Article
Immunology
Qi Tian, Yujia Guo, Shi Feng, Chengli Liu, Peibang He, Jianfeng Wang, Wenrui Han, Chen Yang, Zhan Zhang, Mingchang Li
Summary: CCR2 expression is upregulated in both mouse models and clinical patients with subarachnoid hemorrhage. Inhibition of CCR2 can alleviate neuroinflammation and neuronal apoptosis. CCR2 levels in cerebrospinal fluid are associated with a 6-month prognosis in patients.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Immunology
Heba A. Farid, Rabab H. Sayed, Marwa El-Sayed El-Shamarka, Omar M. E. Abdel-Salam, Nesrine S. El Sayed
Summary: The study aimed to investigate the neuroprotective role of roflumilast in a rotenone-induced rat model of Parkinson's disease. The results showed that roflumilast improved motor activity and coordination, preserved dopaminergic neurons in the striatum, and activated the PI3K/AKT pathway through the stimulation of multiple signaling cascades. These findings indicate that PDE4 inhibition may be a promising therapeutic approach for Parkinson's disease by activating the PI3K/AKT signaling pathway.
INFLAMMOPHARMACOLOGY
(2023)
Article
Immunology
Zhao Fang, Yushanjiang Feierkaiti, Guangji Wang, Xiaoxin Zheng, Xuejun Jiang
Summary: This study aimed to investigate the protective effect of germacrone against cardiac remodeling. The results showed that germacrone could attenuate oxidative stress, inflammation, and apoptosis induced by cardiac remodeling by inhibiting the PI3K/AKT pathway, thus representing a promising therapeutic approach for the treatment of cardiac remodeling.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Yi Han, Shujia Guo, Yunpeng Li, Jiani Li, Linfangzi Zhu, Yuwen Liu, Yufei Lv, Dong Yu, Lan Zheng, Caihong Huang, Cheng Li, Jiaoyue Hu, Zuguo Liu
Summary: The study findings suggest that berberine (BBR) has potential therapeutic effects for dry eye disease (DED), as it can rescue impaired corneal epithelium cells, ameliorate dry eye symptoms, suppress inflammation, protect the ocular surface, and inhibit specific pathways.
Article
Multidisciplinary Sciences
Feng Zhou, Zhenzhi Wang, Kang Xiong, Meiling Zhang, Yuan Wang, Maode Wang
Summary: Subarachnoid hemorrhage can lead to a series of pathological reactions, and traditional Chinese medicine like Alantolactone can be effective in treating brain damage.
Article
Chemistry, Multidisciplinary
Hucheng Ma, Haozhen Ren, Jun Wang, Xianwen Yuan, Xinyu Wu, Xiaolei Shi
Summary: Glabridin can significantly alleviate oxidative stress, inflammation, and apoptosis induced by APAP, exerting a protective effect by activating the PI3K/Akt/Nrf2/HO-1 pathway.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Jianpeng Chen, Zhikai Jiang, Xuao Liu, Kaitao Wang, Weijian Fan, Tingxiang Chen, Zhijie Li, Dingsheng Lin
Summary: The study found that berberine can improve the survival rate of random skin flaps by promoting angiogenesis, inhibiting inflammation, attenuating oxidative stress, and reducing apoptosis.
PHYTOTHERAPY RESEARCH
(2023)
Article
Oncology
Na Li, Fan Yang, Dong-Yan Liu, Jin-Tao Guo, Nan Ge, Si-Yu Sun
Summary: Scoparone inhibits the proliferation, migration, and invasion of pancreatic cancer cells, induces cell cycle arrest and apoptosis, and acts through the PI3K/Akt signaling pathway, both in vitro and in vivo.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Feng Zhou, Zhenzhi Wang, Kang Xiong, Meiling Zhang, Yuan Wang, Maode Wang
Summary: Subarachnoid hemorrhage (SAH) is a common disease that can cause pathological, physiological, and biological reactions. Traditional Chinese medicine, like Alantolactone (ATL), has been found to have anti-inflammatory effects. This study observed the effects of ATL treatment on SAH, and found that it attenuated neurologic deficits, inhibited neuronal apoptosis and inflammation, promoted M2 polarization of microglia, and activated the PI3K/Akt signaling pathway.
Article
Biology
Xuekang Pan, Huajian Shan, Jinyu Bai, Tian Gao, Bao Chen, Zhonghai Shen, Haibin Zhou, Huigen Lu, Lei Sheng, Xiaozhong Zhou
Summary: The cell-permeable itaconate derivative 4-octyl itaconate (OI) attenuates chondrocyte apoptosis and ameliorates cartilage degradation and autophagy inhibition induced by IL-1 beta through the PI3K/AKT/mTOR pathway. OI improves autophagy and reduces inflammation in rat models of osteoarthritis.
COMMUNICATIONS BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maricedes Acosta-Martinez, Maria Zulema Cabail
Summary: Obesity is a global epidemic and a major risk factor for cardiovascular disease, stroke, and mortality. Meta-inflammation, characterized by immune cell accumulation, dysregulation of adipokine synthesis, and increased production of proinflammatory factors, is believed to contribute to obesity's negative health consequences. The crosstalk between macrophages and adipocytes and the impairment of the PI3K/Akt signaling pathway play crucial roles in the development of meta-inflammation and insulin resistance associated with obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Zhuo Feng, Changyuan Wang, Jin Yue, Qiang Meng, Jingjing Wu, Huijun Sun
Summary: Kaempferol can attenuate the development of atherosclerosis by activating the GPER pathway, thus protecting vascular health.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fei Li, Jingyao Li, Pei-Hui Wang, Nanyan Yang, Junyu Huang, Jinxin Ou, Ting Xu, Xin Zhao, Taoshu Liu, Xueying Huang, Qinghuan Wang, Miao Li, Le Yang, Yunchen Lin, Ying Cai, Haisheng Chen, Qing Zhang
Summary: The study found that SARS-CoV-2 infection induces autophagy and apoptosis in cells by upregulating intracellular reactive oxygen species (ROS) levels, inhibiting the PI3K/AKT/mTOR pathway, and ultimately triggering inflammatory responses and cell apoptosis. These findings are crucial for understanding the pathogenic inflammation mechanism induced by SARS-CoV-2 infection and developing anti-inflammatory therapies for COVID-19 patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Cell Biology
Yanyu Lu, Qianqian Min, Xiaoyan Zhao, Li Li, Guojun Zhao, Jianzeng Dong
Summary: Eupatilin has various biological activities, including anticancer, anti-inflammatory, antioxidant, neuroprotective, anti-allergic, and cardioprotective effects. This study aimed to investigate the protective effects of eupatilin on doxorubicin-induced cardiotoxicity. The results demonstrated that eupatilin attenuated inflammation, oxidative stress, and cardiomyocyte apoptosis, and improved doxorubicin-induced cardiac dysfunction by activating the PI3K-AKT signaling pathway. This study provides the first evidence for the therapeutic potential of eupatilin in doxorubicin-induced cardiotoxicity.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Kangfeng Jiang, Jing Yang, Chunlian Song, Fengping He, Liangyu Yang, Xiaobing Li
Summary: The down-regulation of miR-92b in endometritis is associated with inflammatory response, while the overexpression of miR-92b can suppress inflammatory injury by activating the PI3K/AKT/β-catenin pathway, reducing pro-inflammatory cytokines release and cell apoptosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)