Article
Immunology
Rui-ming Deng, Juan Zhou
Summary: Myocardial ischemia/reperfusion injury (MIRI) is a common and serious condition with no effective clinical treatments. The activation of the PI3K/Akt signaling pathway has been shown to have significant protective effects against MIRI through its involvement in antioxidant, anti-inflammatory, autophagy, mitochondrial function, and apoptosis regulation. This review highlights the molecular regulation of PI3K/Akt in MIRI, the effects of ischemic preconditioning and postconditioning, and the potential therapeutic applications of drugs targeting PI3K/Akt.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Qian Zhang, Yuan-Ye Dang, Xiu Luo, Ji-Jun Fu, Zhi-Cong Zou, Xue-Jing Jia, Guo-Dong Zheng, Chu-Wen Li
Summary: Kazinol B (KB), an isoprenylated flavan derived from Broussonetia kazinoki Sieb. (Moraceae) root, has protective effects on hypoxia and reoxygenation-induced cardiac injury in H9c2 rat cardiac myoblasts, and its mechanism involves modulating the AKT and AMPK-mediated Nrf2 induction.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Li-Li Zhu, Gui-Yun Cao, Li-Ying Jia, Guo Zheng, Liang Zhang, Ping Sheng, Zhao-Qing Meng, Xin He, Chun-Feng Zhang, Chong-Zhi Wang, Chun-Su Yuan
Summary: This study investigated the cardioprotective effect of Muscone on AMI rats and found that Muscone significantly reduced myocardial injury, improved cardiac function, and exerted protective effects by inhibiting oxidative stress and apoptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Toxicology
Karolina Kowalska, Marta Justyna Koziel, Dominika Ewa Habrowska-Gorczynska, Kinga Anna Urbanek, Kamila Dominska, Agnieszka Wanda Piastowska-Ciesielska
Summary: The PI3K/Akt signaling pathway is one of the most deregulated pathways in prostate cancer, and DON can affect apoptosis and autophagy in normal prostate epithelial cells by modulating this pathway. High concentrations of DON induce apoptosis, while low concentrations induce autophagy.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wenbin Luo, Yu Tao, Shengnan Chen, Hao Luo, Xiaoping Li, Shuang Qu, Ken Chen, Chunyu Zeng
Summary: This study found that rosmarinic acid (RA) can effectively protect against pulmonary ischemia/reperfusion (IR) injury by activating the PI3K/Akt signaling pathway for antioxidation and anti-apoptosis, suggesting its potential therapeutic value.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Yiming Zhang, Zhaoyi Liu, Jing Lan, Jinliang Wang, Zhiqiang Shen, Guangliang Shi, Shu Li
Summary: Cadmium accumulation in pigs can induce apoptosis in thymus cells and activate oxidative stress pathways, leading to oxidative damage to immune tissues. Additionally, exposure to cadmium can affect antioxidant indices and alter the levels of related genes in the PTEN/PI3K/AKT pathway, ultimately impacting cell survival.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jun Bai, Jun Li, Ning Liu, Hai Jia, Xuemeng Si, Yusong Zhou, Zhian Zhai, Ying Yang, Fazheng Ren, Zhenlong Wu
Summary: This study found that glucosamine can protect porcine trophectoderm (pTr) cells from apoptosis and oxidative damage induced by zearalenone. Further research suggests that glucosamine exerts its protective effect by activating the PI3K/AKT signaling pathway. These findings provide a theoretical basis for the application of glucosamine in alleviating impaired early embryo development.
Article
Pharmacology & Pharmacy
Xueyu Han, Xin Liu, Xin Zhao, Xiukun Wang, Yazhou Sun, Chua Qu, Jinjun Liang, Bo Yang
Summary: Dapagliflozin protects against sepsis-induced cardiac injury by reducing inflammation, apoptosis, and ventricular electrical remodeling, potentially through the activation of the PI3K/Akt pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Food Science & Technology
Linlin Qu, Rongzhan Fu, Xiaoxuan Ma, Daidi Fan
Summary: The study demonstrated that protopanaxatriol-type saponin (PTS) effectively protected against acetaminophen (APAP)-induced liver injury by reducing inflammation, oxidative stress, and hepatic apoptosis, and reversing histological changes. Additionally, PTS showed potential as a novel therapeutic agent for APAP-induced liver injury through the ROS-mediated JNK pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Rehab E. Abdelrahman, Abdel Azeim A. Khalaf, Mohamed A. Elhady, Marwa A. Ibrahim, Eman Hassanen, Peter A. Noshy
Summary: The study showed that OTA exposure in broiler chickens resulted in suppressed immune responses, oxidative stress, and apoptotic effects in various organs, while QUE administration alleviated these immunotoxic effects by modulating the immune system, reducing oxidative stress, and inhibiting apoptosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Chemistry, Medicinal
Jianpeng Chen, Zhikai Jiang, Xuao Liu, Kaitao Wang, Weijian Fan, Tingxiang Chen, Zhijie Li, Dingsheng Lin
Summary: The study found that berberine can improve the survival rate of random skin flaps by promoting angiogenesis, inhibiting inflammation, attenuating oxidative stress, and reducing apoptosis.
PHYTOTHERAPY RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Xiaoya Li, Jiaxin Duan, Shiyou Wang, Jianyong Cheng, Huali Chen, Zelin Zhang, Li Yang, Rongmao Hua, Qingwang Li
Summary: This study found that isorhamnetin can protect oocytes from damage caused by ZEA through the PI3K/Akt signaling pathway, improving developmental capability and inhibiting early apoptosis, oxidative stress, and endoplasmic reticulum stress.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jiang Wei, Jian Cui
Summary: Myocardial infarction is a fatal disease with millions of deaths worldwide every year. The study identified miR-1322 as a significantly differentially expressed miRNA in myocardial ischemia. YY1 was identified as the transcription factor of miR-1322, and LRP8 was found to be the target gene of miR-1322. LRP8 regulates the PI3K/AKT/P70 S6K signaling pathway, leading to cell apoptosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Xuankuai Chen, Kejian Fu, Yingying Lai, Chengji Dong, Zhuliu Chen, Yingying Huang, Guangyao Li, Renhao Jiang, Hongqiang Wu, Anyuan Wang, Shaojie Huang, Liyan Shen, Weiyang Gao, Shi Li
Summary: Tetrahydropalmatine (THP) from celandine can enhance flap survival by modulating autophagy, reducing tissue edema, promoting angiogenesis, and mitigating apoptosis and oxidative stress. THP offers a potential strategy for enhancing multiregional perforator flap survival through the PI3K/AKT/mTOR pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Agriculture, Dairy & Animal Science
Xiaoya Li, Huali Chen, Zelin Zhang, Jiaxin Duan, Rongmao Hua, Xiaodi Li, Li Yang, Jianyong Cheng, Qingwang Li
Summary: This study investigated the therapeutic effect of isorhamnetin on ZEA-induced damage in porcine ovarian granulosa cells and elucidated its molecular mechanism. The results showed that isorhamnetin protected ovarian granulosa cells from ZEA-induced damage, promoting proliferation and alleviating apoptosis, endoplasmic reticulum stress, oxidative stress, and steroidogenesis disorder.
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)