Review
Pharmacology & Pharmacy
Bartlomiej Szabat-Iriaka, Marc Le Borgne
Summary: There is a growing interest in using nanomaterials as drug carriers for diseases such as cancers and CNS disorders. However, the regulatory framework for their human use remains limited. Characterizing the biodistribution of nanomedicines and potential toxicity from their interaction with the CNS is urgently needed.
DRUG DISCOVERY TODAY
(2021)
Review
Materials Science, Multidisciplinary
Fujun Yang, Zhiqiang Kong, Qingyu Ji, Shumeng Li, Jin Sun, Zhonggui He, Shenwu Zhang, Cong Luo
Summary: Platelets, as abundant corpuscles in the blood, play important roles in normal physiological processes and disease occurrence. In recent years, significant progress has been made in platelet-inspired nanotherapeutics, especially in the fields of biotechnology and nanomedicine. This article provides an overview of platelet-inspired nanotherapeutics for biomedical applications. It discusses the recent trends of biomimetic platelet-inspired nanosystems, the functional modulation of platelet aggregation, activation, and inhibition, platelet derivative-based nanotherapeutics, and the clinical application prospects of these emerging nanotherapeutics with their rationale, advantages, and challenges highlighted.
ACS MATERIALS LETTERS
(2023)
Review
Chemistry, Applied
Masoud Hamidi, Oseweuba Valentine Okoro, Peiman Brouki Milan, Mohammad Reza Khalili, Hadi Samadian, Lei Nie, Amin Shavandi
Summary: Fungal exopolysaccharides have diverse potential applications in various industries. However, there are only a few commercialized products based on fungal EPSs in the biomedical field. This review critically discusses the potential biomedical applications of fungal EPSs in tissue engineering, drug and gene delivery.
CARBOHYDRATE POLYMERS
(2022)
Review
Pharmacology & Pharmacy
Lin Tang, Yicheng Feng, Sai Gao, Qingchun Mu, Chaoyong Liu
Summary: Glioblastoma (GBM) is a common malignant primary brain tumor with a poor prognosis. The current standard treatment regimen has limited efficacy, and new therapeutic approaches, such as nanotechnologies for overcoming the blood-brain barrier, hold promise for treating GBM.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Cristobal Garcia Garcia, Sai S. Patkar, Bin Wang, Ramadan Abouomar, Kristi L. Kiick
Summary: Injectable nanocarriers and hydrogels are widely used for various biomedical applications, such as delivering biotherapeutic cargo and serving as matrices for tissue engineering. Recent advances in using recombinant protein-based materials as injectable platforms under physiological conditions have enabled the development of nanoparticles and tissue engineering matrices. Protein-engineered biomaterials offer high customizability and tunable rheological properties, encapsulation efficiencies, and delivery profiles. This review highlights the key advantages of utilizing stimuli-responsive properties of recombinant polypeptide-based materials.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Chemistry, Multidisciplinary
Hai-Qing Song, Yaqian Fan, Yang Hu, Gang Cheng, Fu-Jian Xu
Summary: This review summarizes the potential and advantages of polysaccharide-peptide conjugates in biomedical applications, as well as provides an overview of the design, conjugation chemistry, and applications. In addition, the challenges and demands of polysaccharide-peptide conjugates are also discussed for future prospects.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Girolamo Casella, Silvia Carlotto, Francesco Lanero, Mirto Mozzon, Paolo Sgarbossa, Roberta Bertani
Summary: Cyclic and polyphosphazenes are substrates characterized by -P=N- repeating units, which can be easily substituted with organic groups to create new materials for industrial applications. They have promising biomedical applications, such as antimicrobial agents in drug delivery and immunoadjuvants in tissue engineering. Their properties can be tailored by the number of repetitive units and the nature of the substituent groups.
Review
Pharmacology & Pharmacy
Qiuyue Liu, Jiahui Zou, Zhongjian Chen, Wei He, Wei Wu
Summary: This review elaborates on the development trends of nanomedicines, emerging nanocarriers, in vivo fate and safety of nanomedicines, and their extensive applications. The potential challenges and obstacles hindering the clinical translation of nanomedicines are also discussed. It provides a comprehensive overview of research activities in the field of nanomedicines.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Chemistry, Physical
Lijuan Wang, Yushuang Shang, Jie Zhang, Jiang Yuan, Jian Shen
Summary: The development of keratin-based biomaterials provides a valuable approach for addressing environmental pollutants and transforming waste into wealth. The properties and biomedical applications of keratin biomaterials, such as drug delivery, wound healing, and tissue engineering, are extensively discussed in this review, offering valuable insights for further research and development.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Rajesh Kumar, Dinesh Pratap Singh, Romina Munoz, Mongi Amami, Rajesh Kumar Singh, Shipra Singh, Vinod Kumar
Summary: This review article introduces the potential and research progress of graphene and its derivatives in biomedical applications, and summarizes their effects on human health and the environment.
MATERIALS TODAY CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Sabbir Ansari, Neha Sami, Durdana Yasin, Nazia Ahmad, Tasneem Fatma
Summary: Polyhydroxyalkanoates (PHA) are biological polyesters of hydroxyacids, considered as environmentally friendly alternatives to petroleum-based plastics, with biodegradability and biocompatibility. Research on different PHA in cell culture systems or animal hosts in recent years has shown their potential for applications in medical devices.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Sakshi Priya, Unnati Batra, B. N. Samshritha, Sudhanshu Sharma, Akash Chaurasiya, Gautam Singhvi
Summary: Nanofibers are fibrous nanocarriers that can be synthesized from various materials, including natural polymers. Natural polysaccharides-based nanofibers have gained attention in pharmaceutical and biomedical applications due to their biocompatibility, biodegradability, non-toxicity, and economic advantages. However, there is a lack of research on the scale-up and advanced therapeutic delivery of nanofibers.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Pharmacology & Pharmacy
Hossein Omidian, Sumana Dey Chowdhury, Niloofar Babanejad
Summary: Cryogels, versatile biomaterials composed of synthetic and natural materials, have wide applications in tissue engineering, drug delivery, regenerative medicine, and therapeutics. However, optimizing cryogel properties remains challenging, and researchers are exploring advanced manufacturing techniques and addressing long-term stability. Combination therapies and drug delivery systems using cryogels show promise, but in vivo evaluation and clinical trials are crucial for determining safety and efficacy. Overcoming practical challenges such as scalability, structural integrity, mass transfer constraints, biocompatibility, seamless integration, and cost-effectiveness is essential for the successful application of cryogels in biomedical fields.
Review
Materials Science, Multidisciplinary
Yuanfeng Li, Junjie Chi, Xing Dong, Anh-Tuan Le, Keqing Shi, Yong Liu, Jian Xiao
Summary: G-quadruplex hydrogel is a self-assembled supramolecular hydrogel formed by guanine derivatives, which shows wide biomedical applications such as drug delivery, tissue engineering, and biosensing. Its advantages include biocompatibility, tunable multifunctionality, and cost-effective fabrication process. This review focuses on the fabrication and characterization of G-quadruplex hydrogels, as well as their applications in the biomedical area, aiming to promote the development of this field.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Biophysics
Ismail Es, Antonio A. Malfatti-Gasperini, Lucimara Gaziola de la Torre
Summary: Our study investigated the manufacturing of lipid-based nanotherapeutics with stealth properties for siRNA delivery. The results showed that lipid nanocarriers had a bigger particle diameter and surface charge compared to lipoplexes. The inclusion of PEG-lipid resulted in an increase in the surface charge of lipoplexes, while a significant decrease was observed in the surface charge of lipid nanocarriers. Different structural assemblies were identified for lipoplex and lipid nanocarriers using Synchrotron SAXS.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Food Science & Technology
Kuldeep Dhama, Khan Sharun, Mudasir B. Gugjoo, Ruchi Tiwari, Mahmoud Alagawany, Mohd. Iqbal Yatoo, Pallavi Thakur, Hafiz M. N. Iqbal, Wanpen Chaicumpa, Izabela Michalak, Shaaban S. Elnesr, Mayada R. Farag
Summary: Ocimum basilicum, also known as sweet basil, is a herb with multiple beneficial health effects and medicinal values. It has the potential for treating various ailments and diseases in both humans and animals.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Pharmacology & Pharmacy
Tayyaba Anjum, Nazim Hussain, Hafiz M. N. Iqbal, Artur Jedrzak, Teofil Jesionowski, Muhammad Bilal, Muhammad Bilal
Summary: Anticancer drugs have been produced using heterocyclic compounds, but there is a need for inexpensive and less toxic nanocatalysts for the formation of these compounds. Nanotechnology and nano-medicine provide personalized medicine and new medical technologies. Magnetic nanoparticles have been developed for the manufacturing of heterocyclic compounds for cancer treatment. They can act as diagnostic and therapeutic agents, offering less toxicity and better targeting in therapies such as chemotherapy and thermotherapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Kuldeep Dhama, Firzan Nainu, Andri Frediansyah, Mohd Iqbal Yatoo, Ranjan K. Mohapatra, Sandip Chakraborty, Hao Zhou, Md. Rabiul Islam, Sukamto S. Mamada, Hendrix Indra Kusuma, Ali A. Rabaan, Saad Alhumaid, Abbas Al Mutair, Muhammad Iqhrammullah, Jaffar A. Al-Tawfiq, Mohammed Al Mohaini, Abdulkhaliq J. Alsalman, Hardeep Singh Tuli, Chiranjib Chakraborty, Harapan Harapan
Summary: Newly emerging variants of SARS-CoV-2 continuously pose global public health concerns and can lead to waves of COVID-19 pandemic. These variants can spread quickly across countries, cause severe disease and reduce the efficacy of current vaccines and immunotherapies. The Omicron variant, first identified in South Africa, is currently the only variant of interest. This review provides an overview of SARS-CoV-2 variants, with a focus on the Omicron variant, its lineages, and hybrid variants. The challenges and strategies to counter the Omicron variant amid the ongoing COVID-19 pandemic are also discussed.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Microbiology
Asok Kumar Mariappan, Karikalan Mathesh, Sankar Muthu, Mukesh Bhatt, Megha Sharma, G. Saikumar, Kuldeep Dhama
Summary: This study reports the pathological and molecular identification of Mycobacterium avium causing avian mycobacteriosis in domestic pigeons. Ten adult racing pigeons out of 30 showed severe chronic and debilitating disease followed by death. Clinical signs included chronic emaciation, dullness, ruffled feathers, lameness, and greenish, watery diarrhea. Post-mortem examination revealed multifocal granulomatous lesions in various organs, and PCR analysis confirmed the presence of Mycobacterium avium infection. This is the first detailed report of avian mycobacteriosis in pigeons from India, highlighting the need for strict surveillance to prevent potential zoonotic infections in humans.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2023)
Article
Environmental Sciences
Sobhan Ghanbari, Ali Fatehizadeh, Afshin Ebrahimi, Bijan Bina, Ensiyeh Taheri, Hafiz M. N. Iqbal
Summary: In this study, natural manganese-containing mineral (NMM) was used as a catalyst for heterogeneous catalytic ozonation. The catalytic activity of NMM and H-NMM, which were modified by hydro-thermal aging process, was evaluated for the degradation of 4-chlorophenol (4-CP). The synergistic effect of NMM and H-NMM in the ozonation process showed promising potential for mitigating environmentally related pollutants.
ENVIRONMENTAL RESEARCH
(2023)
Letter
Surgery
Hitesh Chopra, Md. Aminul Islam, Deepak Chandran, Talha B. Emran, Nahed A. El-Shall, Jaffar A. Al-Tawfiq, Kuldeep Dhama
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Letter
Surgery
Sumira Malik, Ishan Pandey, Shristi Kishore, T. Sundarrajan, Shachindra L. Nargund, Arbinda Ghosh, Talha Bin Emran, Wanpen Chaicumpa, Kuldeep Dhama
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Letter
Orthopedics
Ranjit Sah, Aroop Mohanty, Ranjana Rohilla, Bijaya Kumar Padhi, Nahed A. El-Shall, Deepak Chandran, Talha Bin Emran, Wanpen Chaicumpa, Kuldeep Dhama
INTERNATIONAL JOURNAL OF SURGERY OPEN
(2023)
Letter
Infectious Diseases
Ranjan K. Mohapatra, Snehasish Mishra, Kuldeep Dhama, Lawrence Sena Tuglo, Ranjit Sah
NEW MICROBES AND NEW INFECTIONS
(2023)
Review
Pharmacology & Pharmacy
Shin Jie Yong, Alice Halim, Michael Halim, Long Chiau Ming, Khang Wen Goh, Mubarak Alfaresi, Bashayer M. M. AlShehail, Mona A. A. Al Fares, Mohammed Alissa, Tarek Sulaiman, Zainab Alsalem, Ameen S. S. Alwashmi, Faryal Khamis, Nawal A. A. Al Kaabi, Hawra Albayat, Ahmed Alsheheri, Mohammed Garout, Jameela Alsalman, Amal H. H. Alfaraj, Mashael Alhajri, Kuldeep Dhama, Lamees M. M. Alburaiky, Ahlam H. H. Alsanad, Abdelmunim T. T. AlShurbaji, Ali A. A. Rabaan
Summary: It has been more than three years since the emergence of COVID-19, but treatment for long-COVID, a post-COVID-19 syndrome, is still lacking. The lack of funding for post-acute infection syndromes has resulted in the absence of standardized treatment for long-COVID. However, there has been a renewed interest in long-COVID research, with significant funding allocated for the purpose of finding an effective treatment.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)
Review
Agriculture, Dairy & Animal Science
Mahmoud Alagawany, Shaaban S. Elnesr, Ahmed A. Saleh, Nahed Ahmed El-Shall, Mahmoud M. Azzam, Kuldeep Dhama, Mayada R. Farag
Summary: Azolla pinnata, a widely distributed aquatic fern, can be used as a protein source in bird and animal feed. It has various pharmacological properties and can serve as an antioxidant, immunological booster, hepatoprotector, as well as a phytoremediator and bioremediator. Feeding azolla-based diets improves performance and egg production in laying ducks.
WORLDS POULTRY SCIENCE JOURNAL
(2023)
Article
Public, Environmental & Occupational Health
Chiranjib Chakraborty, Manojit Bhattacharya, Abinit Saha, Abdulrahman Alshammari, Metab Alharbi, G. Saikumar, Soumen Pal, Kuldeep Dhama, Sang -Soo Lee
Summary: This study reports the structural and molecular interaction landscape of the favipiravir-SARS-CoV-2 RdRp complex, providing insights into its antiviral mechanism and the design of more potent antiviral drugs. This research has significant implications for future epidemics and pandemics.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Letter
Infectious Diseases
Sandip Chakraborty, Ranjan K. Mohapatra, Deepak Chandran, Hitesh Chopra, Snehasish Mishra, Lawrence Sena Tuglo, Chiranjib Chakraborty, Kuldeep Dhama
NEW MICROBES AND NEW INFECTIONS
(2023)
Letter
Medicine, General & Internal
Hitesh Chopra, Muhammad S. Khan, Simona Cavalu, Pradipta R. Rauta, Kuldeep Dhama, Talha B. Emran
ANNALS OF MEDICINE AND SURGERY
(2023)
Letter
Medicine, General & Internal
Talha B. B. Emran, Hitesh Chopra, Kuldeep Dhama
ANNALS OF MEDICINE AND SURGERY
(2023)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)