期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 98, 期 -, 页码 847-855出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2018.01.010
关键词
Procyanidin A2; Proliferation; Migration; PDGF; KDR; Jak2
资金
- National Natural Science Foundation of China [81302853]
- Shanghai Municipal Commission of Health and Family Planning [201540261, 201640116]
- Huashan Hospital North [HSBY2016014, 2015114, 2015107]
Proanthocyanidin A2 (PA2), one of A-type proanthocyanidins, has been shown to harbor a broad spectrum of pharmacological activities, including anti-inflammatory, antioxidant, anti-HIV, anti-CDV and anti-alpha-glucosidase activities. However, little is known about the role for PA2 in regulating PDGF-induced VSMC proliferation and migration. In the present study, we investigated the possible effects of PA2 on PDGF-BB-induced proliferation, migration and inflammation in VSMCs in vitro to mimic a postangioplasty PDGF shedding condition. Herein, the data clearly show that PA2 markedly inhibited proliferation, migration and inflammatory responses at 0-30 mu g/ml concentration in VSMCs in vitro. 10-30 mu g/ml PA2 inhibited PDGF-mediated NAD(P)H oxidase activation and intracellular ROS formation in VSMCs. Furthermore, the effects exerted by PA2 involve the participation of KDR and Jak-2/STAT-3/cPLA(2) signaling pathways. These data also highlight the possible therapeutic use of PA2 in vascular proliferative diseases, where abnormal proliferation and migration play important pathological roles.
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