Review
Environmental Sciences
Wen-Tien Tsai
Summary: This paper surveyed the updated information about the production and environmental distribution of BPA in Taiwan over the past decade, and summarized the regulatory strategies and countermeasures for managing the environmental risks of BPA by the Taiwan government. The findings showed that most monitoring data were below acceptable risks, and recommended some countermeasures to echo international actions.
Article
Environmental Sciences
Jessica R. Shoaff, Jill Hahn, Antonia M. Calafat, Susan A. Korrick
Summary: This study investigated the impact of exposure to endocrine disrupting chemicals (EDCs) in adolescence. It found that antiandrogenic phthalates are associated with a decrease in math computation scores, particularly among adolescents with greater psychosocial stress.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Pengyu Chen, Jing Yang, Ruihan Wang, Bowen Xiao, Qing Liu, Binbin Sun, Xiaolei Wang, Lingyan Zhu
Summary: In this study, the interaction between graphene oxide (GO) and bisphenol A (BPA) in adult zebrafish was investigated. The results showed that GO enhanced the endocrine disruption effects of BPA in adult zebrafish. Metabolomics analysis supported this conclusion, revealing increased disturbance in metabolic pathways when GO and BPA were combined.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Microbiology
Agnieszka Galazka, Urszula Jankiewicz
Summary: Environmental pollution with organic substances is a major global issue, with particular concern about endocrine disrupting compounds (EDCs) that can harm aquatic species. Alkylphenols, commonly used in households, are a significant source of EDCs in water reservoirs and new methods are being sought for their removal. Bioremediation, using enzymes like laccase from white rot fungi, shows great potential for detoxification and degradation of pollutants in natural and industrial waste.
Review
Endocrinology & Metabolism
Filippo Egalini, Lorenzo Marinelli, Mattia Rossi, Giovanna Motta, Nunzia Prencipe, Ruth Rossetto Giaccherino, Loredana Pagano, Silvia Grottoli, Roberta Giordano
Summary: This paper summarizes the current evidence on the detrimental effects of Endocrine Disrupting Chemicals (EDCs) on pivotal endocrine glands such as the pituitary, thyroid, and adrenal glands. The known and hypothesized mechanisms of endocrine dysfunction caused by EDCs are discussed, along with recent findings from pioneering studies that could shed light on the pathophysiology of hormone-producing adenomas and other poorly understood endocrine diseases. Despite the challenges in studying the long-term effects of EDCs on humans, it represents an intriguing new field of scientific research.
Review
Biochemistry & Molecular Biology
Changhwan Ahn, Eui-Bae Jeung
Summary: Endocrine-disrupting chemicals (EDCs) have significant impacts on biological systems, especially by disrupting hormone balance, affecting reproductive, neurological, and metabolic development and function, and even stimulating tumor growth. EDC exposure during development can disrupt normal development patterns and alter susceptibility to disease. Many chemicals, including bisphenol A, organochlorines, polybrominated flame retardants, alkylphenols, and phthalates, have been identified as risk factors for reproductive, neural, metabolic diseases, and cancers. Endocrine disruption has spread to wildlife and species connected to the food chains. Dietary uptake is an important source of EDC exposure. The relationship and specific mechanism between EDCs and diseases remain unclear. This review focuses on the disease-EDC relationship and disease endpoints associated with endocrine disruption to better understand the EDC-disease relationship, and explores the development of new prevention/treatment opportunities and screening methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Karolina Nowak, Ziga Jakopin
Summary: Due to concerns about endocrine disruption, bisphenol A (BPA) is being phased out and replaced with other substances. This study aimed to evaluate the endocrine-disrupting potential of 18 BPA analogues and their halogenated derivatives. The results showed that some BPA analogues displayed higher endocrine disruption potential than BPA itself. Halogenation was predicted to increase the binding affinity of bisphenols for certain nuclear receptors. Further in vitro experiments are needed to confirm these findings and evaluate the safety of BPA substitutes and their halogenated transformation products.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Yu Han, Wei Shi, Yu Tang, Weishang Zhou, Hongxiang Sun, Jiongming Zhang, Maocang Yan, Lihua Hu, Guangxu Liu
Summary: The study investigated the effects of microplastics and bisphenol A on gonadal development in whiteleg shrimp, revealing significant inhibition of gonadal development probably through interfering with metabolism and disrupting endocrine regulation. Co-exposure to both pollutants was more toxic and led to increased accumulation of BPA in shrimp gonads, potentially due to the Trojan horse effect and cumulative toxic impacts.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Pharmacology & Pharmacy
Linus Wiklund, Anna Beronius
Summary: This study aimed to evaluate evidence on the endocrine disrupting properties of Bisphenol F (BPF) by using a systematic review approach. The study found sufficient evidence to conclude on an endocrine mechanism and postulated two modes of action based on the collected data for BPF.
Review
Environmental Sciences
Radia Bousoumah, Veruscka Leso, Ivo Iavicoli, Pasi Huuskonen, Susana Viegas, Simo P. Porras, Tiina Santonen, Nadine Frery, Alain Robert, Sophie Ndaw
Summary: This study found a lack of recent occupational HBM studies on bisphenols, especially on BPS and BPF. Different methodological designs make comparisons between studies difficult. Few studies have been conducted on the industrial applications of bisphenols outside of Asia.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Editorial Material
Biochemistry & Molecular Biology
Ayami Matsushima, Takamasa Teramoto, Yoshimitsu Kakuta
Summary: The human estrogen-related receptor gamma (ERR gamma) is a constitutive activator of transcription and plays a key role in mitochondrial energy production and energy metabolism. Bisphenol A (BPA), known as an endocrine disruptor, strongly binds to ERR gamma. The crystal structure of ERR gamma in complex with BPA reveals the molecular mechanism of BPA recognition, providing important insights for future studies on endocrine disruptors.
JOURNAL OF BIOCHEMISTRY
(2022)
Review
Environmental Sciences
Ricardo Correia da Silva, Mariana Pires Teixeira, Luciana Souza de Paiva, Leandro Miranda-Alves
Summary: TBT is an environmental contaminant with potent biocidal action that can be found on all continents, including Antarctica. Despite being effectively banned in 2003, it still remains in the environment due to its long half-life and misuse. TBT not only has endocrine-disrupting effects but also has immunotoxic effects, which have been observed in both in vitro and in vivo studies. This review summarizes the literature on the impacts of TBT on the immune system and discusses the gaps in knowledge that still need to be explored.
Review
Environmental Sciences
Maria De Falco, Vincenza Laforgia
Summary: Endocrine-disrupting chemicals (EDCs) are widely spread environmental pollutants that continuously affect humans and animals, particularly sensitive organs like the prostate, leading to an increase in prostate disease incidence due to exposure to estrogenic and anti-androgenic compounds.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Laura Escriva, Johanna Zilliacus, Ellen Hessel, Anna Beronius
Summary: This study conducted a case study on BPAF to explore its compliance with ED criteria. Through systematic data collection and evaluation, it was concluded that BPAF has endocrine disrupting effects on human health.
ENVIRONMENTAL HEALTH
(2021)
Review
Obstetrics & Gynecology
Akshaya Chandrakanth, Sana Firdous, Ramasamy Vasantharekha, Winkins Santosh, Barathi Seetharaman
Summary: Endometriosis is a reproductive disorder that affects women during their reproductive years, characterized by the presence of endometrial-like tissue outside the uterus. This comprehensive review examines the correlation between endocrine disruptors, microRNAs, and endometriosis, highlighting the connection between certain chemicals and altered gene expression. The review also emphasizes the importance of specific microRNAs in the onset and progression of endometriosis.
REPRODUCTIVE SCIENCES
(2023)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)