSCs) and umbilical cord mesenchymal stem cells (ucMSCs) of giant pandas, and identified the PI3K-AKT signaling pathway as a key regulator in ucMSCs.
Article
Endocrinology & Metabolism
Ziyi Li, Yafei Wang, Shilun Li, Yukun Li
Summary: Bone regeneration is a complex process involving the coordination of osteogenesis and osteoclastogenesis, with the balance between osteogenesis and adipogenesis of BMSCs playing a critical role. Recent studies have shown that exosomes from M2 macrophages facilitate osteogenesis and reduce adipogenesis through the miR-690/IRS-1/TAZ axis, potentially serving as a therapeutic tool for bone loss diseases.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Orthopedics
Andrea Pintore, Donato Notarfrancesco, Arnaldo Zara, Antonio Oliviero, Filippo Migliorini, Francesco Oliva, Nicola Maffulli
Summary: The study found that autologous mesenchymal stem cell (MSC) injections can improve clinical and functional outcomes in knee osteoarthritis (KOA) patients, with similar results between autologous bone marrow cells (BMAC) and adipose-derived stromal cells (ADSCs). Measurements of Knee Injury and Osteoarthritis Outcome Score (KOOS), Oxford Knee Score (OKS), and visual analog scale (VAS) were collected from 102 patients with KOA before the procedures, at one month, and at six months post-injection.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Yue Ke, Yu Ye, Jintao Wu, Yanxia Ma, Yuxin Fang, Fei Jiang, Jinhua Yu
Summary: A phosphoserine-loaded chitosan membrane was synthesized to improve the osteogenic effect of chitosan membranes. The incorporation of phosphoserine into chitosan membranes was confirmed and the phosphoserine-chitosan membranes significantly stimulated bone regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jinkui Wang, Mujie Li, Liming Jin, Peng Guo, Zhaoxia Zhang, Chenghao Zhanghuang, Xiaojun Tan, Tao Mi, Jiayan Liu, Xin Wu, Guanghui Wei, Dawei He
Summary: Osteosarcoma is a bone tumor with a high incidence in children and adolescents. The low production of exosomes hinders its development as a drug carrier, but exosome mimetics (EMs) have been developed as an alternative with good drug delivery performance. In this study, EMs were used to encapsulate doxorubicin (EM-Dox) for the treatment of osteosarcoma, and it showed significantly stronger tumor inhibition activity and fewer side effects compared to free doxorubicin. This novel biological nanomedicine system provides a promising opportunity for the development of precision medicine for osteosarcoma.
Article
Clinical Neurology
Meihua Shen, Yijun Zheng, Kaimin Zhu, Zhonghai Cai, Wenwu Liu, Xuejun Sun, Jiankang Liu, Duming Zhu
NEUROLOGICAL RESEARCH
(2020)
Article
Biology
Penglin Xia, Kun Cao, Xuguang Hu, Lei Liu, Danyang Yu, Suhe Dong, Jicong Du, Yang Xu, Bin Liu, Yanyong Yang, Fu Gao, Xuejun Sun, Hu Liu
RADIATION RESEARCH
(2020)
Article
Medicine, Research & Experimental
Yani Zheng, Chao Huang, Xiangqun Yang, Zhiying Zhang
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Ke Ning, Zhen-biao Guan, Hong-tao Lu, Ning Zhang, Xue-jun Sun, Wen-wu Liu
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2020)
Review
Biochemistry & Molecular Biology
Zhou-heng Ye, Ke Ning, Bradley P. Ander, Xue-jun Sun
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2020)
Article
Cell Biology
Chao Huang, Wenbo Zhang, Aijun Sun, Xi Zhang, Jinping Guo, Ruijuan Ji, Liang Qiao, Xuejun Sun, Dongbao Zhao
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Medicine, General & Internal
Yachen Si, Lulu Liu, Jin Cheng, Tingting Zhao, Qi Zhou, Jianpeng Yu, Wei Chen, Jiarong Ding, Xuejun Sun, Hongtao Lu, Zhiyong Guo
Summary: The study demonstrated that hydrogen-rich water can improve crystal deposition, tubular injury, fibrosis, and ROS production in mouse kidneys induced by oxalate diet, and reduce renal injury, inflammation, and oxidative stress indexes. A total of 3,566 differential genes were screened by RNA-seq, and the PI3K/AKT, NF-kappa B, and TGF-beta pathways were identified as key targets for further investigation.
FRONTIERS IN MEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Caiyou Zeng, Xuejun Sun, Bojin Qi, Yipeng Wang, Haibo Wang, Zhejun Tan, Yong Peng, Baoqiang Cong
Summary: This study demonstrates a novel strategy to enhance the strength and ductility of AA2219 Al-6.3Cu alloy arc-welded joints by introducing TiC particles and using a distinctive ultrasonic frequency double-pulsed arc. The fabricated TiCp/Al6.3Cu joint shows a fine-grained structure and a hierarchical alpha-Al grain structure embedded with dense nano-precipitation. The joint exhibits an unprecedented joint coefficient and excellent mechanical performance.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2022)
Article
Cell Biology
Xuan Shi, Lina Zhu, Sheng Wang, Wanli Zhu, Quanfu Li, Juan Wei, Di Feng, Meiyun Liu, Yuanli Chen, Xuejun Sun, Hongtao Lu, Xin Lv
Summary: This study explored the protective effects of magnesium hydride (MgH2) on two types of ARDS models and its underlying mechanism in a lipopolysaccharide (LPS)-induced ARDS model of the A549 cell line. Results showed that MgH2 exerted anti-inflammatory, antioxidant, anti-apoptotic, and barrier-protective effects by regulating molecular signaling pathways. The in vivo study also demonstrated that MgH2-treated mice had a better survival rate and less pathological damage.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Pharmacology & Pharmacy
Xiaoya Li, Xueqi Ma, Xintong Chen, Tingfang Wang, Qing Liu, Yongfang Wang, Zhezhe Li, Juan Hofer, Fangbing Li, Liang Xiao, Xuejun Sun, Jinggang Mo
Summary: This study analyzed the molecular composition of the medusa and polyp of Aurelia coerulea and compared its toxicity with another scyphozoan jellyfish, Stomolophus meleagris. The results showed that A. coerulea medusae and polyps have similar molecular compositions, but their gene expressions are significantly different. A. coerulea medusa displayed weaker toxicity compared to S. meleagris medusa, and the variation in toxin expressions may be an important factor contributing to the difference in toxicity.
Article
Engineering, Manufacturing
Xuejun Sun, Bojin Qi, Zihao Jiang, Caiyou Zeng, Baoqiang Cong
Summary: In this study, different current modes were used to butt-weld 1460 Al-Li alloy plates. The effects of these current modes on the weld microstructure and mechanical properties were compared. The results showed that modulating pulsed current can refine the grains in the weld zone and fusion zone, and significantly increase the quantity and width of a fine strip-like equiaxed grain zone. Both P-VPTIG and DP-VPTIG processes effectively enhanced the strength and elongation of the joints.
JOURNAL OF MANUFACTURING PROCESSES
(2022)
Article
Economics
Jingpei Ma, Xuejun Sun
Summary: The development of green technology allows manufacturers in traditional industries to reduce carbon emissions, but the adoption of this technology varies among manufacturers. By implementing an effective green technology licensing strategy, highly efficient manufacturers can share their technology with less efficient manufacturers. The government has introduced subsidies to promote the use of green technology among manufacturers. However, the effectiveness of these subsidies, especially in the face of intense market competition, is still uncertain. This study develops a game theory model to analyze the optimal subsidy policy for the government.
MANAGERIAL AND DECISION ECONOMICS
(2023)
Editorial Material
Medicine, Research & Experimental
Xuejun Sun, Shigeo Ohta, John H. Zhang
MEDICAL GAS RESEARCH
(2023)
Article
Engineering, Biomedical
Jing Ma, Suhe Dong, Hongtao Lu, Zhongmin Chen, Huijie Yu, Xuejun Sun, Renjun Peng, Wei Li, Sinian Wang, Qisheng Jiang, Fengsheng Li, Li Ma
Summary: This study revealed the protective effect of MgH2, a hydrogen storage nanomaterial, on radiation-induced male fertility impairment. MgH2 improved testicular structure, sperm quality, genetic effect, spermatogenesis, and hormone secretion. It also eliminated free radicals, suppressed ROS production, alleviated oxidative stress, and inhibited apoptosis and inflammation induced by radiation.
BIOMATERIALS RESEARCH
(2022)
Review
Medicine, Research & Experimental
Ke Ning, Yan-Yan Zhou, Ning Zhang, Xue-Jun Sun, Wen-Wu Liu, Cui-Hong Han
MEDICAL GAS RESEARCH
(2020)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
