Article
Cell Biology
Mi-Jeong Kim, Yoon Min, Soo-Kyung Jeong, Juhee Son, Ji Young Kim, Ji Su Lee, Duk-Hwan Kim, Joo Sang Lee, Eunyoung Chun, Ki-Young Lee
Summary: The study reveals that USP15 is significantly downregulated in lung cancer patients, and its knockout leads to increased migration, invasion, and autophagy induction in lung cancer cells. USP15 interacts with BECN1 and deubiquitinates it, thereby attenuating autophagy induction. Additionally, the expression of USP15 is associated with the upregulation of certain oncogenes and downregulation of tumor suppressor genes in lung cancer patients.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Jie Wang, Hai-Bo Yan, Qian Zhang, Wei-Yan Liu, Ying-Hua Jiang, Gang Peng, Fei-Zhen Wu, Xin Liu, Peng-Yuan Yang, Feng Liu
Summary: The ARID1A gene plays a crucial role in cancer metastasis. Silencing ARID1A enhances the migration, invasion, and metastasis abilities of breast cancer cells, affecting the expression of E-cadherin and stabilization of beta-catenin. Inhibiting specific pathways can effectively suppress the migration and invasion of ARID1A-deficient cancer cells.
Article
Cell Biology
Jianye Xu, Jian Zhang, Zongpu Zhang, Zijie Gao, Yanhua Qi, Wei Qiu, Ziwen Pan, Qindong Guo, Boyan Li, Shulin Zhao, Xiaofan Guo, Mingyu Qian, Zihang Chen, Shaobo Wang, Xiao Gao, Shouji Zhang, Huizhi Wang, Xing Guo, Ping Zhang, Rongrong Zhao, Hao Xue, Gang Li
Summary: The study reveals that glioma-derived exosomes may promote glioma proliferation and migration by inducing autophagy and M2-like macrophage polarization, leading to the formation of an immunosuppressive microenvironment. IL-6 and miR-155-3p could be novel biomarkers for diagnosing glioma, while treatments targeting autophagy and the STAT3 pathway may contribute to antitumor immunotherapy.
CELL DEATH & DISEASE
(2021)
Article
Chemistry, Medicinal
Jinxin Che, Zegao Jin, Fangjie Yan, Jieqiong You, Jiangfeng Xie, Binhui Chen, Gang Cheng, Hong Zhu, Qiaojun He, Yongzhou Hu, Bo Yang, Ji Cao, Xiaowu Dong
Summary: The compound 4 was identified as a WSB1 degrader, inhibiting the migration capacity of WSB1-overexpressing cells and showing promising anticancer metastatic effects in vivo.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Pathology
Qi Qi, Chen Chen, Chang Liu, Bin Zhang, Yuchen Ma, Hua Zhang, Wuhao Huang, Changli Wang
Summary: The study demonstrated that linc8087 is downregulated in NSCLC and is significantly associated with poor survival. Overexpression of linc8087 inhibits cell migration and invasion, while its knockdown promotes cell migration and invasion. The findings suggest that linc8087 plays a key role in NSCLC progression and may serve as a meaningful prognostic biomarker and potential therapeutic target.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Biochemistry & Molecular Biology
Yanjia Hu, Hao Liu, Zhaoying Zhu, Xin Qi, Wenjing Yuan, Meng Tian, Denian Wang, Jianguo Xu
Summary: LACTB plays a role in suppressing cell migration and invasion in glioblastoma via the regulation of the RHOC/Cofilin signaling pathway. These findings suggest that LACTB may be a potential treatment target for glioblastoma.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Florent Peglion, Lavinia Capuana, Isabelle Perfettini, Laurent Boucontet, Ben Braithwaite, Emma Colucci-Guyon, Emie Quissac, Karin Forsberg-Nilsson, Flora Llense, Sandrine Etienne-Manneville
Summary: Loss of PTEN promotes cell migration while targeting AMPK activity can counteract this effect. This suggests the important regulatory roles of PTEN and AMPK in tumor invasion and provides new therapeutic opportunities for glioblastoma.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Shasha Zhu, Xiangbing Kong, Mengru Song, Mingyang Chi, Yitong Liu, Peng Zhang, Qiao Zhang, Pingping Shang, Feifei Feng
Summary: miR-223-3p attenuates the migration and invasion of NSCLC cells by regulating NLRP3.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Li Zhang, Xingyue Chen, Shun Yao, Liming Zheng, Xingyue Yang, Yongfeng Wang, Xin Li, Enqin Wu, Biguang Tuo
Summary: Chloride, as a major intracellular anion, plays a crucial role in maintaining ion homeostasis, osmotic pressure, and cell volume. Intracellular chloride channel 1 (CLIC1), besides its function as an ion channel, is involved in cell cycle regulation and intracellular oxidation. It has been found that CLIC1 is highly expressed in tumor cells and associated with malignancy and poor prognosis, suggesting its potential role in systemic diseases.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Ru Wang, Ines Godet, Yongkang Yang, Shaima Salman, Haiquan Lu, Yajing Lyu, Qiaozhu Zuo, Yufeng Wang, Yayun Zhu, Chelsey Chen, Jianjun He, Daniele M. Gilkes, Gregg L. Semenza
Summary: This study discovered that HIFs induce the expression of ADAM12, leading to EGFR signaling activation and subsequently promoting breast cancer cell migration, invasion, and metastasis. Inhibition of ADAM12 expression or activity can effectively reduce tumor cell migration, invasion, and lung metastasis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Jing Sui, Qun Zhao, Yanqiu Zhang, Geyu Liang
Summary: The study found that LINC00961 is significantly downregulated in non-small cell lung cancer (NSCLC) tissues, and it inhibits the expression of miR-19a-3p/miR-19b-3p/miR-125b-5p through the PI3K-AKT/MAPK/mTOR signaling pathway, thereby suppressing tumor cell proliferation and migration while promoting apoptosis. This may provide potential biomarkers for the diagnosis and treatment of NSCLC.
DNA AND CELL BIOLOGY
(2022)
Review
Medicine, Research & Experimental
Qian Yi, Hanwei Cui, Yi Liao, Jianyi Xiong, Xiufeng Ye, Weichao Sun
Summary: MicroRNAs play critical roles in various biological processes; miRNA-338 is identified to participate in the progression of several cancers; the functions and underlying mechanisms of miRNA-338 in tumor progression remain unclear.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Pejman Morovat, Saman Morovat, Arash M. Ashrafi, Shahram Teimourian
Summary: This study investigates the potential pathogenesis roles of the ceRNA network among circRNA/miRNA/mRNA in hepatocellular carcinoma (HCC). By analyzing the differential expression of circRNAs, miRNAs, and mRNAs, as well as their interactions, the study identifies potential prognostic markers and reveals the underlying molecular mechanisms of HCC.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Jun Yuan, Qianqian Ju, Jun Zhu, Yun Jiang, Xuechao Yang, Xiaoyu Liu, Jinyu Ma, Cheng Sun, Jiahai Shi
Summary: RASSF9 is upregulated in non-small cell lung cancer and promotes tumor cell proliferation by targeting the MEK/ERK axis. Therefore, RASSF9 may be a potential druggable target for treating NSCLC.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Wei Li, Junwei Wang, Wenjing Hao, Cuifang Yu
Summary: miR-543-3p plays a suppressive role in inflammation, alleviating LPS-induced inflammatory damage by targeting KLF6, which may be beneficial for the treatment of periodontitis.
BIOSCIENCE REPORTS
(2021)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)